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Medical Forum / General / General / March 2007Just How Much Does Aspirin Effect Blood Clotting?
Aspirin thins out the blood, I understand. Here's something of an explanation: http://askascientist.binghamton.edu/may-jun/18may06ask.html This says that Aspirin is a platelet aggregation inhibitor. But is the viscosity of blood different when aspirin is in the blood? Does aspirin-blood go through small tubes, say syringe needles, more easily? Is it easier to start an IV on someone who has taken aspirin? And how easily detectable is the effect of aspirin on the clotting of blood? Is aspirin-blood noticeably different? Does a cut take significantly longer to scab-up? --- (||) Nehmo (||) > Aspirin thins out the blood, I understand. Here's something of an > explanation: http://askascientist.binghamton.edu/may-jun/18may06ask.html > This says that Aspirin is a platelet aggregation inhibitor. But is the > viscosity of blood different when aspirin is in the blood? No. > Does > aspirin-blood go through small tubes, say syringe needles, more > easily? No. > Is it easier to start an IV on someone who has taken aspirin? No. > And how easily detectable is the effect of aspirin on the clotting of > blood? Not easily detectable. > Is aspirin-blood noticeably different? No. > Does a cut take > significantly longer to scab-up? No. Andrew <>< -- Andrew B. Chung, MD/PhD http://EmoryCardiology.com On Mar 4, 4:55 am, "Andrew B. Chung, MD/PhD" <l...@thetruth.com> wrote: > Nehmowrote: > > Aspirin thins out the blood, I understand. Here's something of an [quoted text clipped - 31 lines] > -- > Andrew B. Chung, MD/PhD http://EmoryCardiology.com Thanks. I had thought there was a difference, and I even heard once (and I know this sounds a little stupid) that before doing something dangerous, like driving a race car or base jumping, you shouldn't take aspirin because if injured, you'll need all the clotting speed you can get. But there is a basis for aspirin being known to inhibiting clotting. Apparently, since the effect is minor, there doesn't seem to be an application for it in everyday life. -- (||) Nehmo (||) > Andrew, in the Holy Spirit, boldly wrote: > [quoted text clipped - 30 lines] > > Thanks. You are welcome. All thanks and praises belong to GOD, Who is the Source of all knowledge and wisdom. > I had thought there was a difference, and I even heard once > (and I know this sounds a little stupid) that before doing something > dangerous, like driving a race car or base jumping, you shouldn't take > aspirin because if injured, you'll need all the clotting speed you can > get. There is a noticeable difference in the time it takes for arterial bleeding from a cut to stop bleeding depending on whether aspirin is being taken daily. For this reason, aspirin is typically held for a few days before when such bleeding is anticipated. > But there is a basis for aspirin being known to inhibiting clotting. > Apparently, since the effect is minor, there doesn't seem to be an > application for it in everyday life. Actually, the anti-platelet function of aspirin is quite potent and effective in the right setting (preventing arterial occlusion). Andrew <>< -- Andrew B. Chung, MD/PhD http://EmoryCardiology.com >> Andrew, in the Holy Spirit, boldly wrote: >> [quoted text clipped - 29 lines] >> > >> > No. think I would have to disagree great doctor hubby who takes only 81 mg a day post MI...etc...and is a very active do it yourselfer..is often tagged with "scabs" etc..and when he scratches one open ...I often watch him hold pressure and Kleenex etc to it...far longer than whatis considered "normal clotting" time for mild skin abrasions... >> Thanks. > [quoted text clipped - 27 lines] > Andrew B. Chung, MD/PhD > http://EmoryCardiology.com >>> > > Does a cut take >>> > > significantly longer to scab-up? [quoted text clipped - 7 lines] > open ...I often watch him hold pressure and Kleenex etc to it...far longer > than whatis considered "normal clotting" time for mild skin abrasions... Platelet aggregation is only one part of the body's anti-bleeding mechanism. There is a difference between clotting time and bleeding time. Aspirin or other anti-platelet drugs affects bleeding, they don't affect the body's intrinsic or extrinsic clotting mechanism. Andrew is correct - a wound doesn't take significantly longer to scab up, but that wound may bleed more vigorously until it does. HMc > Andrew, in the Holy Spirit, boldly wrote: > >> Andrew, in the Holy Spirit, boldly wrote: [quoted text clipped - 32 lines] > > think I would have to disagree great doctor Does not bother me if you do choose to disagree. As for great, that glory belongs to GOD, Whom I love with all my heart, soul, mind, and strength. Laus Deo ! ! ! > hubby who takes only 81 mg a day post MI...etc...and is a very active do it > yourselfer..is often tagged with "scabs" etc..and when he scratches one open > ...I often watch him hold pressure and Kleenex etc to it...far longer than > whatis considered "normal clotting" time for mild skin abrasions... It is likely that your husband's mild skin abrasions are closer to lacerations. I too am an active do-it-yourselfer and have to hold pressure on what my wife believes are "mild skin abrasions." When pressure has to be held to stop the bleeding, there is at least one cut tiny artery in the injury somewhere. As an invasive cardiologist, I do have a lot of experience applying pressure to stop bleeding from arteries that I have punctured to perform catheterizations. On the surface, these wounds do indeed look like "mild skin abrasions." Andrew <>< -- Andrew B. Chung, MD/PhD http://EmoryCardiology.com > But there is a basis for aspirin being known to inhibiting clotting. > Apparently, since the effect is minor, there doesn't seem to be an > application for it in everyday life. > > -- > (||) Nehmo (||) Other than its ability to prevent cardiovascular events or limit the effects of those that do occur, such as heart attack or stroke, by inhibiting platelet aggregation, no -- no application for aspirin at all. None of the commonly viewed "blood thinners" actually thin the blood - the actual viscosity is unchanged. Trental (pentyoxphylline), however does supposedly change the effective viscosity by enhancing red cell flexibility. It's touted as letting blood flow into smaller arterioles thereby being effective in healing ischemic ulcerations of the distal extremities. Sounds good in theory but in practice it doesn't actually work. HMc > > But there is a basis for aspirin being known to inhibiting clotting. > > Apparently, since the effect is minor, there doesn't seem to be an [quoted text clipped - 14 lines] > > HMc Hello Howard Any thoughts concerning Cinnamon another bark ? Bill who ingests a gram a day for preventive blood sugar. (BG) Am I delusional?  SignatureS Jersey USA Zone 5 Shade http://www.ocutech.com/ High tech Vison aid This article is posted under fair use rules in accordance with Title 17 U.S.C. Section 107, and is strictly for the educational and informative purposes. This material is distributed without profit. > Hello Howard > [quoted text clipped - 3 lines] > > Am I delusional? Cinnamon is a great spice.However, its efficacy as a medicine is only demonstrated by rumor, legend and anecdote. HMc > "William Wagner" <not-to-here-williamwag@gmail.com> wrote in message > news:not-to-here-williamwag-E7C7D7.16304504032007@sn-indi.vsrv-sjc.supernews.n [quoted text clipped - 12 lines] > > HMc Still as Jim would point out a small study. 1: Diabetes Care. 2003 Dec;26(12):3215-8. Links Cinnamon improves glucose and lipids of people with type 2 diabetes. € Khan A, Safdar M, Ali Khan MM, Khattak KN, Anderson RA. Department of Human Nutrition, NWFP Agricultural University, Peshawar, Pakistan. OBJECTIVE: The objective of this study was to determine whether cinnamon improves blood glucose, triglyceride, total cholesterol, HDL cholesterol, and LDL cholesterol levels in people with type 2 diabetes. RESEARCH DESIGN AND METHODS: A total of 60 people with type 2 diabetes, 30 men and 30 women aged 52.2 +/- 6.32 years, were divided randomly into six groups. Groups 1, 2, and 3 consumed 1, 3, or 6 g of cinnamon daily, respectively, and groups 4, 5, and 6 were given placebo capsules corresponding to the number of capsules consumed for the three levels of cinnamon. The cinnamon was consumed for 40 days followed by a 20-day washout period. RESULTS: After 40 days, all three levels of cinnamon