On May 10, 10:59 am, lo...@park.com wrote:
Porphyria cutanea tarda in pre-existent lupus erythematosus--is there
an association?"Not on the basis of the abstract posted there isn't.
<<

Listen up .. dckhd ..

The title of the article it's .. name .."is there an association ?" ..
is named that
FOR a **reason**.

The authors and peer reviewers AGREED that the title OF the article
should BE .. "is there an association .. ?" .. as a CALL TO ARMS so to
speak ..

YOUR casual comment makes one believe you to be a .. coward ..

It would go with your nature .. wouldn't it .. cowboy ..

Heh .. heh ..

How could Lupus be linked to an iron OVERLOAD disease.
Everybody says lupus patients are iron DEFICIENT.

Porphyria cutanea tarda in pre-existent lupus erythematosus--is there
an association?
Int J Dermatol. 2007 Nov;46 Suppl 3:50-2.
van Tuyll van Serooskerken AM, Habets JM, Badeloe S, Poblete-
Gutiérrez
P, Frank J.
Department of Dermatology and Euregional Porphyria Center Maastricht-
Aachen (EPCMA), University Hospital Maastricht, Maastricht, The
Netherlands. a...@sder.azm.nl

In lupus erythematosus (LE), vesicles and bullae are only rarely
seen.
However, in some instances such efflorescences might suggest an
association with distinct cutaneous diseases, including erythema
multiforme, toxic epidermal necrolysis or autoimmune blistering
disorders such as bullous pemphigoid, pemphigus vulgaris, and
dermatitis herpetiformis Duhring.
Another blistering disease that has been described in association
with cutaneous and systemic LE is porphyria cutanea tarda (PCT).
PCT is a metabolic disorder caused by a deficiency of the fifth
enzyme
in heme biosynthesis, uroporphyrinogen decarboxylase.
Here, we report on a 57-year-old Caucasian woman of Dutch origin with
a medical history of mild cutaneous LE who developed skin fragility,
blistering skin lesions, milia, and facial hypertrichosis.
Subsequent porphyrin analysis in urine and feces confirmed the
suspected simultaneous manifestation of LE and PCT.

PMID: 17973893
----------------

Measurement of liver iron content by magnetic resonance imaging
in 20 patients with overt porphyria cutanea tarda before phlebotomy
therapy: a prospective study.
Dereure O, Jumez N, Bessis D, Gallix B, Guillot B.
Department of Dermatology, University of Montpellier I,
Hôpital Saint Eloi, Montpellier, France. o-dere...@chu-montpellier.fr

Liver iron content was evaluated by a magnetic resonance imaging-
based
method in 20 consecutive patients with either sporadic or familial
porphyria
cutanea tarda.
Serum ferritin, hepatitis C infection and the presence of the 2 main
mutations
of the hemochromatosis gene were also investigated.
All patients showed good clinical response to phlebotomy.
Initial liver iron content was normal (< 40 micromol/g) in 9 cases,
slightly
increased (40-59 micromol/g) in 3 cases, moderately increased
(60-99 micromol/g) in 6 cases or markedly increased (100-199
micromol/
g)
in 2 cases).
The ferritin level was raised (> 400 ng/ml) in 14/20 patients and
there was
no obvious relationship with liver iron.
Increased liver iron content was observed more frequently in patients
with
hemochromatosis mutation and less frequent in those with hepatitis C
infection.
Clinical response to phlebotomies was slightly better in patients
with
increased
liver iron content even slightly, but patients with normal liver iron
content also
responded well, which suggests that iron depletion is an outstanding
treatment
independent of liver iron content.
This study shows that increased liver iron content is not a constant
finding
in patients with porphyria cutanea tarda, especially in women, and
that it is
not a prerequisite for the efficiency of phlebotomy.

PMID: 18709302

Who loves ya.
Tom

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