"The anti-inflammatory properties of bisphosphonates give the
rationale for the use of these compounds"

Since phytate found in your foods has been shown to be a
"crystallization inhibitor" compared to bisphosphonate another ..
"crystallization inhibitor" .. then one might dedeuce .. phytate to be
a .. bisphosphonate .. a natural bisphosphonate.
Phytate is found in the brown of your grain and in plants to a lesser
extent.

Summary
Expert Opinion on Pharmacotherapy
January 2005, Vol. 6, No. 1, Pages 35-43
(doi:10.1517/14656566.6.1.35)

Bisphosphonates as anti-inflammatory agents in ankylosing spondylitis
and spondylarthropathies
Éric Toussirot‌, Daniel Wendling‌
University Hospital Jean Minjoz Bd Fleming, Department of
Rheumatology, F-25030 Besançon, Cédex, France. eric.toussirot@ufc-
chu.univ-fcomte.fr

NSAIDs remain the cornerstone of the treatment of ankylosing
spondylitis (AS) and spondylarthropathies (SpA), and have been
successfully used for a long time in these diseases. However, some
patients remain refractory or intolerant to NSAIDs and new effective
treatments have recently emerged, namely TNF-α-blocker agents. Other
therapeutic options targeting the bone, such as bisphosphonates, have
also been tried in refractory AS or SpA patients. The anti-
inflammatory properties of bisphosphonates give the rationale for the
use of these compounds in AS and SpA, and include the inhibition of
antigen presenting cells, the modulation of pro-inflammatory cytokine
generation, and also a decreased bone mass in AS. Open trials using
pamidronate gave favourable results, and one controlled study
comparing the efficacy of pamidronate 10 versus 60mg showed that the
60mg dose was effective in AS. Further studies are required to confirm
these preliminary data and to better determine the optimal regimen
(dosage and rhythm) of administration.

"Etidronate versus Phytate"

I guess this answers the question whether phytate IS .. simply ..  a
bisphosphonate .

"Etidronate belongs to a class of medications called bisphosphonates"

Circulation journal : official journal of the Japanese Circulation
Society
Vol.71, No.7(20070620) pp. 1152-1156
Japanese Circulation Society ISSN:13469843
Bibliography

Effect of Crystallization Inhibitors on Vascular Calcifications
Induced by Vitamin D : A Pilot Study in Sprague-Dawley Rats
Abstract
Background
Pathological calcification in soft tissues (ie, ectopic
calcification)
can have severe
consequences.
Hydroxyapatite is the common mineral phase present in all tissue
calcifications.
In general, the development of tissue calcifications requires a pre-
existing
injury as an inducer (heterogeneous nucleant), whereas further
progression requires the presence of other promoter factors (such as
hypercalcemia and/or hyperphosphatemia) and/or a deficiency in
calcification represser factors (crystallization inhibitors and
cellular defense mechanisms).
The present study investigated the capacity of etidronate (a
bisphosphonate
used in osteoporosis treatment) and phytate (a natural product) to
inhibit vascular
calcification in rats.
Methods and Results Six male Sprague-Dawley rats in each of the 3
treatment groups were
subcutaneously injected with either a placebo (physiological serum
solution), etidronate
(0.825μmol・kg^<-1>・day^<-1>) or phytate (0.825μmol・kg^<-1>・day^<-1>)
for 8 days.
Four days into this regimen, calcinosis was induced by subcutaneous
injections of 500,000 IU/kg
vitamin D at Oh, 24h and 48h.
Ninety-six hours after the final vitamin D injection, the rats were
killed and aortas and their hearts
were removed for histological and calcium analyses.
The data showed that phytate-treated rats had lower levels of aortic
calcium than placebo-treated rats.
All groups had similar heart calcium levels.
Conclusions
The present study found that phytate acted as a vascular
calcification
inhibitor.
Thus, the action of polyphosphates could be important in protecting
against vascular
calcification.

Grases Felix 1 Sanchis Pilar 2 Perello Joan 3 Isern Bernat 4 Prieto
Rafel M. 5 Fernandez-Palomeque Carlos 6 Torres Jose J 7
1Laboratory of Renal Lithiasis Research, University Institute of
Health Sciences Research (IUNICS), University of Balearic Islands
2Laboratory of Renal Lithiasis Research, University Institute of
Health Sciences Research (IUNICS), University of Balearic Islands
3Laboratory of Renal Lithiasis Research, University Institute of
Health Sciences Research (IUNICS), University of Balearic Islands
4Laboratory of Renal Lithiasis Research, University Institute of
Health Sciences Research (IUNICS), University of Balearic Islands
5Laboratory of Renal Lithiasis Research, University Institute of
Health Sciences Research (IUNICS), University of Balearic Islands
6University Hospital Son Dureta 7University Hospital Son Dureta
Keyword Crystallization inhibitors Etidronate Phytate Vascular
calcification Vitamin D

------------------------------------------

If bisphosphonate works so well and phytate / phytic acid / chaff of
grain .. IS .. a bisphosphonate / http://tinyurl.com/2pczbp.. then a
buckwheat pancake would be .. indicated?

http://tinyurl.com/2rxqnf

"In buckwheat and spelt wheat a considerable content (about 1% or
more) of phytic acid ( myoinositol phosphate) can be found."

Sooo .. since a pill of bisphosphonate is 200 mg .. then if one
calculates .. that would be what .. ? .. 100 grams of grain would
give
you one gram of phytate / phytic acid .. sooo .. one would need three
quarters of an ounce of wheat grain around twenty grams give or take
a
few grams .. ?

Jeez .. that would be pretty easy .. a bowl of .. barley soup or a
bowl of Red River Cereal .. ?

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk