<<snip>>
PTX-vitamin E boosted by clodronate is an effective treatment that
induces mucosal and bone healing in a median period of 6 months
<<snip>>

Head Neck. 2005 Jan 7; [Epub ahead of print] Related Articles, Links

Major healing of refractory mandible osteoradionecrosis after treatment
combining pentoxifylline and tocopherol: A phase II trial.

Delanian S, Depondt J, Lefaix JL.

Service Oncologie-Radiotherapie, 1, ave Claude Vellefaux, 75010 Paris,
France.

BACKGROUND.: Osteoradionecrosis (ORN) is a nonhealing wound of the bone
that is difficult to manage. Is a treatment combining pentoxifylline
(PTX) and tocopherol (vitamin E) boosted by clodronate effective in
reversing this fibronecrotic process? METHODS.: Eighteen consecutive
patients previously irradiated for head and neck cancer had
exteriorized mandible ORN. Length of exposed bone (L) was 13.4 +/- 8
mm, and the mean subjective objective medical management and analytic
evaluation of injury (SOMA) score was 12.6 +/- 4.9. Between June 1995
and January 2002, all 18 were given a daily oral combination of 800 mg
of PTX and 1000 IU of vitamin E for 6 to 24 months. In addition, the
last eight patients who were the worst cases were given 1600 mg/day
clodronate 5 days a week. RESULTS.: The treatment was well tolerated.
All patients improved at 6 months, with 84% mean L and 67% mean SOMA
score reductions. Sixteen (89%) of 18 patients achieved complete
recovery, 14 in 5 +/- 2.6 months. The remaining two patients exhibited
a 75% response at 6 months. CONCLUSION.: PTX-vitamin E boosted by
clodronate is an effective treatment of mandibular ORN that induces
mucosal and bone healing in a median period of 6 months. (c) 2005 Wiley
Periodicals, Inc. Head Neck 27: XXX-XXX, 2005.

PMID: 15641107 [PubMed - as supplied by publisher]

--------------------------------------------------------------------------------
Who loves ya.
Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking