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Medical Forum / General / General / December 2004

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CBC Interpretation Please

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tech27 - 09 Nov 2004 14:35 GMT
Brief history:

About 13 months ago I had a colonoscopy to remove cancerous polyps which had
caused major bleeding, anemia, extremely low HGB and  RBC as well as small
and misshaped RBC's. I had just started to feel fully recovered, with only a
bit of residual fatigue and only after trying to get back to a busy
schedule.

Now after experiencing similar symptoms as prior to the above
diagnosis/treatment a follow up CBC showed all normal except:

HGB 191
RBC 5.99
HCT 0.553
Abs monocytes 0.970
PT 8.9
ALT 56
Urea 10.7
Creatinine 128

I'm especially puzzled by the high HGB, with was below 90 at the worst. I
know enough to rule out hypoxia as a cause, but then I'm not an MD. I also
understand that creatinine can become elevated occasionally as a result of
benign causes, like alcohol consumption, although this is not my situation.

Any opinions most appreciated.

Thank you.
beachhouse - 09 Nov 2004 16:39 GMT
what units are these laboratory studies in?
hematocrit should be expressed as a percentage... is your hematocrit
supposedly 55%?
hemoglobin should be in grams per deciliter or other similar units...
these numbers don't make any sense without units.

> Brief history:
>
[quoted text clipped - 29 lines]
> Checked by AVG anti-virus system (http://www.grisoft.com).
> Version: 6.0.788 / Virus Database: 533 - Release Date: 11/1/2004
tech27 - 10 Nov 2004 03:09 GMT
Sorry, see below for the units I've added to the original post. . I'm in
Canada. I've just added the units as per the report.

> what units are these laboratory studies in?
> hematocrit should be expressed as a percentage... is your hematocrit
[quoted text clipped - 42 lines]
>> Checked by AVG anti-virus system (http://www.grisoft.com).
>> Version: 6.0.788 / Virus Database: 533 - Release Date: 11/1/2004
bae@cs.toronto.no-uce.edu - 10 Nov 2004 14:32 GMT
>Sorry, see below for the units I've added to the original post. . I'm in
>Canada. I've just added the units as per the report.

Didn't you tell us that you were recently diagnosed as having
Hereditary Hemorrhagic Telangiectasia, a genetic condition in which
defective growth of blood vessels causes sporadic bleeding in many
different organs, and often associated with intestinal polyps?  If you
leave out this very important piece of information I don't see how you
can expect to get a useful answer about your blood work.

IIRC, you were also attending an HHT clinic at a teaching hospital.  If
it were me, that's the first place I'd go for an opinion on those
results.
tech27 - 10 Nov 2004 15:59 GMT
>>Sorry, see below for the units I've added to the original post. . I'm in
>>Canada. I've just added the units as per the report.
[quoted text clipped - 9 lines]
> it were me, that's the first place I'd go for an opinion on those
> results.

Yes, all correct. Sorry I left that out in this post, I was just simply
interested in what the out of normal range results could indicate. I did
attend the clinic, did a whole bunch of tests including the blood work.
Follow up confirmed the diagnosis. Chest x-ray found no AVM (?) in the
chest. I've also had a bone scan done (fully body), but have yet to get the
results.

I don't think the intestinal polyps are related to the HHT. They were
removed and found to be cancerous. Follow up on this condition is ongoing.

The reason I posted here about the CBC is that the doctor noted the
abnormalities, but said that they were not related to the HHT, and so follow
up with a specialist has been scheduled. She said this was not her area of
expertise so declined to speculate on what they might indicate. While I'm
waiting for this appointment, I am just interested in finding out here what
the CBC might indicate.

I've also taken part in an ongoing HHT research project, and am going to get
a DNA test which they tell me will help to screen / diagnose relatives and
children. Apparently HHT is such that they cannot as yet screen for it, as
it is nearly impossible to find the markers, but if they have a sample from
a confirmed HHT case, they are able to pinpoint it and from there be able to
look for it in other relatives. One of the research studies I am
participating in is trying to develop a simpler screening procedure - one of
which involves analyzing one's breath for indicators.

Thanks for your interest.
Dr. Andrew B. Chung, MD/PhD - 09 Nov 2004 20:36 GMT
> Brief history:
>
> About 13 months ago I had a colonoscopy to remove cancerous polyps which had
> caused major bleeding, anemia, extremely low HGB and  RBC as well as small
> and misshaped RBC's.

