Side effects: drugs called statisn. Following this story, and along
with it in the online and print versions, are lists of the side effects
of statins.

Drugs called statins can lower cholesterol levels, a risk factor for
heart disease. But they can also cause serious problems.
Rita Daly and Karen Palmer Report

STAFF REPORTERS

Every day, more than 3 million Canadians pop a cholesterol pill,
comforted by the thought it could one day save their lives.

Dozens of studies have shown these pills, called statins, lower the
body's "bad" cholesterol, a risk factor for heart disease. The drugs
work safely and effectively for millions who suffer with cardiovascular
disease.

But a growing number of researchers, doctors and patients are becoming
concerned that statins - the world's fastest-growing class of drugs
- are being too readily prescribed to people who don't need them and
are causing more serious side effects than previously thought.

The debate has sparked a scientific tug-of-war among medical
researchers, drug makers and regulators, and underlines crucial
questions about how a drug's benefits are weighed against its risks and
who decides whether it should be on the market.

The answers aren't easy. There is no magic number of injuries or
deaths, no standard formula anywhere in the world that determines if a
drug may be unsafe.

One of the more common and known side effects of statins is muscle
pain, but the drugs can also cause muscle damage or myopathy, which can
also be a sign of a rare, potentially fatal muscle-wasting disease
called rhabdomyolysis. It's one of the most serious side effects, along
with liver and kidney damage, particularly at higher doses or when
taken with certain other medications.

Lorraine Smith, 65, of Whitby, was prescribed the statin Zocor strictly
to control her cholesterol. She was on lower doses for seven years when
her cholesterol rose again, and her doctor doubled the dose.

Shortly after, she awoke one morning paralyzed with pain. First her
arm, then her back, her legs, her hands, her fingers - every muscle,
every joint felt so stiff she couldn't move.

"It just seemed overnight, I had pain in my whole body ... it got worse
and worse," Smith says.

Seven different doctors sent her for a battery of tests, scopes and
scans to determine why this once-avid bowler and walker could no longer
shop for more than 10 minutes before the debilitating aches would set
in.

They found nothing. But Smith, who two years later still lives with the
pain, suspects the cholesterol drug was to blame.

Online message boards give her little hope, since they're filled with
hundreds of others who claim to have suffered the same kind of muscle
problems.

"I was shocked to find so many people who were having the exact same
problems."

Statins, such as Lipitor, Zocor and Crestor, are hailed as the wonder
drugs of the 21st century, the "new Aspirin" that lowers cholesterol,
staves off heart attacks and reduces the risk of heart disease, North
America's number one killer.

There are six on the market in Canada, and they're wildly popular.
Doctors wrote more than 15 million prescriptions for statins last year.
More than 8 million were prescribed for Pfizer Inc.'s Lipitor, making
it the nation's - and the world's - top-selling drug. Globally,
statin sales last year reached an unprecedented $26 billion (U.S.)

They're also part of a rapidly growing phenomenon in prescription
medicine - pharmaceuticals geared more to prevention than cure, that
offer a pill to fix years of stress, unhealthy habits or the effects of
aging. In the case of statins, people are expected to be on them for
life, and require regular checkups and blood tests.

Heart experts say millions worldwide benefit from the drugs.

"These are very, very efficacious drugs," says Dr. George Fodor, a
cardiologist and head of research at the University of Ottawa's
Prevention and Rehabilitation Centre who has conducted
industry-sponsored statin studies for more than 15 years. He says
cholesterol drugs have proven over and over to be safe.

"In the United Kingdom, a very conservative country, the statin (Zocor)
was released over the counter (this summer) because it was found safer
than Aspirin. It's an exceedingly safe drug."

Yet critics warn the drugs' side effects are being underplayed in a
marketing push to treat millions more people.

Maple Leafs hockey coach Pat Quinn praised his own cholesterol
medication at a media brunch this summer at Toronto's Hockey Hall of
Fame. Pharmaceutical giant Pfizer paid for the event.

Perched on a stool under television camera lights and surrounded by a
phalanx of reporters, Quinn spoke of his own heart scare two years ago
and the need for 8 million Canadians to get tested for high
cholesterol. He later acknowledged he got a "modest" fee for his
appearance.

"There's a $26 billion-a-year industry that ensures you hear all about
the beneficial side (of the drugs)," says Dr. Beatrice Golomb, a
neurologist at the University of California-San Diego, who is
researching the full spectrum of statin side effects.

"There really isn't any group that makes sure people hear about the
other side."

The drug industry, among the most profitable in the world, constantly
battles an image that Big Pharma is bad. It fights back by arguing it
invests heavily in medical research, is highly regulated and promotes
only products that have already been rigorously tested and approved.

"In the pharmaceutical industry, it somehow becomes very nasty and
suspect because we're marketing drugs," says Sheila Murphy, a
spokesperson for Merck and Co., which makes the statins Zocor and
Mevacor.

Company executives also say they work closely with government
regulators to monitor drug safety, reporting all serious side effects
they come across within 15 days.

Health Canada, the country's regulator, relies on those reports and
voluntary ones filed by health-care professionals - doctors,
pharmacists, hospital workers to search for clues that a drug might be
unsafe. The voluntary system has its flaws. It's estimated fewer than
one in 10 adverse reactions are ever reported, but they are still used
as a surveillance tool.

An analysis of the Canadian adverse drug reaction data, obtained by the
Toronto Star, shows there were 1,739 reports filed where a statin was
suspected in a reaction, from 1988 when the first one hit the market to
the end of 2003.

Of those, 1,024 were deemed serious.

In August, 2001, Bayer's Baycol was pulled from the market because of
dozens of cases worldwide involving rhabdomyolysis, the muscle-wasting
disease. Canadian data show 76 cases of the disease involving Baycol
had been reported by the end of 2003, 31 of which were filed after it
was withdrawn and lawsuits launched.

Health Canada says statin-related rhabdomyolysis cases are "very rare,"
occurring in less than one in 10,000 patients. This month, a U.S. Food
and Drug Administration study found Baycol triggered the potentially
fatal muscle disease 10 times more often than Lipitor, Zocor and
Pravachol, although Bayer disputes the findings.

The latest figures from Health Canada for statins on the market show
that up to the end of October, there were 62 reports of rhabdomyolysis
in patients taking Lipitor, 18 for Zocor, 12 for Merck's Mevacor, five
for Pravachol, made by Bristol-Myers Squibb, and 11 for AstraZeneca's
Crestor.

As of the end of 2003, according to the Star's analysis, there were 44
deaths reported where a statin was suspected - five of which,
involving Baycol, were filed after the drug was pulled. Health Canada
and drug makers say that without further study, it is difficult to know
whether the drug alone or in combination with another medication, or an
underlying medical condition, caused the reactions.

Peter Kung, 43, of Scarborough, will probably never know what caused
the pain and weakness in his right shoulder and arm. A diabetic, he was
already taking medication to help control his blood sugar levels, as
well as blood pressure pills, when prescribed Lipitor. At 5-foot-9 and
205 pounds, he had unsuccessfully tried diet to control his high
cholesterol.

It wasn't until he saw a Lipitor commercial that cited muscle pain as a
common side effect that he decided the risk of muscle damage wasn't
worth the benefits of the drug.

One doctor diagnosed it as frozen shoulder, a common complication of
diabetes, but Kung still wonders if it was the drug.

Golomb, whose research on statins is almost complete, says even a blood
test designed to detect statin-related muscle damage isn't catching all
cases. New evidence shows doctors may be overlooking cases like
Lorraine Smith's, whose test was normal, Golomb says.

Her statin research also involves a $4.5 million study, funded by the
U.S. National Institutes of Health, of patients who have experienced
blackouts and memory loss while on the drug. Such side effects aren't
surprising considering the brain is rich in cholesterol, she says.

Makers of statins have not acknowledged cognitive problems as a side
effect.

Dr. Jack Watters, a senior medical director for Pfizer, says a body of
academic opinion states "if you treat with statins, you will improve
cognitive health and prevent the onset of dementia and Alzheimer's."

--------------------------------------------------------------------------------
`It just seemed overnight, I had pain in my whole body ... it got worse
and worse'

Lorraine Smith, Zocor user

--------------------------------------------------------------------------------

At the core of the statin debate is this question: Is cholesterol a
useful marker for heart disease and, if so, does everyone with high
cholesterol need drugs?

A soft, fat-like substance in blood and cells vital to various
functions, including transporting vitamins to tissue, cholesterol was
first identified as a risk factor in a Massachusetts study in 1950. It
was listed among 240 risk factors, including male baldness, short
stature and creased ear lobes.

Ever since, science has seesawed on just how prominent a role
cholesterol plays and whether it is really a predictor of a fatal heart
attack.

Some heart experts say study data overwhelmingly show cholesterol is a
major risk factor. Other experts have looked at the same data and
concluded high cholesterol doesn't necessarily put you at risk. They
say researchers with financial ties to statin makers are pushing drugs
harder as a convenient alternative to lifestyle changes.

Dr. James Wright, director of the B.C.-government funded Therapeutics
Initiative that evaluates drugs on the market, says independent
analyses of statin studies show middle-aged men with coronary heart
disease have, at best, a 2 per cent better chance of living longer
while on the drugs.

No survival benefit has been proven for women, men over 70, or men at a
lower cardiac risk, he says.

High cholesterol poses a problem if someone in the family had a heart
attack or stroke at a young age - just as smoking, high blood
pressure and lack of exercise are major risk factors for heart disease.
On the other hand, he says, if you have high cholesterol in your family
and there have been no heart attacks, it indicates your cholesterol is
of no consequence.

