> I recommend MIchael Holick's review article in the 7/19/07 NEJM,
> "Vitamin D Deficiency." With respect to CVD, he has the following to
[quoted text clipped - 26 lines]
>
> Marilyn
An interesting view on Dr. Holick and the medical
community
"VITAMIN D AND CANCER: A DERMATOLOGIST'S DILEMMA
Link http://www.cancerdecisions.com/052204_page.html
A Boston professor of dermatology has been asked to resign because he
advocates moderate exposure to sunlight. Michael F. Holick, MD, PhD, a
professor at Boston University, was asked to resign in April from BU's
Department of Dermatology because of a book he wrote, in which he
describes the importance of sunlight in boosting vitamin D levels. He
was also severely criticized for his ties to the indoor tanning
industry.
Department chair Barbara Gilchrest, MD, told the Boston Globe that the
book "is an embarrassment for this institution and an embarrassment
for him." As demanded, Holick resigned his post, but continues to
teach and to direct the medical center's Vitamin D, Skin, and Bone
Research Laboratory, without a cut in pay.
Holick is a talented, experienced and highly respected researcher. He
is a professor of medicine and physiology, and formerly of
dermatology, at Boston University School of Medicine, and (until 2000)
chief of endocrinology, metabolism and nutrition. Since 1987 he has
also been the program director of the University's General Clinical
Research Center.
Department chair Gilchrest's disapproval of Holick stems from the fact
that his statements, superficially at least, seem to be at odds with
the medical profession's consensus on the damaging effects of
sunlight. Dermatologists have been warning the public for years that
sunlight, and specifically ultraviolet A (UVA) and ultraviolet B
(UVB), is implicated in the causation of melanoma, as well as other
less deadly forms of skin cancer.
But the causes of melanoma are still far from established, and there
remain many unanswered questions about the exact relationship of
sunlight exposure to the development of skin cancers. Exactly how much
ultraviolet light constitutes a safe level of exposure is a legitimate
topic for scientific debate. For example, according to the American
Cancer Society, "We do not yet know exactly what causes melanoma ...but
we do know that certain risk factors are linked to the disease....Some
risk factors, such as smoking, can be controlled. Others, like a
person's age or family history, can't be changed. But having a risk
factor, or even several, doesn't mean that a person will get the
disease" ( ACS 2004).
As to sunlight, the ACS says this: "The best way to lower the risk of
melanoma is to avoid too much exposure to the sun and other sources of
UV light.... Avoid being outdoors in sunlight too long, especially in
the middle of the day when UV light is most intense...."
But this view is not universally held. William B. Grant, Ph.D., who
heads the Sunlight, Nutrition and Health Research Center (SUNARC) in
San Francisco strongly disputes it. "This is not particularly good
advice," he told this newsletter. "There are several papers indicating
that occupational exposure to sunlight reduces the risk of melanoma
(Kennedy 2003). "It is having fair skin, a high-fat, low fruit and
vegetable diet, sunburning, etc., that are more linked to melanoma
than total UV exposure."
It seems that many in the medical profession have an almost
religious zeal in suppressing ideas that differ from the orthodox .
The treatment of Dr. Holick a leader in the field of Vitamin d
research is indicative of that. Will those in leadership resort to
misrepresenting facts to improve compliance. A recent story in the
Times seems to indicate that ; From ; " Doctors Bulk at Cancer
Ad ,Citing Lack of Evidence" New Your Times July 10
2007
" The young woman in the American Cancer Society advertisement holds
up a photograph of a smiling blonde. "My sister accidentally killed
herself. She died of skin cancer," reads the headline.
The public service announcement, financed by the sunscreen maker
Neutrogena, is running in 15 women's magazines this summer. It warns
readers that "left unchecked, skin cancer can be fatal," and urges
them to "use sunscreen, cover up and watch for skin changes."
The woman in the picture is a model, not a skin cancer victim. And the
advertisement's implicit message - that those who die of skin cancer
have themselves to blame - has provoked a sharp response from some
public-health doctors, who say the evidence simply does not support
it."
It appears that evidence is not the only reason the ACS provides
information The article notes " Almost all of those deaths are
from melanoma, which makes up only 6 percent of all skin-cancer
cases." The article also notes that some studies suggest that sun
exposure improves survival in melanoma and that " Until that is made
clear, many doctors say, it is premature to suggest that people are
endangering their lives by failing to use sunscreen. "
As for the effect of sunscreens the story notes..."We do have
some pretty good evidence that sunscreen will reduce your risk of the
less lethal forms of skin cancer," Dr. Kramer added. "There's very
little evidence that sunscreens protect you against melanoma, yet you
often hear that as the dominant message." Dr. Kramer works at the
NIH . What was the response of the ACS?
Dr. J. Leonard Lichtenfeld, deputy chief medical officer at the
American Cancer Society, acknowledges that the advertisement is
aggressive. "We have taken some license in taking that message and
using it the way we've used it," he said, "because that's the way to
get the message to our target audience."
http://www.nytimes.com/2007/07/10/health/10skin.html?_r=1&th
&emc=th&oref=slogin and ask yourself are these guys looking out for
me? Thanks Vince
When the medical community believes it has the right to take "license'
with the evidence to improve compliance has a line been
crossed .
