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Medical Forum / General / General / June 2008

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US doctors kill skin cancer with cloned T-cells

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metspitzer - 19 Jun 2008 03:03 GMT
    US doctors have for the first time successfully treated a skin
cancer patient with cells cloned from his own immune system, a study
released Wednesday showed.

The ground-breaking treatment for advanced melanoma, or skin cancer,
led to a long remission for the patient and used his own cloned
infection-fighting T-cells, said doctor Cassian Yee, the lead author
of the study in the New England Journal of Medicine.

Yee and his associates from the Clinical Research Division at Fred
Hutchinson Cancer Research Center in Seattle removed CD4+ T-cells, a
type of white blood cell, from a 52-year-old man whose melanoma had
spread to a groin lymph node and to one of his lungs.

The melanoma was already well advanced and in stage four.

The T-cells which specifically fight melanoma were modified and
expanded in the laboratory and some five billion cells were then
infused into the patient, who received no other kind of treatment.

Two months later no tumors were found during scans of the patient's
organs. And he has been cancer free for two years, Yee said.

"We were surprised by the anti-tumor effect of these CD4 T cells and
its duration of response," Yee said. "For this patient we were
successful, but we would need to confirm the effectiveness of therapy
in a larger study."

It was the first ever case to show that cloned cells from a patient's
own immune system can successful combat skin cancer. If further tests
confirm the efficiency of the method, it could be used in some 25
percent of patients with late-stage skin cancer, the study said.

Using a patient's own immune system to combat cancer, called
immunotherapy, is a growing area of research that aims to develop
less-toxic cancer treatments than standard chemotherapy and radiation.

Some 160,000 cases of melanoma are diagnosed around the world every
year, particularly affecting white men living in very sunny regions.

Although it usually affects the skin, in rare cases it can also infect
the eyes and intestines.

According to the World Health Organization, some 48,000 people die
from melanoma every year.

http://www.breitbart.com/article.php?id=080618212711.38ht6zq0&show_article=1
habshi - 21 Jun 2008 12:54 GMT
    I did propose something like this a few years ago. Our cells
dont recognise cancer cells because they are self. However say a
friend has cancer too. If we inject our cancer  cells into him , his
cells will prolferate to make antibodies against them. We can then
collect these cells and inject them into us and they will kill our
cancer cells

    US doctors have for the first time successfully treated a skin
cancer patient with cells cloned from his own immune system, a study
released Wednesday showed.

The ground-breaking treatment for advanced melanoma, or skin cancer,
led to a long remission for the patient and used his own cloned
infection-fighting T-cells, said doctor Cassian Yee, the lead author
of the study in the New England Journal of Medicine.

Yee and his associates from the Clinical Research Division at Fred
Hutchinson Cancer Research Center in Seattle removed CD4+ T-cells, a
type of white blood cell, from a 52-year-old man whose melanoma had
spread to a groin lymph node and to one of his lungs.

The melanoma was already well advanced and in stage four.

The T-cells which specifically fight melanoma were modified and
expanded in the laboratory and some five billion cells were then
infused into the patient, who received no other kind of treatment.

Two months later no tumors were found during scans of the patient's
organs. And he has been cancer free for two years, Yee said.

"We were surprised by the anti-tumor effect of these CD4 T cells and
its duration of response," Yee said. "For this patient we were
successful, but we would need to confirm the effectiveness of therapy
in a larger study."

It was the first ever case to show that cloned cells from a patient's
own immune system can successful combat skin cancer. If further tests
confirm the efficiency of the method, it could be used in some 25
percent of patients with late-stage skin cancer, the study said.

Using a patient's own immune system to combat cancer, called
immunotherapy, is a growing area of research that aims to develop
less-toxic cancer treatments than standard chemotherapy and radiation.

Some 160,000 cases of melanoma are diagnosed around the world every
year, particularly affecting white men living in very sunny regions.

Although it usually affects the skin, in rare cases it can also infect
the eyes and intestines.

According to the World Health Organization, some 48,000 people die
from melanoma every year.

http://www.breitbart.com/article.php?id=080618212711.38ht6zq0&show_article=1
Jeff - 21 Jun 2008 13:01 GMT
>     I did propose something like this a few years ago.

I am sure that as soon as the director of the NIH saw your proposal, he
immediately awarded grants to work on your proposal.

> Our cells
> dont recognise cancer cells because they are self. However say a
> friend has cancer too. If we inject our cancer  cells into him , his
> cells will prolferate to make antibodies against them. We can then
> collect these cells and inject them into us and they will kill our
> cancer cells

And all of our non-cancer cells, too, dingbat.

Read the info below again. The t-cells came from the patient who had
cancer. Get a clue before making an a.s of yourself.

Jeff

>      US doctors have for the first time successfully treated a skin
> cancer patient with cells cloned from his own immune system, a study
[quoted text clipped - 43 lines]
>
> http://www.breitbart.com/article.php?id=080618212711.38ht6zq0&show_article=1
habshi - 21 Jun 2008 13:13 GMT
>And all of our non-cancer cells, too, dingbat.<

    Maybe we could purify the cells or just use the antiboidies
they make. When we transfuse blood we dont always kill the patient, so
if the killer white cells were from compatible donors we could use
them to inject back into the patient and they would target only the
cancer cells for which they have receptors.
    The technique in the article is only good for skin cancer
cells.
 
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