"Yet, now we've got people and their parents, none of whom have had a
coronary event, all on drugs. It's a crazy concept."

When Lorraine Smith was prescribed Zocor nine years ago, she didn't
have cardiovascular disease, and there was no family history of heart
problems. She did have high cholesterol, mild angina and was a light
smoker.

At first, a 20-milligram dose lowered her cholesterol. Then, it started
to rise again, and Smith's doctor upped her dose, first to 40
milligrams, then, two years ago, to the highest dose possible, 80
milligrams. Within weeks, she became crippled with pain. Smith says she
was aware the drugs could cause mild muscle pain but learned only later
that severe muscle damage is a known side effect of statins, especially
at high doses.

Her family doctor immediately cut the dosage in half, then told her to
stop the drug altogether. No link has been made to the drug, yet the
pain continues, and since going off the drug her cholesterol levels
have risen only slightly.

In August, Merck, Zocor's maker, released a study showing the 80
milligram dose increased the risk of muscle problems and was no more
effective than lower doses.

Company officials contend the drug is safe when used appropriately.

Most clinical trials of statins have primarily studied middle-aged men,
but statin makers - constantly exploring the wider potential for the
drugs - say all indications in those studies show women and elderly
people stand to benefit.

"I contest the fact there is reduced benefit in elderly people," says
Pfizer's Watters.

"The fact that they may not necessarily have been studied doesn't
necessarily show that you can conclude, therefore, that there was no
effect. That is an entirely spurious argument."

Dr. Ruth McPherson, a endocrinologist at the University of Ottawa Heart
Institute, says it would be unethical not to treat women and the
elderly.

"There's nothing different about arteriosclerosis in women versus men
and the elderly versus the young, and if we deny appropriate treatment
to women, just saying we're not going to do this until we have a study
with 10,000 women, it doesn't make any sense."

More than 30 American and British researchers and doctors from medical
schools such as Harvard, Stanford and Johns Hopkins have recently lined
up against this argument, however.

This fall, in a petition to the National Institutes Of Health, they
called for an independent review of U.S. cholesterol guidelines -
revised in 2001 and again this summer - charging millions more will
now be prescribed a drug they may not need and can cause side effects.
Adding force to their demand and spawning accusations of bias was the
revelation that eight of the nine guideline authors had financial ties
to makers of statins, receiving consulting and lecture fees, and
research money.

Canadian cholesterol guidelines, published in the Canadian Medical
Association Journal, have also been revised twice in the past four
years, resulting in more people being prescribed statins.

The four authors of those guidelines have also received money from
statin manufacturers. Three have sat on drug company advisory boards
and three have received research grants to conduct statin studies and
travel expenses to speak at scientific meetings sponsored by
pharmaceutical companies.

The authors, interviewed by the Star, acknowledge while there is a
perception of bias, the guidelines are based on sound scientific
evidence.

"I have family members who are very much upset about the relationship
of drug companies to academia in general, and guideline makers in
particular," says author Dr. Jiri Frolich, a cardiologist at St. Paul's
Hospital at the University of British Columbia.

But "if you really want to be good in your field, I would say it is
almost impossible or extremely difficult not to be touched by industry
in one way or another."

Part of the frenzy surrounding cholesterol has been created by drug
makers battling over the blockbuster statin market.

There are six statins on the market, made by different companies -
and they're at war.

Since the first of these drugs, Merck's Mevacor, hit the market in the
late 1980s, manufacturers have raced to prove one statin is more
effective and safer than the next.

Dozens of clinical trials have been published to show one drug lowered
cholesterol better, another reduced chances of a second heart attack,
while yet another prevented a heart attack from happening at all.

At the same time, statin makers have run costly advertising and
education campaigns, partnering with health organizations to teach the
public about the dangers of cholesterol and flooding doctors' offices
with promotional literature.

Pfizer, which launched Lipitor onto the market in the U.S. in 1996 and
Canada in 1997, has been particularly ambitious, partnering with the
Canadian Diabetes Association as well as entertainment and sports
celebrities, like Pat Quinn.

The meteoric rise of statins has suffered its setbacks.

Bayer has been accused of knowing Baycol's risk long before it warned
the public. Bayer denies the accusation, saying the drug carried
warnings about rhabdomyolysis when it was approved.

It is also the target of numerous lawsuits in which Bayer has agreed to
pay more than $1 billion (U.S.) out of court. A settlement was reached
in March in a Canadian class action commenced by Toronto law firm
Rochon Genova, with no admission of liability on Bayer's part.

Responding to the Star's questions about reported cases linked to
Baycol in Canada, Bayer said in a statement: "It is likely that many of
these events relate to medical conditions that have never been shown to
be associated with statin use."

Kim Coleman, whose 59-year-old mother, Pearl Inwood, died while on
Baycol, says she wonders why the drug wasn't pulled sooner if they knew
it was causing problems.

"We were never aware of this muscle problem," says Coleman, whose
mother died in July, 2001, of complications from severe rhabdomyolysis
at a Kingston hospital and who is part of the class action. "It was the
shock of our lives. One week she was in hospital, the next week she was
gone."

The drug was pulled two weeks after her mother's death.

Crestor, the newest statin to hit the market, has also run into
problems. Health Canada has issued two warnings on the drug since it
came on the market in February, 2003. Last week, the regulator said
there have been 11 reports of rhabdomyolysis in patients using Crestor.

Public Citizen, a 160,000-member consumer advocacy group in the U.S.,
has called for a ban on the drug. And two weeks ago, a senior FDA
researcher named Crestor among five medications that he said needs
closer scrutiny.

Carley Vint-Reed, scientific director of cardiovascular research for
AstraZeneca, says all data available show Crestor to be a safe
molecule.

"It's very clear that all of the statins on the market are safe,
including Crestor. That safety profile has remained in the same
relative risk since the beginning of the first statin."

STATIN-RELATED REACTIONS*
Types of reactions to statins, a class of cholesterol-lowering drugs,
as reported to Health Canada and entered into its Canadian Adverse Drug
Reaction Information System, from the date the drug was approved to the
end of 2003. The reports, filed mainly by health care providers,
reflect a suspicion or opinion that the drug may have been involved in
an adverse reaction, and, alone, cannot be used to establish a cause
and effect relationship. There are other important caveats associated
with this data that should be read. Drugs are listed by active
ingredient, followed by the total number of prescriptions filled in
Canada from 1999 to 2003. In brackets is the brand name the drug was
first marketed as.**

You can look up the specifics of a reaction term using MedlinePlus'
Medical Dictionary

*Data Source: Health Canada. Analysis: Toronto Star
**Source: IMS Health - Canada

ATORVASTATIN, 27.5 million - (LIPITOR) (monograph)

