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Medical Forum / General / General / March 2004Septicaemia
Hi Any heads up on this could prove very helpful. The situation is: Septicaemia, plus a few local infections, CD4 count zero, infections have not responded to the first wave of hospital antibiotic treatment. If theres anything I should know that might be usable to make a difference to the outcome in any way, please let me know. I'll check this in the morning. Thanks, NT >Subject: Septicaemia >From: bigcat@meeow.co.uk (N. Thornton) [quoted text clipped - 14 lines] > >Thanks, NT Best Pract Res Clin Haematol 2002 Jun;15(2):411-26 Iron and infection: competition between host and microbes for a precious element. Marx JJ Eijkman-Winkler Institute for Microbiology, Infectious Diseases and Inflammation, University Medical Centre Utrecht, G04.614, PO Box 85500, 3508 GA Utrecht, The Netherlands. During infection microbes attack host tissues, causing damage to specific organs, sepsis or even death. For proliferation microbes desperately need iron for which they have to compete with the host. Micro-organisms have developed an abundant number of strategies to acquire iron from their specific environment and to transport the element to sites of incorporation into biologically important molecules. As part of the non-specific defence mechanisms against infection, the body modifies iron metabolism in order to make iron less available for micro-organisms. Such processes have a profound effect on the immune system and are also expressed in other forms of inflammation. Microbial iron transport systems are explored as targets for antibiotic treatment and vaccines. In particular, iron chelators, used for the treatment of iron overload may become important drugs for fighting bacterial and viral infections. PMID: 12401315, UI: 22288772 ---------------------------------------------- . Who loves ya. Tom  SignatureJesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking >Subject: Septicaemia >From: bigcat@meeow.co.uk (N. Thornton) [quoted text clipped - 14 lines] > >Thanks, NT In extreme cases of infection .. periotonitis .. they have found by the infusion of 'bleach' .. into the body cavity greatly reduces the septicaemia .. Cost ? about 55 cents .. Who loves ya. Tom SignatureJesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking Nt wrote: > >Any heads up on this could prove very helpful. > > [quoted text clipped - 5 lines] > >difference to the outcome in any way, please let me know. I'll check > >this in the morning. > In extreme cases of infection .. periotonitis .. they have found > by the infusion of 'bleach' .. into the body cavity greatly reduces the > septicaemia .. This piece describes it as a bad bad idea: http://www.jpgmonline.com/article.asp?issn=0022-3859;year=1994;volume=40;issue=3 ;spage=179;epage=84;aulast=Shetty Do you have other info? Thanks, NT >Subject: Re: Septicaemia >From: bigcat@meeow.co.uk (N. Thornton) [quoted text clipped - 24 lines] > >Thanks, NT Actually the link speaks to the use of bleach in the catheter and NOT introduction INTO the gut .. other than accidentally which 'may' cause chemical burn. But .. in the case of extreme sepsis .. chemical burn should / would be .. acceptable .. compared to .. death .. ? Or is that NOT .. your .. take .. on it .. ? Who loves ya. Tom SignatureJesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking >Subject: Re: Septicaemia >From: ironjustice@aol.comdoe (doe) [quoted text clipped - 30 lines] >> >>Thanks, NT J R Coll Surg Edinb 2002 Oct;47(5):700-4 The effects of desferrioxamin and vitamin E as supplements to antibiotics in the treatment of peritonitis in rats. Soybir N, Soybir G, Lice H, Dolay K, Ozseker A, Koksoy F Department of Anesthesiology, Istanbul Memorial Hospital, Istanbul, Turkey. [Medline record in process] AIM: The aim of the study was to determine the effects of vitamin E and the iron chelating agent desferrioxamin (Dfx), supplemented by clindamycin and gentamycin therapy, on peritonitis caused by caecal ligation of a puncture wound in an experimental model. MATERIALS AND METHODS: One hundred and twenty Spraque Dawley rats were