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Medical Forum / Diseases and Disorders / Lupus / June 2009Chelation In Thrombosis
Modification of fibrin structure as a possible cause of thrombolytic resistance Journal of Thrombosis and Thrombolysis Boguslaw Lipinski1 (1) Department of Genetics and Epidemiology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA Published online: 24 June 2009 Abstract This paper presents a concept according to which free radicals, specifically the most biologically active hydroxyl radicals, induce structural modifications in fibrin(ogen) molecules making them resistant to proteolytic degradation. Such changes are analogous to those in congeneticaly altered fibrinogen that give rise to plasmin resistant fibrin clots and consequently to thrombosis. In view of the fact that hydroxyl radicals are generated in the Fenton reaction in the presence of iron and/or copper ions, the use of chelating agents to facilitate thrombolysis is rationalized. Moreover, the resistance of thrombi older than 3 h to proteolytic degradation may be abrogated by the administration of free radical scavengers, particularly those that can be neutralized by virtue of aromatic hydroxylation, such as salicylates and polyphenolic compounds. Keywords Free radicals - Fibrin(ogen) - Proteolysis - Chelating agents - Free radical scavengers Boguslaw Lipinski Email: boguslaw_lipinski@joslin.harvard.edu ----------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Two words for you Tom; birth control. snip << Btch .. You got something to say about .. thrombosis .. ? You got something to say .. to .. me .. ? Heh .. heh .. Only online .. boi .. only online .. Take your little .. atheist .. self .. somewhere .. else .. You stinking .. atheists .. stink up the place .. Stinking .. little .. atheist .. btch .. Modification of fibrin structure as a possible cause of thrombolytic resistance Journal of Thrombosis and Thrombolysis Boguslaw Lipinski1 (1) Department of Genetics and Epidemiology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA Published online: 24 June 2009 Abstract This paper presents a concept according to which free radicals, specifically the most biologically active hydroxyl radicals, induce structural modifications in fibrin(ogen) molecules making them resistant to proteolytic degradation. Such changes are analogous to those in congeneticaly altered fibrinogen that give rise to plasmin resistant fibrin clots and consequently to thrombosis. In view of the fact that hydroxyl radicals are generated in the Fenton reaction in the presence of iron and/or copper ions, the use of chelating agents to facilitate thrombolysis is rationalized. Moreover, the resistance of thrombi older than 3 h to proteolytic degradation may be abrogated by the administration of free radical scavengers, particularly those that can be neutralized by virtue of aromatic hydroxylation, such as salicylates and polyphenolic compounds. Keywords Free radicals - Fibrin(ogen) - Proteolysis - Chelating agents - Free radical scavengers Boguslaw Lipinski Email: boguslaw_lipin...@joslin.harvard.edu ----------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk ----------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk On Jun 27, 7:30 am, ad hominem <firstline.emerge...@gmail.com> wrote:snip << Gearboxes .. atheists .. pedophiles .. psychopaths .. You all .. share .. that predatory nature .. don't ya .. shteater .. Giiiit .. shteater .. Atheist .. BTCH .. Modification of fibrin structure as a possible cause of thrombolytic resistance Journal of Thrombosis and Thrombolysis Boguslaw Lipinski1 (1) Department of Genetics and Epidemiology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA Published online: 24 June 2009 Abstract This paper presents a concept according to which free radicals, specifically the most biologically active hydroxyl radicals, induce structural modifications in fibrin(ogen) molecules making them resistant to proteolytic degradation. Such changes are analogous to those in congeneticaly altered fibrinogen that give rise to plasmin resistant fibrin clots and consequently to thrombosis. In view of the fact that hydroxyl radicals are generated in the Fenton reaction in the presence of iron and/or copper ions, the use of chelating agents to facilitate thrombolysis is rationalized. Moreover, the resistance of thrombi older than 3 h to proteolytic degradation may be abrogated by the administration of free radical scavengers, particularly those that can be neutralized by virtue of aromatic hydroxylation, such as salicylates and polyphenolic compounds. Keywords Free radicals - Fibrin(ogen) - Proteolysis - Chelating agents - Free radical scavengers Boguslaw Lipinski Email: boguslaw_lipin...@joslin.harvard.edu ----------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk |
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