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Medical Forum / General / General / February 2004

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Univ. Pittsburgh compound used in Alzheimers; is it dealing with Manganese??????

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Archimedes Plutonium - 23 Jan 2004 18:37 GMT
Posted the below several days ago. I suspect the Pitts. compound is
not open for discussion as to what it is due to legal patentability.

Just yesterday on PBS of "Ask this old house" was a look into tap
water in some region of Massachusetts and that the brown stain was
mostly Manganese compound in the drinking water.

So, is manganese and especially MagneticManganese so all pervasive in
modern society?

Can someone tell me if Germany when Doctor Alzheimer made the first
discovery of this disease on a women patient named Auguste (excuse the
spelling). Question: was tap water in Germany at that time a new
social phenomenom, unlike well water. And does modern day tap water
from cities in the industrial world concentrate manganese and
especially magnetic-manganese?

Perhaps Alzheimers disease is the result of modern day tap water with
its overload of Manganese compounds and especially magnetic-manganese?
So, is there a European country whose people drink water that is
manganese removed and do they have a low incidence of Alzheimers?

Anyone who has experienced bathtub rings and glass stains because of
the tap water could well appreciate that their bodies drink that water
every day and that although the body does not have dirty rings or
stains, nevertheless the body needs to rid itself of the constant
daily input of unwanted chemicals.

Yes, humans are living longer, but they are also accumulating unwanted
chemicals in their bodies longer.

In that TV program on PBS on Alzheimers it pictorially sketched out
the APP protein and how the cell scissors normally cuts the protein,
and how in Alzheimers that scissors becomes roguish and cuts the APP
in 2 segments where the tiny segment is toxic and becomes beta amyloid
plaque. So the immediate question is whether a brain that takes in
MagneticManganese can alter the Scissors so much that the scissors
starts to cut APP abnormally and thus creates the disease of
Alzheimers.

Subject:
             Pittsburgh compound deal with Mn ?? Re: metal-ions cause
modern diseases of Alzheimers, Parkinson, Prion
        Date:
             21 Jan 2004 20:03:41 -0800
       From:
             a_plutonium@hotmail.com (Archimedes Plutonium)
Organization:
             http://groups.google.com
 Newsgroups:
             sci.bio.technology, sci.chem, sci.med
    Message-ID: <618e71c0.0401212003.60168afc@posting.google.com>

    delcrow@uniserve.com (Del Crow) wrote in message news:<6b500d90.0401211029.1e6390e5@posting.google.com>...
    (snipped)
    >
    > #### Hi, Archi.....Theoretically, because the governments are
hedging
    > on testing for BSE, and the similarity between the human slow
    > neuromuscular diseases are not a popular place for
pharmaceutical
    > cartels to fund transparent research, I suggest that a lot of
    > spontaneous remissions are possible by (1) avoiding manganese
    > pollution, specially where the manganese might have been
electrified
    > or triggered otherwise into its magnetic state; ferromagnetic
    > manganese in drinking water probably causes a black film on
electric
    > kettles and, if you get that, certainly do not microwave with
the same
    > water source.(2) checking ones diet for reasonable intake of
copper is
    > a must; excess copper usually causes symptoms like migraines
(3)don't
    > forget that all the trace minerals have their proper bodily
functions,
    > though there is adjustment and cellular memory involved.
Coenzyme Q10
    > (CoQ10)and Acetyl L-Carnitine should be included in any
    > neuromusculature treatment schedules which one might consider
adding.
    >
    > There are probably lots of cows being slaughtered with
low-grade BSE.
    > Catching CJ from low-grade BSE from eating it, if a person is
    > fortified with a reasonable balance of vitaminns and minerals
is
    > probably quite unlikely.
    >
    > The "inclusion bbodies" probably, even with a core of magnetic
    > manganese would have something of a size limit, being able to
directly
    > "stick" a limited number of iron molecules.
    >
    >  I have to disagree with Bob. Magnetic forcefield is so much
greater
    > than the electron transfer fields in the mitochondrial
functions that
    > it IS more likely than he thinks that the mitochondria is
affected,
    > and oxygen transfer suffers as iron movement is affected.  
Del Crow
    > ######

    Hi DelCrow, I just finished watching Alzheimers profile on PBS. I
    assume the schedule of PBS stations for the 50 states of the USA
are
    about the same and that all 50 states aired this Alzheimers
program
    tonight.

    Anyway I was an intriguing model for the progression of that
disease
    when the APP protein is clipped normally and when it is clipped
    abnormally and results in disease. In that the APP protein when
    abnormally clipped is clipped into 2 segments and the tiny
segment
    goes off toxic and is the beta amyloid.