divided into eight groups. Three groups were used as controls; intraperitoneal (i.p.), subcutaneous (s.c.) and i.p. and s.c., respectively. Group 4 was treated with Dfx, Group 5 with vitamin E and Group 6 with antibiotics. Group 7 was treated with vitamin E in combination with antibiotics, and Group 8 with a combination of antibiotics and Dfx. The rats were studied for 14 days following treatment, and survivors then humanely dispatched. Post-mortem examination was undertaken on all the rats studied. RESULTS: In the control groups, mortality at 14 days was 66%. Rats treated with antibiotics alone (Group 5) had a mortality rate of 40%. Those treated with a combination of antibiotics and vitamin E (Group 7), however, had a mortality rate of only 14%, and those treated with antibiotics and Dfx had a mortality rate of only 7%. CONCLUSION: This study suggests that treatment of peritonitis in rats with a combination of Dfx and antibiotics has a significant beneficial effect on survival, in comparison with treatment with antibiotics alone. PMID: 12463711, UI: 22351117 _________________________________________________________________ Who loves ya. Tom SignatureJesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking >Subject: Re: Septicaemia >From: bigcat@meeow.co.uk (N. Thornton) [quoted text clipped - 24 lines] > >Thanks, NT Crit Care Med 2002 Jul;30(7):1623-1629 Antioxidant protection against iron in children with meningococcal sepsis. Festa M, Mumby S, Nadel S, Gutteridge JM, Quinlan GJ Paediatric Intensive Care Unit, Imperial College School of Medicine at St Mary's Hospital (MF, SN), London, UK; and the Unit of Critical Care, Royal Brompton and Harefield NHS Trust (SM, JMCG, GJQ), London, UK. [Record supplied by publisher] OBJECTIVE: To assess antioxidant protection against iron-catalyzed reactive oxygen species in meningococcal sepsis and to establish whether severity of illness is related to deficiencies in these antioxidant systems. DESIGN: Prospective, controlled study. SETTING: Pediatric intensive care unit of a postgraduate teaching hospital. PATIENTS: Twenty children aged 6 months to 15 yrs (median, 5 yrs) with meningococcal septic shock were studied. Paired convalescent samples taken 8-10 wks after discharge were available in nine children. INTERVENTIONS: Routine management for meningococcal sepsis. MEASUREMENTS AND MAIN RESULTS: Patients were classified for disease severity using the Glasgow Meningococcal Septicaemia Prognostic Score. Paired acute and convalescent samples were compared. Transferrin level (1.77 +/- 0.08 g/L) and total iron-binding capacity (46.2 +/- 2.0 &mgr;M) were significantly decreased in acute patients compared with paired convalescent samples (2.85 +/- 0.10 g/L and 74.4 +/- 2.5 &mgr;M, respectively; p <.0001). The iron saturation of transferrin was significantly increased in acute disease (36.9% +/- 2.5%) compared with convalescence (18.8% +/- 1.5%; p =.0003). Iron-binding antioxidant protection was not significantly different in acute (81.4% +/- 1.7%) and paired convalescent samples (85.6% +/- 2.5%; p =.54). However, patients with more severe meningococcal septicemia (GMSPS, >10; n = 12) had significantly diminished protection (77.5% +/- 2.4%) compared with less severe disease (87.1% +/- 1.6%; p =.0028), and there was a significant correlation between disease severity and iron-binding antioxidant protection (R =.48; p =.00067) in acute disease. Paired ceruloplasmin levels were available in six patients and were decreased in acute disease (0.29 +/- 0.02 g/L) compared with convalescence (0.40 +/- 0.04 g/L), although not statistically significant (p =.076). However, there was a significant correlation between plasma ceruloplasmin and disease severity (Pearson product moment correlation, p =.038) in the acute patients. Iron-oxidizing antioxidant assays were performed in four paired samples and were diminished in acute patients (53.3 +/- 4.4%) compared with convalescence (67.8 +/- 3.2%; p =.015). Acute samples demonstrated a significant relationship between iron-oxidizing antioxidant protection and both disease severity (r =.30; p =.012) and plasma ceruloplasmin levels (r =.48; p =.00067). CONCLUSIONS: Children with meningococcal septicemia exhibit abnormal plasma iron chemistry and decreased protection against iron-catalyzed oxidative damage. Such deficiencies correlate with disease severity. PMID: 12130989 -------------------------------------------------------------------------- ------ Who loves ya. Tom SignatureJesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking >Subject: Re: Septicaemia >From: bigcat@meeow.co.uk (N. Thornton) [quoted text clipped - 24 lines] > >Thanks, NT Biull Eksp Biol Med. 1991 Jul;112(7):65-7. Related Articles, Links [Effects of sodium hypochlorite on oxygen balance and functional state of the small intestine in experimental peritonitis] [Article in Russian] Kulaev GK, Polivoda MD, Ettinger AI, Anurov MV. Sodium hypochlorite, administrated intravenously and intraperitoneally, leads to normal oxygen balance, metabolism and motility of small intestine in peritonitis. Anti-hypoxia effect of this substance is realized by an increase of oxygen content in the blood. It is useful to use sodium hypochlorite in general peritonitis for antibacterial therapy and against tissue hypoxia without side effects. PMID: 1793860 [PubMed - indexed for MEDLINE] -------------------------------------------------------------------------- ------ Who loves ya. Tom SignatureJesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking >Subject: Re: Septicaemia >From: bigcat@meeow.co.uk (N. Thornton) [quoted text clipped - 22 lines] > >Do you have other info? Vestn Khir Im I I Grek. 1993 May-Jun;150(5-6):18-21. Related Articles, Links [Sodium hypochlorite in the treatment of suppurative peritonitis] [Article in Russian] Petrosian EA. The method of indirect electrochemical oxidation was used in treatment of 34 patients with acute purulent peritonitis. Twenty patients treated by the traditional method were taken as a group of comparison. The method consists in the elevation of sensitivity of the polyresistant microflora to antibiotics after the introduction into the abdominal cavity of a warmed to 37 degrees C 0.06--0.08% solution of sodium hypochlorite (100-400 ml), buffered with sodium bicarbonate 0.4 g NaHO3 per 100 ml. A combined application of buffered sodium hypochlorite with antibiotics to patients with local, diffuse and general peritonitis resulted in shorter average terms of treatment correspondingly to (9 +/- 0.9), (13 +/- 1.3), (16 +/- 1.9) days against (17.2 +/- 2.4), (25.0 +/- 3.3), (34.7 +/- 4.1) days after traditional methods of treatment. Only 2 patients died of 13 patients with general peritonitis (15.38%). Thus, modelling the processes of oxidative detoxication and phagocytosis with using a transmitter of acute oxygen--an electrolysis solution of sodium hypochlorite is a practically safe and technically simple method of the active action on the inflammatory process in the abdominal cavity, so it may be widely used in treatment of peritonitis. PMID: 8091571 [PubMed - indexed for MEDLINE] -------------------------------------------------------------------------- ------ Anesteziol Reanimatol. 2001 Mar-Apr;(2):48-51. Related Articles, Links [Electrochemical detoxication of the lymph in the treatment of patients with suppurative-resorptive endotoxicosis] [Article in Russian] Fedoseev AV, Tarasenko SV, Zaitsev OV. A new method for lymph detoxication in patients with pyoresorptive endotoxicosis is proposed. The method is based on electrochemical oxidation of the lymph, is simple and cheap. After 4-h exposure of the lymph with 0.04% sodium hypochlorite the concentration of the main toxic metabolites appreciably decreased, while the levels of total protein and leukocytes changed negligibly. Electrochemical detoxication of the lymph was used in the treatment of 13 patients with pyoresorptive endotoxicosis and led to improvement of the clinical status and rapid decrease in the levels of the major toxic metabolites, which was particularly expressed 3 days after the treatment. No negative effects were observed. Hence, electrochemical detoxication of the lymph appreciably improved the results of treatment of patients with cholestatic endotoxicosis. PMID: 11494902 [PubMed - indexed for MEDLINE] -------------------------------------------------------------------------- ------ Who loves ya. Tom SignatureJesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > >Subject: Re: Septicaemia > Anesteziol Reanimatol. 