Medical Forum / General / General / November 2007
#101 NOVA spoke of human 23 chromosomes whereas apes have 24; new textbook: Stonethrowing Theory, the Central theory of Anthropology
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a_plutonium - 14 Nov 2007 21:07 GMT TextBook: "STONETHROWING THEORY, THE CENTRAL THEORY OF
ANTHROPOLOGY", Archimedes Plutonium
Internet book published 2002-2007 (amassed in
March 2007 in sci.anthropology.paleo, sci.med,
sci.physics)
This is now November of 2007 and after writing alot of these science books I learned to number them in order to keep track and to add a last chapter that allows me to comment on recent news flash updates.
So I wrote the above book back in March or amassed all of my previous posts in March to form a textbook and last night watching Nova about Darwin and Intelligent Design court case in Dover Pennsylvania, they touched on something important to Stonethrowing theory.
They said in that program that the apes of chimps, orangs and gorillas all have 24 chromosomes while humanity has 23. So they further go on to explain that one of the human chromosomes fused with another where the telomeres of one chromosome fused with the telomeres of another chromosome and where this fused chromosome has double the number of centromeres.
They said it was the Human Chromosome #2 that was the fused one.
So, that immediately set my mind to wondering whether Human Chromosome #2 is the chromosome where much or most of the genetics of bone and muscle structure are formed. Is it chromosome #2 wherein lies the ability to throw overarm for humans and not for apes? Is it Chromosome #2 wherein lies the tremendous changes of the fingers hands arms and backbone and rotator cuff and elbow all to perfect Throwing?
Indeed, I must make a search to see if Chromosome #2 is where most of the physiology of bone and muscle structure of humans is played out.
Archimedes Plutonium www.iw.net/~a_plutonium whole entire Universe is just one big atom where dots of the electron-dot-cloud are galaxies
Yousuf Khan - 23 Nov 2007 10:13 GMT > They said in that program that the apes of chimps, orangs and gorillas > all have 24 chromosomes [quoted text clipped - 20 lines] > the physiology of bone > and muscle structure of humans is played out. Why can't Chromosome #2 simply be the chromosome where all of the human brain development came out of?
Yousuf Khan
a_plutonium - 23 Nov 2007 19:59 GMT Someone wrote:
> Why can't Chromosome #2 simply be the chromosome where all of the human > brain development came out of? I was not claiming that #2 chromosome is the site of where the genetics of humanity came into being and diverged from ape ancestors. I was saying that it is highly likely and that it is worthy of research to see if this chromosome bears the divergence of humanity from ape ancestors.
According to Stonethrowing Theory, the difference between humanity and all other primates is our proclivity to throw rocks and stones which catapulted our evolution and causing us to have bipedalism and an ever bigger brain to think out the trajectory and consequences of throwing rocks and stones as well as benefiting the thrower with more mates and offspring. So if we differ from the apes in that we have a fused chromosome as #2 and that we differ from apes in that we are the Throwing Ape, then logic would say that it is highly likely that our Throwing Genetics lies on this #2 chromosome.
So I am not saying definitely 100 percent that throwing genetics is on #2 chromosome but saying that it is very much likely to be the case. That the bone morphology and the muscle genetics that made the human anatomy into a Stonethrower is likely to have connections to chromosome #2.
So I was asking for a diving into research of chromosome #2 as to whether the genetics of bones and muscles is on chromosome #2. Whether Opposable thumb is on #2 and whether Rotator Cuff is on #2 and whether the apes knuckle walking is on their so called #2.
I am saying that the major difference between humanity and the rest of the primates is a spat of evolution wherein we became Stonethrowers and the genetics should bear that out.
Archimedes Plutonium www.iw.net/~a_plutonium whole entire Universe is just one big atom where dots of the electron-dot-cloud are galaxies
Marc Verhaegen - 24 Nov 2007 17:23 GMT Op 23-11-2007 20:59, in artikel e43ae082-09ab-47f5-ab9e-2eb1ab1151b3@d61g2000hsa.googlegroups.com, a_plutonium <a_plutonium@hotmail.com> schreef:
> According to Stonethrowing Theory, the difference between humanity and > all other primates is > our proclivity to throw rocks and stones which catapulted our > evolution and causing us to have > bipedalism and an ever bigger brain Constructing Central Theories about the Uniqueness of Humanity is ok, but 1) throwing, 2) bipedality & 3) big brains have nothing to do with each other:
1) Frans de Waal, evol-psych 22.9.01: Now, please, don't believe everything you hear about apes not throwing. Darwin was talking about monkeys, and Goodall's chimps may not have had much practice. In all research facilities with chimpanzees it is known how well apes throw. This is why projectiles are kept away from them, and why they mostly work with feces. They are deadly accurate, they swing around from the back of their cage and invariably "nail" the one new face in the crowd with deadly accuracy. Ask any worker in such a facility: it's not rare, and no illusion! Out in the open, their skills are even more striking. I used to photograph the Arnhem chimpanzees from across the moat, where they were at about 10 m from me. I had to be extremely careful because young males tended to throw extremely well. They would see my eye go behind the camera, and all of a sudden it turned out they had a stone with them which they'd throw at me. Males more than females, mostly overhand. (Another tidbit in the debate whether they know if our eyes are for seeing or not …). Then there was the mother who came to the reception with her crying son. She complained that our chimps threw stones. After questioning and an account by a bystander it turned out that the boy had thrown first, and that the same stone had come back to him. The estimated distance of this case was 25 m. In short, the idea that apes can't throw is bogus. It has been around for a long time, but should be tested with apes who have had target practice. I invite all man-the-thrower advocates for a visit - at least if they don't mind some smelly stuff coming their way! http://www.uncoveror.com/baboons.htm Curious Child Causes Baboon Fracas - A 3d-grader on a school-outing to the San Jose Zoo caused an ugly scene. His older brother told him not to throw rocks at the red-a.s baboons : when they throw them back, they don't miss. He wanted to see if it was true. George Simms picked up a rock , threw it at the biggest baboon he could see. It whizzed past Bobo, dominant♂ in the Hamadryas , landed just behind him. Bobo noticed who had thrown the rock, flew into a rage, picked it up, threw it back, hitting little George squarely in the forehead, knocking him out cold. The Baboon then proceeded to screech loudly, jumping up+down, showing his teeth. A little girl, Susan Parker, yelled "You bad monkey!" , threw the rock a 3d time. This time it fell just short of an infant baboon. The entire troop became agitated , started to fling rocks, dirt clods, mud & their feces at the children, their teacher& all other Hs within sight, never once missing a target. As children began to drop like flies, adults began to panic, some Pt in the display behind them thought flinging things looked like fun, so they joined in, completely surrounding the bewildered zoo patrons. By the time the apes had nothing more to fling, 9 children & 3 adults lay unconscious, many others were crying & moaning in pain, bleeding & holding on to wounds. Those only needing first aid were treated at the zoo, the rest were rushed to nearby hospitals. The young boy who started it all remains hospitalized in serious condition. As little George Simms & all his classmates learned the hard way, it is not just a myth or an old wives tale. Don't throw rocks at the red-a.s baboons. When they throw them back, they don't miss!"
2) probably predates the human/gibbon split c.18 Ma or so, and mid-Miocene fossils (Morotopithecus) had lumbar vertebrae with transverse processes on the vertebral arch, which suggests they had an upright posture: A.Filler 2007 "The upright ape" & recent papers.
3) Brains larger than in apes & apiths appear AFAWK only in Pleistocene.
a_plutonium - 24 Nov 2007 19:48 GMT Moments like this I wish I was an expert in protein function
--- quoting from http://ghr.nlm.nih.gov/chromosome=2/show/Genes * ABCA12: ATP-binding cassette, sub-family A (ABC1), member 12 * ACVR1: activin A receptor, type I * AGXT: alanine-glyoxylate aminotransferase * ALMS1: Alstrom syndrome 1 * ALS2: amyotrophic lateral sclerosis 2 (juvenile) * APOB: apolipoprotein B (including Ag(x) antigen) * ATG16L1: ATG16 autophagy related 16-like 1 (S. cerevisiae) * BARD1: BRCA1 associated RING domain 1 * BMPR2: bone morphogenetic protein receptor, type II (serine/ threonine kinase) * CNGA3: cyclic nucleotide gated channel alpha 3 * COL3A1: collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) * COL4A3: collagen, type IV, alpha 3 (Goodpasture antigen) * COL4A4: collagen, type IV, alpha 4 * COL5A2: collagen, type V, alpha 2 * CPS1: carbamoyl-phosphate synthetase 1, mitochondrial * CYP1B1: cytochrome P450, family 1, subfamily B, polypeptide 1 * D2HGDH: D-2-hydroxyglutarate dehydrogenase * DCTN1: dynactin 1 (p150, glued homolog, Drosophila) * DFNB59: deafness, autosomal recessive 59 * EDAR: ectodysplasin A receptor * EIF2B4: eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa * HADHA: hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit * HADHB: hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit * MSH2: mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) * MSH6: mutS homolog 6 (E. coli) * NR4A2: nuclear receptor subfamily 4, group A, member 2 * OTOF: otoferlin * PAX3: paired box 3 * PAX8: paired box 8 * SLC3A1: solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1 * SLC40A1: solute carrier family 40 (iron-regulated transporter), member 1 * TPO: thyroid peroxidase
--- end quoting from http://ghr.nlm.nih.gov/chromosome=2/show/Genes
The theme of the textbook Stonethrowing theory is that Throwing behaviour delivered a new species out of the ape species some 10 million years ago all due to one new behaviour-- throwing. Where this new behaviour garnered more food, more mates and which accelerated the change in anatomy of these Throwing creatures to become a human anatomy. What makes us different from apes was a Throwing ape some 10 million years ago. And that history should be traceable in the genetics where the opposable thumb and rotator cuff and the non-knuckle-walking and the hands and fingers and the bipedalism also came about due to the pressure of throwing better demands bipedalism.
