Home | Contact Us | FAQ | Search & Site Map | Link to Us
Sign In | Join | Other 45 Sites in Network
Home
Discussion Groups
General
GeneralCardiologyVisionDentistryPharmacyLaboratoryNutritionAlternative
Diseases and Disorders
AIDSAlzheimer'sArthritisAsthmaCancerBreast CancerDiabetesEpilepsyGlaucomaHepatitisHerpesLupusProstate BPHProstate CancerProstatitisSinusitisTinnitus

Medical Forum / General / General / January 2004

Tip: Looking for answers? Try searching our database.

Neurontin & Muscle Contractions Question, Please

Thread view: 
Enable EMail Alerts  Start New Thread
Thread rating: 
Robert11 - 23 Jan 2004 21:58 GMT
Hello:

Have a strong facial muscle contraction problem caused by trauma which is
presently
being treated with Botox.  This has been only partially successful.

It has been suggested that I try Neurontin, but have several concerns and
questions regarding its usage.  If anyone can answer all (or any) of the
following,
would be most appreciative.

a.  Has Neurontin been successful in decreasing muscle contractions
caused by facial trauma ?

b.  Does Neurontin decrease the transmission of the neurotransmitter
Acetylcholine, and therefore decrease muscle contractions ?

c.  Does this happen to all nerves throughout the body (e.g., is it global
in its effect),
or is it selective ?  How does it discriminate ?

d.  Does it also decrease the transmission of the other neurotransmitters
throughout
the body ?

e.  Acetylcholine (in the drug Aricept) is taken to prevent dementia and
Alzheimer's.
Does decreasing the amount of this chemical in the brain increase the
chances
of bringing on these conditions ?

f.  Can the decrease of the other neurotransmitters bring on other
conditions ?

Much thanks; appreciate any help very much.

B.
Mark London - 24 Jan 2004 03:04 GMT
If you want detailed information about medical information, go to PUBMED and
look at the abstracts of most all published medical articles in the last 3 or
4 decades:      http://www.ncbi.nlm.nih.gov/PubMed/

While there's not a lot of information about Acetylcholine and neurontin,
here's one interesting lab study:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1
1578817&dopt=Abstract


From that, it appears that neurontin may cause a centrally acting stimulation
of acetylcholine receptors, since a drug like atropine, that blocks the
receptors, were able to prevent the memory improving actions of neurontin.
So neurontin would be a good thing.

There is some belief that neurontin can help with muscle problems like yours,
but there haven't been a lot of actual studies.  One of the main problems with
neurontin is that it has to be taken frequently enough to keep serum levels
elevated.  It's definitely worth a try if nothing else has worked, since it's
actions are very different than most other drugs.

There's a NEURONTIN-L mailing list that you could sign on to, if you want more
information.  That list is mainly for people taking neurontin for pain, but
there probably is someone there who could tell you more about any effects
neurontin has for spasms.

In a previous article, "Robert11" <rgsxrose@comcast.net> wrote:
->Hello:
->
->Have a strong facial muscle contraction problem caused by trauma which is
->presently
->being treated with Botox.  This has been only partially successful.
->
->It has been suggested that I try Neurontin, but have several concerns and
->questions regarding its usage.  If anyone can answer all (or any) of the
->following,
->would be most appreciative.
->
->a.  Has Neurontin been successful in decreasing muscle contractions
->caused by facial trauma ?
->
->b.  Does Neurontin decrease the transmission of the neurotransmitter
->Acetylcholine, and therefore decrease muscle contractions ?
->
->c.  Does this happen to all nerves throughout the body (e.g., is it global
->in its effect),
->or is it selective ?  How does it discriminate ?
->
->d.  Does it also decrease the transmission of the other neurotransmitters
->throughout
->the body ?
->
->e.  Acetylcholine (in the drug Aricept) is taken to prevent dementia and
->Alzheimer's.
->Does decreasing the amount of this chemical in the brain increase the
->chances
->of bringing on these conditions ?
->
->f.  Can the decrease of the other neurotransmitters bring on other
->conditions ?
->
->Much thanks; appreciate any help very much.
->
->B.
-
 
Sign In
Join
My Latest Posts
My Monitored Threads
My Blog
My Photo Gallery
My Profile
My Homepage

Start New Thread
Enable EMail Alerts
Rate this Thread



©2008 Advenet LLC   Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.