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Medical Forum / General / General / June 2007Opioids
Many of the Opiod pain killers like Dextropropoxyphene & Oxycodone seem to be sold in pill which combines them with other pain killers like Acetamenophin/Diclofenac etc For eg. Percocet which contains Oxycodone+Acetamenophin Why is this so? Is Dextropropoxyphene or Oxycodone not enough to provide pain relief by itself? Sorry - meant to post this to sci.med.pharmacy not sci.med.pathology > Many of the Opiod pain killers like Dextropropoxyphene & Oxycodone > seem to be sold in pill which combines them with other pain killers [quoted text clipped - 4 lines] > Is Dextropropoxyphene or Oxycodone not enough to provide > pain relief by itself? >Many of the Opiod pain killers like Dextropropoxyphene & Oxycodone >seem to be sold in pill which combines them with other pain killers [quoted text clipped - 4 lines] >Is Dextropropoxyphene or Oxycodone not enough to provide >pain relief by itself? The combination provides significantly more pain relief than the opioid alone, so less opioid is needed, reducing the side effects of opioids (sedation, nausea, respiratory depression, constipation, etc). Especially important for people who need to take opioids long term, such as terminal cancer patients, taking lower doses slows habituation, so opioids remain effective longer at less dangerous doses. >>Many of the Opiod pain killers like Dextropropoxyphene & Oxycodone >>seem to be sold in pill which combines them with other pain killers [quoted text clipped - 11 lines] >as terminal cancer patients, taking lower doses slows habituation, so >opioids remain effective longer at less dangerous doses. I was under the impression this was also done as part of the War on Drugs; try getting high on these combination drugs and the acetaminophen will destroy your liver. >>>Many of the Opiod pain killers like Dextropropoxyphene & Oxycodone >>>seem to be sold in pill which combines them with other pain killers [quoted text clipped - 15 lines] >Drugs; try getting high on these combination drugs and the >acetaminophen will destroy your liver. It might be a contributing factor, but when I was working at a cancer research institute here in Canada about 10 years ago, the pharmacy at the associated hospital was researching the combination for cancer patients and found it had the advantages listed above. The patients much preferred it due to the reduced side effects. We're not fighting a war on drugs up here. In fact, we can buy small doses of codeine (8mg) combined with ASA or acetaminophen OTC. It looks like the original poster is posting from Germany, so likely the medical benefits are enough reason without the political ones. >>>>Many of the Opiod pain killers like Dextropropoxyphene & Oxycodone >>>>seem to be sold in pill which combines them with other pain killers [quoted text clipped - 26 lines] >looks like the original poster is posting from Germany, so likely >the medical benefits are enough reason without the political ones. This is one time I'm perfectly happy to be wrong. If the combo works better and allows for lower dosing of opiates, great! That will reduce the opiate side-effects like constipation and mental fogging. -- David Wright :: alphabeta at prodigy.net These are my opinions only, but they're almost always correct. "Only George Bush could start a war for oil and not get any." -- Bill Maher |
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