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Medical Forum / General / General / January 2008Taking Pills with Prune Juice
Hi everyone, I do not believe it is a good idea to take pills with prune juice or while eating prunes, due to the laxative effect of the prune juice or prunes, and the possibility that the pills may continue on into the duodenum and then the rest of the small intestine too rapidly (so to speak) and not be properly absorbed into the bloodstream by the duodenum (I believe approx. 80% of most absorption takes place in the duodenum). Is my assumption logical and do you agree or disagree. Prune juice and/or prunes in my morning meal accompanied with a hot beverage definitely helps me to have a bowel movement afterward. But I take pills (both prescription and supplements) with my morning meal, and I am afraid there is a risk of them flushing on down before proper absorption, so I avoid taking the pills with prune juice, but I would like to do that. I would appreciate any comments you may have. Thanks...Pete > Hi everyone, > [quoted text clipped - 6 lines] > > Is my assumption logical and do you agree or disagree. I agree your assumption is logical, but wrong. The stuff in the duodenum is passed further along, whether or not it is later absorbed. Rarely do I see pills that say take with fatty (which delays gastric emptying). The effect with prunes is mostly on the large intestine, because the sugars in the prunes are poorly absorbed, which keeps water in your intestines, leading to softer and bigger and/or more frequent stools. > Prune juice and/or > prunes in my morning meal accompanied with a hot beverage definitely helps > me to have a bowel movement afterward. That's the gastrocolic reflex which basically that when your stomach is filled, it sends a signal to your intestines to get ready for more food to digest. It does this by moving the contents and along and emptying the intestine. But it isn't your prunes from that breakfast you're passing, but rather the leftover from the day before. The fastest food will move through is usually a three or four hours unless you're ill. > But I take pills (both prescription > and supplements) with my morning meal, and I am afraid there is a risk of > them flushing on down before proper absorption, so I avoid taking the pills > with prune juice, but I would like to do that. I don't think you have anything to worry about. > I would appreciate any comments you may have. Thanks...Pete Anyday. >> Hi everyone, >> [quoted text clipped - 25 lines] > fastest food will move through is usually a three or four hours > unless you're ill. I am quite familiar with gastroenterology Jeff, but I am telling you that prunes/prune juice, and also bananas (especially when combined with a hot liquid) will cause the gastrocolic reflex you mention (or kickstart) faster than if you didn't eat the banana or prune or drink the prune juice and hot liquid. All laxatives say to separate them from pills by 2 hours (and there are four basic kinds of laxatives as to how they function - as I am sure you know). Even metamucil says to separate it from pills by two hours (and it is just psyllium husk and does not react chemically with the pill or cause a conflict in the liver etc). I believe it is because after the pill starts to dissolve the ingredients may cling to the metamucil somehow (so to speak) and can get carried on out. The same could apply to a prune even though it is reduced to a liquefied form before it passes through the pyloric sphincter. Do you see what I am getting at. I have discussed this with pharmacists long ago and at least a couple (IIRC) agreed it may not by wise to take pills with prunes or prune juice - and all of the OTC laxatives (regardless of what type they are - bulk forming, stimulant, lubricant or saline) say to separate them from pills by two hours, for whatever reason....Pete >> But I take pills (both prescription >> and supplements) with my morning meal, and I am afraid there is a [quoted text clipped - 6 lines] > > Anyday.
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