Statin Adverse Effects FAQ: MYOPATHY AND STATINS

(The Cholesterol-lowering Statin Drug Names: Lipitor, Crestor, Mevacor,
Pravachol, Zocor, Lescol, and Baycol, aka atorvastatin, rosuvastatin,
cerivastatin, fluvastatin, lovastatin, pravastatin, and simvastatin; This
class of drugs is also known as HMG-CoA Reductase Inhibitors, short for
3-Hydroxy-3-Methyl-Glutaryl Coenzyme A Reductase. )

To my physician,

I believe that my symptoms may be due to the adverse effects a_ssociated
with cholesterol-lowering statin drugs.  I need your help to understand the
cause of my symptoms, treatment options, and the prognosis for my recovery.

Please review the references below, published medical studies that show
similar problems a_ssociated with statin drugs.  These are made available
via the National Institutes of Health (NIH,
http://www.ncbi.nlm.nih.gov/Entrez/) library of biomedical journal citations
and other major repositories of medical research.

Also, I am respectfully requesting that you file an adverse effects report
with the FDA (http://www.fda.gov/medwatch/how.htm), and that you please send
a copy of the report to the to the NIH-funded Statin Study, attention: Dr.
Beatrice Golomb, Principal Investigator.
Statin Study website: http://medicine.ucsd.edu/statin/
Statin Study contact info: http://medicine.ucsd.edu/statin/contactinfo.html
UCSD STATIN STUDY E-MAIL ADDRESS: statinstudy@ucsd.edu
MAILING ADDRESS: UCSD Statin Study 9500 Gilman Dr. La Jolla, CA 92093-0995
PHONE NUMBER: (858) 558-4950

Thank you

MYOPATHY AND STATINS

References (updated as of  January 7, 2005):

 1:  Phillips PS.  Ezetimibe and statin-a_ssociated myopathy.Ann Intern
Med. 2004 Oct 19;141(8):649. No abstract available. PMID: 15492351 [PubMed -
indexed for MEDLINE] 2:  Phillips PS, Phillips CT, Sullivan MJ, Naviaux RK,
Haas RH.  Statin myotoxicity is a_ssociated with changes in the
cardiopulmonary function.Atherosclerosis. 2004 Nov;177(1):183-8. PMID:
15488882 [PubMed - in process] 3:  Phillips PS, Haas RH, Bannykh S, Hathaway
S, Gray NL, Kimura BJ, VladutiuGD, England JD; Scripps Mercy Clinical
Research Center.  Statin-a_ssociated myopathy with normal creatine kinase
levels.Ann Intern Med. 2002 Oct 1;137(7):581-5. PMID: 12353945 [PubMed -
indexed for MEDLINE]

And more:

Search terms "STATIN + MYOPATHY":

