>> 1) It's hard to be sure clinically that this is strep. Viral sore
>> throats can look like this too.
[quoted text clipped - 7 lines]
>> 4) Antibiotics might also decrease the risk of someone with a strep
>> throat developing a peritonsillar abscess.

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David Rind
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Fine. Whatever.
Judy Dilworth, M.T. (ASCP)
Microbiology
David Rind - 16 Jul 2007 11:52 GMT
> Fine. Whatever.
>
> Judy Dilworth, M.T. (ASCP)
> Microbiology
I'm assuming that was in response to my post.
When I post misinformation to sci.med, I hope someone who spots that
what I wrote was wrong will post a correction.
What are you hoping people will do when you post misinformation?

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David Rind
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> > "David Rind" <dr...@caregroup.harvard.edu> wrote in message
> >news:f7bsma$etb$1@reader2.panix.com...
[quoted text clipped - 37 lines]
> David Rind
> dr...@caregroup.harvard.edu
It is basically implied and don't know of any direct studies except
this animal model. Anything new studies out there?
1: Acta Pathol Microbiol Immunol Scand [C]. 1983 Aug;91(4):271-81.
LinkOut
Effect of early penicillin treatment on the development of
experimental poststreptococcal glomerulonephritis.Bergholm AM, Holm
SE.
A newly developed experimental model in which poststreptococcal
glomerulonephritis (PSGN) was established in rabbits utilizing viable
group A streptococci, was used to study the possibility of hindering
the development of renal disease by early penicillin treatment. The
development of renal injury was followed by proteinuria, creatinine
clearance, histological and immunological examinations of the kidneys.
Therapy within the first 3 days of infection with i.m. pc-G prevented
the nephritic process.
PMID: 6356782 [PubMed - indexed for MEDLINE]
1: Monatsschr Kinderheilkd. 1992 Aug;140(8):490-2. LinkOut
[Has post-streptococcal glomerulonephritis disappeared?][Article in
German]
Latta K, Ehrich JH, Brodehl J.
Kinderklinik Medizinischen Hochschule Hannover.
We report on 21 children with poststreptococcal glomerulonephritis
(PSGN). The diagnosis was based on clinical and laboratory criteria.
19/21 had a clinically apparent throat infection initially, but only 6
received antibiotic treatment. Initial symptoms were: macrohematuria
(20/21), edema (10/21), arterial hypertension (6/21), reduced
creatinine-clearance (11/21), and proteinuria (18/21). No Patient was
dialyzed. After an interval of 0.3 to 25 months 19 children are
asymptomatic. All patients have normal creatinine-clearances; none is
hypertensive. The present data show that PSGN has not disappeared in
Mid-Europe. Remarkable acute disturbances occurred, which healed in
almost all cases. The importance of accurate bacteriologic diagnosis
and adequate therapy is emphasized.
PMID: 1435810 [PubMed - indexed for MEDLINE]
David Rind - 17 Jul 2007 01:48 GMT
>>I didn't say that strep can't cause glomerulonephritis ("PSGN" in my
>>post above is "post-streptococcal glomerulonephritis). I said that I
[quoted text clipped - 45 lines]
>
> PMID: 1435810 [PubMed - indexed for MEDLINE]
I don't have access to the rabbit study, but would wonder about the
timing of the infection and the treatment. There are lots of
complications of diseases that you can prevent in an animal model if you
start treatment at the moment of injury or infection, but that don't
translate to humans where treatment can't start until the infection
becomes clinically apparent.
No one is likely to perform an RCT since we treat strep throat to
prevent RF and to speed recovery.
The OP was trying to avoid seeing a doctor for an illness that may or
may not have been strep. While everyone would advise him that it's safer
to see a doctor, I don't think anyone would think that it's likely to go
badly if he doesn't. If he really has strep, he's at some small risk of
developing RF if he doesn't get treated. His risk of PSGN is quite low,
and we really don't know that we can modify it at all by treating him.

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David Rind
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