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Medical Forum / Diseases and Disorders / Lupus / October 2007Porphyrin Levels in Lupus
Anybody want to .. guess .. WHY .. this .. little study showed CLEARLY increased porphyrin in lupus patients but when lupus patients are questioned .. ? .. They've never heard of a porphyrin. I wonder if they've heard of .. pyridoxal phosphate .. Thinking about it .. pyridoxine is a B vitamin and phosphate is .. phosphate .. and you know where b-vitamins and phosphates are .. found .. ? Vegetable lecithin is known for its' b-vitamins AND is known for its' .. phosphates .. AND it is known to cure .. dry eye .. as a side effect. Nice side effect .. don't you think .. as opposed to .. death .. ? http://tinyurl.com/2qnmut Indian Journal of Dermatology, Venereology and Leprology Year : 1985 | Volume : 51 | Issue : 4 | Page : 217--218 A Profile of Porhyrins in Cases .of Discoid Lupus Erythematosus Jain C, Handa F, Sidhu KS Correspondence Address: Jain C Porphyrin levels in nineteen cases of discoid lupus erythematosus were compared with porphyrin levels in ten controls using Rimingto.in's technique. The erythrocyte protoporphyrin, urinary uroporphyrin and faecal coproporph rin and faccal protoporphyrin were found to be significantly raised as compared to the controls. ---------------------------- Original Article Heme metabolism and in vitro erythropoiesis in anemia associated with hypochromic microcytosis A. C. Brown 1, J. D. Lutton 1 *, H. A. Pearson 2, J. C. Nelson 1, R. D. Levere 1, N. G. Abraham 1 1Department of Medicine and Anatomy, New York Medical College, Valhalla, New York 2Department of Medicine, Yale University School of Medicine, New Haven, Connecticut *Correspondence to J. D. Lutton, Departments of Medicine and Anatomy, New York Medical College, Valhalla, NY 10595 Funded by: National Institute of Arthritis for Diabetes and Digestive Kidney Diseases; Grant Number: AM 29742 National Institutes of Health; Grant Number: AM 00781 Abstract Heme metabolism and in vitro erythropoietic growth (CFU-E, BFU-E) were examined in bone marrow cells taken from two siblings with apparent familial hypochromic microcytic anemia. Bone marrow cells from both patients grew adequate numbers of CFU-E and BFU-E colonies in culture in the presence of erythropoietin. In addition, small numbers of endogenous CFU-E were seen in 7-day cultures. Assays on bone marrow cells taken from both patients revealed that baseline -aminolevulinic synthase activity was considerably reduced, but increased six to seven fold (to normal levels) when patients' cells were exposed to pyridoxal phosphate (PLP). In both cases, ferrochelatase and -aminolevulinic acid dehydratase activities were normal. Bone marrow heme oxygenase showed no significant differences in activities between normals and patients values in the absence or presence of PLP. In contrast, heme synthesis by patients' bone marrow was less than that of normals. This study demonstrates that bone marrow cells from patients with this rare disorder have some disturbances in heme metabolism, whereas erythropoiesis appeared to be normal when cultured with adequate nutrients in vitro. Keywords pyridoxal phosphate · B-6 deficiency · hemoglobin · iron -------------------------------------------------------------------------------- Received: 30 December 1986; Accepted: 9 July 1987 Digital Object Identifier (DOI) 10.1002/ajh.2830270102 About DOI Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk The correct question is what disorder causes it: "Porphyria cutanea tarda is the most common subtype of porphyria. The disorder results from low levels of the enzyme responsible for the fifth step in heme production. Heme is a vital molecule for all of the body's organs. ..." Jesus ate a mediterranean diet. >> On Oct 23, 1:56 pm, ferr...@paris.com wrote: The correct question is what disorder causes it: >> WHY would that be .. ? The erythrocyte protoporphyrin, urinary uroporphyrin and faecal coproporph rin and faccal protoporphyrin were found to be significantly raised as compared to the controls. Could that be why .. ? Are you saying .. erythrocyte protoporphyrin, urinary uroporphyrin and faecal coproporphrin and faccal protoporphyrin WERE found to be significantly raised .. ? Is that what you are saying .. ? Actually .. the question WAS / is ... **why** .. they've never heard of a porphyrin. BUT .. you HAVE .. and as a matter of fact you even ACT like it is no .. big .. deal .. Now I wonder why THAT would .. be .. You agree then with the REST of your .. cohorts / ilk / childkllgmthrfkrs .. there ARE .. "no porphyrins" .. Eh .. Isn't that .. right .. Except for Jain C .. eh .. he seems to think YOU and your cohorts / ilk / childkllgmthrfkrs are FULL .. of .. **sht** .. And I .. agree .. "The erythrocyte protoporphyrin, urinary uroporphyrin and faecal coproporph rin and faccal protoporphyrin were found to be significantly raised as compared to the controls. " Found to be **raised**. The porphyrins were found to BE .. raised. Now you can't get more of a synopsis than THAT .. WRITE it .. down .. Quickly .. and then place your thumb firmly back where it was .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk The correct question is what disorder causes it: "Porphyria cutanea tarda is the most common subtype of porphyria. The disorder results from low levels of the enzyme responsible for the fifth step in heme production. Heme is a vital molecule for all of the body's organs. ..." Jesus ate a mediterranean diet. >> On Oct 23, 5:50 pm, ferr...@paris.com wrote: The correct question is what disorder causes it: << Actually .. the question WAS / is ... **why** .. they've never heard of a porphyrin. BUT .. you HAVE .. and as a matter of fact you even ACT like it is no .. big .. deal .. Now I wonder why THAT would .. be .. You agree then with the REST of your .. cohorts / ilk / childkllgmthrfkrs .. there ARE .. "no porphyrins" .. Eh .. Isn't that .. right .. Except for Jain C .. eh .. he seems to think YOU and your cohorts / ilk / childkllgmthrfkrs are FULL .. of .. **sht** .. And I .. agree .. "The erythrocyte protoporphyrin, urinary uroporphyrin and faecal coproporph rin and faccal protoporphyrin were found to be significantly raised as compared to the controls. " Found to be **raised**. The porphyrins were found to BE .. raised. Now you can't get more of a synopsis than THAT .. WRITE it .. down .. Quickly .. and then place your thumb firmly back where it was .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk The correct question is what disorder causes it: "Porphyria cutanea tarda is the most common subtype of porphyria. The disorder results from low levels of the enzyme responsible for the fifth step in heme production. Heme is a vital molecule for all of the body's organs. ..." Jesus ate a mediterranean diet. > The correct question is what disorder causes it: > [quoted text clipped - 4 lines] > > Jesus ate a mediterranean diet. Why insult Jesus? place your thumb firmly back where it was .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk |
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