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Medical Forum / General / General / June 2007Brain-Infection Evading Dx
I have serious symptoms, but no answers. It's been progressing for 15 years. Symptoms include: - seizures, daily (I suddenly feel startled, and my head jerks involuntarily). - subdermal nodules - sense of pressure around or behind my right eye - sporadic irregular heartbeat. Confirmed heart murmer and mitral valve prolapse. - confusion - difficulty planning - difficulty with balance - motor control. coordination problems, especially right leg, right arm, right facial muscles - slight paralysis of right facial muscles - degeneration in ability to speak fluently and clearly - sensation of intracranial pressure, occasionally incapacitating I'm disabled professionally and socially. I used to be an honors student at a top university, like some of you reading. Now I'm 34 and when my savings runs out this year, I will end up homeless. I have no dx. Administration of Albendazole (without adjunct steroid) induced on the 2nd day, voices in my head, delusions, severe headache followed by loss of consciousness. Albendazole was discontinued, and the adverse-effects reversed after several days. Several months later, Albendazole-treatment was reattempted. Again, it induced voices in my head, delusions, severe headache followed by loss of consciousness. A doctor who has working experience with Albendazole has advised me: A mere allergic reaction to Albendazole would not account for my response. My reaction suggests the presence of an Albendazole- sensitive pathogen in my brain. Gadolinium-enhanced MRI reveals no sign of Taenia solium in my brain. The negative MRI leads to no diagnosis. But my specific reaction to Albendazole indicates the presence of some Albendazole-sensitive pathogen in my brain. What can be done? > I have serious symptoms, but no answers. It's been progressing for 15 > years. Symptoms include: [quoted text clipped - 39 lines] > > What can be done? Albendazole is a compound that is poorly absorbed by the body. I doubt that the reaction had anything to do with any pathogen inside your brain. I would get to the bottom of the seizures, because whatever are causing these are probably causing the other problems. Jeff Thanks for your kind response. According to an M.D. who works with Albendazole, and has published articles about it, "Albendazole may cause neurological symptoms if administered for active neurocysticercosis (taenia solium), especially if steroids have not been co-administered with it due to an inflammatory reaction from the dying cysts in the brain." Albendazole absorbed by the body well enough to cause brain- inflammation in neurocysticercosis cases. My reaction was neurological, including severe headache followed by loss of consciousness. Is there any reason for your doubt? > Thanks for your kind response. > [quoted text clipped - 8 lines] > neurological, including severe headache followed by loss of > consciousness. Is there any reason for your doubt? Yeah, I don't believe that is the cause. It sounds too far out. You know the MD's name. Go to pubmed (www.pubmed.gov) and look up the articles. If you tell us his name, I can do the same. Jeff, There is an article "Neurocysticercosis--New Millennium, ancient disease and unending debate" 1: Indian J Pediatr. 2003 Apr;70(4): 337-42. On page 340, you may read, "Adverse effects to the drug itself are limited. The inflammatory response to the dying cysts leads to clinical features normally associated with NCC (Neurocysticercosis)." I have the entire article in PDF. My email is thomas_kaplan(at)yahoo.com. Jeff, I appreciate your offer to help. Sometimes, I can do the research I need to; other times, my symptoms prevent me from accomplishing anything. I *don't* assume it's Hydatid-Disease or Neurocysticercosis. My negative MRI rules out Hydatid-Disease and Neurocysticercosis. But Albendazole induces in me a Herxheimer Reaction (http:// en.wikipedia.org/wiki/Herxheimer_reaction). The Herxheimer-Reaction signifies the presence of some infectious-disease. The implication is serious: there is some unidentified, infectious-disease in my brain; means of transmission unknown; prevalence in the general population unknown. It sounds far out, but recall the history of HIV. HIV is a serious infectious-disease, but for many years, HIV went unnoticed by health authorities. My Herxheimer Reaction to Albendazole signifies the presence of an unidentified infectious-disease in my brain. Economic realities encourage doctors to drop my case: To earn money, all a doctor has to do is pretend my Herxheimer-Reaction never happened; they can pretend it was allergic or psycho-somatic; they can prescribe Paxil for the symptoms, and the doctors get paid. But these doctors are neglecting objective evidence. The objective- evidence is the clinically-observable signs I exhibit in response to Albendazole. The evidence is objective, so there's no need for uncertainty. But there's no response to this evidence from authorities. Authorities neglect the objective evidence, allowing the infectious-disease to progress and spread. > I have serious symptoms, but no answers. It's been progressing for 15 > years. Symptoms include: [quoted text clipped - 39 lines] > > What can be done? It looks like they have to know the infestation to know the life cycle (to know the dosing and schedule). http://www.rxlist.com/cgi/generic/albendazole_ids.htm read the other sections as well. Here's one http://journals.tubitak.gov.tr/medical/issues/sag-03-33-6/sag-33-6-9-0307-12.pdf Multiple Infected Cerebral Hydatid Cysts Treated with Albendazole (accidental find- may not be applicable) J |
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