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Medical Forum / General / General / January 2005

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NSAID Definition

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meyerdt@yahoo.com - 06 Jan 2005 18:14 GMT
Is an NSAID simply any anti-inflammatory drug which does not have a
steroid core?  Or must there explicitly be some Cox activity?

As a group of scientists (I am a chemist) in the technical patent
industry, we are trying to clarify our NSAID definition.  I assumed
that as long as the anti-inflammatory agent was not a steroid, it was
an NSAID.  Somebody else thought there needed to be an additional
requirement (i.e. that the molecule also be labeled a Cox inhibitor.)
Thanks,

Dayton
Sbharris[atsign]ix.netcom.com - 07 Jan 2005 00:02 GMT
I don't think COX activity is necessary. Rimadyl/carprofen (a vet
arthritis drug) is generally considered a non-COX inhibiting NSAID. It
probably works higher up in the inflammatory pathway, at NF-kB or
something like that. Similar drugs are in the offing for human use, as
soon as the FDA gets it's head out.
 
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