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Medical Forum / General / General / June 2007Anti-inflammatory effect of phosphatidylcholine
Inflamm Bowel Dis. 2006 Nov;12(11):1058-67. Related Articles, Links Health-related quality of life correlates with clinical and endoscopic activity indexes but not with demographic features in patients with ulcerative colitis. Zahn A, Hinz U, Karner M, Ehehalt R, Stremmel W. Department of Gastroenterology, University Hospital Heidelberg, Germany. alexandra.zahn@med.uni-heidelberg.de BACKGROUND: Inflammatory bowel disease (IBD) impairs health-related quality of life (HRQOL). Our aim was to investigate whether the improvement in the Clinical Activity Index (CAI) and Endoscopic Activity Index (EAI) is significantly correlated with the advancement of HRQOL and its dimensions in ulcerative colitis (UC) and to assess whether demographic and disease-related factors influence patients' experience of HRQOL. This examination was performed in the context of our recently published study of the anti-inflammatory effect of phosphatidylcholine in UC. METHODS: Sixty patients with chronic active UC were treated with phosphatidylcholine or placebo over 3 months. They were asked to complete the Inflammatory Bowel Disease Questionnaire-Deutschland (IBDQ-D) before and after the study. The correlations between CAI and EAI and IBDQ-D scores were calculated. Demographic and disease-related factors were obtained. RESULTS: A statistically significant lowering of CAI and EAI after treatment in the phosphatidylcholine group led to a statistically significant improvement in HRQOL (r = -0.623, P = 0.0003 for CAI; r = -0.511, P = 0.005 for EAI). Constant disease activity indexes in the placebo group accompanied constant HRQOL (r = -0.747, P < 0.0001 for CAI; r = -0.634, P = 0.0002 for EAI). Furthermore, besides a few exceptions, significant correlations between CAI and EAI and the 4 dimensions of the IBDQ-D could be shown. Demographic parameters did not significantly influence the IBDQ-D scores. CONCLUSIONS: This study points out the strong relationship between CAI and EAI and all domains of HRQOL in patients with UC. Therefore, the IBDQ-D is a valid and reliable assessment tool that reflects changes in the health status of UC patients. It is a useful measure of therapeutic efficacy and should be used in clinical trials in IBD. Publication Types: Randomized Controlled Trial Research Support, Non-U.S. Gov't PMID: 17075347 [PubMed - indexed for MEDLINE] ---------------------------------------- Definitions of phosphatidylcholine on the Web: Another name for lecithin. www.enzy.com/glossary/searchresults.asp Lecithin is usually used as synonym for phosphatidylcholine, a phospholipid which is the major component of a phosphatide fraction which may be isolated from either egg yolk (in Greek lekithos - λεκιθος) or soy beans from which it is mechanically or chemically extracted using hexane. It is commercially available in high purity as a food supplement and for medical uses. en.wikipedia.org/wiki/Phosphatidylcholine Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Interesting timing for this post...I just started using a new( to me ) choline supplement called Phoschol because of its supposed intestinal mucosal support. Dave >>On Jun 7, 11:03 am, Beez <bea...@yahoo.com> wrote: Interesting timing for this post...I just started using a new( to me ) choline supplement called Phoschol because of its supposed intestinal mucosal support. Dave<< These guys seem to think it is .. or at least they keep referring to it as .. lecithin .. http://www.neucor.com.my/nutrition_phoscol_565.asp PhosChol 565 PhosChol is a natural product extracted from soya bean. It is rich in lecithin, a major component of human cells. Lecithin exists in the cells of each organ and tissue in our body. The amount of lecithin is extraordinarily high in our brain nervous system, liver and other vital tissues. Hence, it is also known as the basic substance for life. Lecithin is made of unsaturated fatty acids, choline, glycerine, phosphorus, etc. Unsaturated fatty acids are able to reduce cholesterol level, improve blood circulation and prevent arteriosclerosis. Choline and acetyl combine to form a substance called acetylcholine, which is a vital component in brain nervous cells. Benefits - Reduces bad cholesterol Lecithin is able to emulsify fat and dissolve the cholesterol on the blood vessel walls. Reducing blood cholesterol. - Reduces blood pressure and improves blood circulation at joints, hence helps in relieving joints pains. - Improves fatty liver Liver is the biggest organ and the detoxification plant in human body. Excessive alcohol consumption will lead to a storage of neutral fat in the liver which then lead to a symptom called fatty liver. To avoid this, we must restrain from drinking, absorb plenty of good protein and vitamin B groups. Choline