[]

Could it be some component of the mix, not the active drug? Carrier or
preservative?

That's my info too.

I believe that the course is 3 or 4 infusions, and either cannot be
repeated or is ineffective if it is.

Hi George, How are you doing after over a week of no  plaquinal? Right
now my left hand
is swollen and purple  but the Doctor yesterday did not suggest giving
up the plaquinil
just upping the prednisone.  Have taken plaquinil for over 25 years
with no bad
results except for big purple blotches on my hands and arms....Always
had an ambition
to be a super show-girl in Vegas   but guess I had better give up that
dream          ruth

George,
My book called "Worst Pills, Best Pills II...an older adult's guide to Avoiding
Drug induced death or illness"  for Plaquenil
lists dark discoloration of  the skin, nails or inside of mouth, skin rash or
itching,  also mentions unusual bleeding or bruising

Before you Use this drug tell your doctor if you have or have had
allergies to drugs
alcohol dependence
liver problems
severe blood disorders
gastrointestinal disease
glucose-5-phosphate dehydrogenase deficiency
disorders of the nervous system or seizures
psoriasis
eye diseases

Do not drink this alcohol.
___________________________________________________________
Pamidronate
http://www.pamidronate.com/index.jsp?usertrack.filter_applied=true&NovaId=785277
3814828979568#isi

In post-marketing experience, severe and occasionally incapacitating bone,
joint, and/or muscle pain has been reported in patients taking bisphosphonates.

The most common adverse events in bone metastases clinical trials regardless of
causality were as follows: Fluid overload, generalized pain, hypertension,
abdominal pain, anorexia, constipation, nausea, vomiting, urinary tract
infection, bone pain, fever, back pain, arthrosis, headache, anemia,
hypocalcemia, arthralgias, myalgias, and dyspnea.

Caution is advised when IV bisphosphonates are administered with potentially
nephrotoxic drugs.

Patients should be administered an oral calcium supplement of 500 mg and a
multiple vitamin containing 400 IU of vitamin D daily.

Click here for full prescribing information.
http://www.pharma.us.novartis.com/product/pi/pdf/aredia.pdf'
---------------------------------------------------------
When I first read your description it, reminded me of a cancer patient, who had
fluids leaking out of almost every area of his pelois and legs.  I was thinking
edema, lymphedma... or a clot in your arm, combined with the fluid leaking or
infection. If it's dark you would not be able to see red streaks that are a
classic sign of a very serious infection (I forget the name).
Maybe you should run these by someone at ER?  Surely they could rule some things
out and give you an opinion about what's happening?

J - wondering if part of the problem was from the Plaquenil and part of the
problem is the Pamidronate