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Medical Forum / Diseases and Disorders / Lupus / September 2008Preventing Oxidative Stress
"170 g of raisins" One very distinct difference. The raisins work immediately. The supplementation began a month before. "Intense exercise increases lipid peroxidation" ----------------------------- Supplementation with Vitamins C and E May Reduce Exercise-Induced Oxidative Damage in Male Athletes Summary: In a randomized, double-blind, placebo-controlled study involving 14 male amateur trained runners, results indicate that supplementation with vitamins C and E may reduce exercise-induced oxidative damage. The subjects were randomized to 152 mg vitamin C + 50 mg vitamin E or placebo daily for a period of 1 month before participating in a half- marathon race. Blood samples were drawn before the race, after the race, and after 3 hour recovery. Post-race lymphocyte malondialdehyde levels increased in the placebo group alone. Post-race catalase and glutathione peroxidase activities increased in the vitamin-supplemented group alone, whereas superoxide dismutase activity increased in the vitamin and placebo groups. Additionally, heme oxygenase-1 expression increased and Bcl-2 expression decreased post-race in the placebo group alone. Thus, the authors of this study conclude, "Intense exercise increases lipid peroxidation, decreases Bcl-2 expression and induces an antioxidant response in lymphocytes. Supplementation with moderate levels of antioxidant vitamins reduces exercise-induced oxidative damage, but without blocking the cellular adaptation to exercise." Keywords: OXIDATIVE STRESS, OXIDATIVE DAMAGE, EXERCISE - Vitamin C, Vitamin E Reference: "Influence of an Antioxidant Vitamin-Enriched Drink on Pre- and Post-Exercise Lymphocyte Antioxidant System," Sureda A, Pons A, et al, Ann Nutr Metab, 2008; 52(3): 233-240. (Address: Laboratori de Ciències de l'Activitat Física, Departament de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Palma de Mallorca, Spain). ------------------------- Raisins are a good source of antioxidants with a high ORAC value (oxygen radical absorbance capacity). In a randomized, placebo-controlled, cross-over study the researchers investigated the effect of raisins on urinary 8-oxo-d'-deoxyguanosing (8-oxo-2'-dG), a specific marker for DNA damage due to oxidative stress. Four male and four female healthy adult athletes ran a triathlon twice, two weeks apart. Subjects were divided into two groups and received either 170 g of raisins or a glucose drink of equivalent caloric value prior to the swim and halfway through the bike ride and run. The groups were reversed during the second triathlon. Those who consumed the raisins showed virtually no oxidative damage (0.05 µL 8-oxo-2'-dG) compared to those on glucose (1.06 µL). http://www.medicalpost.com/mdlink/english/members/medpost/data/3840/26D. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk On Aug 12, 9:02 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote: oxidative stress << "Reducing the risk of chronic diseases related to oxidative stress" Effects of dietary vitamin E, C and soybean oil supplementation on antioxidant enzyme activities in liver and muscles of rats. Shireen KF, Pace RD, Mahboob M, Khan AT Food Chem Toxicol 2008 Jul 29. The effect of elevated levels of dietary vitamin E, C and a combination of vitamin E and C (E&C) with soybean oil on activities of antioxidant (AOE) enzymes important in the protection against lipid peroxidation was studied in male rats fed with vitamin C (12mg/g), vitamin E (3.68mg/g) or E&C (3.68mg+12mg/g) supplemented diets for 28 days. Catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) activity in liver, pectoralis major (PM) and sartorius (S) muscles was increased significantly in rats fed with dietary vitamin C, E separately, and vitamin C&E combination, except, superoxide dismutase (SOD), which showed no alterations. These results clearly indicated that vitamin E&C separately and E&C together increased AOE activity in liver, PM and S muscle of rats. However, vitamin E and C combination enhanced AOE activity more significantly and our findings suggest the possible role of vitamin C&E and their combination in reducing the risk of chronic diseases related to oxidative stress. