In message
<4dec4509-e16c-47d8-a939-788f4cf758d8@k13g2000hse.googlegroups.com>, Dr
Nympho <vegetarian.p@googlemail.com> wrote

I've never heard of anyone being a "carrier" of Hughes Syndrome, in the
sense that you can carry a gene for blue ears and if you marry another
carrier a known percentage (eg 50%) of your children will have blue
ears.

The general medical view seems to be that one can carry (and hence pass
on) genes that increase the chance of your getting autoimmune disease,
but whether you actually develop one depends on the random happening of
other factors, probably including environment, illnesses especially
virusus, etc. It's not 'certain' that you'll get it in the way that it's
certain that half your offspring will have blue ears.

I am sure, however, that some people will assert that Hughes Syndrome is
directly inherited; or is caused by bad diet, excessive metals,
inappropriate attitude, or improper thoughts. They have yet to prove
their case.

have to start with differentiating between the forms:

The term "primary antiphospholipid syndrome" is used when APS occurs in
the absence of any other related disease. APS is commonly seen in
conjunction with other autoimmune diseases;

the term "secondary antiphospholipid syndrome" is used when APS coexists
with other diseases such as systemic lupus erythematosus (SLE).

In rare cases, APS leads to rapid organ failure due to generalised
thrombosis and a high risk of death; this is termed "catastrophic
antiphospholipid syndrome".

http://www.genome.gov/17516396

"Although APS has been reported to occur in multiple members of the same
family, no clear inheritance pattern has been identified and no gene has
been found to be the sole cause of this condition. One report in 1999
studied families with more than one affected member, examined possible
modes of inheritance, and examined links with certain genes. In seven
families, 30 out of 101 family members met diagnostic criteria for the
syndrome. The data were fitted best by either a dominant (one copy of
the altered gene inherited from one parent causes the condition) or
codominant (features related to the condition from both parents are
observed) model."

you might want to look at
http://www.apsfa.org/
http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Antiphospholi
pid%20Syndrome