1:  Koller H, Neuhaus O, Schroeter M, Hartung HP.  [Myopathies under therapy
with lipid-lowering agents.]Nervenarzt. 2004 Dec 18; [Epub ahead of print]
German. PMID: 15609055 [PubMed - as supplied by publisher] 2:  [No authors
listed]  A warning about one statin at a high dose.Heart Advis. 2004
Nov;7(11):2. No abstract available. PMID: 15580669 [PubMed - indexed for
MEDLINE] 3:  Graham DJ, Staffa JA, Shatin D, Andrade SE, Schech SD, La
Grenade L, GurwitzJH, Chan KA, Goodman MJ, Platt R.  Incidence of
hospitalized rhabdomyolysis in patients treated withlipid-lowering
drugs.JAMA. 2004 Dec 1;292(21):2585-90. Epub 2004 Dec 1. PMID: 15572716
[PubMed - indexed for MEDLINE] 4:  [No authors listed]  Safety of aggressive
statin therapy.Med Lett Drugs Ther. 2004 Nov 22;46(1196):93-5. PMID:
15557874 [PubMed - indexed for MEDLINE] 5:  Anfossi G, Ma_ssucco P, Bonomo
K, Trovati M.  Prescription of statins to dyslipidemic patients affected by
liver diseases: asubtle balance between risks and benefits.Nutr Metab
Cardiovasc Dis. 2004 Aug;14(4):215-24. PMID: 15553600 [PubMed - in process]
6:  Hexeberg S, Retterstol K.  [Hypertriglyceridemia--diagnostics, risk and
treatment]Tidsskr Nor Laegeforen. 2004 Nov 4;124(21):2746-9. Review.
Norwegian. PMID: 15534665 [PubMed - indexed for MEDLINE] 7:  Cheng JW.
Rosuvastatin in the management of hyperlipidemia.Clin Ther. 2004
Sep;26(9):1368-87. PMID: 15531000 [PubMed - in process] 8:  Sniderman AD.
Is there value in liver function test and creatine phosphokinase
monitoringwith statin use?Am J Cardiol. 2004 Nov 4;94(9A):30F-34F. Review.
PMID: 15519289 [PubMed - indexed for MEDLINE] 9:  Johnson TE, Zhang X,
Bleicher KB, Dysart G, Loughlin AF, Schaefer WH,Umbenhauer DR.  Statins
induce apoptosis in rat and human myotube cultures by inhibitingprotein
geranylgeranylation but not ubiquinone.Toxicol Appl Pharmacol. 2004 Nov
1;200(3):237-50. PMID: 15504460 [PubMed - indexed for MEDLINE] 10:  Davidson
MH.  Rosuvastatin safety: lessons from the FDA review and
post-approvalsurveillance.Expert Opin Drug Saf. 2004 Nov;3(6):547-57. PMID:
15500414 [PubMed - in process] 11:  Phillips PS.  Ezetimibe and
statin-a_ssociated myopathy.Ann Intern Med. 2004 Oct 19;141(8):649. No
abstract available. PMID: 15492351 [PubMed - indexed for MEDLINE] 12:
Alsheikh-Ali AA, Kuvin JT, Karas RH.  Risk of adverse events with
fibrates.Am J Cardiol. 2004 Oct 1;94(7):935-8. PMID: 15464682 [PubMed -
indexed for MEDLINE] 13:  Baker SK, Goodwin S, Sur M, Tarnopolsky MA.
Cytoskeletal myotoxicity from simvastatin and colchicine.Muscle Nerve. 2004
Dec;30(6):799-802. PMID: 15389652 [PubMed - in process] 14:  de Lemos JA,
Blazing MA, Wiviott SD, Lewis EF, Fox KA, White HD, RouleauJL, Pedersen TR,
Gardner LH, Mukherjee R, Ramsey KE, Palmisano J, Bilheimer DW,Pfeffer MA,
Califf RM, Braunwald E; A to Z Investigators.  Early intensive vs a delayed
conservative simvastatin strategy in patients withacute coronary syndromes:
phase Z of the A to Z trial.JAMA. 2004 Sep 15;292(11):1307-16. Epub 2004 Aug
30. PMID: 15337732 [PubMed - indexed for MEDLINE] 15:  Krivosic-Horber R,
Depret T, Wagner JM, Maurage CA.  Malignant hyperthermia susceptibility
revealed by increased serum creatinekinase concentrations during statin
treatment.Eur J Anaesthesiol. 2004 Jul;21(7):572-4. No abstract available.
PMID: 15318472 [PubMed - indexed for MEDLINE] 16:  Livingstone C, Al Riyami
S, Wilkins P, Ferns GA.  McArdle's disease diagnosed following
statin-induced myositis.Ann Clin Biochem. 2004 Jul;41(Pt 4):338-40. PMID:
15298748 [PubMed - in process] 17:  Chang JT, Staffa JA, Parks M, Green L.
Rhabdomyolysis with HMG-CoA reductase inhibitors and gemfibrozil
combinationtherapy.Pharmacoepidemiol Drug Saf. 2004 Jul;13(7):417-26. PMID:
15269925 [PubMed - indexed for MEDLINE] 18:  Carvalho AA, Lima UW, Valiente
RA.  Statin and fibrate a_ssociated myopathy: study of eight patients.Arq
Neuropsiquiatr. 2004 Jun;62(2A):257-61. Epub 2004 Jun 23. PMID: 15235728
[PubMed - in process] 19:  Maggini M, Raschetti R, Traversa G, Bianchi C,
Caffari B, Da Cas R, PaneiP.  The cerivastatin withdrawal crisis: a
"post-mortem" analysis.Health Policy. 2004 Aug;69(2):151-7. PMID: 15212862
[PubMed - indexed for MEDLINE] 20:  Delgado-Lopez F, Bautista-Lorite J,
Villamil-Fernandez F.  [Worsening for using statin in carnitine palmityol
transferase deficiencymyopathy]Rev Neurol. 2004 Jun 1-15;38(11):1095.
Spanish. No abstract available. PMID: 15202093 [PubMed - indexed for
MEDLINE] 21:  Takagi A, Shiio Y.  [Pravastatin-a_ssociated polymyositis, a
case report]Rinsho Shinkeigaku. 2004 Jan;44(1):25-7.  Japanese. PMID:
15199734 [PubMed - indexed for MEDLINE] 22:  Jamal SM, Eisenberg MJ,
Christopoulos S.  Rhabdomyolysis a_ssociated with
hydroxymethylglutaryl-coenzyme A reductaseinhibitors.Am Heart J. 2004
Jun;147(6):956-65. Review. PMID: 15199341 [PubMed - indexed for MEDLINE] 23:
Bellosta S, Paoletti R, Corsini A.  Safety of statins: focus on clinical
pharmacokinetics and drug interactions.Circulation. 2004 Jun 15;109(23 Suppl
1):III50-7. Review. PMID: 15198967 [PubMed - indexed for MEDLINE] 24:  Lado
Lado FL, Rodriguez Moreno C, Cinza Sajurjo S, Duran Parrondo C, PazoNunez M,
Lois Pernas A, Masa Vazquez L.  [Statin-induced rhabdomyolysis and renal
failure: also with fluvastatine]An Med Interna. 2004 May;21(5):235-7.
Spanish. PMID: 15176926 [PubMed - indexed for MEDLINE] 25:  Guyton JR.
Extended-release niacin for modifying the lipoprotein profile.Expert Opin
Pharmacother. 2004 Jun;5(6):1385-98. Review. PMID: 15163282 [PubMed -
indexed for MEDLINE] 26:  Takagi S.  [Neurological complication due to the
drug and the maneuver for the treatmentand prevention of cerebrovascular
diseases: iatrogenic neurology]Rinsho Shinkeigaku. 2003 Nov;43(11):877-9.
Review.  Japanese. PMID: 15152491 [PubMed - indexed for MEDLINE] 27:
Shepherd J.  A prospective study of pravastatin in the elderly at risk: new
hope for olderpersons.Am J Geriatr Cardiol. 2004 May-Jun;13(3 Suppl
1):17-24. Review. PMID: 15133425 [PubMed - indexed for MEDLINE] 28:  Rando
LP, Cording SA, Newnham HH.  Successful reintroduction of statin therapy
after myositis: was there anothercause?Med J Aust. 2004 May 3;180(9):472-3.
No abstract available. PMID: 15115429 [PubMed - indexed for MEDLINE] 29:
Fux R, Morike K, Gundel UF, Hartmann R, Gleiter CH.  Ezetimibe and
statin-a_ssociated myopathy.Ann Intern Med. 2004 Apr 20;140(8):671-2. No