is one of the B vitamins that helps to improves fatty liver. - Improves skin metabolism Lecithin intake ensures a good blood circulation which improves skin metabolism and hence brings lustre to the skin. Those who constantly feel cold at their limbs may take lecithin supplement to improve blood circulation at those parts. - Improves hair condition Lecithin contains inositol which is nourishing to hair and scalp. - Natural tranquillizer According to clinical reports, lecithin is a natural tranquilizer in improving the disorder of autonomic nervous system. As a natural tranquillizer, lecithin is able to respond to various pressure and restlessness. Each tablet contains: Phosphatidyl Choline 565mg Suggested use: - Below 25 years old => 1 ~ 2 tablets daily - 25 ~ 45 years old => 1 ~ 2 tablets daily - Above 45 years old => 2 ~ 3 tablets daily Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk They just completed a dose finding study for pancolitis that seems to have had positive results. I'm watching this one closely. >>>On Jun 7, 11:03 am, Beez <bea...@yahoo.com> wrote: > Interesting timing for this post...I just started using a new( to [quoted text clipped - 73 lines] > DEAD PEOPLE WALKING > http://tinyurl.com/zk9fk I've got Crohns disease; what use should I make of this information? 1. Take supplements containing lecithin? or eat [quoting ] Choline, the major constituent of PC, is found in soybeans, liver, oatmeal, cabbage, and cauliflower. Soybeans, egg yolks, meat, and some vegetables contain PC. Lecithin (containing 10-20% PC) is added to many processed foods in small amounts for the purpose of maintaining texture consistency. 2. does anyone have a list of foods with anti inflammatory properties? If we eat them all what would be the likely incremental beneficial effect I wonder....? John Inflamm Bowel Dis. 2006 Nov;12(11):1058-67. Related Articles, Links >>On Jun 9, 2:07 pm, "John H" <j...@yahoo.com.au> wrote: I've got Crohns disease; what use should I make of this information? 1. Take supplements containing lecithin? or eat [quoting ] Choline, the major constituent of PC, is found in soybeans, liver, oatmeal, cabbage, and cauliflower. Soybeans, egg yolks, meat, and some vegetables contain PC. Lecithin (containing 10-20% PC) is added to many processed foods in small amounts for the purpose of maintaining texture consistency.<< The fact they say the liver of an animal supplies lecithin gives a bit of evidence .. the liver in US also would contain / needs .. it .. ? Sooo .. whether or not eating liver FOR the lecithin is the way to go or not would make use of your ability to decipher .. evidence. They say we should eat our green leafy vegetables WITH our meals to 'offset' the oxidation which happens when we eat meat. The antioxidants in the green leafies will offset the oxidation. Sooo .. since antioxidants are .. GOOD .. for us .. then the fact a food DESTROYS it .. makes the case AGAINST that .. food / meat .. BEING 'bad' .. stronger. Soo .. since the substance .. lecithin is found in many different foods and most NOT of animal origin then one might think the inclusion of these foods that do NOT cause oxidation BUT do contain lecithin / ie: foods of vegetable origin would be a prudent / smart thing to do. >> 2. does anyone have a list of foods with anti inflammatory properties? If we eat them all what would be the likely incremental beneficial effect I wonder....? John<< Any foods which contain antioxidants / foods of .. **plant** origin. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk >>On Jun 9, 6:45 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote: Any foods which contain antioxidants / foods of .. **plant** origin. << >> 2. does anyone have a list of foods with anti inflammatory properties?<< http://www.webmd.com/diet/guide/20061101/antioxidants-found-unexpected-foods Antioxidant Riches Found in Unexpected Foods Beans, Berries, Spices, and Potatoes Are Antioxidant Powerhouses By Jennifer Warner WebMD Medical NewsReviewed by Brunilda Nazario, MDJune 17, 2004 -- Blueberries may be the poster children for antioxidant abundance, but a new study suggests the humble bean may be a more deserving candidate. The largest and most advanced analysis of the antioxidant content of common foods to date shows that disease-fighting antioxidants may be found in unexpected fruits and vegetables, such as beans, artichokes, and even the much-maligned Russet potato. Researchers found that small red beans contain more disease-fighting antioxidants than both wild and cultivated blueberries, which have been heralded in recent years for their high antioxidant content. In fact, three of the top five antioxidant-rich foods studied were beans. The study also shows that nuts and spices, such as ground cloves, cinnamon, and oregano, are rich in antioxidants, although they are generally consumed in much smaller amounts than fruits and