Body's mechanisms, to control excess intakes and effects therefrom,
can be to discourage more intakes, more excretion or to resist/
restrict its use. How body's mechanisms resist or restrict excessive
use of excessive intakes which may either accumulate and stored OR may
become bio-unavailable. Pls tell me about such accumulation and bio-
unavailabilty.

It depends on the substance.

And then there are the things that your body makes _more_ toxic.

Go get a toxicology book. They are rather thick, though.

bob