 |
 | Home | Contact Us | FAQ | Search & Site Map | Link to Us |
 | Sign In | Join | Other 45 Sites in Network |
Medical Forum / General / General / January 2005Re: Forensics / liver iron / African Americans
Intresting, but it best to recall that the iron causes all disease and it comes from eating meat thesis has been discredited in detail and in whole so beating a dead horse puts no iron in it's backbone. Even more intresting is that the facts by which it was discredited was provided by none other then our iron obsessed frieend in the mistaken assumption that it supported the thesis but which fell apart before his very eyes. But like the flat earthers, he continues to do a salvage jobon that which he destroyed in the first place. ><<snip>> >heavy liver iron staining is relatively common in African Americans. ><<snip>> > >BMC Clin Pathol. 2005 Jan 10;5(1):2 [Epub ahead of print] Links > >Stainable hepatic iron in 341 African American adults at >coroner/medical examiner autopsy. > >Barton JC, Acton RT, Richardson AK, Brissie RM. > >BACKGROUND: Results of previous autopsy studies indicate that increased >hepatic iron stores or hepatic iron overload is common in African >Americans dying in hospitals, but there are no reports of hepatic iron >content in other cohorts of African Americans. METHODS: We investigated >the prevalence of heavy liver iron deposition in African American >adults. Using established histochemical criteria, we graded Perls' acid >ferrocyanide-reactive iron in the hepatocytes and Kupffer cells of 341 >consecutive African American adults who were autopsied in the >coroner/medical examiner office. Heavy staining was defined as grade 3 >or 4 hepatocyte iron or grade 3 Kupffer cell iron. RESULTS: There were >254 men and 85 women (mean age +/- 1 SD: 44 +/- 13 y vs. 48 +/- 14 y, >respectively; p = 0.0255); gender was unstated or unknown in two >subjects. Approximately one-third of subjects died of natural causes. >Heavy staining was observed in 10.2% of men and 4.7% of women. 23 >subjects had heavy hepatocyte staining only, six had heavy Kupffer cell >staining only, and one had a mixed pattern of heavy staining. 15 >subjects had histories of chronic alcoholism; three had heavy staining >confined to hepatocytes. We analyzed the relationships of three >continuous variables (age at death in years, hepatocyte iron grade, >Kupffer cell iron grade) and two categorical variables (sex, cause of >death (natural and non-natural causes)) in all 341 subjects using a >correlation matrix with Bonferroni correction. This revealed two >positive correlations: hepatocyte with Kupffer cell iron grades (p ><0.01), and male sex with hepatocyte iron grade (p <0.05). We also >analyzed the relationship of steatosis, inflammation, and >fibrosis/cirrhosis in 30 subjects with heavy iron staining using a >correlation matrix with Bonferroni correction. There were significant >positive correlations of steatosis with inflammation (r = 0.5641; p ><0.01), and of inflammation with fibrosis/cirrhosis (r = 0.6124; p ><0.01). CONCLUSIONS: The present results confirm and extend previous >observations that heavy liver iron staining is relatively common in >African Americans. The pertinence of these observations to genetic and >acquired causes of iron overload in African Americans is discussed. > >PMID: 15642113 [PubMed - as supplied by publisher] > >------------------------------------------------------------------------------- >- > >Who loves ya. >Tom > >Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com >Man Is A Herbivore! >http://pages.ivillage.com/ironjustice/manisaherbivore >DEAD PEOPLE WALKING >http://pages.ivillage.com/ironjustice/deadpeoplewalking How IS .. your .. hyperferritinemia .. there .. big .. guy .. Do you KNOW what .. hyperferritinemia .. means .. Maybe I should spell it .. for .. you .. ? h-y-p-e-r-f-e-r-r-i-t-i-n-e-m-i-a What will you do when your last and only finger gives out there .. boi .. ? <<snip>> A TfSat of 25% appeared as a threshold value <<snip>> Haematologica. 2005 Jan;90(1):31-7. Related Articles, Links The soluble transferrin receptor as a marker of iron homeostasis in normal subjects and in HFE-related hemochromatosis. Brandao M, Oliveira JC, Bravo F, Reis J, Garrido I, Porto G. CBAS, Abel Salazar Institute for the Biomedical Sciences, Porto, Portugal. BACKGROUND AND OBJECTIVES: The soluble transferrin receptor (sTfR) is a clinical marker of erythropoietic activity, also used in the diagnosis of iron deficiency. In the present paper we explore the meaning of this parameter in normal physiological conditions of iron homeostasis and in the setting of iron overload due to hereditary hemochromatosis (HH). DESIGN AND METHODS: Reference values for sTfR were established in a population of 42 apparently healthy subjects, analyzed in relation to other hematologic parameters, namely, hemoglobin (Hb), mean corpuscular volume (MCV), transferrin saturation (TfSat) and serum ferritin. The same analysis was done in a group of 45 patients with HH who were homozygous for the C282Y mutation of HFE and had a wide range of TfSat values. In addition, individual serial profiles were analyzed in three patients. RESULTS: In normal subjects circulating sTfR correlated significantly with the TfSat level, reflecting the systemic effect of iron availability on the erythropoietic activity in a normal physiological steady state. A TfSat of 25% appeared as a threshold value, below which there was a progressive increase in sTfR; this increase in sTfR occurred concomitantly with a decrease in Hb, MCV and serum ferritin. In HH patients the up-regulation of sTfR started at TfSat values as high as 50%. INTERPRETATION AND CONCLUSIONS: The fact that sTfR up-regulation started at higher TfSat values in HH patients suggests that the recognition of systemic iron available for erythropoiesis is altered in this condition. Based on these results, a new hypothesis is advanced, proposing that the HFE protein in involved as a sensor of systemic iron availability, via the soluble transferrin receptor. PMID: 15642666 [PubMed - in process] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking Oh, there is some cause for concern here, low iron causes mental confusion. The subject line and the thread to which you replied are different, are we a bit confused. "How IS .. your .. hyperferritinemia .. there .. big .. guy .. Do you KNOW what .. hyperferritinemia .. means .. Maybe I should spell it .. for .. you .. ?" No thanks, you just did, twice, more confusion, concern increases. I looked it up, has nothing to do with: "What will you do when your last and only finger gives out there .. boi" It has nothing to do with fingers but with lens of the eye. All manner of mental confusion in evidence here, time to hit the jeritol I say, they do still sell it up there don't they? But one can understand how the mind might spin after knowing one's thesis was destroyed by the very information presented in support of it. |
Reply to this Message |
 Sign In
 Join
 My Latest Posts My Monitored Threads My Blog My Photo Gallery My Profile My Homepage Start New Thread Enable EMail Alerts Rate this Thread
|
©2008 Advenet LLC Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.