While this refers to cancer issues . I wonder if the same dynamic is
work at the NCEP or the ATP 3 guideline committees in regard to
improving compliance to their advice Thanks Vince
Andrew B. Chung, MD/PhD - 20 Jul 2007 18:27 GMT
> > I recommend MIchael Holick's review article in the 7/19/07 NEJM,
> > "Vitamin D Deficiency." With respect to CVD, he has the following to
[quoted text clipped - 132 lines]
> &emc=th&oref=slogin and ask yourself are these guys looking out for
> me?
Possibly if it is GOD's will that you will be afflicted with skin
cancer if you choose to subject your skin to excessive exposure to
sunlight and the ACS message convinces you to protect your skin from
such excessive sunlight exposure.
Dr. Lichtenfeld represents and is looking out for the interests of the
ACS, which has the mission of decreasing the incidence of cancer in
America.
> Thanks Vince
Thanks be to GOD.
> When the medical community believes it has the right to take "license'
> with the evidence to improve compliance has a line been
> crossed .
Dr. Lichtenfeld does not represent the medical community.
> While this refers to cancer issues . I wonder if the same dynamic is
> work at the NCEP or the ATP 3 guideline committees in regard to
> improving compliance to their advice
Those involved in NCEP and/or ATP 3 guidelines have the mission of
reducing the incidence of cardiovascular disease in America.
> Thanks Vince
Again, thanks be to GOD.
Be hungry... be healthy... be blessed:
http://HeartMDPhD.com/PressRelease
Prayerfully in Jesus' awesome love,
Andrew <><
--
Andrew B. Chung, MD/PhD
Cardiologist
MarilynMann - 20 Jul 2007 18:47 GMT
> When the medical community believes it has the right to take "license'
> with the evidence to improve compliance has a line been
> crossed .
> While this refers to cancer issues . I wonder if the same dynamic is
> work at the NCEP or the ATP 3 guideline committees in regard to
> improving compliance to their advice Thanks Vince-
What specifically are they doing to improve compliance?
Marilyn
> I recommend MIchael Holick's review article in the 7/19/07 NEJM,
> "Vitamin D Deficiency."
That article is too new to allow free viewing. http://www.ajcn.org/cgi/content/full/79/3/362
seems to duplicate much of what he has to say.
--
Ron
MarilynMann - 21 Jul 2007 21:16 GMT
Interesting clinical trials:
The Effect of Calcium and Vitamin D in Patients With Heart Failure
(KarViDII)
http://clinicaltrials.gov/ct/show/NCT00497900;jsessionid=9BEEBD2F978D518176B4A76
98DAA9090?order=38
Vitamin D Deficiency, Insulin Resistance and FGF-23
http://clinicaltrials.gov/ct/show/NCT00491322?order=5
Vitamin D and Blood Pressure
http://clinicaltrials.gov/ct/show/NCT00459563?order=10
Vitamin D Deficiency: Bone Loss and Vascular Dysfunction
http://clinicaltrials.gov/ct/show/NCT00235586?order=15
Vitamin D and Carboxy PTH Fragments in Coronary Calcification
http://clinicaltrials.gov/ct/show/NCT00502268?order=21
Vitamin D Supplementation to Patients With Type 2 Diabetes
http://clinicaltrials.gov/ct/show/NCT00400491?order=36
ADVANCE: Study to Evaluate Cinacalcet Plus Low Dose Vitamin D on
Vascular Calcification in Subjects With Chronic Kidney Disease
Receiving Hemodialysis
http://clinicaltrials.gov/ct/show/NCT00379899?order=43
Treatment of Obesity With Vitamin D (40.000 IE Per Week for 1 Year)
http://clinicaltrials.gov/ct/show/NCT00243256?order=52
Marilyn
MarilynMann - 21 Jul 2007 23:44 GMT
Vitamin D and vascular calcification.
Current Opinion in Lipidology. 18(1):41-46, February 2007.
Zittermann, Armin; Schleithoff, Stefanie S; Koerfer, Reiner
Abstract:
Purpose of review: Vascular calcification is frequently found in
patients with osteoporosis, atherosclerosis and chronic kidney
disease, leading to high morbidity and mortality rates. The effects of
vitamin D excess and deficiency on vascular calcification are reviewed
in this article.
Recent findings: There is evidence from experimental studies that
mediacalcinosis induced by vitamin D excess is an active and
reversible process. Vitamin D excess, however, is rarely seen in the
general human population. Experimental data also demonstrate that
physiologic vitamin D actions include the inhibition of processes that
are important for intimal and medial artery calcification such as pro-
inflammatory cytokine release, adhesion molecule release, and
proliferation and migration of vascular smooth muscle cells. In uremic
rats, low levels of the vitamin D hormone calcitriol are associated
with massive vascular and soft tissue calcifications. Whereas
retrospective studies already indicate a beneficial effect of active
vitamin D on mortality rates in chronic kidney disease, little is yet
known about the effect of vitamin D deficiency on cardiovascular
morbidity and mortality in the general population.
Summary: Available data indicate that vitamin D exerts a biphasic
'dose response' curve on vascular calcification with deleterious
consequences not only of vitamin D excess but also of vitamin D
deficiency.
* * *
Marilyn