abstract available. PMID: 15096354 [PubMed - indexed for MEDLINE] 30:  Roten
L, Schoenenberger RA, Krahenbuhl S, Schlienger RG.  Rhabdomyolysis in
a_ssociation with simvastatin and amiodarone.Ann Pharmacother. 2004
Jun;38(6):978-81. Epub 2004 Apr 06. PMID: 15069169 [PubMed - indexed for
MEDLINE] 31:  Fauchais AL, Iba Ba J, Maurage P, Kyndt X, Bataille D,
Hachulla E, ParentD, Queyrel V, Lambert M, Michon Pasturel U, Hatron PY,
Vanhille P, Devulder B.  [Polymyositis induced or a_ssociated with
lipid-lowering drugs: five cases]Rev Med Interne. 2004 Apr;25(4):294-8.
French. PMID: 15050796 [PubMed - indexed for MEDLINE] 32:  Scott LJ, Curran
MP, Figgitt DP.  Rosuvastatin: a review of its use in the management of
dyslipidemia.Am J Cardiovasc Drugs. 2004;4(2):117-38. Review. PMID: 15049723
[PubMed - indexed for MEDLINE] 33:  Moosmann B, Behl C.  Selenoprotein
synthesis and side-effects of statins.Lancet. 2004 Mar 13;363(9412):892-4.
Review. PMID: 15031036 [PubMed - indexed for MEDLINE] 34:  Sinzinger H,
O'Grady J.  Professional athletes suffering from familial
hypercholesterolaemia rarelytolerate statin treatment because of muscular
problems.Br J Clin Pharmacol. 2004 Apr;57(4):525-8. PMID: 15025753 [PubMed -
indexed for MEDLINE] 35:  Koumis T, Nathan JP, Rosenberg JM, Cicero LA.
Strategies for the prevention and treatment of statin-induced myopathy:
isthere a role for ubiquinone supplementation?Am J Health Syst Pharm. 2004
Mar 1;61(5):515-9. Review. No abstract available. PMID: 15018231 [PubMed -
indexed for MEDLINE] 36:  Rosenson RS.  Current overview of statin-induced
myopathy.Am J Med. 2004 Mar 15;116(6):408-16. Review. PMID: 15006590
[PubMed - indexed for MEDLINE] 37:  Schaefer WH, Lawrence JW, Loughlin AF,
Stoffregen DA, Mixson LA, Dean DC,Raab CE, Yu NX, Lankas GR, Frederick CB.
Evaluation of ubiquinone concentration and mitochondrial function relative
tocerivastatin-induced skeletal myopathy in rats.Toxicol Appl Pharmacol.
2004 Jan 1;194(1):10-23. PMID: 14728975 [PubMed - indexed for MEDLINE] 38:
Andreou ER, Ledger S.  Potential drug interaction between simvastatin and
danazol causingrhabdomyolysis.Can J Clin Pharmacol. 2003 Winter;10(4):172-4.
PMID: 14712320 [PubMed - indexed for MEDLINE] 39:  Jamil S, Iqbal P.
Rhabdomyolysis induced by a single dose of a statin.Heart. 2004
Jan;90(1):e3. PMID: 14676266 [PubMed - indexed for MEDLINE] 40:
Riesco-Eizaguirre G, Arpa-Gutierrez FJ, Gutierrez M, Toribio E.  [Severe
polymyositis with simvastatin use]Rev Neurol. 2003 Nov 16-30;37(10):934-6.
Spanish. PMID: 14634922 [PubMed - indexed for MEDLINE] 41:  Zeman M, Zak A,
Vecka M, Romaniv S.  [Long-term hypolipidemic treatment of mixed
hyperlipidemia with a combinationof statins and fibrates]Cas Lek Cesk. 2003
Aug;142(8):500-4.  Czech. PMID: 14626567 [PubMed - indexed for MEDLINE] 42:
Wang TD, Chen WJ, Lin JW, Cheng CC, Chen MF, Lee YT.  Efficacy of
fenofibrate and simvastatin on endothelial function andinflammatory markers
in patients with combined hyperlipidemia: relations withbaseline lipid
profiles.Atherosclerosis. 2003 Oct;170(2):315-23. PMID: 14612213 [PubMed -
indexed for MEDLINE] 43:  Foody JM, Krumholz HM.  Are statins indicated for
the primary prevention of CAD in octogenarians?antagonist viewpoint.Am J
Geriatr Cardiol. 2003 Nov-Dec;12(6):357-60. Review. PMID: 14610384 [PubMed -
indexed for MEDLINE] 44:  Shammas NW, Kapalis MJ, Deckert J, Harris M,
Dippel EJ, Labroo A, McKinneyD.  Effectiveness of statin-gemfibrozil
combination therapy in patients with mixedhyperlipidemia: experience of a
community lipid clinic and safety review fromthe literature.Prev Cardiol.
2003 Fall;6(4):189-94. PMID: 14605512 [PubMed - indexed for MEDLINE] 45:
Pasternak R.  Ask the doctor. I am a 64-year-old woman with high cholesterol
caused by badgenes (familial hypercholesterolemia). Without medication, my
cholesterol isabove 450 mg/dL. So I am taking high-dose Lipitor (80 mg/day),
WelChol, andZetia to lower my cholesterol. I sometimes have pain and
stiffness in my knees,and my shoulder, elbow, and wrist joints, plus the
muscles in between, are stiffin the morning and hurt during the day. Two
years ago I was diagnosed withbursitis in my hips. Could these problems be
from the Lipitor? If so, is thereanother statin I could take that wouldn't
do this?Harv Heart Lett. 2003 Oct;14(2):8. No abstract available. PMID:
14576039 [PubMed - indexed for MEDLINE] 46:  Corsini A.  The safety of
HMG-CoA reductase inhibitors in special populations at highcardiovascular
risk.Cardiovasc Drugs Ther. 2003 May;17(3):265-85. Review. PMID: 14574085
[PubMed - indexed for MEDLINE] 47:  Johi RR, Mills R, Halsall PJ, Hopkins
PM.  Anaesthetic management of coronary artery bypa_ss grafting in a patient
withcentral core disease and susceptibility to malignant hyperthermia on
statintherapy.Br J Anaesth. 2003 Nov;91(5):744-7. PMID: 14570802 [PubMed -
indexed for MEDLINE] 48:  Newman CB, Palmer G, Silbershatz H, Szarek M.
Safety of atorvastatin derived from analysis of 44 completed trials in
9,416patients.Am J Cardiol. 2003 Sep 15;92(6):670-6. PMID: 12972104
[PubMed - indexed for MEDLINE] 49:  Wolszakiewicz J, Bilinska M,
Wolkanin-Bartnik J, Piotrowicz R.  [Skeletal myopathy a_ssociated with
concomitant use of statin and cyclosporin ina heart transplant patient -
case report]Kardiol Pol. 2002 Nov;57(11):446-7.  Polish. PMID: 12961006
[PubMed - in process] 50:  Luh JY, Karnath BM.  Issues in statin-a_ssociated
myopathy.JAMA. 2003 Aug 20;290(7):888; author reply 888-9. No abstract
available. PMID: 12928463 [PubMed - indexed for MEDLINE] 51:  Hyman MH.
Issues in statin-a_ssociated myopathy.JAMA. 2003 Aug 20;290(7):888; author
reply 888-9. No abstract available. PMID: 12928462 [PubMed - indexed for
MEDLINE] 52:  Kiortsis DN, Nikas S, Hatzidimou K, Tsianos E, Elisaf MS.
Lipid-lowering drugs and serum liver enzymes: the effects of body weight
andbaseline enzyme levels.Fundam Clin Pharmacol. 2003 Aug;17(4):491-4. PMID:
12914553 [PubMed - indexed for MEDLINE] 53:  [No authors listed]  Statins:
new data in secondary prevention and diabetes. Pravastatin andsimvastatin
are the best-a_ssessed statins.Prescrire Int. 2003 Aug;12(66):143-8. PMID:
12908497 [PubMed - indexed for MEDLINE] 54:  Muller T.  [Statin-induced
Parkinson's-syndrome. Reader's letter on the article by J.Finsterer in "Der
Nervenarzt" (2003) 74:115-122]Nervenarzt. 2003 Aug;74(8):726-7. Epub 2003
May 10.  German. No abstractavailable. PMID: 12904874 [PubMed - indexed for