vegetables. Antioxidants are believed to help prevent and repair oxidative stress, a process that damages cells within the body and has been linked to the development of cancer, heart disease, Alzheimer's disease, and Parkinson's disease. Ranking Antioxidant-Rich Foods The study, which appears in the June 9 issue of the Journal of Agricultural and Food Chemistry, used updated technology to assess the antioxidant content of more than 100 foods, including fruits, vegetables, cereals, breads, nuts, and spices. Each food was analyzed for antioxidant concentration and ranked according to antioxidant capacity per serving size. But researchers note that the total antioxidant capacity of a food does not necessarily reflect their potential health benefit. "A big factor in all of this is what happens in the digestion and absorption process," says Researcher Ronald Prior, PhD, a chemist and nutritionist with the USDA's Arkansas Children's Nutrition Center in Little Rock, Ark. "With some of these compounds, it appears that even though they have a high antioxidant capacity, they may not be absorbed." Cranberries, blueberries, and blackberries were ranked highest among the fruits studied. Beans, artichokes, and Russet potatoes were tops among the vegetables. Pecans, walnuts, and hazelnuts were the winners in the nut category, and ground cloves, cinnamon, and oregano were the top three antioxidant-rich spices. Here's the list of the top 20 food sources of antioxidants, based on their total antioxidant capacity per serving size: Rank Food item Serving size Total antioxidant capacity per serving size 1 Small Red Bean (dried) Half cup 13727 2 Wild blueberry 1 cup 13427 3 Red kidney bean (dried) Half cup 13259 4 Pinto bean Half cup 11864 5 Blueberry (cultivated) 1 cup 9019 6 Cranberry 1 cup (whole) 8983 7 Artichoke (cooked) 1 cup (hearts) 7904 8 Blackberry 1 cup 7701 9 Dried Prune Half cup 7291 10 Raspberry 1 cup 6058 11 Strawberry 1 cup 5938 12 Red Delicious apple One 5900 13 Granny Smith apple One 5381 14 Pecan 1 ounce 5095 15 Sweet cherry 1 cup 4873 16 Black plum One 4844 17 Russet potato (cooked) One 4649 18 Black bean (dried) Half cup 4181 19 Plum One 4118 20 Gala apple One 3903 Researchers also found that cooking method also had a significant effect on the antioxidant content of the foods tested, but those effects were not consistent. For example, cooked Russet and red potatoes had much lower antioxidant levels than those found in raw potatoes. Boiling also decreased antioxidant levels in carrots, but cooking tomatoes increased their antioxidant content. Putting Antioxidants in Perspective Registered dietitian David Grotto says he was amazed to see that unexpected foods, such as beans, potatoes, and artichokes, were so highly ranked by the study. "With the onslaught of 'no carbs' going on out there, it's nice that we can show that the potato brings more to the table than just carbohydrates," says Grotto, who is director of nutrition at Block Center for Integrative Cancer Care in Evanston, Ill. "The message here is diverse diet is still optimal," Grotto tells WebMD. "You don't want to be on the all-red-bean diet because it may have the unique set of antioxidants that are attributed to beans, but it may not have many of the antioxidants that you would find in a wild blueberry." Nor does it mean that you should limit your diet to only the foods that made the study's top 20 list or start popping antioxidant supplements. "What we're discovering is that we only know about a thimbleful of all the antioxidants that are probably within foods," says Grotto, who is also a spokesman for the American Dietetic Association. "What's unique about eating foods vs. supplements is that there is always more bang for the buck in eating the foods, and you get a lot of those compounds that we really don't fully understand the benefits of yet." Grotto recommends the following tips to incorporate more antioxidant- rich foods into your diet: Make bean cubes. Process leftover beans with a little vegetable broth in a food processor until it forms a thin paste. Pour into ice cube trays, and then use the frozen cubes to thicken soups and sauces. Substitute beans for meats. Most recipes that call for ground or cubed meats, such as stews and casseroles, also work with beans like lentils, chickpeas, or black beans in the starring role. Be berry sneaky. Toss a handful of berries on your breakfast cereal or blend them into fruit smoothies for a healthy breakfast or snack. But don't despair if your favorite food didn't make the list. Antioxidants are only one piece of the healthy eating puzzle. "Some of those foods that are low in antioxidants may have other positive benefits, such as fiber, minerals, and other nutrients that are important," says Prior. SOURCES: Wu, X. Journal of Agricultural and Food Chemistry, June 9, 2004; vol 52: pp 4026-4037. Ronald Prior, PhD, research chemist/ nutritionist, USDA; Arkansas Children's Nutrition Center, Little Rock, Ark. News release, American Chemical Society. David Grotto, RD, spokesperson, American Dietetic Association; director of nutrition, Block Center for Integrative Cancer Care, Evanston, Ill. ©2005-2006 WebMD, Inc. All rights reserved. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk "Researchers also found that cooking method also had a significant effect on the antioxidant content of the foods tested, but those effects were not consistent. For example, cooked Russet and red potatoes had much lower antioxidant levels than those found in raw potatoes. Boiling also decreased antioxidant levels in carrots, but cooking tomatoes increased their antioxidant content." Hard for people with a narrow bowel to eat the right foods; berries especially block me up... No one (except a pig) eats raw potato. John 1. A recent study found omega 3 boost can help with Chrons disease. 2. Try fasting and caloric restriction, these tend to reduce inflammatory mediators and will give your gut a rest. John. > I've got Crohns disease; what use should I make of this information? > [quoted text clipped - 10 lines] > > Inflamm Bowel Dis. 2006 Nov;12(11):1058-67. Related Articles, Links You should take it with a very big grain of salt. This poster has unproven "theories" based on a case of stomach bug he picked up in Mexico. (As I recall from previous posts.) There is no basis to suggest that IBD can be cured using his methods. Legitimate research has been done to show that "Parasite" control does not cure IBD. The diet advice should also be likely considered improper. A dietician, with knowledge about the complications of IBD, would be a better choice. Have a good day, Nina >>On Jun 9, 2:07 pm, "John H" <j...@yahoo.com.au> wrote: 2. does anyone have a list of foods with anti inflammatory properties? << I tried to find this one earlier but only ran across it again today .. It should theoretically should be very good .. since they throw IN the aforementioned .. lecithin .. ------------------------------------------------------------------------- Branston baked beans now brainy with omega-3 4/6/2007 - Premier Foods has given canned baked beans a makeover and enhanced their healthy profile by adding omega-3 fatty acids. The company today launched a new line of its branded Branston baked beans with fish oils. 'Branstein' baked beans are designed to support cognitive development, amongst other benefits. This is the latest innovation in the omega-3 product category, where formulators have think up increasingly competitive and novel approaches in order to harness the benefits of the profitable industry. According to Frost & Sullivan, the European omega-3 market - worth around €160m (£108m) in 2004 - is expected to grow at rates of 8 per cent on average to 2010. The packaged goods market has been left wide open for health and wellness trends to make their mark following the demise of the low carb trend in recent years, according to ProductScan Online. The Datamonitor division highlighted omega-3 among the four trends set to characterize health and wellness trends in packaged goods. Branstein baked beans taste like the regular version of the product, but a 210g serving contains 17 per cent of UK's recommended daily intake of omega-3. An entire can of Branstein beans contains 34 per cent. While it acknowledges that omega-3 enhanced products can bolster intake of the fatty acids, the British Nutrition Foundation (BNF) still recommends a varied consumption of oily fish. "For people who don't like fish, alternative products can be useful," BNF nutrition scientist Anna Denny told NutraIngredients. The new types of value-added products could be especially practical for children, she added, as they often do not like the types of oily fish that are high in omega-3. This in turn is part of the marketing plug behind Branstein baked beans. "Branstein Baked Beans is the smart choice for parents who are keen to get more of the goodness of omega 3 in to their kids," said Rob Stacey, marketing manager for Branston. The company has not said whether the omega-3 is derived from fish oil or vegetarian sources. In the past, there has been concern over foods containing the shorter chain fatty acid ALA, from plants, flagging omega-3 content, when the main benefits have been seen to relate to longer chain DHA and EPA. According to Denny, consumers must choose omega-3 manufactured foods with the same caution they should use in choosing all foods - paying attention to variables such as salt and caloric content. "Choose products that are already recommended as part of a healthy balanced diet," said Denny. Branstein Baked Beans are launching nationally this week and have a recommended retail price of 55p. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk |
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