reduced the mean fasting serum glucose (18-29%), triglyceride (23-30%), LDL cholesterol (7-27%), and total cholesterol (12-26%) levels; no significant changes were noted in the placebo groups. Changes in HDL cholesterol were not significant. CONCLUSIONS: The results of this study demonstrate that intake of 1, 3, or 6 g of cinnamon per day reduces serum glucose, triglyceride, LDL cholesterol, and total cholesterol in people with type 2 diabetes and suggest that the inclusion of cinnamon in the diet of people with type 2 diabetes will reduce risk factors associated with diabetes and cardiovascular diseases. PMID: 14633804 [PubMed - indexed for MEDLINE] SignatureS Jersey USA Zone 5 Shade http://www.ocutech.com/ High tech Vison aid This article is posted under fair use rules in accordance with Title 17 U.S.C. Section 107, and is strictly for the educational and informative purposes. This material is distributed without profit. >> "William Wagner" <not-to-here-williamwag@gmail.com> wrote in message >> news:not-to-here-williamwag-E7C7D7.16304504032007@sn-indi.vsrv-sjc.supernews.n [quoted text clipped - 41 lines] >associated with diabetes and cardiovascular diseases. >PMID: 14633804 [PubMed - indexed for MEDLINE] Also the full text of the above study is freely available: Khan A, Safdar M, Ali Khan MM, Khattak KN, Anderson RA. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care. 2003 Dec;26(12):3215-8. PMID: 14633804 [PubMed - indexed for MEDLINE] <http://care.diabetesjournals.org/cgi/content/full/26/12/3215> With the exception of one study, other diabetes and blood pressure related cinnamon studies have also given positive results: Mancini-Filho J, Van-Koiij A, Mancini DA, Cozzolino FF, Torres RP. Antioxidant activity of cinnamon (Cinnamomum Zeylanicum, Breyne) extracts. Boll Chim Farm. 1998 Dec;137(11):443-7. PMID: 10077878 [PubMed - indexed for MEDLINE] <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra ctPlus&list_uids=10077878> "... SIGNIFICANCE: These results suggest that the cinnamon extracts can be used as food antioxidant together with the improvement of food palatability. Further studies are in processing of analysing the sinergic association of extracts with synthetic antioxidant and to identify compounds with antioxidant activity in cinnamon extracts." Jarvill-Taylor KJ, Anderson RA, Graves DJ. A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll Nutr. 2001 Aug;20(4):327-36. PMID: 11506060 [PubMed - indexed for MEDLINE] <http://www.jacn.org/cgi/content/full/20/4/327> "... CONCLUSION: Together, these results demonstrate that the MHCP is an effective mimetic of insulin. MHCP may be useful in the treatment of insulin resistance and in the study of the pathways leading to glucose utilization in cells." Qin B, Nagasaki M, Ren M, Bajotto G, Oshida Y, Sato Y. Cinnamon extract (traditional herb) potentiates in vivo insulin-regulated glucose utilization via enhancing insulin signaling in rats. Diabetes Res Clin Pract. 2003 Dec;62(3):139-48. PMID: 14625128 [PubMed - indexed for MEDLINE] <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra ctPlus&list_uids=14625128> "... These results suggest that the cinnamon extract would improve insulin action via increasing glucose uptake in vivo, at least in part through enhancing the insulin-signaling pathway in skeletal muscle." Qin B, Nagasaki M, Ren M, Bajotto G, Oshida Y, Sato Y. Cinnamon extract prevents the insulin resistance induced by a high-fructose diet. Horm Metab Res. 2004 Feb;36(2):119-25. PMID: 15002064 [PubMed - indexed for MEDLINE] <http://www.thieme-connect.com/DOI/DOI?10.1055/s-2004-814223> "... These results suggest that early CE administration to HFD-fed rats would prevent the development of insulin resistance at least in part by enhancing insulin signaling and possibly via the NO pathway in skeletal muscle." Kim SH, Hyun SH, Choung SY. Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice. J Ethnopharmacol. 