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Medical Forum / Diseases and Disorders / Lupus / January 2004Kadian
Hi, Has anyone heard of, or perhaps even used Kadian for pain? It is a time release version of Morphine. Ultram is a big no-no for me. It has caused spontaneous graft failure in transplant patients, and that's just not an option. My alkaline phosphatase level is high, as is my GTTP. My liver is becoming inflamed due to the pancreatitis, so the tylenol component of the Percocet is a problem. Also, the Duragesic patch is no longer covering the neuropathy pain. I don't suppose it really ever did cover it entirely. I have been resistant to Fentanyl in the past, when I have had procedures such as the ERCP. Throw in the aches and pains of this lovely autoimmune disorder, and you have a nice mess. I'm down to 3 mg of Prednisone daily as of last Friday. I don't think that is helping either. I was told at transplant clinic to schedule myself another cortisol stimulation test soon. Hopefully I will find some answers there. Top posting since it might be easier for you. Kadian seems to be a different name brand for MS-Contin http://www.infagra.com/m/ms-contin.html Extended-Release Morphine Sulfate Formulations for Cancer Pain ... There were no clinically important, statistically significant differences between Kadian ® and MS Contin ® in pain assessments, rescue medication usage ... http://www.medscape.com/viewarticle/406155 - I can't access the above (to see what else they say) because I'm not subscribed to medscape. (but maybe you are?) I've been following a lady on the breast cancer newsgroup who has MS. She seems to have stopped her pancreatitis with a statin drug, but when I finally got a clearer answer from her and just looked that up, it has a kidney transplant rejection warning on it. Also has a warning about liver levels, so not the right one for you http://www.somersetmedicalcenter.com/11196.cfm I've been following discussions on m.h.a. about milk thistle (which might have anti-inflammatory properties), but it's currently in long term clinical trials at NCCAM (National Cancer Complementary something or other) for efficacy of treating cancers, for toxicity and for side effects and how it clears the system and what organs it might affect. pancreatitis - itis inflammation. I wonder what life is like living without a pancreas? Have we ever discussed or have you ever asked your doctors? J > Hi, > [quoted text clipped - 17 lines] > myself another cortisol stimulation test soon. Hopefully I will find > some answers there. That is what I take Wes, only the name mine goes by here in Canada anyhow, is MS contin... (OR morphine sulphate -continuous release) They also have an oxycodone 'contin' which is the same narcotic which is in your percodan/percocet without the aspirin/tylenol to get to your liver; it works the same way as percodan/cet does and the contin form lasts up to 12 hours like the kadian (or ms contin). It works extremely well so if you can get it go for it!  Signature((((Hugs)))) from Shelagh | Hi, | [quoted text clipped - 17 lines] | myself another cortisol stimulation test soon. Hopefully I will find | some answers there. Regarding the liver - would milk thistle (silymarin) be suitable for you? My liver enzymes have improved greatly since I started taking milk thistle capsules. They haven't been this good since before I started Methotrexate. My new rheumatologist found it great too. From what I have looked up in the medical database of my university, it seems milk thistle is good for several kinds of liver disease (as well as mushroom poisoning). There isn't supposed to be any side effects, although too high doses can cause the runs. Hope the inflammations clear up, Nina <www.medhelp.org/forums/hepatitis/messages/30248a.html> I appreciate your question which is both straightforward but complex. Yes, you can live without a pancreas although you would prefer not to. Living without a pancreas is not like living without a gallbladder or appendix or even spleen. A person without a pancreas will be diabetic and will have to take insulin. That's because the pancreas is the organ that makes insulin. Patients without a pancreas or with a badly damaged pancreas often have diabetes that is hard to control. Sometimes, if we have to remove some one's pancreas, we try to leave just a little behind to help control or prevent diabetes. In addition, individuals without a pancreas have to take pills to help them digest their food because they no longer have a pancreas to make enzymes necessary for digestion. These pills have to be taken with all meals and snacks. Without the pills, people with pancreas problems can develop diabetes and weight loss. ================================== So, it can be done, but it doesn't sound easy. Course, neither does your situation, Wes. Can you have a pancreatic transplant, or would that even solve it? Would the pancreatitis just return in that one? Hugs Wes... I'm so sorry you're in such pain all the time. I hope the morphine will take all of your pains away. Maggie [ >A person without a pancreas will be diabetic and will have to take >insulin. That's because the pancreas is the organ that makes insulin. >Patients without a pancreas or with a badly damaged pancreas often have >diabetes that is hard to control. Sometimes, if we have to remove some >one's pancreas, we try to leave just a little behind to help control or >prevent diabetes. My wife has lupus AND diabetes (and other stuff...). We have grilled several consultants on "Does lupus damage the pancreas, causing diabetes?". The answer is somewhere between "Don't know" and "No it doesn't"; one said that for whatever reason Lupus rarely damages those organs which produce secretions. That of course doesn't mean that the same person cannot have both lupus and pancreas-problems, only that the one probably does not cause the other :( SignatureAndy [Chair, N E Lupus Group] See http://www.northeastlupus.org.uk for more! Andy Wrote: >>>>We have grilled several consultants on "Does lupus damage the pancreas, causing diabetes?". The answer is somewhere between "Don't know" and "No it doesn't"; one said that for whatever reason Lupus rarely damages those organs which produce secretions.