So one behaviour --- Throwing --- caused the existence of humanity from apes.
And the genetics should bear it out.
I am told that Human Chromosome #2 is the second largest human chromosome so it has alot of genes. And from the above it appears that this chromosome has BMPR2: bone morphogenetic protein receptor, type II (serine/threonine kinase)
Now do the apes of chimpanzees or orangutans or gorilla or bonobo have BMPR2?
So that if we make a gene by gene correlation where apes have a gene but humans do not or where humans have a muscle bone anatomy gene and apes do not. Well, we can get to the very heart and foundation of the science of Anthropology and before the end of this century that anthropology as a science should be a nearly completed science where the only future questions are just details.
Archimedes Plutonium www.iw.net/~a_plutonium whole entire Universe is just one big atom where dots of the electron-dot-cloud are galaxies
a_plutonium - 25 Nov 2007 06:21 GMT > Moments like this I wish I was an expert in protein function > [quoted text clipped - 84 lines] > where the only future > questions are just details. The title says most of it. And this textbook has really come a very long way ever since I watched a TV program showing Pickford and Senut in Africa finding Orrorin and then the program talking about bipedalism and its Savannah theory. And which the Pickford groove in the femur was the telltale signature of bipedalism.
So in all these many years I have been looking for the unique signature for Throwing, such as Rotator Cuff or finger bones. When all along, if I had been smarter I should have said, look at the genetics and there probably exists a unique body chemical that is unique to the human capacity to throw overarm and with such speed and accuracy.
So I would concentrate the research for a chemical protein or hormone by the genetics and especially Chromosome #2.
Archimedes Plutonium www.iw.net/~a_plutonium whole entire Universe is just one big atom where dots of the electron-dot-cloud are galaxies
a_plutonium - 25 Nov 2007 19:44 GMT --- quoting from Wikipedia on BMP --- [edit] List of Bone Morphogenetic Proteins
BMP Known functions Gene Locus BMP1 *BMP1 does not belong to the TGF-β family of proteins. It is a metalloprotease that acts on procollagen I, II, and III. It is involved in cartilage development. Chromosome: 8; Location: 8p21 BMP2 Acts as a disulfide-linked homodimer and induces bone and cartilage formation. It is a candidate as a retinoid mediator. Plays a key role in osteoblast differentiation. Chromosome: 20; Location: 20p12 BMP3 Induces bone formation Chromosome: 14; Location: 14p22 BMP4 Regulates the formation of teeth, limbs and bone from mesoderm. It also plays a role in fracture repair. Chromosome: 14; Location: 14q22-q23 BMP5 Performs functions in cartilage development. Chromosome: 6; Location: 6p12.1 BMP6 Plays a role in joint integrity in adults. Chromosome: 6; Location: 6p12.1 BMP7 Plays a key role in osteoblast differentiation. It also induces the production of SMAD1. Also key in renal development and repair. Chromosome: 20; Location: 20q13 BMP8a Involved in bone and cartilage development Chromosome: 1; Location: 1p35-p32 BMP8b Expressed in the hippocampus. Chromosome: 1; Location: 1p35-p32 BMP10 May play a role in the trabeculation of the embryonic heart. Chromosome: 2; Location: 2p14 BMP15 May play a role in oocyte and follicular development. Chromosome: X; Location: Xp11.2
--- end quoting Wikipedia ---
What I am looking for is that the difference between Humans and Apes is a genetics for Throwing abilities. Humans have that genetics which apes do not. I am looking for the genes for Throwing and I may have to expand the chromosomes not confined to just chromosome 2.
So I want a protein that is unique to the excellent throwing ability found in the Human species and not found in apes.
In order to be the "best thrower" in the world, I suspect the proteins for ligaments should be near the top in my search. And of the arm bones the elbow region should be the vital region in throwing for it is the first region that is damaged when baseball pitchers start to become unhealthy. So the elbow region is the "weak point in the throwing- system" so I should focus on what genetics of the human elbow are unique to humanity and not found in apes.
Now I do not see a BMP above that focuses or is concentrated or is dense to the elbow region but maybe someone has found such a protein that is dense to the elbow region of humanity.
Archimedes Plutonium www.iw.net/~a_plutonium whole entire Universe is just one big atom where dots of the electron-dot-cloud are galaxies
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