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Medical Forum / General / General / May 2005

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Fibromyalgia an oxidative disorder

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doe - 25 Dec 2003 04:48 GMT
Rheumatol Int. 2003 Dec 20 [Epub ahead of print].  Related Articles, Links  

Free radicals and antioxidants in primary fibromyalgia: an oxidative stress
disorder?

Bagis S, Tamer L, Sahin G, Bilgin R, Guler H, Ercan B, Erdogan C.

Physical Medicine and Rehabilitation Department, Mersin University Medical
School, Mersin, Turkey.

The role of free radicals in fibromyalgia is controversial. In this study, 85
female patients with primary fibromyalgia and 80 age-, height-, and
weight-matched healthy women were evaluated for oxidant/antioxidant balance.
Malondialdehyde is a toxic metabolite of lipid peroxidation used as a marker of
free radical damage. Superoxide dismutase is an intracellular antioxidant
enzyme and shows antioxidant capacity. Pain was assessed by visual analog
scale. Tender points were assessed by palpation. Age, smoking, body mass index
(BMI), and duration of disease were also recorded. Malondialdehyde levels were
significantly higher and superoxide dismutase levels significantly lower in
fibromyalgic patients than controls. Age, BMI, smoking, and duration of disease
did not affect these parameters. We found no correlation between pain and
number of tender points. In conclusion, oxidant/antioxidant balances were
changed in fibromyalgia. Increased free radical levels may be responsible for
the development of fibromyalgia. These findings may support the hypothesis of
fibromyalgia as an oxidative disorder.

PMID: 14689230 [PubMed - as supplied by publisher]

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Mark London - 26 Dec 2003 03:33 GMT
Yet another study on fibromyalgia that initially looks interesting to the
casual reader.  But look at the significant statement, that the oxidation
markers showed no correlation with either pain or tender points.  In other
words, this is probably yet another case of the oxidative stress simply either
being a trigger for fibromyalgia, or being the result of fibromyalgia.  Many
health conditions trigger fibromyalgia, and oxidative stress is one
of many.  In Turkey, it might happen to be a major one, due to pollution and
diet.  Many people with fibromyalgia are deficient in magnesium, and a
magnesium deficiency can cause lipid peroxidation.   Such studies do little to
help people who already have fibromyalgia, since taking antioxidants doesn't
cure the pain in fibromyalgia.  The damage is done, at that point.  So all
such a study does is to give us another reason why oxidative stress is bad
you, as if we didn't know that to begin with?

In a previous article, ironjustice@aol.comdoe (doe) wrote:
->Free radicals and antioxidants in primary fibromyalgia: an oxidative stress
->disorder?
->Bagis S, Tamer L, Sahin G, Bilgin R, Guler H, Ercan B, Erdogan C.
->Physical Medicine and Rehabilitation Department, Mersin University Medical
->School, Mersin, Turkey.
->The role of free radicals in fibromyalgia is controversial. In this study, 85
->female patients with primary fibromyalgia and 80 age-, height-, and
->weight-matched healthy women were evaluated for oxidant/antioxidant balance.
->Malondialdehyde is a toxic metabolite of lipid peroxidation used as a marker of
->free radical damage. Superoxide dismutase is an intracellular antioxidant
->enzyme and shows antioxidant capacity. Pain was assessed by visual analog
->scale. Tender points were assessed by palpation. Age, smoking, body mass index
->(BMI), and duration of disease were also recorded. Malondialdehyde levels were
->significantly higher and superoxide dismutase levels significantly lower in
->fibromyalgic patients than controls. Age, BMI, smoking, and duration of disease
->did not affect these parameters. We found no correlation between pain and
->number of tender points. In conclusion, oxidant/antioxidant balances were
->changed in fibromyalgia. Increased free radical levels may be responsible for
->the development of fibromyalgia. These findings may support the hypothesis of
->fibromyalgia as an oxidative disorder.
->
->PMID: 14689230 [PubMed - as supplied by publisher]
->
->--------------------------------------------------------------------------
->------
->
->Who loves ya.
->Tom
->Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
->Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
->DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
->
->
-
tom hennessy - 01 May 2005 21:25 GMT
J Med Food. 2005 Spring;8(1):47-52. Related Articles, Links

Green tea extract and catechin ameliorate chronic fatigue-induced oxidative
stress in mice.

Singal A, Kaur S, Tirkey N, Chopra K.

Pharmacology Division, University Institute of Pharmaceutical Sciences,
Panjab University, Chandigarh, India.

Chronic fatigue syndrome (CFS) is an illness characterized by persistent
and relapsing fatigue, often accompanied by numerous symptoms involving
various body systems. The etiology of CFS remains unclear, but a number of
studies have shown that oxidative stress may be involved in its
pathogenesis. The present study was designed to investigate the protective
effect of green tea extract (GTE) and catechin in the mouse model of CFS.
Animals were subjected to a forced swimming test session of 6 minutes every
day for 7 days; a significant increase in immobility time on successive
days represented the CFS in mice. Biochemical analysis revealed that the
chronic swim test significantly increased lipid peroxidation levels and
decreased glutathione levels in mouse whole-brain homogenate. Treatment
with GTE (25 or 50 mg/kg, i.p.) and catechin (50 or 100 mg/kg, i.p.) for 7
days reversed the increase in immobility time. Protection was correlated
with the lowered levels of lipid peroxidation and restoration of reduced
glutathione levels in the brains of fatigued mice. These findings strongly
suggest the pivotal role of oxidative stress in the pathophysiology of CFS
and that GTE and catechin could be used as potential agents in the
management of CFS and warrant the inclusion of GTE and catechin in the
treatment regimen of CFS patients.

PMID: 15857209 [PubMed - in process]

----------------------------------------------------------------------------
----

Who loves ya.
Tom
Signature

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

 
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