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Medical Forum / Diseases and Disorders / Lupus / January 2004Vasculitis
I have had very severe vasculitis in my hands and feet during the 1980 so it involved swelling and pain in my toes and fingers. on the whole it resolved when my lupus was treated at that time prednisolone was the treatment used .It consisted of red painful lumps, which leads to numbness in the feet and hands eventually. It is not pleasant ,but can lead to cerebral involvement which can lead to strokes which did happen in my case , so it should not be taken lightly . Warmest wishes Erina Erina, I'm sorry to hear that you have vasculitis. Did I read correctly that you did have a stroke? I feel for you as strokes have run in my father's family as well as My wife's family. My wife, Kelley (43), has been battling both SLE and DLE throughout her system since Apr01. It has now turned on to her kidneys, heart and caused vasculitis in her brain among a host of symptoms. Both we and her doctors at Walter Reed are very concerned. We don't know what her longterm prognosis will be (hopeful, but realistic too), but Kelley gave me a bad scare over the holidays as her kidneys and bowels shut down for several days as a result of severe dehydration due to catching the flu. Unfortunately, I was the culprit that brought it home to her. 10 days at Walter Reed got her up and going again thank God. Neither of us is ready for my to be a single parent of our 3-year old daughter, Kelsey (who is currently staying with my sister for the next 2 months while Kelley recuperates). Kelley finds herself being forced to face this head on now as she was in denial for a long time. It is hard for me as her caregiver as I feel that I'm standing on the sidelines only offering comfort, but it is the best that I can offer. regards, Daniel > I have had very severe vasculitis in my hands and feet during the 1980 so it > involved swelling and pain in my toes and fingers. on the whole it resolved [quoted text clipped - 5 lines] > Warmest wishes > Erina <AntonsonDJ@comcast.net> wrote in message : Erina, : I'm sorry to hear that you have vasculitis. Did I read correctly that you [quoted text clipped - 11 lines] : regards, : Daniel Oh Daniel that is just wonderful ! .... I mean the fact that you can and are offering her comfort and support! That is so much more than alot of the members here have in their court and it says alot about your character as well as the obvious fact that you love her! I wish you both tremendous good luck and an excellent prognosis which finds you both doting on each other in your 'old age'! <g> Hugs from Shelagh Daniel I have survived 22 year since my stroke but I am considerably dis disabled now. I have had to fight my Drs all along the way. Offering comfort is very valuable to the patient. It is the small things that are often appreciated most in life because they show you care and love them, Warmest wishes Erina > <AntonsonDJ@comcast.net> wrote in message > : Erina, [quoted text clipped - 31 lines] > which finds you both doting on each other in your 'old age'! <g> > Hugs from Shelagh Hi Daniel, I was glad to see you back here again. I am so sorry to hear that Kelley has had such a bad time. It sounds best that Kelsey be with her auntie for a while. There is no way either of you could handle looking after her right now. The focus has to be on Kelley's recovery. I don't know what to say, really. Things can turn around suddenly and Kelley could find herself doing much better. Even so, she will have an uphill climb. I know how long it can take to come back from a lengthy flare. I am glad that she has you for support. I hope you have someone with whom you can share your emotions. All this is hard on the caregiver too. We are here, whenever you need to talk. I wish you and your family all the best. I will keep you in my thoughts. BJ-Sk. Canada > Erina, > [quoted text clipped - 35 lines] > > Warmest wishes > > Erina Hi, I have had lupus for all my adult life and a few years ago I was diagnosed with Antiphospholipid Syndrome too. I have been treated with warfarin, aspirin,cyclophosphamide, imuran and prednisolone for it as it has caused CNS symptoms and the docs think I get cerebral vasculits ( tho they have never looked inside my brain so I dont see how they can say for sure). A couple of years ago I had some numbness in my face and the dr put me on a short booster course of prednisolone straight away as he thought the cerebral vasculitis might be coming back. It soon cleared up and I was able to go back to my "normal" meds. My point is that vasculitis, tho scary, usually responds to treatment once properly diagnosed. Lynne > I have had very severe vasculitis in my hands and feet during the 1980 so it > involved swelling and pain in my toes and fingers. on the whole it resolved [quoted text clipped - 5 lines] > Warmest wishes > Erina  Signaturefor an alternative look at current events, go to http://www.greenpeace.org.uk/ While vasculitis secondary to some primary autoimmune disease such as lupus may respond to prednisolone alone, primary autoimmune vasculitides do not all go into remission on a corticosteroid alone. A number of the primary autoimmune vasculitides require more aggressive treatment. Bruce >Subject: Vasculitis Int Immunol. 