    So I wonder if in Prion disease a similar sort of model follows
where
    the prion protein is sort of like this protruding out protein
that
    should be clipped but in Prion disease an abnormal clipping may
    result. I just wonder if that clipping model from Alzheimers
transfers
    across to Prion disease. But of course no-one actually knows what
the
    prion protein function is, unlike APP protein where its function
is
    somewhat better known.

    I gain the sense that perhaps prion disease is just a milder form
of
    Alzheimers and this would be especially true if the function of
prion
    protein is anyway similar to the function of APP in Alzheimers.

    DelCrow-- from watching that program I was hoping to make some
sort of
    link with magnetic Manganese and the research to date on
Alzheimers.
    It was mentioned that a University of Pittsburg team of
researchers
    pursued a compound that stuck to the amyloid plaques, was able to
    trespass the blood-brain-barrier, stick to the plaques briefly
and
    then exit. I wonder if the Pittsburgh compound has anything to do
with
    Manganese, and especially magnetic manganese?

    From looking at the Periodic Chart of Chemical Elements I see
iron
    surrounded by not only Mn but also Re, Os, Ru, Rh, and Co. So I
wonder
    whether these metals have ions and magnetic ions. I also wonder
    whether Iron itself has metal ions that are magnetic and whether
they
    are toxic to brain tissue.

    From watching this program, I wonder how Magnetic Manganese
*could
    cause* Alzheimers. Perhaps when the molecular shears or clippers
or
    scissors to cut the APP protein is deformed by magneticmanganese.
In
    this way the disease is caused both genetically in that certain
    scissors are vulnerable and by environment when magnetic
manganese
    gets into the body.

    Archimedes Plutonium
    whole entire Universe is just one big atom where dots
    of the electron-dot-cloud are galaxies
Steve Turner - 23 Jan 2004 23:20 GMT
>Perhaps Alzheimers disease is the result of modern day tap water with
>its overload of Manganese compounds and especially magnetic-manganese?
>So, is there a European country whose people drink water that is
>manganese removed and do they have a low incidence of Alzheimers?

AP: You're a crackpot.  But you are using your head, which is more
than I can say for ... a lot of people.  You have the curiosity and
creativity which well serve the scientific mind.  Why don't you go
back to school and get up to speed on real science: what is known and
what is fuzzy and what is not known.  With the proper background I
think you could make some significant contributions...

Steve Turner

Real address contains worldnet instead of spamnet
Del Crow - 24 Jan 2004 23:46 GMT
> >Perhaps Alzheimers disease is the result of modern day tap water with
> >its overload of Manganese compounds and especially magnetic-manganese?
[quoted text clipped - 11 lines]
>
> Real address contains worldnet instead of spamnet
####
The "real science" might be initiated by speculation or social
demand. Changing magnetic moment of ions is a normal cellular
function. Why is that Manganese where there should be copper on that
abnormal prion? How abnormal is that magnetic manganese anyhow? There
are hundreds of prion-forming locations on genes. Presumably different
cellular demands trigger the formation of different amino strings from
different locations. More info is needed without unreasonable
industrial/governmental/pharmaceutical interference. Public insistence
is necessary, right? Del Crow #####
Steve Turner - 25 Jan 2004 15:44 GMT
> The "real science" might be initiated by speculation or social
>demand. Changing magnetic moment of ions is a normal cellular
[quoted text clipped - 5 lines]
>industrial/governmental/pharmaceutical interference. Public insistence
>is necessary, right? Del Crow #####

Not sure what you're getting at, particularly with respect to the
penultimate sentence.

I have no objection to avant-garde creativity in science.  That's how
truly new stuff comes about.  But being wildly creative does not
excuse one from playing by the rules and it does not provide license
for ignoring or contradicting previous knowledge willy-nilly.  Take as
an example AP's assertion that a greater incidence of AD in women
implies a causative agent found in the kitchen.  This hypothesis, if I
can call it that, has a very long Occam's beard and exemplifies the
common syndrome of accomodating a narrow subset of data at the expense
of the wider view.  It's called "making the data fit the hypothesis,"
which is the reverse of how it's done in science.  This is what
separates science from crackpotism.

Another example, from the Feb/Mar issue of Mother Earth News, is an ad
for a "water machine" which will "open up the bond angle from 104 in
ordinary water to 114 or more so it can take on nutrients and
electrons that destroy free radicals..."  This kind of thing may sound
impressive to the scientifically illiterate, but to a scientist it's
so crackpot it's actually quite humorous. Scientists can make this
distinction because they know that this ad ignores or contradicts
everything known about bonding and solvent-solute interactions (for
example).  It's a prime example peppering the purest balderdash with
scientific-sounding words in an attempt to make it sound erudite.  But
it's really just crap with some big words thrown in.

