Venous stasis / thrombosis is considered to be a possible cause of
Multiple Sclerosis . http://tinyurl.com/ysflvy
Venous stasis / thrombosis is a hallmark of increased red blood cell
production.
In children when one removes the speen they manifest increased red
blood cell production.
<<snip>>
polycythemia afterwards
<<snip>>
When one goes to altitude one manifests increased red blood cell
production and ataxia.
In THIS case splenectomy / removal of spleen manifests Multiple
Sclerosis **implicating** .. increased red blood cell production /
venous stasis as a possible cause.
------------------------------------------------------------

Multiple Sclerosis Following Splenectomy as a Treatment for Idiopathic
Thrombocytopenic Purpura

Hideaki MATSUI1), Fukashi UDAKA1), Akiko TAMURA1), Masaya ODA1),
Tamotsu KUBORI1), Kazuto NISHINAKA1) and Masakuni KAMEYAMA1)

1) Department of Neurology, Sumitomo Hospital, Osaka

(Received for publication November 26, 2004)
(Accepted for publication March 7, 2005)

Abstract
A 27-year-old woman was admitted to our hospital with tetraparesis,
dysesthesia and hypoesthesia of all regions below the breasts, urinary
disturbance, and difficulty in breathing. Since age 21 idiopathic
thrombocytopenic purpura (ITP) was diagnosed and steroid therapy was
continued. At age 26, she had splenectomy for her ITP. On admission,
steroid pulse therapy was administered with a tentative diagnosis of
transverse myelitis. Symptoms gradually ameliorated. At age 29, she
gradually lost her left vision, and multiple sclerosis was diagnosed
and steroid therapy was administered, and her left vision gradually
ameliorated. There are several reports describing other autoimmune
disorders that arise after splenectomy. Since the spleen acts as a
major pool of type 2 helper T cells, it is plausible that peripheral
type 1 helper T cell activity may increase after splenectomy,
promoting the development of autoimmune disorders. We considered there
would be a close relation between splenectomy for ITP and multiple
sclerosis in this case.

Key words: multiple sclerosis, idiopathic thrombocytopenic purpura,
splenectomy, autoimmune disorders, T cell

http://www.jstage.jst.go.jp/article/internalmedicine/44/7/44_747/_article
----------------------------------------
<<snip>>
polycythemia afterwards
<<snip>>

Pediatr Blood Cancer. 2007 Nov;49(6):781-5. Links
Laboratory markers of thrombosis risk in children with hereditary
spherocytosis.
Troendle SB, Adix L, Crary SE, Buchanan GR.
Division of Hematology-Oncology, Department of Pediatrics, University
of Texas Southwestern Medical Center, Dallas, Texas.

BACKGROUND:
Recent data suggest that adults with hereditary spherocytosis (HS) may
be protected from atherothrombosis before splenectomy but have
increased risk of thrombosis following splenectomy. In order to aid in
making informed decisions regarding splenectomy in children with HS,
we conducted a retrospective study of several surrogate laboratory
markers of thrombosis risk in children with HS.
METHODS:
A retrospective record review was performed on 246 children with HS.
Platelet count and hemoglobin concentration were recorded prior to and
following splenectomy in each patient. Serum cholesterol levels were
collected from the record when available.
RESULTS:
Prior to splenectomy, hypocholesterolemia was common. Mean platelet
counts in 31 evaluable patients pre- and post-splenectomy were 334 and
608 x 10(9)/L, respectively (P < 0.001). Twenty-nine patients (94%)
exhibited persistent thrombocytosis following splenectomy. Hemoglobin
values following splenectomy often rose to higher than age and gender-
matched norms, with 30% of measurements greater than the 90th
percentile and 17% greater than the 97th percentile. CONCLUSIONS:
The findings of hypocholesterolemia before splenectomy and
thrombocytosis and mild polycythemia afterwards support the hypothesis
that patients with HS might be protected from thrombosis before
splenectomy and/or more susceptible afterwards. Prospective studies of
additional prothrombotic biomarkers and thrombotic events in HS
patients are warranted. Pediatr Blood Cancer 2007;49:781-785. (c) 2007
Wiley-Liss, Inc.

PMID: 17854065 [PubMed - in process]

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