RHABDOMYOLYSIS 43SGOT INCREASED 42CREATINE KINASE INCREASED 41SGPT
INCREASED 41MUSCLE PAIN 33MYOCARDIAL INFARCTION 23WEAKNESS GENERALIZED
23NAUSEA 22ABDOMINAL PAIN 20MYALGIA 20HEPATIC ENZYMES INCREASED
19MUSCLE WEAKNESS 19RASH 18ALKALINE PHOSPHATASE SERUM INCR 17CREATINE
PHOSPHOKINASE INCREASED 16FATIGUE 16CHEST PAIN 15CONDITION AGGRAVATED
15FEVER 15HEADACHE 15HYPERTENSION 15DIARRHOEA 14ITCHING 14PAIN
14BRONCHITIS 13BREATH SHORTNESS 12CEREBROVASCULAR DISORDER 12CORONARY
ARTERY DISORDER 12COUGHING 12LDH INCREASED 12LEG PAIN 12MYOSITIS
12PANCREATITIS 12STROKE 12CPK INCREASED 11CREATININE BLOOD INCREASED
11RENAL FAILURE ACUTE 11VOMITING 11BILIRUBIN INCREASED 10CONVULSIONS
10INSOMNIA 10MUSCLE ACHE 10PRURITUS 10WEIGHT DECREASE 10BLOOD PRESSURE
INCREASED 9FALL 9GAMMA-GT INCREASED 9INFECTION 9JAUNDICE 9LIVER
FUNCTION TESTS ABNORMAL NOS 9PROSTATIC DISORDER 9VISION DECREASED
9WALKING DIFFICULTY 9BACK PAIN 8DIZZINESS 8GAMMA-GLUTAMYLTRANSFERASE
INCR. 8HAEMOGLOBIN DECREASED 8HEART ATTACK 8URINARY TRACT INFECTION
8ARTHRITIS 7CHOLELITHIASIS 7CONSTIPATION 7ERYTHEMA 7HERNIA NOS
7HYPOTENSION 7JOINT PAIN 7MALAISE 7SINUSITIS 7ANGINA PECTORIS 6ANXIETY
6APPETITE DECREASED 6BLOOD SUGAR INCREASED 6BREATHING DIFFICULT
6BURNING SENSATION 6CHRONIC OBSTRUCT AIRWAYS DISEASE 6CRAMPS LEGS
6DIABETES MELLITUS 6DYSPEPSIA 6DYSPNOEA 6FEELING UNWELL 6FIBRILLATION
ATRIAL 6GASTRITIS 6HEPATITIS 6HYPERGLYCAEMIA 6HYPERTRIGLYCERIDAEMIA
6MUSCLE CRAMP 6MYOGLOBINURIA 6OEDEMA LEGS 6PALPITATION 6PNEUMONIA
6RENAL FAILURE NOS 6TINGLING SKIN 6WEIGHT INCREASE 6ADENOCARCINOMA NOS
5ALLERGIC REACTION 5ANGINA PECTORIS AGGRAVATED 5ANGIOEDEMA 5ANOREXIA
5ASTHENIA 5CATARACT 5CELLULITIS 5DERMATITIS 5GASTROESOPHAGEAL REFLUX
5INFECTION VIRAL 5LEUCOPENIA 5MYOPATHY 5NEOPLASM NOS 5PAIN
NECK/SHOULDER 5PULMONARY CARCINOMA 5THROMBOCYTOPENIA 5URINE
DISCOLOURATION 5VISION BLURRED 5ARTHRALGIA 4ARTHRITIS AGGRAVATED 4BOWEL
OBSTRUCTION 4BRUISE 4BUN INCREASED 4CARCINOMA 4CONGESTIVE HEART FAILURE
4CORONARY ARTERY OCCLUSION 4ESR INCREASED 4EYE HAEMORRHAGE 4HEPATIC
FAILURE 4HIATUS HERNIA 4LEUKOCYTOSIS 4OEDEMA 4PANCREATITIS ACUTE
4PARAESTHESIA 4POLYMYOSITIS 4SLEEP DISTURBED 4TACHYCARDIA 4ANAEMIA
3ANEURYSM 3ANGINA UNSTABLE 3APPETITE LOST 3ARTERIOSCLEROSIS 3BULLOUS
ERUPTION 3CARPAL TUNNEL SYNDROME 3CHEST TIGHTNESS OF 3CHOLECYSTITIS
3COLON CARCINOMA 3DEPRESSION 3DIVERTICULITIS 3EFFICACY, LACK OF
3EPIGASTRIC PAIN NOT FOOD-RELATED 3EYELID OEDEMA 3GASTRO-INTESTINAL
DISORDER NOS 3GASTROINTESTINAL TRACT BLEED NOS 3GYNAECOMASTIA 3HDL
DECREASED 3HEARTBURN 3HOARSENESS 3INFECTION LOCALISED 3LACTIC
DEHYDROGENASE ACTIVITY INC 3LIPID METABOLISM DISORDER NOS 3MACULAR
DEGENERATION 3MEMORY LOSS 3OEDEMA PERIORBITAL 3PANCYTOPENIA 3PLEURAL
EFFUSION 3POST-OPERATIVE WOUND INFECTION 3PROTEINURIA 3PULMONARY OEDEMA
3RBC DECREASED 3RENAL CALCULUS 3RENAL COLIC 3RETROSTERNAL PAIN
3SWELLING NON-INFLAMMATORY 3SYNCOPE 3TIREDNESS 3UNCONSCIOUSNESS
3URINARY FREQUENCY 3VASCULAR DISORDER 3ABDOMINAL PAIN LOWER 2ABDOMINAL
PAIN UPPER 2ABSCESS 2ALOPECIA 2AMYLASE INCREASED 2ANAEMIA APLASTIC
2ARRHYTHMIA 2ASTHMA 2BACK ACHE 2BALANCE DIFFICULTY 2BICARBONATE RESERVE
DECREASED 2BLISTERS 2BLOATING 2BLOOD SUGAR DECREASED 2BONE DISORDER
2BONE PAIN 2BRADYCARDIA 2BREAST CANCER 2BURN 2CANDIDIASIS
2CARDIOMYOPATHY 2CEREBRAL VASCULAR DISTURBANCE 2CHEST CONGESTION 2CHEST
DISCOMFORT 2CHEST PRESSURE SENSATION OF 2CHILLS 2CHOLANGITIS
2COAGULATION DISORDER 2COLITIS ULCERATIVE AGGRAVATED 2CONFUSION
2CONJUNCTIVITIS 2CONSCIOUSNESS DECREASED 2CRAMPS 2CYST NOS 2DEHYDRATION
2DELIRIUM 2DEPRESSION AGGRAVATED 2DIABETES MELLITUS AGGRAVATED
2DUODENAL ULCER 2ECCHYMOSIS 2ECG ABNORMAL 2ELECTROLYTE ABNORMALITY
2ENCEPHALITIS 2ENCEPHALOPATHY 2EPISTAXIS 2ERUCTATION 2FLATULENCE
2FRACTURE PATHOLOGICAL 2GALL BLADDER DISORDER 2GALL BLADDER STONES
2GASTROENTERITIS 2GI HAEMORRHAGE 2HAEMATOMA 2HAEMATURIA 2HAEMORRHAGE
NOS 2HAIR LOSS 2HEART DISORDER 2HEPATIC FUNCTION ABNORMAL 2HEPATITIS
CHOLESTATIC 2HEPATOMEGALY 2HYDRONEPHROSIS 2HYPOCALCAEMIA 2HYPOGLYCAEMIA
2HYPOPROTEINAEMIA 2HYPOXIA 2KIDNEY STONE 2LACTATE BLOOD INCREASE 2LOWER
RESP. TRACT INFECTION 2MEDICATION ERROR 2MENORRHAGIA 2METASTASES NOS
2MOUTH ULCERATION 2MOVEMENTS REDUCED 2MUSCLE DISCOMFORT 2MUSCLE
TENDERNESS ANY SITE 2NAIL DISCOLOURATION 2NEUROPATHY 2NEUTROPENIA
2NON-ACCIDENTAL OVERDOSE 2NUMBNESS 2NUMBNESS LOCALIZED 2OEDEMA OF
EXTREMITIES 2OEDEMA PERIPHERAL 2OSTEOPOROSIS 2PAIN LEGS 2PROTHROMBIN
TIME PROLONGED 2RASH MACULO-PAPULAR 2RASH SCALY 2RECTAL PROLAPSE 2RENAL
FAILURE CHRONIC 2RENAL FUNCTION ABNORMAL 2RESPIRATORY DISORDER
2RESPIRATORY DISTRESS 2RESPIRATORY DYSFUNCTION NOS 2RIGORS 2SEMEN
ABNORMAL 2SEPSIS 2SERUM LIPID ABNORMAL NOS 2SHAKING 2SKIN
DISCOLOURATION 2SKIN DISORDER 2SKIN DRY 2SKIN ULCERATION 2SLEEP
DIFFICULT 2SLEEP DISORDER 2SMALL INTESTINE OBSTRUCTION 2SPEECH DISORDER
2STRENGTH LOSS OF 2SUICIDE ATTEMPT 2SWALLOWING IMPAIRED 2TASTE
ALTERATION 2TASTE PERVERSION 2TEMPERATURE ELEVATION 2THROAT SORE
2THROAT SWELLING NON-SPECIFIC 2THROAT TIGHTNESS 2TOOTH DISORDER
2TRANSIENT ISCHAEMIC ATTACK 2UPPER RESP TRACT INFECTION 2UREA BLOOD
LEVEL INCREASED 2WEAKNESS VOLUNTARY MUSCLE 2ABDOMINAL DISCOMFORT
1ABDOMINAL DISTENSION 1ACCIDENTAL OVERDOSE 1ACIDOSIS LACTIC 1ACIDOSIS
METABOLIC 1ACNE 1AGITATION 1ALLERGIC CONJUNCTIVITIS 1ALLERGY 1ALP
INCREASED 1ANAEMIA AGGRAVATED 1ANAEMIA HAEMOLYTIC 1ANAPHYLAXIS 1ANGER
1ANGINAL ATTACK 1AORTIC ANEURYSM RUPTURE 1AORTIC STENOSIS 1AORTIC VALVE
STENOSIS 1APPENDICITIS 1APPETITE INCREASED 1ARRHYTHMIA VENTRICULAR
1ARTHRITIC-LIKE PAIN 1ASCITES 1ASTHENIA LEGS 1ATRIAL FLUTTER 1ATRIAL
FLUTTER/ FIBRILLATION 1BACK DISCOMFORT 1BELCHING 1BILIARY COLIC