MEDLINE] 55:  Bannwarth B.  Drug-induced myopathies.Expert Opin Drug Saf.
2002 May;1(1):65-70. Review. PMID: 12904161 [PubMed - indexed for MEDLINE]
56:  Davidson MH.  Controversy surrounding the safety of cerivastatin.Expert
Opin Drug Saf. 2002 Sep;1(3):207-12. Review. PMID: 12904136 [PubMed -
indexed for MEDLINE] 57:  Jacobson TA.  Combination lipid-lowering therapy
with statins: safety issues in thepostcerivastatin era.Expert Opin Drug Saf.
2003 May;2(3):269-86. Review. PMID: 12904106 [PubMed - indexed for MEDLINE]
58:  Ito MK.  Advances in the understanding and management of dyslipidemia:
usingniacin-based therapies.Am J Health Syst Pharm. 2003 Jul 1;60(13 Suppl
2):S15-21; quiz S25. PMID: 12901026 [PubMed - indexed for MEDLINE] 59:
Clotet B, Negredo E.  HIV protease inhibitors and dyslipidemia.AIDS Rev.
2003 Jan-Mar;5(1):19-24. Review. PMID: 12875104 [PubMed - indexed for
MEDLINE] 60:  Arenas J, Martin MA.  [Metabolic intolerance to
exercise]Neurologia. 2003 Jul-Aug;18(6):291-302. Review.  Spanish. PMID:
12838448 [PubMed - indexed for MEDLINE] 61:  Andrejak M, Gras V, Ma_ssy ZA,
Caron J.  [Adverse effects of statins]Therapie. 2003 Jan-Feb;58(1):77-83.
Review.  French. PMID: 12822204 [PubMed - indexed for MEDLINE] 62:  Liem AH,
Jukema JW, van Veldhuisen DJ.  Secondary prevention in coronary heart
disease patients with low HDL: whichoptions do we have?Int J Cardiol. 2003
Jul;90(1):15-21. Review. PMID: 12821213 [PubMed - indexed for MEDLINE] 63:
Teichholz LE.  Statin-a_ssociated myopathy with normal creatine kinase
levels.Ann Intern Med. 2003 Jun 17;138(12):1008; author reply 1008-9. No
abstractavailable. PMID: 12809468 [PubMed - indexed for MEDLINE] 64:
Torgovnick J, Arsura E.  Statin-a_ssociated myopathy with normal creatine
kinase levels.Ann Intern Med. 2003 Jun 17;138(12):1007; author reply 1008-9.
No abstractavailable. PMID: 12809467 [PubMed - indexed for MEDLINE] 65:
Hyman MH.  Statin-a_ssociated myopathy with normal creatine kinase
levels.Ann Intern Med. 2003 Jun 17;138(12):1007; author reply 1008-9. No
abstractavailable. PMID: 12809466 [PubMed - indexed for MEDLINE] 66:  Toma
E, Loignon M.  Statin-a_ssociated myopathy with normal creatine kinase
levels.Ann Intern Med. 2003 Jun 17;138(12):1007-8; author reply 1008-9. No
abstractavailable. PMID: 12809465 [PubMed - indexed for MEDLINE] 67:  Ornato
JP.  Should you worry about the side effects of statins? Statin dose,
health, andother drugs affect side-effect risk.Health News. 2003
Jun;9(6):1-2. No abstract available. PMID: 12793395 [PubMed - indexed for
MEDLINE] 68:  Davidson MH.  Combination lipid-lowering therapy in
diabetes.Curr Diab Rep. 2003 Jun;3(3):263-8. Review. PMID: 12762976
[PubMed - indexed for MEDLINE] 69:  Schmitz G, Drobnik W.  Pharmacogenomics
and pharmacogenetics of cholesterol-lowering therapy.Clin Chem Lab Med. 2003
Apr;41(4):581-9. Review. PMID: 12747606 [PubMed - indexed for MEDLINE] 70:
Worz CR, Bottorff M.  Treating dyslipidemic patients with lipid-modifying
and combination therapies.Pharmacotherapy. 2003 May;23(5):625-37. Review.
PMID: 12741437 [PubMed - indexed for MEDLINE] 71:  Bays H, Dujovne C.
Colesevelam HCl: a non-systemic lipid-altering drug.Expert Opin
Pharmacother. 2003 May;4(5):779-90. Review. PMID: 12740000 [PubMed - indexed
for MEDLINE] 72:  Paragh G, Balogh Z, Romics L.  [Antilipemic therapy and
rhabdomyolysis]Orv Hetil. 2003 Mar 16;144(11):515-20. Review.  Hungarian.
PMID: 12731338 [PubMed - indexed for MEDLINE] 73:  Gotto AM Jr.  Risks and
benefits of continued aggressive statin therapy.Clin Cardiol. 2003 Apr;26(4
Suppl 3):III3-12. Review. PMID: 12708633 [PubMed - indexed for MEDLINE] 74:
Thompson PD, Clarkson P, Karas RH.  Statin-a_ssociated myopathy.JAMA. 2003
Apr 2;289(13):1681-90. Review. PMID: 12672737 [PubMed - indexed for MEDLINE]
75:  Braun RN, Halhuber MJ, Hitzenberger G.  [Information regarding adverse
drug effects and treatment indications ("packageinserts") exemplified by
cervistatin (Lipobay)]Wien Med Wochenschr. 2003;153(3-4):80-2.  German.
PMID: 12658968 [PubMed - indexed for MEDLINE] 76:  Lee TH.  Ask the doctor.
At age 62 I'm a bit overweight and have diabetes. I take astatin, and my LDL
cholesterol is good (84 mg/dL). But my HDL is low (30 mg/dL)and my
triglycerides are above 300 mg/dL. Are high triglycerides a problem?Harv
Heart Lett. 2003 Mar;13(7):8. No abstract available. PMID: 12654588
[PubMed - indexed for MEDLINE] 77:  [No authors listed]  How a statin might
destroy a drug company.Lancet. 2003 Mar 8;361(9360):793. No abstract
available. PMID: 12642039 [PubMed - indexed for MEDLINE] 78:  Smith CC,
Bernstein LI, Davis RB, Rind DM, Shmerling RH.  Screening for statin-related
toxicity: the yield of transaminase and creatinekinase measurements in a
primary care setting.Arch Intern Med. 2003 Mar 24;163(6):688-92. PMID:
12639201 [PubMed - indexed for MEDLINE] 79:  Gotto AM Jr.  Safety and statin
therapy: reconsidering the risks and benefits.Arch Intern Med. 2003 Mar
24;163(6):657-9. No abstract available. PMID: 12639194 [PubMed - indexed for
MEDLINE] 80:  Ballantyne CM, Corsini A, Davidson MH, Holdaas H, Jacobson TA,
LeitersdorfE, Marz W, Reckless JP, Stein EA.  Risk for myopathy with statin
therapy in high-risk patients.Arch Intern Med. 2003 Mar 10;163(5):553-64.
Review. PMID: 12622602 [PubMed - indexed for MEDLINE] 81:  Bennett WE, Drake
AJ 3rd, Shakir KM.  Reversible myopathy after statin therapy in patients
with normal creatinekinase levels.Ann Intern Med. 2003 Mar 4;138(5):436-7.
No abstract available. PMID: 12614104 [PubMed - indexed for MEDLINE] 82:
Farmer JA.  Statins and myotoxicity.Curr Atheroscler Rep. 2003
Mar;5(2):96-100. Review. PMID: 12573193 [PubMed - indexed for MEDLINE] 83:
Glueck CJ, Streicher P.  Cardiovascular and medical ramifications of
treatment of subclinicalhypothyroidism.Curr Atheroscler Rep. 2003
Jan;5(1):73-7. Review. PMID: 12562546 [PubMed - indexed for MEDLINE] 84:
Sinzinger H.  Statin-induced myositis migrans.Wien Klin Wochenschr. 2002 Nov
30;114(21-22):943-4. PMID: 12528328 [PubMed - indexed for MEDLINE] 85:  Yim
BT, Chong PH.  Niacin-ER and lovastatin treatment of hypercholesterolemia
and mixeddyslipidemia.Ann Pharmacother. 2003 Jan;37(1):106-15. Review. PMID:
12503944 [PubMed - indexed for MEDLINE] 86:  Gazarin S, Abd-El-Hady H,
Gheith O, Rasem M, Saad M, El-Sayed K, Sobh M,Amer G.  Neuromuscular
