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Medical Forum / General / General / December 2008

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Two questions about the liver.

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Frederick Williams - 22 Dec 2008 11:17 GMT
(1) What is the significance of Alt = 565, AP = 965, Bil = 76?
(2) Can liver malfunction causing itchiness?
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But you see, I can believe a thing without understanding it.
It's all a matter of training.
--Lord Peter Wimsey in Dorothy L Sayers' _Have His Carcase_

Mark & Steven Bornfeld - 22 Dec 2008 17:46 GMT
> (1) What is the significance of Alt = 565, AP = 965, Bil = 76?
> (2) Can liver malfunction causing itchiness?

1) These are values for liver function tests.  Alt= alanine
aminotransferase, AP=Alkaline phosphatase, Bil= bilirubin.
    These values should always be stated with the laboratory normals, to
see if you are in or out of the normal range.

http://www.gastromd.com/lft.html

2) Itching is a common problem with cholestatic liver disease:

http://cpmcnet.columbia.edu/dept/gi/itching.html

Steve

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Mark & Steven Bornfeld DDS
http://www.dentaltwins.com
Brooklyn, NY
718-258-5001

Robert1 - 22 Dec 2008 23:19 GMT
On Dec 22, 3:17 am, Frederick Williams <frederick.willia...@tesco.net>
wrote:
> (1) What is the significance of Alt = 565, AP = 965, Bil = 76?
> (2) Can liver malfunction causing itchiness?
> --
> But you see, I can believe a thing without understanding it.
> It's all a matter of training.
> --Lord Peter Wimsey in Dorothy L Sayers' _Have His Carcase_

As was mentioned by the other poster reference ranges are important
especially with numbers without units attached to them. Different
countries use different units and thus a 76 involving units of mg/dl
would almost be impossible to obtain. I presume the 76 relates to
micromoles/l in which case the upper limit of normal would be 20.

An elevated Alk =AP would indicate cholestasis which is equivalent to
liver congestion. Chemicals may spill out into circulation because of
that congestion and become elevated. Some of those chemicals can cause
one to itch. The old theories related to bile salts as the cause of
such itching have come into question. It appears that they and of
themselves are not the source. In any case any diagnostic workup
involving itching, pruritus involves bile salt analysis as a marker of
cholestasis.
Mark & Steven Bornfeld - 23 Dec 2008 19:05 GMT
> On Dec 22, 3:17 am, Frederick Williams <frederick.willia...@tesco.net>
> wrote:
[quoted text clipped - 19 lines]
> involving itching, pruritus involves bile salt analysis as a marker of
> cholestasis.

Thanks for the clarification.

Steve

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Mark & Steven Bornfeld DDS
http://www.dentaltwins.com
Brooklyn, NY
718-258-5001

Frederick Williams - 26 Dec 2008 11:04 GMT
> (1) What is the significance of Alt = 565, AP = 965, Bil = 76?
> (2) Can liver malfunction causing itchiness?

Thank you for the replies.

Signature

But you see, I can believe a thing without understanding it.
It's all a matter of training.
--Lord Peter Wimsey in Dorothy L Sayers' _Have His Carcase_

 
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