>Rev Esp Enferm Dig. 2004 Dec;96(12):818-828. Related Articles, Links
>
>Iron overload and genotype 3 are associated with liver steatosis in
>chronic hepatitis C.
>
>[Article in English, Spanish]
>
>Fernandez Salazar L, Alvarez Gago L, Aller de la Fuente R, Orduna
>Domingo A, Arranz Santos T, de la Calle Valverde F, Del Olmo Martin L,
>de Luis Roman D, Gonzalez Hernandez J.
>
>Servicio de Aparato Digestivo. Hospital Clinico Universitario.
>Valladolid, Spain.
>
>Objective: to determine epidemiological, biochemical, virological, and
>histological factors associated with liver steatosis in chronic
>hepatitis C. Subjects: the medical histories of 53 patients biopsied
>for chronic hepatitis C diagnosis between June 2000 and December 2002
>were retrospectively studied. Epidemiological, biochemical, and
>virological data were collected. Patients with hepatitis B virus or
>human immunodeficiency virus coinfection were excluded. Liver biopsy
>specimens were reviewed and scored by one pathologist. Weight and
>height were measured at liver biopsy time. The statistic association
>between qualitative and quantitative variables and the presence of
>liver steatosis was studied. Results: steatosis was identified in 52%
>of biopsies. There was no statistic association with age, sex, method
>of transmission, duration of infection, alcohol consumption, other
>diseases, body mass index, glucose, triglycerides, cholesterol, AST,
>ALT, GGT, alkaline phosphatase, bilirubin, or viral load. Liver
>steatosis was associated with serum iron, transferrin saturation, and
>ferritin. Genotype 3 was also associated with steatosis. Piecemeal
>necrosis, hepatocellular injury, Kupffer cell hyperplasia, liver iron,
>and portal fibrosis were also associated with steatosis. A multivariate
>analysis showed that genotype 3, Kupffer cell hyperplasia, and liver
>iron were associated with the presence of steatosis. Conclusions: liver
>steatosis in chronic hepatitis C associates with genotype 3, Kupffer
>cell hyperplasia, and iron overload. Hepatic steatosis also associates
>with greater inflammation and fibrosis, and must be considered to
>contribute to disease progression.
>
>PMID: 15634182 [PubMed - as supplied by publisher]
>
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