toxicity in nephrotic patients treated with fluvastatin.J Nephrol. 2002
Nov-Dec;15(6):690-5. PMID: 12495286 [PubMed - indexed for MEDLINE] 87:
Black C, Jick H.  Etiology and frequency of rhabdomyolysis.Pharmacotherapy.
2002 Dec;22(12):1524-6. PMID: 12495162 [PubMed - indexed for MEDLINE] 88:
Xydakis AM, Ballantyne CM.  Combination therapy for combined dyslipidemia.Am
J Cardiol. 2002 Nov 20;90(10B):21K-29K. Review. PMID: 12467937 [PubMed -
indexed for MEDLINE] 89:  Mantel-Teeuwisse AK, Klungel OH, Herings RM, van
Puijenbroek EP, PorsiusAJ, de Boer A.  Myopathy due to statin/fibrate use in
the Netherlands.Ann Pharmacother. 2002 Dec;36(12):1957-60. PMID: 12452761
[PubMed - indexed for MEDLINE] 90:  Bolego C, Baetta R, Bellosta S, Corsini
A, Paoletti R.  Safety considerations for statins.Curr Opin Lipidol. 2002
Dec;13(6):637-44. Review. PMID: 12441888 [PubMed - indexed for MEDLINE] 91:
Prasad GV, Wong T, Meliton G, Bhaloo S.  Rhabdomyolysis due to red yeast
rice (Monascus purpureus) in a renal transplantrecipient.Transplantation.
2002 Oct 27;74(8):1200-1. PMID: 12438974 [PubMed - indexed for MEDLINE] 92:
Kind AH, Zakowski LJ, McBride PE.  Rhabdomyolysis from the combination of a
statin and gemfibrozil: an uncommonbut serious adverse reaction.WMJ.
2002;101(7):53-6. PMID: 12426921 [PubMed - indexed for MEDLINE] 93:
Schuff-Werner P, Kohlschein P.  [Current therapy of hypercholesterolemia.
How much statin does your patientneed?]MMW Fortschr Med. 2002 Aug
8;144(31-32):24-6.  German. PMID: 12422725 [PubMed - indexed for MEDLINE]
94:  Hare CB, Vu MP, Grunfeld C, Lampiris HW.  Simvastatin-nelfinavir
interaction implicated in rhabdomyolysis and death.Clin Infect Dis. 2002 Nov
15;35(10):e111-2. Epub 2002 Oct 25. PMID: 12410494 [PubMed - indexed for
MEDLINE] 95:  Phillips PS, Haas RH, Bannykh S, Hathaway S, Gray NL, Kimura
BJ, VladutiuGD, England JD; Scripps Mercy Clinical Research Center.
Statin-a_ssociated myopathy with normal creatine kinase levels.Ann Intern
Med. 2002 Oct 1;137(7):581-5. PMID: 12353945 [PubMed - indexed for MEDLINE]
96:  Lewin JJ 3rd, Nappi JM, Taylor MH.  Rhabdomyolysis with concurrent
atorvastatin and diltiazem.Ann Pharmacother. 2002 Oct;36(10):1546-9. PMID:
12243603 [PubMed - indexed for MEDLINE] 97:  Sinzinger H, Chehne F,
Lupattelli G.  Oxidation injury in patients receiving HMG-CoA reductase
inhibitors: occurrencein patients without enzyme elevation or myopathy.Drug
Saf. 2002;25(12):877-83. PMID: 12241128 [PubMed - indexed for MEDLINE] 98:
Aboulafia DM, Johnston R.  Simvastatin-induced rhabdomyolysis in an
HIV-infected patient with coronaryartery disease.AIDS Patient Care STDS.
2000 Jan;14(1):13-8. PMID: 12240878 [PubMed - indexed for MEDLINE] 99:
Vivekananthan K, Mehra MR, Uber PA, DeGruiter H, Lavie CJ, Milani RV.
Comparison of the efficacy and safety of pravastatin and simvastatin in
hearttransplantation.J A_ssoc Physicians India. 2002 May;50(5):682-4. PMID:
12186124 [PubMed - indexed for MEDLINE] 100:  Evans M, Rees A.  Effects of
HMG-CoA reductase inhibitors on skeletal muscle: are all statins
thesame?Drug Saf. 2002;25(9):649-63. Review. PMID: 12137559 [PubMed -
indexed for MEDLINE] 101:  Sinzinger H, Wolfram R, Peskar BA.  Muscular side
effects of statins.J Cardiovasc Pharmacol. 2002 Aug;40(2):163-71. Review.
PMID: 12131545 [PubMed - indexed for MEDLINE] 102:  Heart Protection Study
Collaborative Group.  MRC/BHF Heart Protection Study of cholesterol lowering
with simvastatin in20,536 high-risk individuals: a randomised
placebo-controlled trial.Lancet. 2002 Jul 6;360(9326):7-22. Summary for
patients in: Curr Cardiol Rep.2002 Nov;4(6):486-7. PMID: 12114036 [PubMed -
indexed for MEDLINE] 103:  Bae J, Jarcho JA, Denton MD, Magee CC.  Statin
specific toxicity in organ transplant recipients: case report and reviewof
the literature.J Nephrol. 2002 May-Jun;15(3):317-9. Review. PMID: 12113605
[PubMed - indexed for MEDLINE] 104:  de Sauvage Nolting PR, Buirma RJ,
Hutten BA, Kastelein JJ; Dutch ExPRESSInvestigator Group.  Two-year efficacy
and safety of simvastatin 80 mg in familialhypercholesterolemia (the
Examination of Probands and Relatives in StatinStudies With Familial
Hypercholesterolemia [ExPRESS FH]).Am J Cardiol. 2002 Jul 15;90(2):181-4. No
abstract available. PMID: 12106856 [PubMed - indexed for MEDLINE] 105:
Liamis G, Kakafika A, Bairaktari E, Miltiadous G, Tsimihodimos V,Goudevenos
J, Achimastos A, Elisaf M.  Combined treatment with fibrates and small doses
of atorvastatin in patientswith mixed hyperlipidemia.Curr Med Res Opin.
2002;18(3):125-8. PMID: 12094821 [PubMed - indexed for MEDLINE] 106:
Williams D, Feely J.  Pharmacokinetic-pharmacodynamic drug interactions with
HMG-CoA reductaseinhibitors.Clin Pharmacokinet. 2002;41(5):343-70. Review.
PMID: 12036392 [PubMed - indexed for MEDLINE] 107:  Sinzinger H.  Flu-like
response on statins.Med Sci Monit. 2002 May;8(5):CR384-8. PMID: 12011782
[PubMed - indexed for MEDLINE] 108:  [No authors listed]  Statin
stories.Diabetes Obes Metab. 2002 Mar;4(2):138. No abstract available. PMID:
11993442 [PubMed - indexed for MEDLINE] 109:  Maxa JL, Melton LB, Ogu CC,
Sills MN, Limanni A.  Rhabdomyolysis after concomitant use of cyclosporine,
simvastatin, gemfibrozil,and itraconazole.Ann Pharmacother. 2002
May;36(5):820-3. PMID: 11978159 [PubMed - indexed for MEDLINE] 110:  Foxton
J.  Statin safety.Nurs Stand. 2001 Sep 19-25;16(1):20. No abstract
available. PMID: 11977679 [PubMed - indexed for MEDLINE] 111:  Gensini GF,
Conti AA, Conti A, Panti A.  [From prevention to cardiovascular
rehabilitation: statins and evidence-basedmedicine]Ital Heart J Suppl. 2002
Jan;3(1):91-4. Review.  Italian. PMID: 11899580 [PubMed - indexed for
MEDLINE] 112:  Sica DA, Gehr TW.  3-Hydroxy-3-methylglutaryl coenzyme A
reductase inhibitors and rhabdomyolysis:considerations in the renal failure
patient.Curr Opin Nephrol Hypertens. 2002 Mar;11(2):123-33. Review. PMID:
11856903 [PubMed - indexed for MEDLINE] 113:  Omar MA, Wilson JP.  FDA
adverse event reports on statin-a_ssociated rhabdomyolysis.Ann Pharmacother.
2002 Feb;36(2):288-95. Review. PMID: 11847951 [PubMed - indexed for MEDLINE]
114:  Prieto JC.  [Safety profile of statins]Rev Med Chil. 2001
Nov;129(11):1237-40.  Spanish. PMID: 11836874 [PubMed - indexed for MEDLINE]
115:  Sica DA, Gehr TW.  Rhabdomyolysis and statin therapy: relevance to the
elderly.Am J Geriatr Cardiol. 2002 Jan-Feb;11(1):48-55. Review. PMID:
11773716 [PubMed - indexed for MEDLINE] 116:  Banga JD.  [Myotoxicity and