2001 Mar-Apr;(2):48-51. Related Articles, Links > [quoted text clipped - 19 lines] > > PMID: 11494902 [PubMed - indexed for MEDLINE] Excellant stuff Tom, thank you. I found stacks more articles on several promising techniques: when this time is past I'll post them for everyone. Cheers! NT > Hi > [quoted text clipped - 9 lines] > > Thanks, NT Any more input on this would be very welcome, this is still an ongoing situation. Thanks, NT >Subject: Re: Septicaemia >From: bigcat@meeow.co.uk (N. Thornton) [quoted text clipped - 19 lines] > >Thanks, NT http://www.medscape.com/viewarticle/410024 The Potential of Bismuth-Thiols for Treatment and Prevention of Infection You may wish to do a search of lactoferrin and here is a recent article .. http://www.medscape.com/viewarticle/464466 Who loves ya. Tom SignatureJesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > http://www.medscape.com/viewarticle/410024 > [quoted text clipped - 6 lines] > Who loves ya. > Tom Great, I'll get onto that now. The links dont yield anything readable, but I'll search on the keywords. Thanks! NT > ironjustice@aol.comdoe (doe) wrote in message news:<20040301054501.06534. > > You may wish to do a search of lactoferrin and here is a recent article .. > > > > http://www.medscape.com/viewarticle/464466 > Great, I'll get onto that now. The links dont yield anything readable, > but I'll search on the keywords. > > Thanks! NT OK I turned up plenty on bismuth thiols, but not lactoferrin. Lactoferrin yielded page after page of rubbish. The medscape articles arent accessible: do you have any other leads on this? Thanks, NT >Subject: Re: Septicaemia Below are snips from two separate posters .. <<snip>> > > Recently I have seen two seriously disabled ME sufferers make > > remarkable recover with UV blood irradiation treatment. Also my wife > > has found the treatment cleared a recurrent staph infection that > > defeated antibiotics. Only 200ml of blood is cycled out and back in. The "dead stuff" is not filtered so it results in an immune response. That's how it works. It certainly cleared up a strain of antibiotic resistant Staphylococcus aureus that my wife had. The high cost is due to time involved. The procedure takes at least a hour. It can't be rushed. <<snip>> Who loves ya. Tom SignatureJesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking >Subject: Re: Septicaemia Int Immunopharmacol. 2004 Mar;4(3):455-9. Related Articles, Links Deferoxamine administration in septic animals: improved survival and altered apoptotic gene expression. Messaris E, Antonakis PT, Memos N, Chatzigianni E, Leandros E, Konstadoulakis MM. Laboratory of Surgical Research, First Department of Propaedeutic Surgery, Hippocrateion Hospital, Athens Medical School, University of Athens, Vas Sofias 114, Ano Patisia, Athens 111 41, Greece. Background: Oxidative damage is one of the major factors that lead to cell damage, organ dysfunction and death in sepsis. Thus, an attractive candidate for the pharmacologic treatment of the septic syndrome is desferoxamine (DFX), an antioxidant iron chelator used for the removal of iron and a potential free radical scavenger. Objective: The impact of DFX administration on the survival of septic animals. The effect on cell integrity and cycle of vital organs. Methods: Sepsis was induced in 40 rats using the cecal ligation and puncture method (CLP) and 20 rats randomly received twice subcutaneously DFX (total dose: 40 mg/kg). Rats were monitored for 36 h and all vital organs were harvested for pathology examination and immunohistochemical detection of Bax, Bcl-2, cytochrome c and caspase-8 apoptosis regulating proteins. Results: Mean survival in the DFX group was 34.2 h (median 36.0, S.D. 4.4) and 30.2 h (median 36.0, S.D. 9.1) in the control group (p=0.04), while 36 h after follow up 85% of the DFX-treated rats and 55% of placebo rats were alive (p=0.04). Expression of pro-apoptotic bax protein