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Medical Forum / General / General / February 2005Mode of action of Clonazepam
Hello everyone, Dr. Cheney, one of the world's most reknown researchers and physicians for Chronic Fatigue Syndrome (CFS), recommends his patients to take Clonazepam. See e.g. here: http://www.cfsresearch.org/cfs/cheney/33nf.htm . He thinks that it protects the patients' brains against what he calls "excitatory neurotoxicity". I would be very grateful if one or some of you could take the time to have a look the above-named page and provide an expert's view. The reason for my interest: As a patient with CFS, I've been taking Clonazepam for several years because of this recommendation, and because I think that it improves my quality of sleep. However, I'm not sure about the sleep effect (I'd have to withdraw from the medication and try it again to verify the effect). And I have a bit of an unpleasant feeling taking Clonazepam because every doctor I go to is quite aghast that I'm taking it! How strong do you think are the scientific grounds for Cheney's opinion? Does it seem plausibel to you? Thanks in advance for all comments! Kind regards Holger Long and winded explanation for a problem with iron levels in the brain .. The drug in question is an iron binder .. It works by disallowing the oxidation of the iron ... Epilepsy Res 2001 Jan;43(1):59-66 Effects of antiepileptic drugs on rat platelet aggregation: ex vivo and in vitro study. Rajtar G, Zolkowska D, Czechowska G, Kleinrok Z Department of Pharmacology and Toxicology, Medical University, Jaczewskiego 8, PL 20-090, Lublin, Poland. The influence of conventional antiepileptic drugs (valproate, phenobarbital, diazepam, clonazepam, carbamazepine and diphenylhydantoin) on rat platelet activation induced by arachidonic acid (AA) or adenosine-5'-diphosphate (ADP) was investigated both ex vivo and in vitro on platelet-rich plasma (PRP). It was found that only diazepam, and to a smaller extent clonazepam, impaired rat platelet function. These benzodiazepines did not affect ex vivo platelet aggregation induced by ADP but dose-dependent inhibition of platelet aggregation and malondialdehyde (MDA) synthesis were observed, when the platelets were stimulated with AA (ED(50) of diazepam for aggregation was 2.7 mg/kg and that for MDA synthesis - 3.9 mg/kg). In in vitro study, diazepam was found to be a potent inhibitor of AA-induced platelet aggregation (IC(50) 1.2 microg/ml) and MDA synthesis (IC(50) 4.0 microg/ml). Higher concentrations of diazepam were required to inhibit ADP-induced aggregation (IC(50) 29.0 microg/ml). Clonazepam also exhibited a concentration-dependent inhibitory effect on AA-induced platelet aggregation and MDA synthesis but this effect was weaker when compared to diazepam. The present data demonstrate that diazepam possesed a strong inhibitory effect on rat platelet activation. The correlation between the reduction of platelet aggregation and the synthesis of MDA may suggest that the observed effect of diazepam is due to the inhibition of the cyclooxygenase pathway of the AA metabolism in platelet. PMID: 11137387, UI: 20578853 ----------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking |
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