rhabdomyolisis due to statins]Ned Tijdschr Geneeskd. 2001 Dec
8;145(49):2371-6. Review.  Dutch. PMID: 11770264 [PubMed - indexed for
MEDLINE] 117:  Hamilton-Craig I.  Statin-a_ssociated myopathy.Med J Aust.
2001 Nov 5;175(9):486-9. Review. PMID: 11758079 [PubMed - indexed for
MEDLINE] 118:  Bernini F, Poli A, Paoletti R.  Safety of HMG-CoA reductase
inhibitors: focus on atorvastatin.Cardiovasc Drugs Ther. 2001;15(3):211-8.
Review. PMID: 11713888 [PubMed - indexed for MEDLINE] 119:  Chazerain P,
Hayem G, Hamza S, Best C, Ziza JM.  Four cases of tendinopathy in patients
on statin therapy.Joint Bone Spine. 2001 Oct;68(5):430-3. PMID: 11707010
[PubMed - indexed for MEDLINE] 120:  Federman DG, Hussain F, Walters AB.
Fatal rhabdomyolysis caused by lipid-lowering therapy.South Med J. 2001
Oct;94(10):1023-6. PMID: 11702815 [PubMed - indexed for MEDLINE] 121:  Baker
SK, Tarnopolsky MA.  Statin myopathies: pathophysiologic and clinical
perspectives.Clin Invest Med. 2001 Oct;24(5):258-72. Review. No abstract
available. PMID: 11603510 [PubMed - indexed for MEDLINE] 122:  Igel M,
Sudhop T, von Bergmann K.  Metabolism and drug interactions of
3-hydroxy-3-methylglutaryl coenzymeA-reductase inhibitors (statins).Eur J
Clin Pharmacol. 2001 Aug;57(5):357-64. Review. PMID: 11599653 [PubMed -
indexed for MEDLINE] 123:  Tomlinson B, Chan P, Lan W.  How well tolerated
are lipid-lowering drugs?Drugs Aging. 2001;18(9):665-83. Review. PMID:
11599634 [PubMed - indexed for MEDLINE] 124:  Bangratz S.  [Complications in
heart transplantation: diagnosis and treatment]Presse Med. 2001 Sep 1;30(24
Pt 2):8-12. Review.  French. PMID: 11577591 [PubMed - indexed for MEDLINE]
125:  Omar MA, Wilson JP, Cox TS.  Rhabdomyolysis and HMG-CoA reductase
inhibitors.Ann Pharmacother. 2001 Sep;35(9):1096-107. Review. Erratum in:
Ann Pharmacother2001 Oct;35(10):1296. PMID: 11573861 [PubMed - indexed for
MEDLINE] 126:  Boger RH.  Drug interactions of the statins and consequences
for drug selection.Int J Clin Pharmacol Ther. 2001 Sep;39(9):369-82. Review.
PMID: 11563683 [PubMed - indexed for MEDLINE] 127:  Comarow A.  Rest easy,
statin users. Benefits dwarf risks for these cholesterol drugs.US News World
Rep. 2001 Sep 3;131(8):45. No abstract available. PMID: 11550394 [PubMed -
indexed for MEDLINE] 128:  Shek A, Ferrill MJ.  Statin-fibrate combination
therapy.Ann Pharmacother. 2001 Jul-Aug;35(7-8):908-17. Review. PMID:
11485144 [PubMed - indexed for MEDLINE] 129:  Lupattelli G, Palumbo B,
Sinzinger H.  Statin induced myopathy does not show up in MIBI
scintigraphy.Nucl Med Commun. 2001 May;22(5):575-8. PMID: 11388581 [PubMed -
indexed for MEDLINE] 130:  Fosslien E.  Mitochondrial medicine--molecular
pathology of defective oxidativephosphorylation.Ann Clin Lab Sci. 2001
Jan;31(1):25-67. Review. PMID: 11314862 [PubMed - indexed for MEDLINE] 131:
Moghadasian MH, Mancini GB, Frohlich JJ.  Pharmacotherapy of
hypercholesterolaemia: statins in clinical practice.Expert Opin
Pharmacother. 2000 May;1(4):683-95. Review. PMID: 11249510 [PubMed - indexed
for MEDLINE] 132:  Oldemeyer JB, Lund RJ, Koch M, Meares AJ, Dunlay R.
Rhabdomyolysis and acute renal failure after changing
statin-fibratecombinations.Cardiology. 2000;94(2):127-8. PMID: 11173785
[PubMed - indexed for MEDLINE] 133:  Sinzinger H, Lupattelli G, Chehne F.
Increased lipid peroxidation in a patient with CK-elevation and muscle
painduring statin therapy.Atherosclerosis. 2000 Nov;153(1):255-6. No
abstract available. PMID: 11058722 [PubMed - indexed for MEDLINE] 134:
Guyton JR.  Combination drug therapy for combined hyperlipidemia.Curr
Cardiol Rep. 1999 Sep;1(3):244-50. Review. PMID: 10980849 [PubMed - indexed
for MEDLINE] 135:  Ozdemir O, Boran M, Gokce V, Uzun Y, Kocak B, Korkmaz S.
A case with severe rhabdomyolysis and renal failure a_ssociated
withcerivastatin-gemfibrozil combination therapy--a case report.Angiology.
2000 Aug;51(8):695-7. PMID: 10959522 [PubMed - indexed for MEDLINE] 136:
Gavish D, Leibovitz E, Shapira I, Rubinstein A.  Bezafibrate and simvastatin
combination therapy for diabetic dyslipidaemia:efficacy and safety.J Intern
Med. 2000 May;247(5):563-9. PMID: 10809995 [PubMed - indexed for MEDLINE]
137:  Liebhaber MI, Wright RS, Gelberg HJ, Dyer Z, Kupperman JL.
Polymyalgia, hypersensitivity pneumonitis and other reactions in
patientsreceiving HMG-CoA reductase inhibitors: a report of ten cases.Chest.
1999 Mar;115(3):886-9. PMID: 10084510 [PubMed - indexed for MEDLINE] 138:
Guyton JR, Capuzzi DM.  Treatment of hyperlipidemia with combined
niacin-statin regimens.Am J Cardiol. 1998 Dec 17;82(12A):82U-84U;
discussion 85-86U. Review. PMID: 9915667 [PubMed - indexed for MEDLINE] 139:
Athyros VG, Papageorgiou AA, Hatzikonstandinou HA, Didangelos TP, CarinaMV,
Kranitsas DF, Kontopoulos AG.  Safety and efficacy of long-term
statin-fibrate combinations in patients withrefractory familial combined
hyperlipidemia.Am J Cardiol. 1997 Sep 1;80(5):608-13. PMID: 9294990
[PubMed - indexed for MEDLINE] 140:  Tikkanen MJ.  Statins: within-group
comparisons, statin escape and combination therapy.Curr Opin Lipidol. 1996
Dec;7(6):385-8. Review. PMID: 9117143 [PubMed - indexed for MEDLINE] 141:
De Pinieux G, Chariot P, Ammi-Said M, Louarn F, Lejonc JL, Astier A,Jacotot
B, Gherardi R.  Lipid-lowering drugs and mitochondrial function: effects of
HMG-CoA reductaseinhibitors on serum ubiquinone and blood lactate/pyruvate
ratio.Br J Clin Pharmacol. 1996 Sep;42(3):333-7. PMID: 8877024 [PubMed -
indexed for MEDLINE] 142:  Reijneveld JC, Koot RW, Bredman JJ, Joles JA, Bar
PR.  Differential effects of 3-hydroxy-3-methylglutaryl-coenzyme A
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143:  Peters TK.  Safety profile of fluvastatin.Br J Clin Pract Suppl. 1996
Jan;77A:20-3. Review. PMID: 8729586 [PubMed - indexed for MEDLINE] 144:
Laaksonen R, Jokelainen K, Sahi T, Tikkanen MJ, Himberg JJ.  Decreases in
serum ubiquinone concentrations do not result in reduced levels inmuscle
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Leitersdorf E, Muratti EN, Eliav O, Meiner V, Eisenberg S, Dann EJ,Sehayek
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1994 May;96(5):401-7. PMID: 8192170 [PubMed - indexed for MEDLINE] 146:
Dromer C, Vedrenne C, Billey T, Pages M, Fournie B, Fournie A.
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French. PMID: 1496277 [PubMed - indexed for MEDLINE]