2006 Mar 8;104(1-2):119-23. Epub 2005 Oct 5. PMID: 16213119 [PubMed - indexed for MEDLINE] <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra ctPlus&list_uids=16213119> "... These results suggest that cinnamon extract has a regulatory role in blood glucose level and lipids and it may also exert a blood glucose-suppressing effect by improving insulin sensitivity or slowing absorption of carbohydrates in the small intestine." H. G. Preuss, B. Echard, M. M. Polansky, and R. Anderson Whole cinnamon and aqueous extracts ameliorate sucrose-induced blood pressure elevations in spontaneously hypertensive rats. J. Am. Coll. Nutr., April 1, 2006; 25(2): 144 - 150. <http://www.jacn.org/cgi/content/abstract/25/2/144> "... Conclusions: Cinnamon is used for flavor and taste in food preparation, but cinnamon may have additional roles in glucose metabolism and BP regulation. Therefore, BP regulation may not only be influenced favorably by limiting the amounts of dietary substances that have negative effects on BP and insulin function but also by the addition of beneficial ones, such as cinnamon, that have positive effects." K. Vanschoonbeek, B. J. W. Thomassen, J. M. Senden, W. K. W. H. Wodzig, and L. J. C. van Loon Cinnamon Supplementation Does Not Improve Glycemic Control in Postmenopausal Type 2 Diabetes Patients J. Nutr., April 1, 2006; 136(4): 977 - 980. <http://jn.nutrition.org/cgi/content/abstract/136/4/977> "... We conclude that cinnamon supplementation (1.5 g/d) does not improve whole-body insulin sensitivity or oral glucose tolerance and does not modulate blood lipid profile in postmenopausal patients with type 2 diabetes. More research on the proposed health benefits of cinnamon supplementation is warranted before health claims should be made." Preuss HG, Echard B, Polansky MM, Anderson R. Whole cinnamon and aqueous extracts ameliorate sucrose-induced blood pressure elevations in spontaneously hypertensive rats. J Am Coll Nutr. 2006 Apr;25(2):144-50. PMID: 16582031 [PubMed - indexed for MEDLINE] <http://www.jacn.org/cgi/content/abstract/25/2/144> "... CONCLUSIONS: Cinnamon is used for flavor and taste in food preparation, but cinnamon may have additional roles in glucose metabolism and BP regulation. Therefore, BP regulation may not only be influenced favorably by limiting the amounts of dietary substances that have negative effects on BP and insulin function but also by the addition of beneficial ones, such as cinnamon, that have positive effects." Mang B, Wolters M, Schmitt B, Kelb K, Lichtinghagen R, Stichtenoth DO, Hahn A. Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. Eur J Clin Invest. 2006 May;36(5):340-4. PMID: 16634838 [PubMed - indexed for MEDLINE] <http://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-2362.2006.01629.x> "... CONCLUSIONS: The cinnamon extract seems to have a moderate effect in reducing fasting plasma glucose concentrations in diabetic patients with poor glycaemic control." Kannappan S, Jayaraman T, Rajasekar P, Ravichandran MK, Anuradha CV. Cinnamon bark extract improves glucose metabolism and lipid profile in the fructose-fed rat. Singapore Med J. 2006 Oct;47(10):858-63. PMID: 16990960 [PubMed - indexed for MEDLINE] <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra ctPlus&list_uids=16990960> <http://www.sma.org.sg/smj/4710/4710a4.pdf> (full text) "... CONCLUSION: These findings indicate the improvement of glucose metabolism in-vivo by CBEt in fructose-fed rats." T. P. J. Solomon, A. K. Blannin Effects of short-term cinnamon ingestion on in vivo glucose tolerance Diabetes, Obesity and Metabolism (OnlineEarly Articles). Published article online: 08 Feb 2007 doi:10.1111/j.1463-1326.2006.00694.x <http://www.blackwell-synergy.com/doi/abs/10.1111/j.1463-1326.2006.00694.x> "... Conclusions: These data illustrate that cinnamon spice supplementation may be important to in vivo glycaemic control and insulin sensitivity in humans, and not only are its effects immediate, they also appear to be sustained for 12 h." Wang JG, Anderson RA, Chu MC, Sauer MV, Guarnaccia MM, Lobo RA. The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study. Fertil Steril. 