2002 Mar; 14(3): 267-73. Related Articles, Links Antioxidants inhibit mercuric chloride-induced early vasculitis. Wu Z, Turner DR, Oliveira DB. Division of Renal Medicine, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK. z.wu@sghms.ac.uk In the Brown Norway (BN) rat, mercuric chloride (HgCl(2)) induces a T(h)2-dominated autoimmune syndrome which includes an early phase of mast cell-dependent vasculitis. We have shown in vitro that oxidative stress up-regulates IL-4 in mast cells and predisposes to degranulation. The aim of this study was to determine whether administration of antioxidants inhibits HgCl(2)-induced early vasculitis in vivo, and, if so, to examine whether modulation of the oxidative/antioxidative balance influences IgE and IL-4 expression by mast cells in situ. Groups of rats were given HgCl(2) + saline, HgCl(2) + N-acetyl-L-cysteine (NAC), saline + saline or saline + NAC respectively and blood was taken and animals killed 48 h later. NAC significantly reduced both HgCl2-induced early vasculitis and HgCl(2)-enhanced IgE expression on mast cells with a trend to a decrease in HgCl(2)-enhanced IL-4 expression in these cells. In addition, there was an increased rat mast cell protease (RMCP) II concentration in the serum after HgCl(2) injection and the elevated levels of RMCP II stimulated by HgCl(2) were totally abolished by the administration NAC in the HgCl(2) + NAC group. However, there was no significant change in serum total IgE concentrations between the HgCl(2) + saline group and the HgCl(2) + NAC group. The non-sulphydryl-containing antioxidants desferrioxamine and pyruvate demonstrated a similar effect in inhibiting HgCl(2)-induced early vasculitis. Our data show that administration of an antioxidant to BN rats reduces HgCl(2)-induced early vasculitis, suggesting that oxidative stress plays a role in the pathogenesis of HgCl(2)-induced early vasculitis. This finding may have implications for the understanding of the initiation in this experimental model of T(h)2 cell-driven autoimmunity and possibly of analogous human diseases. PMID: 11867563 [PubMed - indexed for MEDLINE] -------------------------------------------------------------------------- ------ Who loves ya. Tom SignatureJesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking Doe, I am treated at St. Georges hospital now but by Dr. Axford , the rheumatologist and immunologist. I also trained there years ago Warm wishes Erina > >Subject: Vasculitis > [quoted text clipped - 43 lines] > Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore > DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking >Subject: Re: Vasculitis >From: "Erina" erina@btinternet.com [quoted text clipped - 5 lines] >Warm wishes >Erina Seems to me the name Oliveira DB rings a bell ..? Is she the same person who 'rang the alarm' as to the persecution she encountered when she 'stepped up' and attempted to 'discuss' the problems she found with the trials of the iron binder / chelator desferrioxamine .. ? She is heavily into the iron studies and she might not be adverse to attempting to understand the implications of too much iron in the body .. which leads to a depletion of 'anti'oxidants. Vasculitis has been recently SHOWN to be implicated in the SAME syndrome .. iron overload. **For the first time, we present one patient with vasculitis of the central nervous system associated with systemic hemochromatosis in superficial siderosis. Therapeutic approach included immunosuppressive therapy and venupunctures in the patient with vasculitis and hemochromatosis, and symptomatic treatment with chelating agents and antioxidants. The patient remained clinically stable for the follow-up period of up to 2 years. CONCLUSIONS: Our case underlines the pathogenetic heterogeneity of superficial siderosis and favors the early diagnosis for prompt initiation of therapy. Besides treatment of the underlying condition, antioxidants and radical scavengers may be effective in halting the progression of the disease** Acta Neurol Scand. 2003 Jan;107(1):54-61. Related Articles, Links Superficial siderosis of the central nervous system: pathogenetic heterogeneity and therapeutic approaches. Leussink VI, Flachenecker P, Brechtelsbauer D, Bendszus M, Sliwka U, Gold R, Becker G. Department of Neurology, University of Wurzburg, Germany. verena.leussink@mail.uni-weurzburg.de OBJECTIVE: Superficial siderosis of the central nervous system (CNS) is a rare chronic progressive disorder caused by chronic subarachnoid hemorrhage. We present four patients with superficial siderosis of the CNS to describe the characteristic symptoms, and to discuss the pathogenetic heterogeneity and possible new therapeutic approaches. RESULTS: The causes of chronic subarachnoid bleeding in superficial siderosis were different. In two patients surgical treatment of ependymoma or cerebral cavernomas were the underlying diseases. No cause was detected in one patient. For the first time, we present one patient with vasculitis of the central nervous system associated with systemic hemochromatosis in superficial siderosis. Therapeutic approaches included exstirpation of cavernomas as the source of chronic bleeding in one patient, immunosuppressive therapy and venupunctures in the patient with vasculitis and hemochromatosis, and symptomatic treatment with chelating agents and antioxidants. The patients remained clinically stable for the follow-up period of up to 2 years. CONCLUSIONS: Our cases underline the pathogenetic heterogeneity of superficial siderosis and favor the early diagnosis for prompt initiation of therapy. Besides treatment of the underlying condition, antioxidants and radical scavengers may be effective in halting the progression of the disease. PMID: 12542514 [PubMed - indexed for MEDLINE] -------------------------------------------------------------------------- ------ >> >Subject: Vasculitis >> [quoted text clipped - 6 lines] >> Division of Renal Medicine, St George's Hospital Medical School, Cranmer >> Terrace, London SW17 0RE, UK. z.wu@sghms.ac.uk >> PMID: 11867563 [PubMed - indexed for MEDLINE] >> >> -------------------------------------------------------------------------- Who loves ya. Tom SignatureJesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking |
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