Search terms: STATIN + MYOSITIS

1:  [No authors listed]  Safety of aggressive statin therapy.Med Lett Drugs
Ther. 2004 Nov 22;46(1196):93-5. PMID: 15557874 [PubMed - indexed for
MEDLINE] 2:  Sniderman AD.  Is there value in liver function test and
creatine phosphokinase monitoringwith statin use?Am J Cardiol. 2004 Nov
4;94(9A):30F-34F. Review. PMID: 15519289 [PubMed - indexed for MEDLINE] 3:
Phillips PS, Phillips CT, Sullivan MJ, Naviaux RK, Haas RH.  Statin
myotoxicity is a_ssociated with changes in the cardiopulmonary
function.Atherosclerosis. 2004 Nov;177(1):183-8. PMID: 15488882 [PubMed - in
process] 4:  Livingstone C, Al Riyami S, Wilkins P, Ferns GA.  McArdle's
disease diagnosed following statin-induced myositis.Ann Clin Biochem. 2004
Jul;41(Pt 4):338-40. PMID: 15298748 [PubMed - in process] 5:  Takagi A,
Shiio Y.  [Pravastatin-a_ssociated polymyositis, a case report]Rinsho
Shinkeigaku. 2004 Jan;44(1):25-7.  Japanese. PMID: 15199734 [PubMed -
indexed for MEDLINE] 6:  Bellosta S, Paoletti R, Corsini A.  Safety of
statins: focus on clinical pharmacokinetics and drug
interactions.Circulation. 2004 Jun 15;109(23 Suppl 1):III50-7. Review. PMID:
15198967 [PubMed - indexed for MEDLINE] 7:  Rando LP, Cording SA, Newnham
HH.  Successful reintroduction of statin therapy after myositis: was there
anothercause?Med J Aust. 2004 May 3;180(9):472-3. No abstract available.
PMID: 15115429 [PubMed - indexed for MEDLINE] 8:  Fauchais AL, Iba Ba J,
Maurage P, Kyndt X, Bataille D, Hachulla E, Parent D,Queyrel V, Lambert M,
Michon Pasturel U, Hatron PY, Vanhille P, Devulder B.  [Polymyositis induced
or a_ssociated with lipid-lowering drugs: five cases]Rev Med Interne. 2004
Apr;25(4):294-8.  French. PMID: 15050796 [PubMed - indexed for MEDLINE] 9:
Riesco-Eizaguirre G, Arpa-Gutierrez FJ, Gutierrez M, Toribio E.  [Severe
polymyositis with simvastatin use]Rev Neurol. 2003 Nov 16-30;37(10):934-6.
Spanish. PMID: 14634922 [PubMed - indexed for MEDLINE] 10:  Foody JM,
Krumholz HM.  Are statins indicated for the primary prevention of CAD in
octogenarians?antagonist viewpoint.Am J Geriatr Cardiol. 2003
Nov-Dec;12(6):357-60. Review. PMID: 14610384 [PubMed - indexed for MEDLINE]
11:  Shammas NW, Kapalis MJ, Deckert J, Harris M, Dippel EJ, Labroo A,
McKinneyD.  Effectiveness of statin-gemfibrozil combination therapy in
patients with mixedhyperlipidemia: experience of a community lipid clinic
and safety review fromthe literature.Prev Cardiol. 2003 Fall;6(4):189-94.
PMID: 14605512 [PubMed - indexed for MEDLINE] 12:  Badawy O, Wierzbicki AS,
Hilton R.  Combination fibrate-statin therapy for the treatment of
severehypertriglyceridaemia in renal disease.Int J Clin Pract. 2003
Apr;57(3):249-51. PMID: 12723736 [PubMed - indexed for MEDLINE] 13:
Thompson PD, Clarkson P, Karas RH.  Statin-a_ssociated myopathy.JAMA. 2003
Apr 2;289(13):1681-90. Review. PMID: 12672737 [PubMed - indexed for MEDLINE]
14:  Sinzinger H.  Statin-induced myositis migrans.Wien Klin Wochenschr.
2002 Nov 30;114(21-22):943-4. PMID: 12528328 [PubMed - indexed for MEDLINE]
15:  Black C, Jick H.  Etiology and frequency of
rhabdomyolysis.Pharmacotherapy. 2002 Dec;22(12):1524-6. PMID: 12495162
[PubMed - indexed for MEDLINE] 16:  Lawrence JM, Reckless JP.
Fluvastatin.Expert Opin Pharmacother. 2002 Nov;3(11):1631-41. Review. PMID:
12437496 [PubMed - indexed for MEDLINE] 17:  Mehra MR, Uber PA,
Vivekananthan K, Solis S, Scott RL, Park MH, Milani RV,Lavie CJ.
Comparative beneficial effects of simvastatin and pravastatin on
cardiacallograft rejection and survival.J Am Coll Cardiol. 2002 Nov
6;40(9):1609-14. PMID: 12427413 [PubMed - indexed for MEDLINE] 18:  Evans M,
Rees A.  Effects of HMG-CoA reductase inhibitors on skeletal muscle: are all
statins thesame?Drug Saf. 2002;25(9):649-63. Review. PMID: 12137559
[PubMed - indexed for MEDLINE] 19:  Aronow WS.  Pharmacologic therapy of
lipid disorders in the elderly.Am J Geriatr Cardiol. 2002
Jul-Aug;11(4):247-56. Review. PMID: 12091773 [PubMed - indexed for MEDLINE]
20:  Patel DN, Pagani FD, Koelling TM, Dyke DB, Baliga RR, Cody RJ, Lake
KD,Aaronson KD.  Safety and efficacy of atorvastatin in heart transplant
recipients.J Heart Lung Transplant. 2002 Feb;21(2):204-10. PMID: 11834348
[PubMed - indexed for MEDLINE]