was significantly increased in the heart, liver and kidney of animals in the DFX group compared to the control group. Conclusions: Treatment with the polymeric iron chelator DFX significantly increases survival of septic subjects and alters the expression of bax, an apoptosis regulating protein in certain organs (heart, liver and kidney). PMID: 15037222 [PubMed - in process] -------------------------------------------------------------------------- ------ Who loves ya. Tom SignatureJesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > Hi > [quoted text clipped - 9 lines] > > Thanks, NT You've posted about a cat and abscess, a wound healing on someone's back and other infection related posts. How about more details? http://www.wrongdiagnosis.com/s/septicemia/causes.htm http://www.wrongdiagnosis.com/s/septicemia/intro.htm J > > The situation is: Septicaemia, plus a few local infections, CD4 count > > zero, infections have not responded to the first wave of hospital [quoted text clipped - 3 lines] > > difference to the outcome in any way, please let me know. I'll check > > this in the morning. > You've posted about a cat and abscess, a wound healing on someone's back > and other infection related posts. > How about more details? OK. An experimental last ditch treatment involved killing all CD4 cells and all bone marrow. This is human, not cat. Bone marrow was then transplanted back to regnerate the immune system. While the treament seemed successful initially, the first bone marrow transplant failed. The patient now has a zero CD4 count and has developed septicaemia. The septicaemia has been treated with antibiotics IV and direct into the spinal fluid. However the level of infection has not improved, the bacteria are antibiotic resistant. A second bone marrow transplant can not be done unless the septicaemia is resolved first. So we're now getting into experimental treatments that show promising results, and last ditch treatment options. Desferrioxamin and vitamin E are now being tried in addition to the antibiotics. From the study quoted earlier in this thread: Rats treated with antibiotics alone (Group 5) had a mortality rate of 40%. Those treated with a combination of antibiotics and vitamin E (Group 7), however, had a mortality rate of only 14%, and those treated with antibiotics and Dfx had a mortality rate of only 7%. At the moment I'm searching for all potential treatment options, we need to pull something out of the hat here, if in any way possible. So far I've looked at studies on: Opebecan Protein C Teicoplanin desferrioxamin vitamin E antioxidants sodium hypochlorite BPI21 Cecropin B colloidal silver - report, no study, would like a proper study on this one. garlic plasmapheresis and leaucapheresis blood exchange Current treatment is: antibiotics IV antibiotics into the CSF ventilation blood exchange vitamin E desferrioxamin The treatment is in the hands of a research team, I'm searching for any studies on any techniques that are worth trying here. Given the extremity of the situation, rat-based studies are enough to work on when all else has failed. If there are any techniques I've missed here, or anything else, I'm all ears. Thanks, NT bigcat@meeow.co.uk (N. Thornton) wrote in message news:<a7076635.0402210404. > > > The situation is: Septicaemia, plus a few local infections, CD4 count > > > zero, infections have not responded to the first wave of hospital [quoted text clipped - 3 lines] > > > difference to the outcome in any way, please let me know. I'll check > > > this in the morning. > OK. An experimental last ditch treatment involved killing all CD4 > cells and all bone marrow. This is human, not cat. Bone marrow was [quoted text clipped - 56 lines] > > Thanks, NT OK, the infections are: Neisseria meningitidis (meningococcus) Staphylococcus aureus Regards, NT >Subject: Re: Septicaemia >From: bigcat@meeow.co.uk (N. Thornton) >Date: 2/23/2004 5:00 PM Mountain Standard Time >Message-id: <a7076635.0402231600.7ecec5f5@posting.google.com> >OK, the infections are: >Neisseria meningitidis (meningococcus) Crit Care Med 2002 Jul;30(7):1623-9 Antioxidant protection against iron in children with