Steve Turner

Real address contains worldnet instead of spamnet
Del Crow - 26 Jan 2004 23:13 GMT
> > The "real science" might be initiated by speculation or social
> >demand. Changing magnetic moment of ions is a normal cellular
[quoted text clipped - 36 lines]
>
> Real address contains worldnet instead of spamnet

##### Hi Steve...
Some quite reasonable commentary can be found at
http://forum.lef.org/forum21/topic22726.html#22754.
Apparently only the MnSOD has mitochondrial function according to Tom.
How variable is that magnetic moment (right term?) of Manganese? Then,
what is the controlling action? Does the iron (Heme carrier)also vary?
Without efficient interplay of these miniscule forces nothing will
work right.  That thing about water angles and "living" vs "dead"
water: I always thought it was just thhe ozone and oxygen content
which made it more "alive", maybe this is also "magnetic moment".
Still scanning.  Del Crow  @@@@#
Del Crow - 26 Jan 2004 20:32 GMT
> Posted the below several days ago. I suspect the Pitts. compound is
> not open for discussion as to what it is due to legal patentability.
[quoted text clipped - 170 lines]
>      whole entire Universe is just one big atom where dots
>      of the electron-dot-cloud are galaxies

##### Hi, Archi.  That the 254 known codons all produce long strings
of the 20 amino acids...all of or some of them only, quite
consistently, each in its own conception of correct sequenceing and
attachment of metal ions, subject to cellular memory (several human
generations, then called genetic predisposition, etc)upon demand by
cellular signals is only starting to be understood, if scanning the
abstracts is any indication at all.

Everything is vibration. All senses are based on vibration, We see
vibration. Light hits something, the vibration changes, etc. Each
metal ion has vibration which the cells can change by adjusting the
magnetic moment slightly. The electron cloud repositions to a minor
orbital pattern and abracadabra, slight magnetic effect happens. The
metal ion can be towed about into correct address position. Nothing to
it, our feeble brains just can't understand what our cells know
extremwly well.

We ignore natural taste drives (wild animals go to natural mineral
outcrops or "licks", etc)...Some of us might still believe an MD who
says "You don't need supplements".

Is magnetic manganese the only problem? Certainly not. Can the cell
adjust the magnetic moment of this junk prion? Can it be adequately
isolated so the cell will not be euthanized by lymphocytes recognizing
a sick cell? The problem compounds when there are too many junk
prions. So what to do....

I vaguely remember stuff read fifteen or so years ago in Pearson &
Shaw's book LIFE EXTENSION (a practical scientific approach) because I
realize my supplements would be termed "orthomolecular" and it seems
like I'm following recommendations they made regarding minerals and
amino acids.

There is another Life Extension, www.lef.org and they have supplement
suggestions for most of these neuromuscular debilitations which,
again, are similar to the P&S stuff.

Does the political/industrial/pharmacartel deliberately squelch
science?  I really do think so. Ask Mark Purdey. Look up Royal Raymond
Rife's history on the Rife Forum (Yahoo).  I hope you keep up the
work, I'm offline at the end of this month.    Del Crow
Archimedes Plutonium - 27 Jan 2004 06:56 GMT
(snip)

> ##### Hi, Archi.  That the 254 known codons all produce long strings
> of the 20 amino acids...all of or some of them only, quite
[quoted text clipped - 22 lines]
> a sick cell? The problem compounds when there are too many junk
> prions. So what to do....

Hello DelCrow,

I am still pondering how the APP scissors in Alzheimers makes two cuts
of above and a tinier fragment below in which this tiny fragment is
beta amyloid and wanders off to congregate into plaque. I am wondering
if the MagneticManganese is the cause of this normal Scissors turning
into a rogue scissors and thus the fundamental cause of Alzheimers
disease? So does the MagneticManganese get into the Chromosome #21
where Downs Syndrome starts and where fast-acting hereditary
Alzheimers starts? Does the MagneticManganese enter into the
Chromosome 21 and thus cause the creation of faulty rogue scissors? Or
does the MagneticManganese alter the scissors after Chromosome #21 has
created partially rogue scissors.

I am trying to find out where MagneticManganese ends up creating rogue
scissors that then starts producing the beta amyloid fragment.

DelCrow, I am suspicious of aluminum. I have no hard evidence that
aluminum causes any major disease. My suspicion lies mainly on the
fact that aluminum is mostly a modern age industrial chemical for
which human contact was rare before the last 200 or 300 years. New
chemicals in wide contact with humans has a good chance of creating
new diseases never before encountered. But I have no evidence pointing
to aluminum as a cause of Alzheimers, Parkinsons or Prion.

