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Medical Forum / Diseases and Disorders / Lupus / January 2008Phytate In Disguise
Since phytate has gone up against etidronate .. who IS this .. etidronate .. ? This study the author simultaneously speaks to etidronate as the drug used and then switches right into .. risedronate .. so they must consider bisphosphonates .. or some bisphosphonates to BE .. relatively the same .. ? http://tinyurl.com/3yttlg "Fractures occurred in 7 patients in the placebo group and one patient in the risedronate group. The relative risk in the risedronate group as compared with the placebo group was 0.14 (95% confidence interval, 0.02 to 1.11). The number of fractures per 1000 patient-years was 14 and 92 for the etidronate and placebo groups, respectively. Treatment with etidronate prevents further loss of BMD in patients with ALS and leads to the prevention of fractures." Etidronate for fracture prevention in amyotrophic lateral sclerosis: A randomized controlled trial. Author(s): Sato Y, Honda Y, Iwamoto J Affiliation(s): Department of Neurology, Mitate Hospital, 3237 Yugeta, Tagawa 826-0041, Japan. Publication date & source: 2006-11, Bone., 39(5):1080-6. Epub 2006 Jun 14. Publication type: Incidence of fractures is high in patients with amyotrophic lateral sclerosis (ALS) as compared to age-matched healthy controls. Our previous cross-sectional study showed that immobilization-induced hypercalcemia (i.e., increased bone resorption) and 25-hydroxyvitamin D (25-OHD) deficiency contribute to reduced bone mineral density (BMD). This study aims to address the possibility that treatment with etidronate may reduce the bone resorption and lower the incidence of fractures in patients with ALS. ALS patients were randomly assigned to daily treatment with 400 mg of etidronate (n = 41) or a placebo (n = 41) and followed for 2 years. At baseline, both groups had low BMD with high levels of serum ionized calcium and pyridinoline cross- linked carboxy-terminal telopeptide of type I collagen (ICTP). In the etidronate group, serum calcium and ICTP levels decreased significantly during the study period, while the levels in the placebo group were increased. Over 2 years, serum 25-OHD reduced to the potentially osteomalacic level (less than 5 mg/mL) in both groups. BMD decreased by 3.6% in the etidronate group and decreased by 12.1% in the placebo group (P < 0.0001). Fractures occurred in 7 patients in the placebo group and one patient in the risedronate group. The relative risk in the risedronate group as compared with the placebo group was 0.14 (95% confidence interval, 0.02 to 1.11). The number of fractures per 1000 patient-years was 14 and 92 for the etidronate and placebo groups, respectively. Treatment with etidronate prevents further loss of BMD in patients with ALS and leads to the prevention of fractures. Index of Published Studies Page last updated: 2006-11-04 ----------------------------------------------- You know there seems to be a bisphosphonate found in your .. grub. Phytate / phytic acid .. found in the chaff of your grain and in your plants compared to .. etidronate. http://tinyurl.com/2wuhuk Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Since phytate has gone up against etidronate .. who IS this .. etidronate .. ? << http://www.abdn.ac.uk/R&I/business/bone_res.shtml Business & Research > Commercialisation > Innovation Showcase > Novel bone resorption inhibitors Innovation Showcase Novel bone resorption inhibitors Potential: We have discovered a novel class of compounds that have potent inhibitory effects on bone resorption as assessed by studies using various in vitro assay systems. We believe that these compounds may be of clinical value in the prevention and treatment of osteoporosis and other disorders associated with increased bone resorption. The potential market for these drugs is huge. The osteoporosis market alone in the U.S.A. is thought to comprise 30 million patients and is worth approximately $2.0 Billion (U.S.) Inhibitors of bone resorption are also used to treat many common bone diseases including cancer- associated bone disease, hypercalcaemia, and Paget's disease of bone. Technology: The project is in the area of biotechnology using cell culture based assays and other model systems to develop novel inhibitors of bone resorption. Concept: We already have evidence that the compounds we have discovered are effective at inhibiting bone breakdown in vitro. The Proof of Concept to be tested is that these compounds can be developed into effective drugs for the treatment of patients with bone disease in clinical practice. Contact: Dr Liz Rattray Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > This study the author simultaneously speaks to etidronate as the drug > used and then switches right into .. risedronate .. so they must [quoted text clipped - 67 lines] > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk On Jan 7, 8:55 am, ironjustice <ironjust...@cashette.com> wrote: Since phytate has gone up against etidronate .. who IS this .. etidronate .. ? << "Bisphosphonate drugs include: Risedronate brand name Actonel Alendronate brand name Fosamax Ibandronate brand name Boniva" http://arthritis.about.com/od/actonelrisedronate/a/osteoarthritis.htm Risedronate (Actonel) May Slow Joint Destruction In Knee Osteoarthritis From Carol & Richard Eustice, Your Guide to Arthritis. FREE Newsletter. Sign Up Now! About.com Health's Disease and Condition content is reviewed by Kate Grossman, MD Osteoporosis Drug May Also Delay Need For Joint Replacement Surgery Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Since phytate has gone up against etidronate .. who IS this .. > etidronate .. ? << [quoted text clipped - 118 lines] > > - Show quoted text - phytate has gone up against the bisphosphonate etidronate << This is taken from the site below and it is an anti soy site .. but it does show how the world looks at this natural substance found in your food .. this natural .. cancer killing rheumatoid arthritis curing .. bisphosphonate. http://www.rheumatic.org/soy.htm Soybeans are also high in phytic acid or phytates. This is an organic acid, present in the bran or hulls of all seeds, which blocks the uptake of essential minerals-calcium, magnesium, iron and especially zinc-in the intestinal tract. Although not a household word, phytates have been extensively studied. Scientists are in general agreement that grain and legume based diets high in phytates contribute to widespread mineral deficiencies in third world countries. Analysis shows that calcium, magnesium, iron and zinc are present in the plant foods eaten in these areas, but the high phytate content of soy and rice based diets prevents their absorption. The soybean has a higher phytate content than any other grain or legume that has been studied. Furthermore, it seems to be highly resistant to many phytate reducing techniques such as long, slow cooking. Only a long period of fermentation will significantly reduce the phytate content of soybeans. Thus fermented products such as tempeh and miso provide nourishment that is easily assimilated, but the nutritional value of tofu and bean curd, both high in phytates, is questionable. When precipitated soy products are consumed with meat, the mineral blocking effects of the phytates are reduced. The Japanese traditionally eat tofu as part of a mineral-rich fish broth. Vegetarians who consume tofu and bean curd as a substitute for meat and dairy products risk severe mineral deficiencies. The results of calcium, magnesium and iron deficiency are well known, those of zinc are less so. Zinc is called the intelligence mineral because it is needed for optimal development and functioning of the brain and nervous system. It plays a role in protein synthesis and collagen formation, it Is involved in the blood sugar control mechanism and thus protects against diabetes; it is needed for a healthy reproductive system. Zinc is a key component in numerous vital enzymes and plays a role in the immune system. Phytates found in soy products interfere with zinc absorption more completely than with other minerals. Literature extolling soy products tends to minimize the role of zinc in human physiology, and to gloss over the deleterious effect of diets high in phytic acid. Milk drinking is given as the reason second generation Japanese in America grow taller than their native ancestors. Some investigators postulate that the reduced phytate content of the American diet-whatever maybe its other deficiencies-is the true explanation, pointing out that Asian and Oriental children who do not get enough meat and fish products to counteract the effects of a high phytate diet, frequently suffer rickets, stunting and other growth problems. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > On Jan 7, 8:55 am, ironjustice <ironjust...@cashette.com> wrote: Since > phytate has gone up against etidronate .. who IS this .. [quoted text clipped - 149 lines] > > - Show quoted text - phytate has gone up against the bisphosphonate etidronate << They'd have us believe .. peas .. will kill us .. too .. ? http://www.ingentaconnect.com/content/jws/jsfa/2001/00000081/00000012/art00918 Phytate content and phytate degradation by endogenous phytase in pea (Pisum sativum) Authors: Fredrikson M.1, *; Alminger M.L.1; Carlsson N-G.1; Sandberg A- S.1 Source: Journal of the Science of Food and Agriculture, Volume 81, Number 12, 15 September 2001 , pp. 1139-1144(6) Publisher: John Wiley & Sons, Ltd. Abstract: In order to rapidly reduce the content of inositol tri-hexaphosphates in pea flour by action of the endogenous phytase, raw materials as well as incubation conditions have been evaluated. The phytate (inositol hexaphosphate) content was analysed in 27 pea varieties; the influence of storage time and the difference in phytate content between the germ and the cotyledon were determined. Furthermore, degradation of inositol phosphates by the endogenous phytase enzyme was studied in pea flour, germ and cotyledon. To find the maximum phytate degradation, the effects of temperature and pH during pea flour incubation were investigated. The most efficient phytate degradation in pea flour incubation was achieved at pH 7.5 and 45 °C. At this condition an almost complete degradation of phytate and a 66% reduction in the sum of inositol hexa-, penta-, tetra- and triphosphates were reached in 10 h. The storage time of pea seeds or removal of the germ did not have a major effect on the phytate content. Since several inositol pentaphosphate isomers were produced during phytate degradation, it can be concluded that peas contain several phytate-degrading enzymes, or one phytate-degrading enzyme with unspecific initial hydrolysation pattern. (c) 2001 Society of Chemical Industry. Keywords: Pisum sativum; inositol phosphate; phytate; phytase Language: English Document Type: Research article DOI: 10.1002/jsfa.918 Affiliations: 1: * Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > phytate has gone up against the bisphosphonate etidronate << > [quoted text clipped - 223 lines] > > - Show quoted text - On Jan 8, 9:32 am, ironjustice <ironjust...@cashette.com> wrote:Scientists are in general agreement that grain and legume based diets high in phytates contribute to widespread mineral deficiencies in third world countries. << These would be the .. **same** .. guys it has been shown to be **killing** millions of children with malaria by giving them .. iron supplementation. http://tinyurl.com/33apsu "For a number of years, there has been a concern about giving iron to populations, particularly children, that have malaria, and this seems to have been borne out in this study," said Mr. Black. " Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > phytate has gone up against the bisphosphonate etidronate << > [quoted text clipped - 223 lines] > > - Show quoted text - |
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