meningococcal sepsis. Festa M, Mumby S, Nadel S, Gutteridge JM, Quinlan GJ Paediatric Intensive Care Unit, Imperial College School of Medicine at St Mary's Hospital, London, UK. OBJECTIVE: To assess antioxidant protection against iron-catalyzed reactive oxygen species in meningococcal sepsis and to establish whether severity of illness is related to deficiencies in these antioxidant systems. DESIGN: Prospective, controlled study. SETTING: Pediatric intensive care unit of a postgraduate teaching hospital. PATIENTS: Twenty children aged 6 months to 15 yrs (median, 5 yrs) with meningococcal septic shock were studied. Paired convalescent samples taken 8-10 wks after discharge were available in nine children. INTERVENTIONS: Routine management for meningococcal sepsis. MEASUREMENTS AND MAIN RESULTS: Patients were classified for disease severity using the Glasgow Meningococcal Septicaemia Prognostic Score. Paired acute and convalescent samples were compared. Transferrin level (1.77 +/- 0.08 g/L) and total iron-binding capacity (46.2 +/- 2.0 microM) were significantly decreased in acute patients compared with paired convalescent samples (2.85 +/- 0.10 g/L and 74.4 +/- 2.5 microM, respectively; p <.0001). The iron saturation of transferrin was significantly increased in acute disease (36.9% +/- 2.5%) compared with convalescence (18.8% +/- 1.5%; p =.0003). Iron-binding antioxidant protection was not significantly different in acute (81.4% +/- 1.7%) and paired convalescent samples (85.6% +/- 2.5%; p =.54). However, patients with more severe meningococcal septicemia (GMSPS, >10; n = 12) had significantly diminished protection (77.5% +/- 2.4%) compared with less severe disease (87.1% +/- 1.6%; p =.0028), and there was a significant correlation between disease severity and iron-binding antioxidant protection (R =.48; p =.00067) in acute disease. Paired ceruloplasmin levels were available in six patients and were decreased in acute disease (0.29 +/- 0.02 g/L) compared with convalescence (0.40 +/- 0.04 g/L), although not statistically significant (p =.076). However, there was a significant correlation between plasma ceruloplasmin and disease severity (Pearson product moment correlation, p =.038) in the acute patients. Iron-oxidizing antioxidant assays were performed in four paired samples and were diminished in acute patients (53.3 +/- 4.4%) compared with convalescence (67.8 +/- 3.2%; p =.015). Acute samples demonstrated a significant relationship between iron-oxidizing antioxidant protection and both disease severity (r =.30; p =.012) and plasma ceruloplasmin levels (r =.48; p =.00067). CONCLUSIONS: Children with meningococcal septicemia exhibit abnormal plasma iron chemistry and decreased protection against iron-catalyzed oxidative damage. Such deficiencies correlate with disease severity. PMID: 12130989, UI: 22122887 >Staphylococcus aureus Years ago I had noticed and questioned research groups as to the use of OTHER bacteria to 'fight' bacteria .. due to .. the finding in / on fish that there were some luminescent bacteria which seemed to be killing the meningococcal strain. I had received 'less than encouraging' .. answers .. A year or so ago while researching I did find a few studies in which the researchers ARE / were finding strains of luminescent bacteria which they were finding in the darndest places which they are / were theorizing were / ARE going to be potential treatments .. by introducing them to a host which is / was being ravaged by bacteria. THAT may be an avenue. I'll try to find some of the studies. Who loves ya. Tom SignatureJesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > >Subject: Re: Septicaemia > >From: bigcat@meeow.co.uk (N. Thornton) > >OK, the infections are: > >Neisseria meningitidis (meningococcus) > Crit Care Med 2002 Jul;30(7):1623-9 > [quoted text clipped - 64 lines] > Who loves ya. > Tom excellant, ty. Regards, NT >Subject: Re: Septicaemia >From: bigcat@meeow.co.uk (N. Thornton) >Date: 2/24/2004 1:29 PM Mountain Standard Time >Message-id: <a7076635.0402241229.1475e21a@posting.google.com> I didn't mention ... phytic acid .. Natural iron chelator .. Since studies have now recommended the COMBINED treatment of different antibiotics .. [Inhibitory effect of inositol hexasulfate and inositol hexaphosphoric acid (phytic acid) on the proliferation of the human immunodeficiency virus (HIV) in vitro] Kansenshogaku Zasshi. 