<<<<< ---------------------- I didn't know your wife had diabetes. Type I or II? My mom had T2, but I still wonder if it was AI--they say T2 isn't. From what I've been reading, there's unknown causes for pancreatitis & also, it can be auto immune. I would think that auto immune diabetes/pancreatits could *easily* be linked to Lupus. OTOH, nothing says that someone with Lupus, has just one AI disease. RA, Reiters. Psoriatic Arthritis, AI thyroidism, asthma, diabetes T1, etc. etc., are all AI diseases that can be present with & in addition to Lupus. Maggie [ >I didn't know your wife had diabetes. Type I or II? My mom had T2, but >I still wonder if it was AI--they say T2 isn't. Type II, variety "Brittle" - which means that it doesn't respond to treatment the way the doctor's textbook says :) SignatureAndy [Chair, N E Lupus Group] See http://www.northeastlupus.org.uk for more! > [ > >I didn't know your wife had diabetes. Type I or II? My mom had T2, but > >I still wonder if it was AI--they say T2 isn't. > > > Type II, variety "Brittle" - which means that it doesn't respond to > treatment the way the doctor's textbook says :) I'm sorry, Andy. as far as I know milk thistle doesn't have any drug interactions either... Lyndal > Regarding the liver - would milk thistle (silymarin) be suitable for you? My > liver enzymes have improved greatly since I started taking milk thistle [quoted text clipped - 7 lines] > > Nina Glad to hear that - I just got Milk Thistle today... Leslie > as far as I know milk thistle doesn't have any drug interactions either... > [quoted text clipped - 14 lines] > > > > Nina Hi Wes, As usual, you will have to depend on some of the clever ones to answer your question. I only wanted to tell you that I am sorry that you are still in so much pain. My thoughts and good vibes will be flying in your direction. I hope you get relief soon. BJ-Sask. Canada > Hi, > [quoted text clipped - 17 lines] > myself another cortisol stimulation test soon. Hopefully I will find > some answers there. Hi Wes, I am sorry to hear that you are in such pain. I remember back to my own days and nights of intractible pain, and all I can say is that it feels so good when it stops, and I can say that every time it *has* stopped. I'm sorry to hear that you cannot take Ultram. I remember what your posts meant to me when I was feeling poorly. So I wanted to write back and send you a bunch of well-wishes and think-happys that might make you feel better. You are not alone, Mair > Hi, > [quoted text clipped - 17 lines] > myself another cortisol stimulation test soon. Hopefully I will find > some answers there. I don't use Kadian (it is mentioned on the chronic pain newsgroup) but I sure hope it helps you. Oxycodone is available without tylenol, aspirin, ibuprofen.. under the name Oxycontin. You use the Duragesic patch now? What's your dosage? Could that be increased? Maybe changing the patch every 2 days rather than 3? I dunno. I really hope something is found for you! HUGS Nicole > I don't use Kadian (it is mentioned on the chronic pain newsgroup) but I > sure hope it helps you. [quoted text clipped - 7 lines] > HUGS > Nicole My dose of Duragesic is 25 mcg/hour, the smallest. It probably could be increased, but I'm not sure I want to continuw with it. It wears off too soon. I have read that body temperature has an effect. body temperature has a lot to do with it - I had a bout with night sweats and overdosed! > > I don't use Kadian (it is mentioned on the chronic pain newsgroup) but I > > sure hope it helps you. [quoted text clipped - 11 lines] > be increased, but I'm not sure I want to continuw with it. It wears > off too soon. I have read that body temperature has an effect. Oh, the Duragesic can be increased a lot. The patches go up in strength quite a bit. Body temp is what regulates the med to be released. So if that's a problem, it won't work "properly" I've read about several people using one patch for only 48 hrs. And still using something else for breakthru pain. I just hope your dr is willing to work with you. Pain management is so important in any disease. take care Nicole Signature3 of every 10 Americans Know Someone With Lupus Help find the cure. www.lupus.org > > I don't use Kadian (it is mentioned on the chronic pain newsgroup) but I > > sure hope it helps you. [quoted text clipped - 11 lines] > be increased, but I'm not sure I want to continuw with it. It wears > off too soon. I have read that body temperature has an effect. Wesley, just wanted to add my wishes for you to find some relief. You have had way too much bad stuff happen to you. Gretchen Thanks for the well wishes everyone! I will see the pain specialist next Monday, and I will take all of the questions and advice received here with me. > Hi, > [quoted text clipped - 17 lines] > myself another cortisol stimulation test soon. Hopefully I will find > some answers there. Good luck on Monday, Wes. Let us know how it goes, and what is decided. We all want you to feel better. BJ-Sk. Canada > Thanks for the well wishes everyone! I will see the pain specialist > next Monday, and I will take all of the questions and advice received [quoted text clipped - 21 lines] > > myself another cortisol stimulation test soon. Hopefully I will find > > some answers there. |
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