Is an NSAID simply any anti-inflammatory drug which does not have a
steroid core? Or must there explicitly be some Cox activity?
As a group of scientists (I am a chemist) in the technical patent
industry, we are trying to clarify our NSAID definition. I assumed
that as long as the anti-inflammatory agent was not a steroid, it was
an NSAID. Somebody else thought there needed to be an additional
requirement (i.e. that the molecule also be labeled a Cox inhibitor.)
Thanks,
Dayton
Sbharris[atsign]ix.netcom.com - 07 Jan 2005 00:02 GMT
I don't think COX activity is necessary. Rimadyl/carprofen (a vet
arthritis drug) is generally considered a non-COX inhibiting NSAID. It
probably works higher up in the inflammatory pathway, at NF-kB or
something like that. Similar drugs are in the offing for human use, as
soon as the FDA gets it's head out.