Search terms: STATIN + MYALGIA

1:  Koller H, Neuhaus O, Schroeter M, Hartung HP.  [Myopathies under therapy
with lipid-lowering agents.]Nervenarzt. 2004 Dec 18; [Epub ahead of print]
German. PMID: 15609055 [PubMed - as supplied by publisher] 2:  Rundek T,
Naini A, Sacco R, Coates K, DiMauro S.  Atorvastatin decreases the coenzyme
Q10 level in the blood of patients at riskfor cardiovascular disease and
stroke.Arch Neurol. 2004 Jun;61(6):889-92. PMID: 15210526 [PubMed - indexed
for MEDLINE] 3:  Takagi A, Shiio Y.  [Pravastatin-a_ssociated polymyositis,
a case report]Rinsho Shinkeigaku. 2004 Jan;44(1):25-7.  Japanese. PMID:
15199734 [PubMed - indexed for MEDLINE] 4:  Scott LJ, Curran MP, Figgitt DP.
Rosuvastatin: a review of its use in the management of dyslipidemia.Am J
Cardiovasc Drugs. 2004;4(2):117-38. Review. PMID: 15049723 [PubMed - indexed
for MEDLINE] 5:  Newman CB, Palmer G, Silbershatz H, Szarek M.  Safety of
atorvastatin derived from analysis of 44 completed trials in
9,416patients.Am J Cardiol. 2003 Sep 15;92(6):670-6. PMID: 12972104
[PubMed - indexed for MEDLINE] 6:  Andrejak M, Gras V, Ma_ssy ZA, Caron J.
[Adverse effects of statins]Therapie. 2003 Jan-Feb;58(1):77-83. Review.
French. PMID: 12822204 [PubMed - indexed for MEDLINE] 7:  Thompson PD,
Clarkson P, Karas RH.  Statin-a_ssociated myopathy.JAMA. 2003 Apr
2;289(13):1681-90. Review. PMID: 12672737 [PubMed - indexed for MEDLINE] 8:
Athyros VG, Papageorgiou AA, Athyrou VV, Demitriadis DS, Pehlivanidis
AN,Kontopoulos AG.  Atorvastatin versus four statin-fibrate combinations in
patients with familialcombined hyperlipidaemia.J Cardiovasc Risk. 2002
Feb;9(1):33-9. PMID: 11984215 [PubMed - indexed for MEDLINE] 9:  Taher TH,
Dzavik V, Reteff EM, Pearson GJ, Woloschuk BL, Francis GA.  Tolerability of
statin-fibrate and statin-niacin combination therapy indyslipidemic patients
at high risk for cardiovascular events.Am J Cardiol. 2002 Feb
15;89(4):390-4. PMID: 11835917 [PubMed - indexed for MEDLINE] 10:  Chazerain
P, Hayem G, Hamza S, Best C, Ziza JM.  Four cases of tendinopathy in
patients on statin therapy.Joint Bone Spine. 2001 Oct;68(5):430-3. PMID:
11707010 [PubMed - indexed for MEDLINE] 11:  Penzak SR, Chuck SK, Stajich
GV.  Safety and efficacy of HMG-CoA reductase inhibitors for treatment
ofhyperlipidemia in patients with HIV infection.Pharmacotherapy. 2000
Sep;20(9):1066-71. PMID: 10999499 [PubMed - indexed for MEDLINE] 12:
Spieker LE, Noll G, Hannak M, Luscher TF.  Efficacy and tolerability of
fluvastatin and bezafibrate in patients withhyperlipidemia and persistently
high triglyceride levels.J Cardiovasc Pharmacol. 2000 Mar;35(3):361-5. PMID:
10710119 [PubMed - indexed for MEDLINE] 13:  Papadakis JA, Ganotakis ES,
Jagroop IA, Winder AF, Mikhailidis DP.  Statin + fibrate combination therapy
fluvastatin with bezafibrate orciprofibrate in high risk patients with
vascular disease.Int J Cardiol. 1999 Jun 1;69(3):237-44. PMID: 10402106
[PubMed - indexed for MEDLINE] 14:  Peters TK.  Safety profile of
fluvastatin.Br J Clin Pract Suppl. 1996 Jan;77A:20-3. Review. PMID: 8729586
[PubMed - indexed for MEDLINE]

Search terms: STATIN + POLYMYOSITIS

1:  Takagi A, Shiio Y.  [Pravastatin-a_ssociated polymyositis, a case
report]Rinsho Shinkeigaku. 2004 Jan;44(1):25-7.  Japanese. PMID: 15199734
[PubMed - indexed for MEDLINE] 2:  Bellosta S, Paoletti R, Corsini A.
Safety of statins: focus on clinical pharmacokinetics and drug
interactions.Circulation. 2004 Jun 15;109(23 Suppl 1):III50-7. Review. PMID:
15198967 [PubMed - indexed for MEDLINE] 3:  Fauchais AL, Iba Ba J, Maurage
P, Kyndt X, Bataille D, Hachulla E, Parent D,Queyrel V, Lambert M, Michon
Pasturel U, Hatron PY, Vanhille P, Devulder B.  [Polymyositis induced or
a_ssociated with lipid-lowering drugs: five cases]Rev Med Interne. 2004
Apr;25(4):294-8.  French. PMID: 15050796 [PubMed - indexed for MEDLINE] 4:
Riesco-Eizaguirre G, Arpa-Gutierrez FJ, Gutierrez M, Toribio E.  [Severe
polymyositis with simvastatin use]Rev Neurol. 2003 Nov 16-30;37(10):934-6.
Spanish. PMID: 14634922 [PubMed - indexed for MEDLINE] 5:  Bannwarth B.
Drug-induced myopathies.Expert Opin Drug Saf. 2002 May;1(1):65-70. Review.
PMID: 12904161 [PubMed - indexed for MEDLINE] 6:  Chazerain P, Hayem G,
Hamza S, Best C, Ziza JM.  Four cases of tendinopathy in patients on statin
therapy.Joint Bone Spine. 2001 Oct;68(5):430-3. PMID: 11707010 [PubMed -
indexed for MEDLINE]

Arduini A, Peschechera A, Giannessi F, Carminati P.

Improvement of statin-a_ssociated myotoxicity by L-carnitine.

J Thromb Haemost. 2004 Dec;2(12):2270-1. No abstract available.

PMID: 15613049 [PubMed - in process]