1989 Jul;63(7):676-83. Unique Identifier : AIDSLINE MED/90131940 Otake T; Shimonaka H; Kanai M; Miyano K; Ueba N; Kunita N; Kurimura T _________________________________________________________________ Abstract: The monosaccharide substances inositol hexasulfate (IHS) and inositol hexaphosphoric acid (Phytic acid, IHP) were investigated for their antiviral effect on the human immunodeficiency virus (HIV) in vitro. In MT-4 cells IHS completely inhibited the cytopathic effect of HIV and the HIV specific antigen expression at a concentration of 1.67 mg/ml. IHP moderately inhibited both of HIV effects as mentioned above. _________________________________________________________________ Keywords: *Antiviral Agents English Abstract Human HIV/*DRUG EFFECTS/GROWTH & DEVELOPMENT HTLV-I Infections/PATHOLOGY Inositol/*ANALOGS & DERIVATIVES/PHARMACOLOGY Monocytes/DRUG EFFECTS/MICROBIOLOGY Phytic Acid/*PHARMACOLOGY JOURNAL ARTICLE SOURCE: National Library of Medicine. NOTICE: This material may be protected by Copyright Law (Title 17, U.S.Code). Who loves ya. Tom SignatureJesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > I didn't mention ... phytic acid .. > > Natural iron chelator .. Thanks Tom. Theres no HIV involved in this case though. Given another study you mentioned, iron chelation might possibly inhibit bacterial growth too - do you know of a study of phytic acid used to control bacteria? Thanks, NT >Subject: Re: Septicaemia >From: bigcat@meeow.co.uk (N. Thornton) >Date: 2/25/2004 7:01 PM Mountain Standard Time >Message-id: <a7076635.0402251801.793be0ef@posting.google.com> It seems apotransferrin may be the .. key .. J Biomed Mater Res. 2003 Jul 1;66A(1):21-8. Related Articles, Links The inhibitory activity of serum to prevent bacterial adhesion is mainly due to apo-transferrin. Ardehali R, Shi L, Janatova J, Mohammad SF, Burns GL. Department of Bioengineering, University of Utah, Salt Lake City, Utah 84112-9202, USA. A marked, up to 5-fold, reduction in bacterial adhesion to Tecoflex polyurethane (PU) surfaces was observed in the presence of bovine/human serum or plasma at 0.5% or higher concentrations in the medium. Further investigation of the phenomenon resulted in identification, isolation, and characterization of the serum component with the ability to significantly reduce bacterial adhesion. Upon fractionation of bovine serum by an anion exchange chromatography, protein pools were made and analyzed by immunoelectrophoresis and by polyacrylamide gel electrophoresis in the presence of SDS and were examined for their effect on the adhesion of Staphylococcus epidermidis to PU surfaces. The pool exhibiting a significant inhibitory effect was subjected to further biochemical tests, which resulted in the identification of transferrin (Tf) as its predominant protein. Bacterial adhesion studies in the presence of purified Tf revealed that holo-Tf (iron-containing form) had no influence on bacterial adhesion at any concentration. Only apo-Tf (iron-lacking form) exerted the inhibitory effect, in a dose responsive manner at concentrations of 10 microg/mL or higher. Bacteria remained viable when suspended at the low apo-Tf concentrations, sufficient to prevent bacterial adhesion. Copyright 2003 Wiley Periodicals, Inc. PMID: 12833427 [PubMed - indexed for MEDLINE] -------------------------------------------------------------------------- ------ Who loves ya. Tom SignatureJesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > >From: bigcat@meeow.co.uk (N. Thornton) > 10 microg/mL or higher. Bacteria remained viable when suspended at the low > apo-Tf concentrations, sufficient to prevent bacterial adhesion. Copyright OK, now how would that affect a human with septicaemia? How does bacterial adhesion play a role there? Does it make a dfference if the circulating bugs are in the blood or attatched to something? Regards, NT |
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