WHEN increased red blood cells are accompanied BY ..
hypercoagulability .. a paradox .. ?

Think they are .. aware .. sickle cell IS .. erythrocytosis .. ?

I suppose that would be why they don't use .. bloodletting .. ?

Am J Med. 2003 Dec 15;115 (9):721-8 14693325
Hypercoagulability in sickle cell disease: a curious paradox.
[My paper] Kenneth I Ataga , Eugene P Orringer
There is evidence of activation of both blood coagulation and
platelets in sickle cell disease. For example, plasma samples obtained
in the steady state and during painful crisis demonstrate high levels
of thrombin generation, depletion of anticoagulant proteins, and
abnormal activation of the fibrinolytic system. Similarly, exposure of
surface markers such as CD62P and CD40L, along with increased
circulating levels of thrombospondin, signal platelet activation. In
addition to its effects on the cleavage of fibrinogen and its ability
to activate platelets, the increase in circulating thrombin levels,
with its wide-ranging effects on endothelial cells and blood vessels,
may be important in the pathophysiology of sickle cell disease.
Therefore, treatments that could decrease thrombin generation or
platelet activation may be beneficial in both the treatment of sickle
cell disease and the prevention of complications that characterize
this genetic disorder. This review discusses hypercoagulability in the
various forms of sickle cell disease, including homozygous sickle cell
anemia, hemoglobin SC disease, hemoglobin SD disease, and sickle cell-
beta-thalassemia.

Who loves ya.
Tom

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