1BILIRUBINAEMIA 1BLADDER CARCINOMA 1BLEEDING TIME INCREASED 1BLOOD
PRESSURE DROP ARTERIAL 1BLOOD SEDIMENTATION INCREASED 1BLOOD UREA
INCREASED 1BLOOD UREA NITROGEN INCREASED 1BONE NECROSIS 1BRAIN NEOPLASM
MALIGNANT 1BREAST NEOPLASM FEMALE 1BREAST PAIN FEMALE 1BREAST PAIN MALE
1BRONCHOSPASM 1BURNING MUCOSAL 1BURSITIS 1CALCIUM DEPOSITS 1CALCULUS
URINARY BLADDER 1CERVICAL SMEAR TEST POSITIVE 1CERVIX CARCINOMA 1CHANGE
IN BOWEL HABITS 1CHEST BURNING PAIN OF 1CHEST X-RAY ABNORMAL
1CHOLESTASIS INTRAHEPATIC 1CHOLESTEROL BLOOD DECREASED 1CHOLESTEROL
BLOOD REDUCED 1CHOLESTEROL SERUM INCREASED 1CIRRHOSIS BILIARY
1CLAUDICATION INTERMITTENT 1COAGULATION TIME INCREASED 1COGNITIVE
DISORDERS 1COMA 1CONFUSIONAL STATE 1CONGENITAL ANOMALY NOS 1CONGESTIVE
CARDIAC FAILURE AGGR 1CONVULSIONS GRAND MAL 1CORNEAL OPACITY 1CORONARY
ARTERY SPASM 1CORONARY DISEASE 1CRAMP ABDOMINAL 1CROHN'S DISEASE
AGGRAVATED 1CRYING ABNORMAL 1CYANOSIS PERIPHERAL 1DEJECTION EMOTIONAL
1DERMATOMYOSITIS 1DISCOMFORT BODILY 1DISORIENTATION 1DISSEM. INTRAVASC.
COAGULATION 1DOWN'S SYNDROME 1DROWSINESS 1DRUG MALADMINISTRATION 1DRY
EYES 1DRY LIPS 1DYSPHAGIA 1EAR ACHE 1ECG ABNORMALITIES NON-SPECIFIC
1ECZEMA 1EIGHTH NERVE LESION NOS 1EMPHYSEMA 1ENDOMETRIAL ADENOCARCINOMA
1EPIGLOTTITIS 1ERECTION DECREASED 1ERYTHROCYTOPENIA 1EXHAUSTION
1EXTRASYSTOLE VENTRICULAR 1EXUDATE NIPPLES 1EYE INFECTION 1EYE PAIN
1FACE OEDEMA 1FAECAL ABNORMALITY NOS 1FAECAL OCCULT BLOOD POSITIVE
1FAECES DISCOLOURED 1FAECES PALE 1FATIGUE EXTREME 1FEELING COLD
1FEELING HIGH 1FEELING OF WARMTH 1FIBRILLATION ATRIAL AGGRAVATED 1FLANK
PAIN 1FLUSHING 1FORGETFULNESS 1FRACTURE RIB 1FRACTURE VERTEBRAL
1GANGRENE 1GASTRIC CARCINOMA 1GASTRIC ULCER 1GENITAL NEOPLASM MALIGNANT
MALE 1GINGIVITIS 1GLAUCOMA 1GLOTTIC OEDEMA 1GOUT 1HAEMATEMESIS
1HAEMOPTYSIS 1HAEMORRHAGE BRAIN STEM 1HAEMORRHAGE NASAL 1HAIR THINNING
1HEAD PRESSURE 1HEARING DECREASED 1HEART FAILURE 1HEART MALFORMATION
1HEART MURMUR 1HEART POUNDING 1HEART THROBBING 1HEMIPARESIS 1HEPATIC
CIRRHOSIS 1HEPATIC METASTASES 1HEPATIC NECROSIS 1HEPATIC NEOPLASM
1HEPATIC STEATOSIS 1HEPATITIS FULMINANT 1HEPATITIS TOXIC
1HEPATOCELLULAR DAMAGE 1HERNIA INGUINAL 1HIGH DENSITY LIPOPROTEIN
DECREASE 1HIP DISLOCATION 1HIVES 1HOT FLUSHES 1HYPERBILIRUBINAEMIA
1HYPERCHOLESTEROLAEMIA 1HYPERMAGNESAEMIA 1HYPERPARATHYROIDISM
1HYPERPHOSPHATAEMIA 1HYPERTENSION AGGRAVATED 1HYPERVENTILATION
1HYPOKALAEMIA 1HYPOMAGNESAEMIA 1HYPONATRAEMIA 1HYPOTHYROIDISM 1ILEUS
PARALYTIC 1IMPOTENCE 1INCREASED INSULIN REQUIREMENT 1INDIGESTION
1INFECTION BACTERIAL 1INFERTILITY MALE 1INFLICTED INJURY
1INFLUENZA-LIKE SYMPTOMS 1INJECTION SITE REACTION 1IRRITABILITY
1IRRITABLE BOWEL SYNDROME 1JOINT ACHE 1JOINT SWELLING NON-INFLAMMATORY
1KIDNEY DYSFUNCTION 1LDH INCREASED SERUM 1LDL INCREASED 1LEG ULCER (EXC
VARICOSE) 1LENTICULAR OPACITY 1LEUKAEMIA 1LIGHT-HEADED FEELING 1LIPASE
INCREASED 1LIVER AND BILIARY SYSTEM DISORDERS 1LIVER FATTY 1LOW DENSITY
LIPOPROTEIN INCREASED 1LUMBAR PAIN 1LYMPHOMA MALIGNANT 1MEMORY
IMPAIRMENT 1MENIERE'S SYNDROME 1MIGRAINE 1MITRAL VALVE INCOMPETENCE
1MOOD SWINGS 1MOUTH DRY 1MOUTH IRRITATION 1MULTIPLE MYELOMA 1MULTIPLE
ORGAN FAILURE 1MUSCLE DEGENERATION 1MUSCLE DISORDER 1MUSCLE RIGIDITY
1MUSCLE SPASTICITY 1MUSCLE STIFFNESS 1MUSCLE WASTING 1MUSCULO-SKELETAL
SYSTEM DISORDERS 1MYOCARDIAL ISCHAEMIA 1NECROSIS ISCHAEMIC 1NEOPLASM
1NEPHROTIC SYNDROME 1NERVOUSNESS 1NEURITIS 1NEUROLOGIC DISORDER NOS
1NEUROPATHY PERIPHERAL 1NEUTROPHILIA 1NOCTURIA 1NON-HODGKIN'S LYMPHOMA
1NOSEBLEED 1NPN INCREASED 1OEDEMA MOUTH 1OEDEMA PULMONARY 1OESOPHAGEAL
VARICES 1OLIGOSPERMIA 1ORAL NEOPLASM BENIGN 1OVARIAN TUMOUR BENIGN
1PAIN BURNING 1PAIN RIGHT UPPER QUADRANT 1PALLOR 1PANCREAS CARCINOMA
1PANCREATITIS NECROTISING 1PANNICULITIS 1PARALYSIS 1PARALYSIS FACIAL
1PASSED OUT 1PELVIC PAIN 1PERIODONTITIS 1PERIPHERAL GANGRENE
1PERITONITIS 1PERSONALITY DISORDER 1PERSPIRATION EXCESSIVE 1PEYRONIE'S
DISEASE 1PHLEBITIS 1PHOTOSENSITIVITY REACTION 1PLATELET PRODUCTION
DECREASED 1PNEUMONIA LOBAR 1PNEUMONITIS 1POLYCYTHAEMIA 1POLYDIPSIA
1POLYURIA 1POTASSIUM SERUM DECREASED 1POTASSIUM SERUM INCREASED
1PRE-SYNCOPE 1PRICKING SKIN SENSATION 1PROSTATIC SPECIFIC ANTIGEN INCR.
1PROSTATISM AGGRAVATED 1PSYCHIATRIC DISORDERS 1PULMONARY CONGESTION
1PULMONARY FIBROSIS 1PULMONARY INFILTRATION 1PULSE RATE INCREASED
1PULSE WEAK 1PYELONEPHRITIS 1PYLORIC ULCER 1PYOGENIC GRANULOMA
1QUADRIPLEGIA 1RASH BULLOUS 1RASH ERYTHEMATOUS 1RASH PETECHIAL 1RASH
PUSTULAR 1RECTAL BLEEDING 1RECTAL CARCINOMA 1RECURRENT CANCER 1RENAL
CARCINOMA 1RENAL CYST 1RENAL FAILURE AGGRAVATED 1RESPIRATORY LESION
1RESPIRATORY SYSTEM DISORDER 1RESTLESSNESS MARKED 1RHINITIS 1SCALP
TENDERNESS 1SENSORY DISTURBANCE 1SEPTICAEMIA 1SERUM IRON DECREASED
1SHIVERING 1SHIVERS 1SICK SINUS SYNDROME 1SKIN FLUSHED 1SKIN NECROSIS
1SKIN NODULE 1SKIN REACTION LOCALISED 1SLEEP DECREASED 1SLEEPLESSNESS
1SLURRED SPEECH 1SOMNOLENCE 1SPASMS 1SPINAL FRACTURES 1SPINE
MALFORMATION 1SPLEEN DISORDER 1ST ELEVATED 1STEVENS JOHNSON SYNDROME
1STOMACH UPSET 1STOMATITIS 1SUBARACHNOID HAEMORRHAGE 1SUGAR BLOOD LEVEL
INCREASED 1SUGAR FASTING BLOOD LEVEL INCR 1SUICIDAL TENDENCY
1SWALLOWING PAINFUL 1TENDINITIS 1TENDON INJURY 1TESTICULAR PAIN
1THERAPEUTIC RESPONSE DECREASED 1THIRST 1THORACIC PAIN 1THROMBOSIS
1THYROID CARCINOMA 1THYROID DISORDER 1TIA 1TINNITUS 1TOOTH
DISCOLOURATION 1TREMOR 1URETHRAL CALCULUS 1URIC ACID BLOOD INCREASED
1URINARY INCONTINENCE 1URINARY RETENTION 1URINE CONSTITUENTS ABNORMAL
1URINE PRODUCTION SCANTY 1URTICARIA 1UTERINE CARCINOMA 1UTERINE FIBROID
1UTERINE PROLAPSE 1UTEROVAGINAL PROLAPSE 1VAGINAL CANDIDIASIS 1VEIN
VARICOSE 1VERTIGO 1VISION ABNORMAL 1VISUAL IMPAIRMENT 1VITAMIN B12
DEFICIENCY 1

