I read on the web that there is a new  leukotriene out this month (1/2005),
Zyflo (zileuton).

There have already two such medicines available for years (prescribed for
asthma and rhinitis), Accolate and Singular.

Is there anything different about this new one, Zyflo? Any difference in its
effects? Have there been comparative studies between the three?

I also read on the web that some doctors prescribe to their patients to
crumble a Singular tablet in a bottle of saline nasal spray, such as Ocean,
to use topically for rhinitis. Is there any evidence that these meds are
effective when applied topically like that? If so, one would think they
might come out with a nasal spray (rhinitis) and inhaler (asthma), rather
than another kind of tablet. (It doesn't seem like having patients crumble
tablets meant to be swallowed into a nasal spray is such a good idea. There
are different fillers and excipients in a tablet, not only the med. And who
knows what might be on the patient's hand, that he crumbles the tablet with?
But if there is evidence that these meds work topically, they should come
out with topical versions.)

Anyone have any info on Zyflo?