Uh-oh.  Would be concerned that margins were not clear.  Why wasn't
surgical removal of diseased colon considered?

> I had just started to feel fully recovered, with only a
> bit of residual fatigue and only after trying to get back to a busy
[quoted text clipped - 11 lines]
> Urea 10.7
> Creatinine 128

Couple of points here:

(1) The above is more than a CBC (there's PT, Urea, Creatinine) and
then also less than a CBC (no WBC or platelets).

(2) The numbers are "off" and almost nonsensical.  

> I'm especially puzzled by the high HGB, with was below 90 at the worst. I
> know enough to rule out hypoxia as a cause, but then I'm not an MD. I also
> understand that creatinine can become elevated occasionally as a result of
> benign causes, like alcohol consumption, although this is not my situation.

Would suggest you go over the test results with the physician who
ordered these tests for you.  I would be concerned about renal failure
causing the elevations in both Urea and creatitine.  This would not
explain the elevated Hgb.

> Any opinions most appreciated.
>
> Thank you.

You are welcome.

All praises belong to my heavenly Father, Whom I love with all my
heart, soul, mind, and strength :-)

Servant to the humblest person in the universe,

Andrew

--
Dr. Andrew B. Chung, MD/PhD
Board-Certified Cardiologist
http://www.heartmdphd.com/

**
Who is the humblest person in the universe?
http://makeashorterlink.com/?L26062048

What is all this about?
http://makeashorterlink.com/?R20632B48

Is this spam?
http://makeashorterlink.com/?N69721867
aa.anewsa@awatcherra.com - 09 Nov 2004 21:00 GMT
This is the most recent in a score or so of single news group threads
turned into a multi group unrelated thread by brother chung.  This
suggests the extreems to which he will go to turn our attention away from
his extreem loss of face, which details we need not dicuss here now.   He
projects unto others some of those inner feelings he can not shake, and
well we understand why.   In the clear contridiction between his words and
his behavior and judgement there is a lesson to be learned.  We pray he
begin that painful journey for his own sake.
Goomba38 - 09 Nov 2004 22:00 GMT
> This is the most recent in a score or so of single news group threads
> turned into a multi group unrelated thread by brother chung.  This
[quoted text clipped - 4 lines]
> his behavior and judgement there is a lesson to be learned.  We pray he
> begin that painful journey for his own sake.

And yet you felt the need to crosspost this drivel
yet more?
Alan - 09 Nov 2004 22:44 GMT
>This is the most recent in a score or so of single news group threads
>turned into a multi group unrelated thread by brother chung.  This
[quoted text clipped - 4 lines]
>his behavior and judgement there is a lesson to be learned.  We pray he
>begin that pa      infuljourneyforhisownsake.

Why don't you lead him on his way on his painful journey? As soon as you
have learnt how to cut cross-posts.
Cheers, Alan
--
Steve Harris  sbharris@ROMAN9.netcom.com - 11 Nov 2004 02:26 GMT
> Brief history:
>
[quoted text clipped - 22 lines]
>
> Any opinions most appreciated.

In US units your HCT is 55.3%, which is indeed a tad high. If you're
not hypoxic, there's really no way of getting to the bottom of an
overly high HCT without doing a bone marrow biopsy. See a
hematologist.

Your hemoglobin in US units is 19.1 grams/dl or grams %, which is
entirely consistant with your hematocrit, and suggests nothing
peculiar on its own.

At least you know your iron stores have been repleted after being
anemic from the polyps and/or telangectasia. Perhaps you've been
anemic for so long that after iron repletion your marrow hasn't turned
off quite yet and you've overshot.  No, don't quote me. I have no idea
if that's possible.

SBH
tech27 - 11 Nov 2004 02:35 GMT
"Steve Harris sbharris@ROMAN9.netcom.com" <sbharris@ix.netcom.com> wrote in
message news:79cf0a8.0411101826.60eaf0a3@posting.google.com...

Thank you very much for your insights.
aisling - 07 Dec 2004 01:49 GMT
hi tech.  i was diagnosed w/ hht five years ago, and have been poked at
by doctors since.  i was curious about the test that analyzes breath to
look for indicators.  that is nothing i've ever heard before.

aisling
 
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