CERIVASTATIN, 1.5 million, Off market in Aug, 2001 -
(BAYCOL)(monograpgh not available)

RHABDOMYOLYSIS 76CREATINE KINASE INCREASED 46MUSCLE PAIN 41WEAKNESS
GENERALIZED 26MUSCLE WEAKNESS 25MYALGIA 24CPK INCREASED 22CREATINE
PHOSPHOKINASE INCREASED 21SGOT INCREASED 18PAIN 16WALKING DIFFICULTY
16BACK PAIN 14CREATININE BLOOD INCREASED 13LEG PAIN 13NAUSEA 13SGPT
INCREASED 13RENAL FAILURE ACUTE 12FATIGUE 11MYOGLOBINURIA 11HEPATIC
ENZYMES INCREASED 10MUSCLE ACHE 9MYOSITIS 9BREATH SHORTNESS 8DIARRHOEA
8HEADACHE 8RENAL FAILURE NOS 8URINE DISCOLOURATION 8DIZZINESS 7LDH
INCREASED 7PAIN NECK/SHOULDER 6VOMITING 6CHEST PAIN 5ANGINA PECTORIS
4APPETITE DECREASED 4APPETITE LOST 4INFLUENZA-LIKE SYMPTOMS 4JOINT PAIN
4JOINT STIFFNESS 4MALAISE 4MOBILITY DECREASED 4WEIGHT DECREASE
4ASTHENIA LEGS 3BURNING SENSATION 3CARDIAC ARREST 3CONDITION AGGRAVATED
3COUGHING 3FAECAL INCONTINENCE 3FALL 3ITCHING 3KIDNEY DYSFUNCTION
3MUSCLE WASTING 3MYOPATHY 3PROTEINURIA 3RASH 3STROKE 3WEIGHT INCREASE
3ABDOMINAL PAIN 2BLOOD SUGAR INCREASED 2BREATHING DIFFICULT 2BUN
INCREASED 2CHEST DISCOMFORT 2CHILLS 2CRAMPS 2CRAMPS LEGS 2DYSPNOEA
2ERYTHEMA 2EYE PAIN 2FATIGUE EXTREME 2FEVER 2FLANK PAIN 2HAEMATURIA
2HEARTBURN 2HYPERKALAEMIA 2INSOMNIA 2JOINT INFLAMMATION 2LETHARGY
2LEUCOPENIA 2MUSCLE ATROPHY 2MUSCLE CRAMP 2MUSCLE DEGENERATION 2MUSCLE
DISORDER 2MUSCLE SPASTICITY 2NEUROPATHY PERIPHERAL 2NIGHTMARES
2NUMBNESS 2NUMBNESS LOCALIZED 2OEDEMA PERIORBITAL 2PASSED OUT
2POTASSIUM SERUM INCREASED 2RECTAL BLEEDING 2RENAL PAIN 2SINUSITIS
2STOMACH UPSET 2SWEATING INCREASED 2TACHYCARDIA 2THROAT SWELLING
NON-SPECIFIC 2VISION BLURRED 2ABDOMEN ENLARGED 1ABDOMINAL PAIN UPPER
1ALKALINE PHOSPHATASE SERUM INCR 1ALLERGIC REACTION 1ALOPECIA 1AMBITION
LOSS OF 1ANAPHYLACTIC SHOCK 1ANGINA PECTORIS AGGRAVATED 1ANGINA
UNSTABLE 1ANXIETY 1APHONIA 1ARTHRALGIA 1ASCITES 1ASPHYXIA 1BACK ACHE
1BACK DISCOMFORT 1BALANCE DIFFICULTY 1BILIRUBIN INCREASED 1BLACK-OUT
(NOT AMNESIA) 1BLISTERS 1BLOOD UREA NITROGEN INCREASED 1BONE PAIN
1BRADYCARDIA 1BRUISE 1BULLOUS ERUPTION 1CARDIAC ARRHYTHMIA NOS 1CARPAL
TUNNEL SYNDROME 1CATARACT 1CEREBROVASCULAR DISORDER 1CHEST PRESSURE
SENSATION OF 1CHEST TIGHTNESS OF 1CHOKING 1CHOLECYSTITIS 1CHOLESTEROL
SERUM INCREASED 1CIRRHOSIS BILIARY 1COGNITIVE FUNCTION ABNORMAL
1CONVULSIONS 1DEBILITY MARKED 1DEHYDRATION 1DEPRESSION 1DEPRESSION
AGGRAVATED 1DIAPHORESIS 1DIGESTION IMPAIRED 1EAR RINGING 1ELECTROLYTE
ABNORMALITY 1EMBOLISM LIMB 1EMOTIONAL LABILITY 1EPIGASTRIC PAIN NOT
FOOD-RELATED 1ERECTION DECREASED 1EYE ABNORMALITY 1FACE OEDEMA
1FASCIITIS 1FEELING UNWELL 1GAIT ABNORMAL 1GAMMA-GLUTAMYLTRANSFERASE
INCR. 1GASTRITIS 1GASTROESOPHAGEAL REFLUX 1HEAD PAIN 1HEARING DECREASED
1HEART DISORDER 1HEAVINESS IN LIMBS 1HEPATIC FAILURE 1HEPATITIS 1HIVES
1HYPERGLYCAEMIA 1HYPERTONIA 1HYPERURICAEMIA 1HYPOTENSION 1HYPOXIA
1INDIFFERENCE 1IRRITABILITY 1JAUNDICE 1KIDNEY STONE 1LARYNGEAL OEDEMA
1LARYNGOSPASM 1LIVER ENLARGEMENT 1LIVER FUNCTION TESTS ABNORMAL NOS
1LUMBAR DISC LESION 1MEDICATION ERROR 1MEMORY DISTURBANCE 1MENTAL
DULLNESS 1MOVEMENTS REDUCED 1MUSCLE STIFFNESS 1MUSCLE TENDERNESS ANY
SITE 1MUSCLE TONE FLACCID 1MUSCULO-SKELETAL SYSTEM DISORDERS
1MYOCARDIAL INFARCTION 1OEDEMA 1OEDEMA LEGS 1OEDEMA PERIPHERAL
1OLIGURIA 1OVARIAN CARCINOMA 1PAIN GROIN 1PAIN LEGS 1PALPITATION
1PANCREAS CARCINOMA 1PARAESTHESIA 1PERIPHERAL ISCHAEMIA 1POLYARTHRITIS
GENERALIZED 1POLYMYALGIA RHEUMATICA 1PRICKING SKIN SENSATION 1PRURITUS
1PULSE IRREGULARITY NOS 1RED EYE 1RENAL FUNCTION ABNORMAL 1RENAL
TUBULAR NECROSIS 1RESTLESSNESS MARKED 1SENSORY DISTURBANCE 1SKELETAL
MALFORMATION 1SKELETAL PAIN 1SKIN COLD CLAMMY 1SLEEP DECREASED
1SLEEPINESS 1SMELL CHANGE 1SPASMS 1STRENGTH LOSS OF 1SUFFOCATION
FEELING 1SWALLOWING DIFFICULT 1SYNOVITIS 1TACHYCARDIA VENTRICULAR
1TASTE LOSS 1THERAPEUTIC RESPONSE DECREASED 1THORACIC PAIN 1THROAT
IRRITATION 1THROMBOCYTOPENIA 1THYROID DISORDER 1TINNITUS 1TIREDNESS
1TONGUE DISORDER 1TONGUE INFLAMMATION 1TONGUE OEDEMA 1TONGUE SWELLING
NON-SPECIFIC 1TREMOR 1UREA BLOOD LEVEL INCREASED 1URINARY TRACT
INFECTION 1URINE ABNORMAL 1VASCULAR DISORDER 1VISION ABNORMAL 1VISION
DECREASED 1WEAKNESS VOLUNTARY MUSCLE 1

FLUVASTATIN, 1.5 million - (LESCOL) (monograph not available)

EFFICACY, LACK OF 3FATIGUE 3MYOCARDIAL INFARCTION 3NAUSEA 3PANCREATITIS
3PRURITUS 3RASH 3WEAKNESS GENERALIZED 3ANAEMIA 2DYSPNOEA 2FALL 2HAIR
LOSS 2HEADACHE 2HEPATITIS CHOLESTATIC 2JAUNDICE 2LIPASE INCREASED
2MOUTH DRY 2MUSCLE PAIN 2MUSCLE WEAKNESS 2SGPT INCREASED 2WEIGHT
DECREASE 2ABDOMINAL PAIN 1ALLERGIC REACTION 1ALOPECIA 1ANGIOEDEMA
1ANOREXIA 1APPETITE DECREASED 1ASTHENIA 1BILIRUBIN INCREASED
1BILIRUBINURIA 1BRADYCARDIA 1CARDIAC ARREST 1CHEST PAIN 1CHILLS
1CONVULSIONS 1CORONARY ARTERY OCCLUSION 1COUGHING 1CPK INCREASED
1CRACKLES 1CREATINE KINASE INCREASED 1CREATININE BLOOD INCREASED
1DEHYDRATION 1DROWSINESS 1DRUGGEDNESS 1ESR INCREASED 1FEELING UNWELL
1FLUSHING 1FRACTURE PATHOLOGICAL 1GAMMA-GLUTAMYLTRANSFERASE INCR.
1GAMMA-GT INCREASED 1HAEMATOMA 1HEPATIC FAILURE 1HEPATITIS 1HIGH
DENSITY LIPOPROTEIN DECREASE 1HYPERCHOLESTEROLAEMIA 1HYPERGLYCAEMIA
1HYPOAESTHESIA 1HYPOTENSION 1INTRAOCULAR PRESSURE INCREASED 1ITCHING
1LEUCOPENIA 1LIPS SWELLING NON-SPECIFIC 1LUPUS ERYTHEMATOSUS SYSTEMIC
1MUSCLE ACHE 1MUSCLE CRAMP 1MYALGIA 1MYOPATHY 1MYOSITIS 1NEUROPATHY
PERIPHERAL 1NUMBNESS 1OEDEMA LEGS 1OEDEMA PULMONARY 1PARAESTHESIA
1PHOSPHATASE ALKALINE INCREASED 1PNEUMONIA 1RASH ERYTHEMATOUS 1RENAL
FAILURE NOS 1SCLERAL DISCOLOURATION 1SGOT INCREASED 1SHAKING 1SYNCOPE
1TIREDNESS 1UNCONSCIOUSNESS 1URINE DISCOLOURATION 1URTICARIA 1VOMITING
1WHEEZES 1

LOVASTATIN, 2.8 million - (MEVACOR) (no monograph available)

MYALGIA 17NAUSEA 11HEPATIC ENZYMES INCREASED 10CREATINE PHOSPHOKINASE
INCREASED 9RHABDOMYOLYSIS 8ABDOMINAL PAIN 7DIZZINESS 7MUSCLE WEAKNESS
7CHEST PAIN 6CREATININE BLOOD INCREASED 6HEADACHE 6PRURITUS 6SGOT
INCREASED 6ASTHENIA 5CREATINE KINASE INCREASED 5JAUNDICE 5MYOPATHY
5MYOSITIS 5RASH 5VOMITING 5BILIRUBINAEMIA 4CONFUSION 4FATIGUE 4FEVER
4HAIR LOSS 4HEPATIC FUNCTION ABNORMAL 4HEPATITIS 4ITCHING 4MUSCLE ACHE
4MYOCARDIAL INFARCTION 4VISION BLURRED 4ALLERGIC REACTION 3CARCINOMA
3COUGHING 3DEPRESSION 3DIARRHOEA 3DYSPNOEA 3HAEMATURIA 3IMPOTENCE
3INSOMNIA 3MUSCLE CRAMP 3MUSCLE PAIN 3MYOGLOBINURIA 3PAIN 3PHOSPHATASE
ALKALINE INCREASED 3RENAL FAILURE ACUTE 3RESPIRATORY INSUFFICIENCY
3WEAKNESS GENERALIZED 3ABDOMINAL PAIN UPPER 2ALOPECIA 2ANGINA PECTORIS
AGGRAVATED 2ANOREXIA 2BILIRUBIN INCREASED 2BLOOD IN STOOL 2CONDITION
AGGRAVATED 2CPK INCREASED 2ESR INCREASED 2EYE PAIN 2FACE OEDEMA 2FAECES
PALE 2GAMMA-GLUTAMYLTRANSFERASE INCR. 2GI HAEMORRHAGE 2HEART DISORDER
2HEPATIC FAILURE 2JAUNDICE CHOLESTATIC 2LDH INCREASED SERUM 2LEG PAIN
2MOVEMENTS REDUCED 2MUSCLE STIFFNESS 2NEUTROPENIA 2OEDEMA PERIORBITAL
2PANCREATITIS 2PANCYTOPENIA 2PARAESTHESIA 2PROTEINURIA 2RASH
ERYTHEMATOUS 2RASH MACULO-PAPULAR 2RESPIRATORY DISORDER 2SEXUAL
FUNCTION ABNORMAL 2SGPT INCREASED 2SWEATING INCREASED 2URINE
DISCOLOURATION 2VISION ABNORMAL 2ALKALINE PHOSPHATASE SERUM INCR
1AMNESIA 1ANAEMIA 1ANEURYSM 1ANGINA PECTORIS 1ANGIONEUROTIC OEDEMA
1ANXIETY 1APATHY 1APPETITE DECREASED 1ARTERITIS 1ARTHRALGIA 1ASYSTOLIA
1ATAXIA 1BALANCE DIFFICULTY 1BLADDER CARCINOMA 1BLOATING 1BLOOD IN
URINE 1BLOOD UREA NITROGEN INCREASED 1BREAST PAIN FEMALE 1CARCINOMA
SQUAMOUS 1CATARACT 1CEREBRAL INFARCTION 1CHEST PAIN PRECORDIAL 1CHEST
TIGHTNESS OF 1CHLOASMA 1CHOLESTASIS INTRAHEPATIC 1COLITIS ULCERATIVE
1CORNEAL OPACITY 1CORONARY DISEASE 1CRAMPS LEGS 1CYST NOS 1DEPRESSED
STATE 1DEPRESSION AGGRAVATED 1DERMATITIS 1DROWSINESS 1DRUG LEVEL
INCREASED 1DYSPHAGIA 1DYSPHASIA 1EAR PAIN 1ECG ABNORMAL 1ENCEPHALOPATHY
1EOSINOPHILIC GRANULOMA 1EPISTAXIS 1ERUPTION 1ERYTHEMA 1EXHAUSTION 1EYE
ABNORMALITY 1FAECES DISCOLOURED 1FAINTNESS 1FALL 1FAT TISSUE INCREASED
1FIBRILLATION ATRIAL 1FRACTURE PATHOLOGICAL 1GAIT UNSTEADY 1GASTRIC
ACID DECREASED 1HAEMORRHAGE NOS 1HEARTBURN 1HEPATIC DISEASE 1HEPATIC
NECROSIS 1HEPATOMEGALY 1HEPATOTOXIC EFFECT 1HIVES 1HOT FLUSHES
1HYPERTENSION 1HYPERTHYROIDISM 1HYPOAESTHESIA 1HYPOCHLORAEMIA
1HYPONATRAEMIA 1IRITIS 1IRRITABILITY 1JOINT PAIN 1JOINT STIFFNESS 1LDH
INCREASED 1LE RASH 1LE SYNDROME 1LEUCOPENIA 1LIBIDO DECREASED 1LIVER
TENDER 1MALAISE 1MELAENA 1MEMORY IMPAIRMENT 1MICTURITION DISORDER
1MIGRAINE 1MOUTH DRY 1MUSCLE ATROPHY 1MUSCLE DISORDER 1MUSCLE RIGIDITY
1MUSCLE SPASTICITY 1MYELITIS TRANSVERSE 1MYELOPATHY 1NAIL DISORDER
1NERVOUSNESS 1NEUROPATHY 1NEUROTOXICITY 1NYSTAGMUS 1OEDEMA GENERALISED
1OEDEMA GENITAL 1OESOPHAGOSPASM 1OLIGURIA 1PALLOR 1PARANOID REACTION
1PERSONALITY DISORDER 1PHARYNGITIS 1PLEURAL EFFUSION 1PLEURISY
1PNEUMONIA 1PROTHROMBIN TIME PROLONGED 1PULSE RATE INCREASED 1PURPURA
1RAYNAUD'S PHENOMENON 1RENAL FUNCTION ABNORMAL 1RETINAL DISORDER
1SEPSIS 1SKIN DISORDER 1SKIN DRY 1SKIN ERYTHEMA DESQUAMATIVE 1SKIN
ULCERATION 1SLEEP DISORDER 1SOMNOLENCE 1SPASMS 1SPEECH DISORDER 1SPINAL
CORD COMPRESSION 1SPUTUM INCREASED 1TASTE PERVERSION 1TENDINITIS
1THERAPEUTIC RESPONSE DECREASED 1THROMBOCYTOPENIA 1TINGLING SKIN
1TINNITUS 1TREMOR 1TREMOR LIMB 1URINARY INCONTINENCE 1URINE ABNORMAL
1URTICARIA 1VEIN DISORDER 1VERTIGO 1VISION DECREASED 1VISUAL FIELD
DEFECT 1WALKING DIFFICULTY 1WEAKNESS VOLUNTARY MUSCLE 1

PRAVASTATIN, 9.2 million (PRAVACHOL) (monograph)

