Statin Adverse Effects FAQ: RHABDOMYOLYSIS AND STATINS

(The Cholesterol-lowering Statin Drug Names: Lipitor, Crestor, Mevacor,
Pravachol, Zocor, Lescol, and Baycol, aka atorvastatin, rosuvastatin,
cerivastatin, fluvastatin, lovastatin, pravastatin, and simvastatin; This
class of drugs is also known as HMG-CoA Reductase Inhibitors, short for
3-Hydroxy-3-Methyl-Glutaryl Coenzyme A Reductase. )

To my physician,

I believe that my symptoms may be due to the adverse effects a_ssociated
with cholesterol-lowering statin drugs.  I need your help to understand the
cause of my symptoms, treatment options, and the prognosis for my recovery.

Please review the references below, published medical studies that show
similar problems a_ssociated with statin drugs.  These are made available
via the National Institutes of Health (NIH,
http://www.ncbi.nlm.nih.gov/Entrez/) library of biomedical journal citations
and other major repositories of medical research.

Also, I am respectfully requesting that you file an adverse effects report
with the FDA (http://www.fda.gov/medwatch/how.htm), and that you please send
a copy of the report to the to the NIH-funded Statin Study, attention: Dr.
Beatrice Golomb, Principal Investigator.
Statin Study website: http://medicine.ucsd.edu/statin/
Statin Study contact info: http://medicine.ucsd.edu/statin/contactinfo.html
UCSD STATIN STUDY E-MAIL ADDRESS: statinstudy@ucsd.edu
MAILING ADDRESS: UCSD Statin Study 9500 Gilman Dr. La Jolla, CA 92093-0995
PHONE NUMBER: (858) 558-4950

In Canada:

Health Canada:
http://www.hc-sc.gc.ca/hpfb-dgpsa/tpd-dpt/index_adverse_report_e.html

PharmaWatch:
http://www.pharmawatch.net/

Thank you

RHABDOMYOLYSIS AND STATINS

References (updated as of  January 7, 2005):

FDA adverse event reports on statin-a_ssociated rhabdomyolysis.

Omar MA, Wilson JP.
Ann Pharmacother. 2002 Feb;36(2):288-95. Review.
PMID: 11847951

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1
1847951&dopt=Abstract

Of 871 reports detailing 601 cases in a 29 month time frame, the list of
statin, number of cases, and percentage of the whole follows:

simvastatin, 215 (35.8%);

cerivastatin, 192 (31.9%);

atorvastatin, 73 (12.2%);

pravastatin, 71 (11.8%);

lovastatin, 40 (6.7%);

fluvastatin, 10 (1.7%)

As of August, 2001, there were at least 81rhabdomyolysis deaths a_ssociated
with Non-Baycol statins.
http://www.essentialdrugs.org/edrug/archive/200108/msg00064.php

The Public Citizen petition to the FDA, August 20,2001:

http://www.citizen.org/publications/release.cfm?ID=7051

At that time the count of deaths by statin-induced rhabdomyolysis:

     Outcome
    Number of Cases
    Percent of  Total Deaths

     Deaths

     Atorvastatin
    13
    18.1%

     Cerivastatin
    20
    27.8%

     Fluvastatin
    1
    1.4%

     Lovastatin
    5
    6.9%

     Pravastatin
    9
    12.5%

     Simvastatin
    24
    33.3%

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