2007 Feb 9; [Epub ahead of print] PMID: 17296187 [PubMed - as supplied by publisher] <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra ctPlus&list_uids=17296187> "Cinnamon extract has been shown to reduce insulin resistance in in vitro and in vivo studies by increasing phosphatidylinositol 3-kinase activity in the insulin signaling pathway and thus potentiating insulin action. Fifteen women with polycystic ovary syndrome (PCOS) were randomized to daily oral cinnamon and placebo for 8 weeks. Comparisons of post-treatment to baseline insulin sensitivity indices using fasting and 2-hour oral glucose tolerance tests showed significant reductions in insulin resistance in the cinnamon group but not in the placebo group. A larger trial is needed to confirm the findings of this pilot study and to evaluate the effect of cinnamon extract on menstrual cyclicity." SignatureMatti Narkia > Aspirin thins out the blood, I understand. Here's something of an > explanation:http://askascientist.binghamton.edu/may-jun/18may06ask.html [quoted text clipped - 7 lines] > --- > (||) Nehmo (||) Vitamin K is good for clotting. Paula You can bleed to death from certain procedures like a liver biopsy if the doctor doesn't know you are taking aspirin regularly. It changes the prothrombin time significantly MD I'm not sure that it changes the protime. It may change a test called "platelet aggregation" however. A severely diseased liver, however, will change your protime result (increasing it) because clotting factors are produced in the liver. Patients with cirrhosis and other liver diseases have increased protimes - not because of aspirin but because of reduced liver function. (Am I correct, Dr. Chung???) As I remember years ago from MT training, clotting is a cascade of clotting factors (which I had to know once - don't remember it all any more), ending with the platelets. Aspirin affects the platelets - NOT the clotting factors. Check out the page below - this lists medications that change platelet function vs. clotting factors. Clotting is a very complicated body function. If you are deficient in any of the clotting factors you won't clot (i.e. hemophilia and other clotting factor diseases). Judy Dilworth, M.T. (ASCP) Microbiology (but trained in all areas of lab at one time) http://www-admin.med.uiuc.edu/hematology/Medications.htm > You can bleed to death from certain procedures like a liver biopsy if > the doctor doesn't know you are taking aspirin regularly. It changes > the prothrombin time significantly > > MD > I'm not sure that it changes the protime. It may change a test called > "platelet aggregation" however. A severely diseased liver, however, will > change your protime result (increasing it) because clotting factors are > produced in the liver. Patients with cirrhosis and other liver diseases have > increased protimes - not because of aspirin but because of reduced liver > function. (Am I correct, Dr. Chung???) You are correct. > As I remember years ago from MT training, clotting is a cascade of clotting > factors (which I had to know once - don't remember it all any more), ending [quoted text clipped - 10 lines] > > http://www-admin.med.uiuc.edu/hematology/Medications.htm Would only add that clotting is also very tightly regulated with additional factors that when deficient causes folks to be hypercoagulable (clot too easily). All of these factors are made by the liver with many dependent on vitamin K as a cofactor for their synthesis. Andrew <>< -- Andrew B. Chung, MD/PhD http://EmoryCardiology.com > > You can bleed to death from certain procedures like a liver biopsy if > > the doctor doesn't know you are taking aspirin regularly. It changes > > the prothrombin time significantly > > > > MD > You can bleed to death from certain procedures like a liver biopsy if > the doctor doesn't know you are taking aspirin regularly. It changes > the prothrombin time significantly No it doesn't. It has no effect whatsoever on the prothrombin time. All the effects are on the cyclo-oxygenase pathways in the platelets. Thanks, Manky. I didn't know the real reason but I knew it didn't affect protimes. I remember a few things from basic coagulation, but haven't done the testing in years. I suppose it's like riding a bike - you remember after you're put up on it again and pedal around for awhile :-). Judy Dilworth, M.T. (ASCP) Microbiology > No it doesn't. > > It has no effect whatsoever on the prothrombin time. All the effects are > on the cyclo-oxygenase pathways in the platelets. It is my understanding that in about 25% of the people taking asprin that the platelet function is unimpaired. This is also true to about the same extent