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > "170 g of raisins" > [quoted text clipped - 65 lines] > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk On Aug 19, 7:05 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote: Oxidative stress << "Amelioration by dietary or pharmacological antioxidants" Rheumatology, Vol 38, 529-534, Copyright © 1999 by British Society for Rheumatology -------------------------------------------------------------------------------- ORIGINAL PAPERS Oxidative stress in systemic lupus erythematosus and allied conditions with vascular involvement PR Ames, J Alves, I Murat, DA Isenberg and J Nourooz-Zadeh Department of Haematology, St Thomas' Hospital, London, UK. OBJECTIVE: To evaluate the occurrence and clinical significance of lipid peroxidation (oxidative stress) in rheumatic diseases characterized by vascular involvement. PATIENTS AND METHODS: Plasma 8- epi-PGF2alpha (oxidative stress marker) was measured by gas chromatography-mass spectrometry in 36 patients with systemic lupus erythematosus (SLE), 13 with systemic sclerosis (SSc), 13 with systemic vasculitis [Wegener's granulomatosis (WG), n = 4; Churg Strauss syndrome (CSS), n = 3; Behcet syndrome, n = 6], 12 with rheumatoid arthritis (RA) and in 23 healthy controls (n = 23). RESULTS: 8-epi- PGF2alpha levels were higher in patients with SLE (P = 0.007), SSc (P < 0.001) and vasculitis (P = 0.001) than in controls. In SLE, a positive Coombs' test and arterial hypertension independently predicted 8-epi- PGF2alpha concentrations (P = 0.004 and P = 0.001, respectively). SLE patients not taking prednisolone showed higher 8- epi-PGF2alpha concentrations than SLE patients on prednisolone (P = 0.02). In the latter group, a dose response relationship was noted between 8-epi- PGF2alpha and steroid dosage (r = 0.6, P = 0.0003). In WG and CSS, 8- epi-PGF2alpha concentrations correlated with disease activity (r = 0.8, P = 0.01) and were higher than in patients with Behcet disease (P = 0.003). CONCLUSIONS: Oxidative stress may be pathogenetically relevant in some autoimmune rheumatic diseases with vascular involvement. Amelioration of some clinical manifestations of these diseases may be envisaged by targeting lipid peroxidation with dietary or pharmacological antioxidants. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk On Aug 28, 10:38 am, ironjustice <ironjust...@cashette.com> wrote:Oxidative stress << "Oxidative stress may contribute to debilitating symptoms in SLE" Oxidative stress in systemic lupus erythematosus: relationship to disease activity and symptoms I Avalos Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA; Divisions of Rheumatology and Clinical Pharmacology, T-3219 MCN, Vanderbilt University School of Medicine, 1161 21st Ave South Nashville, TN 37232-6248, USA; ingrid.avalos@vanderbilt.edu C P Chung A Oeser Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA G L Milne Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA J D Morrow Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA T Gebretsadik A Shintani C Yu Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA C M Stein Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA Oxidative stress may play a role in the pathogenesis of systemic lupus erythematosus (SLE). We examined the hypothesis that oxidative stress was associated with indices of lupus disease activity and severity of symptoms. Urinary F2 isoprostane excretion, a validated marker of oxidative stress, was measured in 95 patients with SLE and 103 healthy controls. Outcome measures included SLEDAI and SLICC scores, the modified health assessment questionnaire, the fatigue severity scale (FSS), and visual analogue scales (VAS) for fatigue, pain and overall disease activity. F2 isoprostane excretion was compared in patients and controls, and its relationship with clinical variables in SLE examined. F2 isoprostane excretion did not differ significantly among patients with lupus (2.7 ± 2.3 ng/mg Cr) and control subjects (2.2 ± 1.4 ng/mg Cr) (P = 0.70). In patients with lupus, F2 isoprostane concentrations were independently associated with higher patient reported disease activity (VAS) (OR = 1.52, P = 0.01), fatigue (FSS, OR = 1.52, P = 0.03) and lower quality of life (OR = 0.73, P = 0.05), but not with objective markers or inflammation or disease activity. In conclusion, F2 isoprostane excretion is associated with patient- reported symptoms in SLE but not with measures of inflammation, SLEDAI or SLICC. Oxidative stress may contribute to debilitating symptoms such as fatigue in SLE. Key Words: isoprostanes • oxidative stress • systemic lupus erythematosus Lupus, Vol. 16, No. 3, 195-200 (2007) DOI: 10.1177/0961203306075802 Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk "Oxidative stress may contribute to debilitating symptoms in SLE"<< Serum oxidant/antioxidant status of patients with systemic lupus erythematosus. Taysi S, Gul M, Sari RA, Akcay F, Bakan N. Department of Biochemistry, Faculty of Medicine, Ataturk University, Erzurum, Turkey. Seytaysi@hotmail.com The levels of malondialdehyde and ceruloplasmin, and superoxide dismutase activity were higher, while transferrin concentration and the activities of glutathione peroxidase and catalase were lower in serum of patients with systemic lupus erythematosus (n=24) compared with healthy controls (n=20). Disease activity index correlated positively with serum malondialdehyde level (r=0.47, p<0.05), erythrocyte sedimentation rate (r=0.41, p<0.05) and C-reactive protein concentration (r=0.41, p<0.05), while it correlated negatively with serum superoxide dismutase (r=0.42, p<0.05) and glutathione peroxidase (r=-0.44, p<0.05) activities in patients. No such correlations were found in healthy control subjects. It remains to be seen whether correlations found between disease activity score and serum malondialdehyde level, and also activities of serum superoxide dismutase and glutathione peroxidase enzymes observed in the present study may be used to predict prognosis in patients with systemic lupus erythematosus. PMID: 12241014 Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk On Aug 19, 7:05 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote: "Reducing the risk of chronic diseases related to oxidative stress" Effects of dietary vitamin E, C and soybean oil supplementation on antioxidant enzyme activities in liver and muscles of rats. << What recipes use raisins and soybean oil / lecithin .. ? Raisin bread .. Mmmm .. http://www.redorbit.com/news/health/850503/your_life_health_news/inde... Your LIFE: HEALTH NEWS By MADELEINE BAILEY Soya eases sore eyes SOYA lecithin, an ingredient found in margarine, has been found to cure and prevent dry eye syndrome. This condition affects up to four million people in the UK and is caused by ageing, contact lenses, central heating, air conditioning and staring at computer screens. Eyes become dry and sore and if not treated their surface layer could end up damaged. Soya lecithin helps stop the eyes' moisture from evaporating. In a clinical trial of 382 people, 89 per cent of sufferers reported an improvement. (c) 2007 Daily Mirror. ------------------------- http://www.irishpharmacist.ie/ New soya-based dry eye treatment launched A spray treatment for dry eye conditions that uses soya lecithin to mimic the eye’sown lipid layer has been launched in Ireland. Clarymist, which is sprayed on toclosed rather than open eyes, was developed to treat dry eye syndrome, which a 2000 study1 suggested affects 10% of the population. Soya lecithin acts as an analogue to the eye’s lipid layer, which controls the rate of evaporation of tear fluid.The manufacturers say that most dry eye cases are caused by a deficient or disrupted lipid layer, which leads to abnormally fast evaporation of tears and subsequent irritation. Clarymist stabilises this lipid layer,thus sealing in the tears and alleviating the burning, scratching and grittiness associated with dry eye syndrome.By spraying Clarymist on to the closed eyelid, an even distribution of natural oils across the outer surface of the tear film is ensured through blinking action.One of the main reasons the lipid layer is disrupted is because of insufficient blinking, which typically occurs during long hours spent in front of a computeror television.Other contributing factors to dry eyes are dehydration due to central heating and air-conditioning,various prescription drugs and ailments,such as rheumatoid arthritis and diabetes. Contact lens wearers are also prone to dry eye conditions,which may worsen with ageing.Optometrist and senior lecturer in optometry at Aston University, UK, Dr Frank Eperjesi, said: “Clarymist is the first dry eye treatment of its kind and will come as a welcome relief to many sufferers.The extensive clinical research behind it alsoshows its values as a treatment for the causes rather than the symptoms of dry eyes. It is asignificant breakthrough in eye health. ”Clarymist’s RRP is €19.95 for 10ml. Reference1. Albietz J. Prevalence of dry eyesubtypes in clinical optometric practice.Optometry and Vision Science 2000; 77: 357-63 --------------------- http://rosacea.ii.net/news/2005/11/dry-eye-and-linoleic-acid.html Systemic linoleic and gamma-linolenic acid therapy in dry eye syndrome with an inflammatory component. Cornea, 2003 Mar;22(2):97-101. Barabino S, Rolando M, Camicione P, Ravera G, Zanardi S, Giuffrida S, Calabria G. Department of Neurosciences, University of Genoa, via Siccardi 14, 18030 Sanremo, Genoa, Italy. Abstract: Purpose. To evaluate the efficacy and anti-inflammatory activity of systemic linoleic (LA) and [gamma]-linolenic acid (GLA), which decrease chronic inflammation in rheumatoid arthritis, on the ocular surface of patients with keratoconjunctivitis sicca. Methods: In a randomized clinical trial, 26 patients with aqueous- deficient keratoconjunctivitis sicca were consecutively selected from patients presenting to Department of Neurosciences, Ophthalmology and Genetics, University of Genoa. The diagnosis was based on dry eye symptom survey score, Schirmer-1 test values, positive vital staining with lissamine green, and fluorescein break-up time (FBUT). All patients had ocular surface inflammation based on HLA-DR expression, a major histocompatibility class II antigen, on epithelial bulbar conjunctiva samples. The subjects were randomly divided into two groups of 13 patients each. The study group received tablets containing LA (28.5 mg) and GLA (15 mg) twice daily for 45 days and used tears; the control group received a tear substitute and a placebo tablet for 45 days. Results: Statistically significant changes in symptoms (p < 0.005), lissamine green staining (p < 0.005), and ocular surface inflammation (p < 0.05) occurred in the study group compared with controls. HLA-DR expression varied from 58.5 +/- 14.1% positive conjunctival cells to 41.3 +/- 18.9% in the treated group and from 61.4 +/- 21.9% to 58.0 +/- 13.3% in the controls. No statistically significant difference between groups was found for FBUT and the Schirmer-1 test. Conclusions: Therapy with LA and GLA and tear substitutes reduces ocular surface inflammation and improves dry eye symptoms. Long-term studies are needed to confirm the role of this new therapy for keratoconjunctivitis sicca. --------------------------- http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/pho_028... Saturated fatty acids, such as palmitic and stearic, make up 19 to 24% of soya lecithin; the monounsaturated oleic acid contributes 9 to 11%; linoleic acid provides 56 to 60%; and alpha-linolenic acid makes up 6 to 9%. http://en.wikipedia.org/wiki/Gamma-linolenic_acid gamma-Linolenic acid (GLA) is an omega-6 essential fatty acid found primarily in vegetable oils. The human body produces GLA from linoleic acid (LA). Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Hey, Rusty. welcome. Guess there's no point in you telling me about how you don't want me on 'your' threads, since I already said I wouldn't be on them if you didn't include alt.med.fibromyalgia in your crosspostings. Yet here you are. Your invitation to me. Just wanted to mention that your link about Jesus being a vegetarian hasn't been functional for quite a while. Not that it's a particular loss. On Aug 13, 12:02 am, "ironjust...@aol.com" <ironjust...@aol.com> wrote: > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk On Aug 19, 8:24 pm, Michael B <baugh...@bellsouth.net> wrote: snip << Lefty .. you've been told to stay off my posts .. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk |
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