NAUSEA 11CREATINE PHOSPHOKINASE INCREASED 9FATIGUE 9ABDOMINAL PAIN
8MUSCLE WEAKNESS 8MUSCLE PAIN 7MYALGIA 7RASH 7CHEST PAIN 6CREATINE
KINASE INCREASED 6HEADACHE 6HEPATITIS 6LDH INCREASED 6PRURITUS
6VOMITING 6WEAKNESS GENERALIZED 6CREATININE BLOOD INCREASED 5DIZZINESS
5HEPATIC ENZYMES INCREASED 5MUSCLE ACHE 5RHABDOMYOLYSIS 5SGOT INCREASED
5ALKALINE PHOSPHATASE SERUM INCR 4INSOMNIA 4JAUNDICE 4PAIN 4RASH
ERYTHEMATOUS 4URINE DISCOLOURATION 4WALKING DIFFICULTY 4WEIGHT DECREASE
4ANOREXIA 3ASTHENIA 3CONDITION AGGRAVATED 3DIARRHOEA 3DYSPNOEA 3FACE
OEDEMA 3FAECES DISCOLOURED 3FEVER 3GASTRO-INTESTINAL DISORDER NOS
3IMPOTENCE 3ITCHING 3LETHARGY 3MALAISE 3MYOSITIS 3NIGHTMARES 3SGPT
INCREASED 3THERAPEUTIC RESPONSE DECREASED 3VISION BLURRED 3ARRHYTHMIA
2ARTHRALGIA 2BALANCE DIFFICULTY 2BILIRUBIN INCREASED 2BREATH SHORTNESS
2BUN INCREASED 2CATARACT 2CONJUNCTIVITIS 2CONSTIPATION 2DYSPEPSIA
2EPIGASTRIC PAIN NOT FOOD-RELATED 2EPISTAXIS 2ERYTHEMA 2ESR INCREASED
2HAIR TEXTURE ABNORMAL 2HIVES 2HYPERGLYCAEMIA 2HYPOTENSION 2JOINT PAIN
2LUPUS ERYTHEMATOSUS SYSTEMIC 2MUSCLE CRAMP 2MYOCARDIAL INFARCTION
2NEPHRITIS 2NUMBNESS LOCALIZED 2PAIN LEGS 2PANCREATITIS 2PETECHIAE
2PHOTOSENSITIVITY REACTION 2PNEUMONIA 2POLYURIA 2PULMONARY CARCINOMA
2PULMONARY FIBROSIS 2RENAL FAILURE ACUTE 2SWEATING INCREASED 2TINGLING
SKIN 2TINNITUS 2TONGUE OEDEMA 2URTICARIA 2VERTIGO 2VISION ABNORMAL
2VISION DECREASED 2ABDOMINAL DISCOMFORT 1ACCOMMODATION ABNORMAL
1ACIDOSIS LACTIC 1ACNE 1ALLERGIC REACTION 1ANAEMIA APLASTIC 1ANAEMIA
MICROCYTIC 1ANAPHYLACTIC SHOCK 1ANKLE OEDEMA 1ANTINUCLEAR FACTOR TEST
POSITIVE 1ANXIETY 1APPETITE ABSENT 1ASCITES 1ATAXIA 1ATRIAL FLUTTER/
FIBRILLATION 1AURA 1BICARBONATE RESERVE DECREASED 1BILIRUBINAEMIA
1BLADDER CARCINOMA 1BLINDNESS 1BLISTERS 1BLOOD IN URINE 1BREAST
ENLARGEMENT MALE 1BREAST NEOPLASM MALIGNANT FEMALE 1BREAST PAIN MALE
1BULLOUS ERUPTION 1BURNING SENSATION 1BURSITIS 1CHILLS 1CONFUSION
1CONGESTIVE HEART FAILURE 1CONJUNCTIVAL DISCOLOURATION 1CONSCIOUSNESS
DECREASED 1COUGHING 1CPK INCREASED 1CRAMP ABDOMINAL 1CRAMPS LEGS
1CRYOGLOBULINAEMIA 1DEPRESSED STATE 1DEPRESSION 1DERMATITIS 1DIABETES
MELLITUS 1DIPLOPIA 1DISORIENTATION 1DREAMING ABNORMAL 1EXHAUSTION 1EYE
HAEMORRHAGE 1EYE IRRITATION 1EYE PAIN 1EYELID OEDEMA 1FAECES PALE 1FALL
1FEELING UNWELL 1GAMMA-GT INCREASED 1GASTROESOPHAGEAL REFLUX 1GI
NEOPLASM BENIGN 1GINGIVAL BLEEDING 1GINGIVAL HYPERTROPHY 1GOUT
AGGRAVATED 1GYNAECOMASTIA 1HAEMATURIA 1HAIR LOSS 1HALLUCINATION VISUAL
1HEARING DECREASED 1HEPATITIS CHOLESTATIC 1HOT FLUSHES
1HYPERCHOLESTEROLAEMIA 1HYPERLIPAEMIA 1HYPOXIA 1INDIGESTION 1INFECTION
1INFLUENZA-LIKE SYMPTOMS 1INTELLECT IMPAIRED 1JOINT ACHE 1JOINT
DYSFUNCTION 1JOINT INFLAMMATION 1LACTATE BLOOD INCREASE 1LEG PAIN
1LEUCOPENIA 1LEUKOCYTOSIS 1LIBIDO DECREASED 1LIVER FATTY 1LIVER
FUNCTION TESTS ABNORMAL NOS 1LIVER TENDER 1LOWER RESP. TRACT INFECTION
1MENSES ONSET DELAYED 1MENTATION IMPAIRED 1MICTURITION FREQUENCY 1MOOD
SWINGS 1MUSCLE DISORDER 1MUSCLE RIGIDITY 1MUSCLE SPASTICITY 1MUSCLE
STIFFNESS 1MUSCLE WASTING 1MYELOFIBROSIS 1MYELOPROLIFERATIVE DISORDER
1NAIL DISCOLOURATION 1NEPHRITIS INTERSTITIAL 1NERVOUSNESS 1NEUROPATHY
PERIPHERAL 1NUMBNESS 1PAIN GROIN 1PALPITATION 1PARAESTHESIA
1PHARYNGITIS 1PHOTOSENSITIVITY TOXIC REACTION 1PLEURAL PAIN 1PNEUMONIA
LOBAR 1POLYMYALGIA RHEUMATICA 1POTASSIUM SERUM INCREASED 1PROTEINURIA
1PRURITUS ANI 1PSORIASIS 1PSORIASIS AGGRAVATED 1PURPURA ALLERGIC 1RASH
MACULO-PAPULAR 1RENAL FUNCTION ABNORMAL 1RENAL SCLEROSIS 1SCOTOMA
1SEBORRHOEA 1SEPSIS SECONDARY 1SKIN DISCOLOURATION 1SKIN DRY 1SLEEP
DISTURBED 1SLEEP RESTLESS 1STAGGERING GAIT 1STOMACH UPSET 1SUBGLOTTIC
OEDEMA 1SUICIDAL TENDENCY 1SUICIDE 1SUICIDE ATTEMPT 1SWELLING
NON-INFLAMMATORY 1SWOLLEN ABDOMEN 1TASTE ALTERATION 1TASTE BITTER
1TASTE LOSS 1TASTE METALLIC 1THROMBOCYTOPENIA 1THROMBOSIS VENOUS DEEP
1TIREDNESS 1UNCONSCIOUSNESS 1URINARY CASTS 1URINE FLOW DECREASED
1VISION DISORDERS 1WHEALS 1

ROSUVASTATIN, 0.4 million - (CRESTOR) (no monograph available)

ABDOMINAL PAIN 5MUSCLE PAIN 5ITCHING 4MUSCLE ACHE 4BLOOD IN URINE
3DIZZINESS 3SGOT INCREASED 3ALLERGIC REACTION 2BILIRUBIN INCREASED
2CREATININE BLOOD INCREASED 2ERYTHEMA 2HEADACHE 2LDH INCREASED 2MUSCLE
WEAKNESS 2MYALGIA 2NAUSEA 2NEPHROPATHY NOS 2OEDEMA 2OEDEMA PERIPHERAL
2PANCREATITIS 2PROTEINURIA 2RASH 2SGPT INCREASED 2SWEATING INCREASED
2VOMITING 2WEAKNESS GENERALIZED 2ABDOMINAL DISTENSION 1ACNE 1ALKALINE
PHOSPHATASE SERUM INCR 1ANAEMIA HAEMOLYTIC 1ANAEMIA NORMOCYTIC
1ANGIOEDEMA 1APHONIA 1ARTHRALGIA 1BACK PAIN 1BLINDNESS TEMPORARY
1BLOATING 1BLOOD PRESSURE INCREASED 1BLOOD SUGAR INCREASED 1BRADYCARDIA
1BREAST ENGORGEMENT 1BURNING SENSATION 1CARPAL TUNNEL SYNDROME 1CHEST
PAIN 1CONDITION AGGRAVATED 1COOMBS DIRECT TEST POSITIVE 1COUGHING 1CPK
INCREASED 1CRAMPS 1CREATINE KINASE INCREASED 1DIARRHOEA 1DIVERTICULITIS
1DYSPEPSIA 1DYSPNOEA 1ECG ABNORMAL SPECIFIC 1EYE ABNORMALITY 1EYE
IRRITATION 1FEELING UNWELL 1FEVER 1GAMMA-GT INCREASED 1GUILLAIN-BARRE
SYNDROME 1HAEMATURIA 1HEART DISORDER 1HEART FLUTTERING 1HYPERTHYROIDISM
1INFLUENZA-LIKE SYMPTOMS 1INSOMNIA 1INTRAOCULAR PRESSURE INCREASED 1JAW
STIFFNESS 1JOINT PAIN 1LACRIMATION ABNORMAL 1MIGRAINE 1MUSCLE CRAMP
1MUSCLE RIGIDITY 1MYOCARDIAL INFARCTION 1MYOSITIS 1NAIL DISORDER
1OEDEMA LEGS 1PAIN 1PAIN LEGS 1PALPITATION 1PEPTIC ULCER 1PETECHIAE
1PETECHIAE ORAL MUCOSA 1PROTHROMBIN TIME PROLONGED 1PRURITUS 1PULSE
RATE INCREASED 1RASH MACULO-PAPULAR 1RENAL FAILURE ACUTE 1SALIVA VISCID
1SKIN PEELING 1SUGAR BLOOD LEVEL INCREASED 1THROAT SORE
1THROMBOCYTOPENIA 1TINGLING SKIN 1TREMOR 1UNCONSCIOUSNESS 1URINE
DISCOLOURATION 1URTICARIA 1VASCULITIS 1VENOUS THROMBOSIS 1VISION DOUBLE
1

SIMVASTATIN - 12.4 million (ZOCOR) (monograph)

