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Medical Forum / General / General / March 2008Oxidation and Fatigue
Fatigue Therapy Research results from University of Kentucky, Department of Physiology update understanding of fatigue therapy March 30th, 2008 (NewsRx.com) -- Current study results from the report, 'Free radicals and muscle fatigue: Of ROS, canaries, and the IOC,' have been published. According to a study from the United States, "Skeletal muscle fibers continually generate reactive oxygen species (ROS) at a slow rate that increases during muscle contraction. This activity-dependent increase in ROS production contributes to fatigue of skeletal muscle during strenuous exercise." "Existing data suggest that muscle-derived ROS primarily act on myofibrillar proteins to inhibit calcium sensitivity and depress force. Decrements in calcium sensitivity and force are acutely reversible by dithiothreitol, a thiol-selective reducing agent. These observations suggest that thiol modifications on one or more regulatory proteins are responsible for oxidant-induced losses during fatigue. More intense ROS exposure leads to losses in calcium regulation that mimic pathologic changes and are not reversible. Studies in humans, quadrupeds, and isolated muscle preparations indicate that antioxidant pretreatment can delay muscle fatigue. In humans, this phenomenon is best defined for N-acetylcysteine (NAC), a reduced thiol donor that supports glutathione resynthesis. NAC has been shown to inhibit fatigue in healthy adults during electrical muscle activation, inspiratory resistive loading, handgrip exercise, and intense cycling," wrote M.B Reid and colleagues, University of Kentucky, Department of Physiology. The researchers concluded: "These findings identify ROS as endogenous mediators of muscle fatigue and highlight the importance of future research to (a) define the cellular mechanism of ROS action and (b) develop antioxidants as novel therapeutic interventions for treating fatigue." Reid and colleagues published their study in Free Radical Biology & Medicine (Free radicals and muscle fatigue: Of ROS, canaries, and the IOC. Free Radical Biology & Medicine, 2008;44(2):169-79). -------------------------------------------------- http://tinyurl.com/ynpdhm "Iron-chelating agents, N-acetyl-L-cysteine (NAC), apocynin,probucol, and edaravone, are useful in preventing cardiovascular injury and diseases." Recent Patents on Anti-Infective Drug Discovery, 2006, 1, 17-31171574-891X/06 $100.00+.00(c) 2006 Bentham Science Publishers Ltd.Recent Progress in Pharmacological Research of Antioxidants inPathological Conditions: Cardiovascular Health Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Fatigue Therapy > Research results from University of Kentucky, Department of Physiology [quoted text clipped - 60 lines] > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk Yeah, give them antioxidants before exercise and you never grow muscles ... No pain no gain - without the oxidative damage you cannot stimulate muscle growth. You do need ROS and possibly AA metabolites such as PGF/PGE2 to improve your physique. That's how it works and why herbivores can never be successful athletes ... Taka On Mar 24, 6:23 pm, Taka <taka0...@gmail.com> wrote:You do need ROS and possibly AA metabolites such as PGF/PGE2 to improve your physique. << "With the AA metabolites, the tissue may be permanently stuck in the original destructive phase of inflammation" You can have it both ways .. taka .. ? Must be nice .. http://tinyurl.com/2bjotq Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > > Fatigue Therapy > > Research results from University of Kentucky, Department of Physiology [quoted text clipped - 70 lines] > > - Show quoted text - > On Mar 24, 6:23 pm, Taka <taka0...@gmail.com> wrote:You do need ROS > and possibly AA metabolites [quoted text clipped - 4 lines] > > You can have it both ways .. taka .. ? Fortunately yes, if you think quantitatively and not only qualitatively. Also there are tissues which are better off without AA such as stem cells but highly differentiated and specialized cells may (notice the MAY) require it for optimal functioning. Also optimal function in short term doesn't equal preservation of the function for the longest time possible. I do believe we need prostaglandins (isolated from PROSTAte) for reproduction, childhood growth and muscle growth in sports. But there is an important threshold for the AA content in cells beyond which you may have rather destructive than constructive inflammatory response. The AA metabolites called leukotrienes are responsible for the destructive phase and this is what you get when you are messing with Omega-3 to inhibit the prostaglandin production. If you are unfortunate to be overloaded with AA, as most westerners are, the antioxidants specifically inhibiting 5-LOX (making the leukotrienes) like AKBA may be useful together with exercise which will help you to burn the excessive AA stores. Go to check this holly plant called Boswellia serrata but don't come back telling me all it does is reducing the iron ... Taka On Mar 26, 7:40 am, Taka <taka0...@gmail.com> wrote: don't come back telling me all it does is reducing the iron << Why exactly iyho would it be registered as .. "not compatible with copper or iron" .. ? There are only a few reasons for that kind of precautionary .. labling .. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > > On Mar 24, 6:23 pm, Taka <taka0...@gmail.com> wrote:You do need ROS > > and possibly AA metabolites [quoted text clipped - 25 lines] > > Taka
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