for plavex (sp). Usually no platelet function testing is done after dosing to determine effect, because there is no theraputic alternative. Do not take this as an authoritive reference....I am posting this to verify what I have heard and did not read in a published article. > Aspirin thins out the blood, I understand. Here's something of an > explanation: http://askascientist.binghamton.edu/may-jun/18may06ask.html [quoted text clipped - 7 lines] > --- > (||) Nehmo (||) > Aspirin thins out the blood, I understand. Here's something of an > explanation:http://askascientist.binghamton.edu/may-jun/18may06ask.html [quoted text clipped - 7 lines] > --- > (||) Nehmo (||) It causes hemolysis .. decreases the NUMBER of red blood cells. It treats .. erythrocytosis .. too many red blood cells .. which CAUSES hyperviscosity / blood thickening .. and the fact iron destroys red blood cells / hemolysis .. NOW .. lowers / decreases / eliminates the .. viscosity .. and now it is .. blood .. thinning .. THAT is WHY it works in polycythemia .. erythrocytosis .. increased red blood cell production. Pediatr Res. 1978 Sep;12(9):927-31. Links Aspirin-induced hemolysis: the role of concomitant oxidant (H2O2) challenge.Stockman JA 3rd, Lubin B, Oski FA. Studies were conducted in an attempt to determine the hemolytic potential of acetylsalicylic acid (ASA) on normal intact red blood cells (RBCs). ASA (25 mg/100 ml) did not impair RBC G-6-PD, glutathione peroxidase or catalase activity, glutathione stability, or hexose monophosphate shunt activity. Hemolysis was not observed after incubation with ASA alone but was quickly noted after exposure to ASA (25 mg/100 ml) and H2O2 (1.2%). Hemolysis did not occur with H2O2 alone but was directly proportional to the ASA concentration. Hemolysis was preceded by peroxidation of membrane lipid and was inhibited by the presence of the antioxidant, thymol. With ASA and H2O2 a marked reduction in membrane phosphatidyl ethanolamine occurred with oxidation of 20:4 and 22:6 fatty acids. No effect on phospholipids or fatty acids occurred with either ASA or H2O2 alone. Salicylic acid, singly or with H2O2, does not exhibit these effects. PMID: 714540 [PubMed - indexed for MEDLINE] Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk http://tinyurl.com/3yfg4t RESEARCH PAPER Year : 2004 | Volume : 36 | Issue : 4 | Page : 226-230 Acute and chronic effects of aspirin on hematological parameters and hepatic ferritin expression in mice Merchant MA, Modi Deepak N Department of Zoology, Wilson College Chowpatty Mumbai - 400 007, India Date of Submission 06-May-2004 Date of Decision 03-Jul-2003 Date of Acceptance 09-Feb-2004 Correspondence Address: Department of Zoology, Wilson College Chowpatty Mumbai - 400 007, India deepaknmodi@hotmail.com » Abstract OBJECTIVE: To examine the acute and chronic effects of aspirin on peripheral blood and bone marrow counts and hepatic ferritin expression in mice. MATERIAL AND METHODS: Adult male albino mice were orally administered aspirin at a dose of 600 mg/kg thrice daily for 7 days or 150 mg/kg once daily for 6/7 days up to 25 weeks. At the end of the experiment the red and white blood cell counts, hemoglobin, and packed cell volume were estimated. Bone marrow films were studied to estimate the rate of erythropoiesis and leucopoiesis. Expression of liver ferritin was tested by immunohistochemistry. RESULTS: Acute or chronic doses of aspirin reduced the RBC count, hemoglobin and other red cell indices as compared to controls. The WBC counts were higher in the treated animals as compared to the untreated animals. Both the treatment regimens appeared to suppress the rate of erythropoiesis in the marrow, while the rate of leucopoiesis appeared to increase in the marrow of the treated animals. Aspirin treatment did not significantly affect the expression of ferritin in the liver. CONCLUSION: Aspirin in either acute or chronic doses induces anemia associated with leucocytosis in mice; the anemia does not seem to be induced due to alterations in iron metabolism. The drug appears to use multiple targets which affect red cell production and maturation processes. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk |
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