I am also suspicious of Fluorine and although fluorine is not a
Metal-ion, nonetheless fluorine is highly reactive. Pure fluorine is
so reactive that it can even "burn" water as if water were gasoline
(an analogy). And Fluorine is one of those modern chemicals which was
rare some 200 to 300 years on backward. We even treat our drinking
water with fluorine for tooth decay. And nowadays most pans and pots
are coated with a fluorine compound of teflon. And clothing apparel of
Goretex is flourine compound. So fluorine in modern age is prevalent.
So how much flourine gets into the human body and into the brain?

And fluorine can often be a replacer where chlorine is required for
some bodily function or cellular function. So it is suspicious of me
to think that perhaps one of these diseases of Alzheimers or
Parkinsons or Prion may be initiated in cells where chlorine molecules
have been replaced by fluorine molecules. Like with aluminum I have no
hard core evidence that fluorine is a problem and the cause of a
disease. I do know that Alzheimers is different from Parkinsons is
different from Prion even though all 3 have similarities. And that is
why I explore the idea that not only MagneticManganese but also
aluminum and also fluorine, not to mention numerous other Metal-ions.

Archimedes Plutonium
whole entire Universe is just one big atom where dots
of the electron-dot-cloud are galaxies
John Savage - 06 Feb 2004 22:41 GMT
>So, is manganese and especially MagneticManganese so all pervasive in
>modern society?

Manganese has indeed become "all prevasive" in the environment, though I
don't know whether this could have any adverse consequences or whether
it converts to a biologically available form. But the ordinary dry cell
flashlight battery is packed full of Manganese Dioxide. During the last
80 or so years, the invention and proliferation of portable electric
gadgets has seen many households discard hundreds of cells per year. Before
the modern suburban garbage collection, these old cells were liberally
discarded throughout the environment or buried or burned in the backyard
garden refuse pile. Clearly, there is always a trace amount of manganese in
any soil, but the use of the Leclanche dry cells has seen a redistribution
of hundreds of tons of the stuff per year, with it being cast far and wide,
and once in the soil some of it must make its way into the waterways and
garden soil, though in what form I hesitate to guess.

Also, in my very limited observations, it does seem that in old age people
may contract one of Alzheimers or Parkinsons, but rarely if ever both.
Signature

John Savage       (news address invalid; keep news replies in newsgroup)

Archimedes Plutonium - 07 Feb 2004 07:08 GMT
> >So, is manganese and especially MagneticManganese so all pervasive in
> >modern society?
[quoted text clipped - 15 lines]
> Also, in my very limited observations, it does seem that in old age people
> may contract one of Alzheimers or Parkinsons, but rarely if ever both.

John, several times a year our local water is analyzed for elements,
minerals and other matter. Seems to me if water is analyzed so often
and easily that a analysis of several Alzheimers, Parkinsons and Prion
victims should be easily performed.

If such a analysis were performed and if the data comes in that
Alzheimers has larger amounts of a specific metal-ion than normal
brains, likewise Parkinsons for a different specific metal-ion and
likewise for Prion. I am surprized that no science research has
investigated this possibility.

I do not know how long lasting magnetic manganese can occur. If it
causes Prion disease, then we know how persistant prion disease can be
in dead animals, although oven burning seems to end it. Suggesting a
persistant metal ion.

John, you are not clear as to whether a victim of simultaneous
Alzheimers and Parkinsons ever existed. If one existed then I wonder
if an autopsy for chemical analysis can be performed.

If such an analysis were performed for these three diseases and it
turns out that for example Alzheimers has a higher amount of aluminum
in the body then normal and that Parkinsons has a higher amount of a
chlorofluor compound and that Prion has a higher amount of
magneticmanganese than a normal body. And that a victim of both
Alzheimers and Parkinsons simultaneously has both chlorofluor and
magneticmanganese.

I don't see battery composition as getting into contact with humans,
except if magneticmanganese is longlived and gets into the water
supply. Has anyone found a municipal water high in magneticmanganese?
And if so, are the residents having higher rates of say Parkinsons? I
do know that Parkinsons seems to be a regional disease of the Midwest
USA.

John, do you know if aluminum has some dangerous form. I suppose
no-one has analyzed the amounts of aluminum in a normal body and
whether Alzheimers of Parkinsons have larger amounts of aluminum than
normal brains.

Archimedes Plutonium
whole entire Universe is just one big atom where dots
of the electron-dot-cloud are galaxies
 
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