CREATINE KINASE INCREASED 17MUSCLE PAIN 17MYALGIA 16CREATINE
PHOSPHOKINASE INCREASED 14NAUSEA 14FATIGUE 13DIZZINESS 11MUSCLE
WEAKNESS 11MYOCARDIAL INFARCTION 11MUSCLE ACHE 10RHABDOMYOLYSIS 10SGOT
INCREASED 10SGPT INCREASED 10VISION BLURRED 10CREATININE BLOOD
INCREASED 9HEADACHE 9CHEST PAIN 8DIARRHOEA 8VOMITING 8HEPATITIS 6PAIN
6RASH 6ARTHRALGIA 5BILIRUBIN INCREASED 5JOINT PAIN 5LEG PAIN 5MUSCLE
CRAMP 5PAIN LEGS 5WEAKNESS VOLUNTARY MUSCLE 5ABDOMINAL PAIN 4ALKALINE
PHOSPHATASE SERUM INCR 4ANOREXIA 4CONDITION AGGRAVATED 4CPK INCREASED
4DYSPNOEA 4HAIR LOSS 4LEUKOCYTOSIS 4LIGHT-HEADED FEELING 4MALAISE
4MYOPATHY 4NUMBNESS LOCALIZED 4PAIN NECK/SHOULDER 4PALPITATION
4PROTEINURIA 4PRURITUS 4WALKING DIFFICULTY 4WEAKNESS GENERALIZED
4WEIGHT DECREASE 4ADENOCARCINOMA NOS 3ALOPECIA 3ANGINA PECTORIS
AGGRAVATED 3BACK PAIN 3BREATH SHORTNESS 3CHILLS 3DEPRESSION 3FEVER
3HAEMATURIA 3JAUNDICE 3JOINT STIFFNESS 3LETHARGY 3MUSCLE DISCOMFORT
3NIGHTMARES 3OEDEMA LEGS 3RENAL FAILURE ACUTE 3SEPSIS 3SWEATING
INCREASED 3UREA BLOOD LEVEL INCREASED 3URINE DISCOLOURATION 3ALLERGIC
REACTION 2ANAEMIA 2ANEURYSM 2ANGINA PECTORIS 2ANTINUCLEAR FACTOR TEST
POSITIVE 2ANXIETY 2APPETITE DECREASED 2ASTHENIA 2BONE PAIN 2COLON
CARCINOMA 2CONSCIOUSNESS DECREASED 2CONSTIPATION 2CONVULSIONS 2CRAMPS
LEGS 2DERMATITIS 2ECG ABNORMAL 2ERYTHEMA 2ESR INCREASED 2EYE IRRITATION
2FALL 2FLATULENCE 2FRACTURE PATHOLOGICAL 2GAMMA-GLUTAMYLTRANSFERASE
INCR. 2GASTRO-INTESTINAL DISORDER NOS 2HEPATIC ENZYMES INCREASED
2HEPATIC NEOPLASM MALIGNANT 2HYPOTHYROIDISM 2INSOMNIA 2INTESTINAL
FISTULA 2ITCHING 2JAUNDICE CHOLESTATIC 2LIPS SWELLING NON-SPECIFIC
2MACULAR DEGENERATION 2MULTIPLE ORGAN FAILURE 2MYOSITIS 2OEDEMA 2OEDEMA
OF EXTREMITIES 2PANCREATITIS NECROTISING 2PHOSPHATASE ALKALINE
INCREASED 2PLEURAL EFFUSION 2POLYMYALGIA RHEUMATICA 2POTASSIUM SERUM
INCREASED 2SINUSITIS 2THROMBOSIS 2URTICARIA 2VASCULITIS 2ABDOMINAL
DISCOMFORT 1ABSCESS 1ACIDOSIS 1AKINESIA 1AMYLASE INCREASED
1ANAPHYLACTIC REACTION 1ANGINA UNSTABLE 1ANGIOEDEMA 1ANOSMIA 1APPETITE
LOST 1ARTERIAL BLOOD PRESSURE DECREASED 1ARTHRITIS AGGRAVATED
1ATHEROSCLEROSIS 1ATRIAL FIBRILLATION PAROXYSMAL 1BLOOD IN URINE 1BLOOD
PRESSURE INCREASED 1BLOOD SUGAR INCREASED 1BLOOD UREA DECREASED 1BODY
ODOUR 1BONE METASTASES 1BOWEL PERFORATION 1BRAIN METASTASES 1BREAST
NEOPLASM BENIGN FEMALE 1BREAST NEOPLASM FEMALE 1BREAST TENDERNESS
1BRONCHITIS 1BRUISE 1BULLOUS ERUPTION 1BUN INCREASED 1CALF PAIN
1CARDIOMYOPATHY 1CARDIOVASCULAR DISORDERS, GENERAL 1CATARACT
1CELLULITIS 1CEREBROVASCULAR DISORDER 1CHANGE IN BOWEL HABITS 1CHEST
DISCOMFORT 1CHEST X-RAY ABNORMAL 1CHRONIC OBSTRUCT AIRWAYS DISEASE
1CLUBFOOT 1CONGENITAL ANOMALY NOS 1CONJUNCTIVAL HAEMORRHAGE 1CORONARY
ARTERY DISORDER 1CORONARY ARTERY OCCLUSION 1COUGHING 1CRAMP ABDOMINAL
1DEATH 1DEPRESSED STATE 1DIABETES MELLITUS 1DREAMING ABNORMAL 1DRUG -
FOOD INTERACTION 1DYSAESTHESIA 1DYSPEPSIA 1DYSURIA 1EFFICACY, LACK OF
1EMBOLISM ARTERIAL 1ENCEPHALOPATHY 1EOSINOPHILIA 1ERECTION DECREASED
1ERYTHEMA MULTIFORME 1EYE PAIN 1FACE OEDEMA 1FAECES PALE 1FATIGUE
EXTREME 1FEELING OF WARMTH 1FEELING UNWELL 1FOLATE SERUM TEST ABNORMAL
1GAMMA-GT INCREASED 1GASTROESOPHAGEAL REFLUX 1GASTROINTESTINAL TRACT
BLEED NOS 1GLOMERULONEPHRITIS 1GYNAECOMASTIA 1HAEMORRHAGE INTRACRANIAL
1HAEMORRHOIDS 1HAIR TEXTURE ABNORMAL 1HEARING DECREASED 1HEART FAILURE
1HEARTBURN 1HEPATIC FAILURE 1HEPATIC NECROSIS 1HEPATITIS CHRONIC ACTIVE
1HEPATITIS TOXIC 1HEPATOMEGALY 1HIRSUTISM 1HYPERCHOLESTEROLAEMIA
1HYPERKALAEMIA 1HYPERTENSION 1HYPOCHLORAEMIA 1HYPOGLYCAEMIA
1HYPONATRAEMIA 1HYPOREFLEXIA 1HYPOTENSION 1IMMUNOGLOBULINS INCREASED
1IMPOTENCE 1INFECTION LOCALISED 1INFECTION SUSCEPTIBILITY INCR
1INFECTION VIRAL 1INFLUENZA-LIKE SYMPTOMS 1INTESTINAL PERFORATION
1INTRAOCULAR PRESSURE INCREASED 1ISCHAEMIA PERIPHERAL 1JERKY MOVEMENT
NOS 1KERATOSIS 1LDH INCREASED 1LDH INCREASED SERUM 1LE SYNDROME 1LIBIDO
DECREASED 1LOWER RESP. TRACT INFECTION 1LYMPHOPENIA 1MEMORY DISTURBANCE
1MEMORY LOSS 1METABOLIC AND NUTRITIONAL DISORDERS 1MOUTH DRY 1MUSCLE
ATROPHY 1MUSCLE DISORDER 1MUSCLE RIGIDITY 1MUSCLE SPASTICITY 1MUSCLE
STIFFNESS 1MUSCLE WASTING 1MYOCARDIAL ISCHAEMIA 1MYOGLOBINURIA 1NAIL
DISORDER 1NASAL CONGESTION 1NEOPLASM 1NEOPLASM NOS 1NEPHROLITHIASIS
1NEUROLOGIC DISORDER NOS 1NEUROPATHY 1NEUROPATHY PERIPHERAL 1NOCTURIA
1NOSEBLEED 1NUMBNESS 1NYSTAGMUS 1OEDEMA CEREBRAL 1OEDEMA PERIPHERAL
1OLIGURIA 1OVARIAN CYST 1OVARIAN DISORDER 1PAIN GROIN 1PANCREAS
CARCINOMA 1PANCREATITIS ACUTE 1PARAESTHESIA 1PERIPHERAL GANGRENE
1PHOTOPHOBIA 1PLASMA OSMOLALITY DECREASED 1PNEUMONIA 1PROSTATIC
DISORDER 1PSORIASIS AGGRAVATED 1PSYCHOSIS 1PSYCHOSIS AGGRAVATED
1PULMONARY CARCINOMA 1PULSE RATE INCREASED 1PURPURA 1RASH ERYTHEMATOUS
1RASH MACULO-PAPULAR 1RASH PURPURIC 1RENAL FAILURE NOS 1RESPIRATORY
DISORDER 1RETINAL VASCULAR DISORDER NOS 1RIGORS 1SALIVA DECREASED
1SCHIZOPHRENIC REACTION 1SHAKING 1SKIN HYPERPIGMENTATION 1SLEEP
DECREASED 1SLEEP DISTURBED 1SPASMS 1STOMACH UPSET 1SUGAR BLOOD LEVEL
INCREASED 1SWELLING NON-INFLAMMATORY 1TACHYCARDIA SUPRAVENTRICULAR
1TASTE LOSS 1TASTE PERVERSION 1TENDON INJURY 1THERAPEUTIC RESPONSE
DECREASED 1THROAT SORE 1THROAT TIGHTNESS 1THROMBOCYTOPENIA
1THROMBOCYTOSIS 1THYROID CYST 1THYROID ENLARGED 1TINNITUS 1TIRED EYE
1TIREDNESS 1UNCONSCIOUSNESS 1URINARY FREQUENCY 1URINARY INCONTINENCE
1URINARY TRACT INFECTION 1URINE VOLUME DEFICIENT 1UTERINE FIBROID
1VERTIGO 1VESICULAR ERUPTION 1VESICULAR RASH 1VISION DECREASED 1VISUAL
DISTURBANCE 1VOMITING BLOOD 1WEIGHT INCREASE 1