Bull Exp Biol Med. 2003 Oct;136(4):362-5.  Links

Oxidative modification of erythrocyte membranes in the acute stage of severe
craniocerebral trauma and its correction with clonidine.

Karmen NB.

Institute of Experimental and Theoretical Biophysics, Russian Academy of
Sciences, Pushchino. emaevsky@iteb.ru

Acute posttraumatic stage of severe craniocerebral trauma was characterized by
considerable activation of lipid peroxidation and exhaustion of the antioxidant
enzyme system. Oxidative modification of membranes was accompanied by
structural and functional changes. The antihypoxic effect of clonidine was
realized directly in the lipid phase of membranes. This preparation inhibited
lipid peroxidation and activated antioxidant enzymes, which prevented the
development of structural and functional changes in membranes.

PMID: 14714083 [PubMed - in process]

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