 |
 | Home | Contact Us | FAQ | Search & Site Map | Link to Us |
 | Sign In | Join | Other 45 Sites in Network |
Medical Forum / Diseases and Disorders / Lupus / March 2007Bloodletting is consistently effective
Lupus has no .. known .. cause. http://tinyurl.com/2qnmut Year : 1985 | Volume : 51 | Issue : 4 | Page : 217--218 A Profile of Porhyrins in Cases .of Discoid Lupus Erythematosus Jain C, Handa F, Sidhu KS Correspondence Address: Jain C Porphyrin levels in nineteen cases of discoid lupus erythematosus were compared with porphyrin levels in ten controls using Rimingto.in's technique. The erythrocyte protoporphyrin, urinary uroporphyrin and faecal coproporph rin and faccal protoporphyrin were found to be significantly raised as compared to the controls. ---------------------------------------------------------------------------------------- <<snip>> In patients who were bled frequently urinary uroporphyrin excretion decreased <<snip>> Acta Derm Venereol Suppl (Stockh). 1982;100:107-18. Links Phlebotomy treatment of porphyria cutanea tarda.Lundvall O. The effect of phlebotomy on 44 patients (33 men and 11 women) with porphyria cutanea tarda (PCT) is described. All had typical biochemical and clinical signs of PCT. The patients were bled until slight anemia and signs of iron deficiency. In patients who were bled frequently and who were not given iron supplements in conjunction with phlebotomy, urinary uroporphyrin excretion decreased to 1 mg (or 1.2 mumol) a day or less in 1-8 months (mean 4 months) and then continued to decrease long after the treatment had been stopped and became normal in many patients. A decrease in porphyrin excretion comparable to that in patients treated with phlebotomy occurred in only two out of 12 controls. Remission occurred in patients treated with phlebotomy who had iron overload as well as in patients with quantitatively normal iron stores and in patients abstaining from alcohol as well as in patients who continued their abuse of alcohol. The disappearance of skin fragility and ulcers coincided roughly with the time when the urinary excretion of uroporphyrin decreased to about 1 mg (1.2 mumol) a day. After 43 remissions (in 43 patients) not followed by iron medication, one relapse occurred after a period of 20 months. In 5 patients in whom their iron stores were replenished a relapse occurred in all within 18 months. After longer observation periods relapses occurred also after remissions not followed by iron medication. During observation periods of 3-10 years 15 out of 41 patients relapsed biochemically. These had re-accumulated iron stores spontaneously. The results indicate that phlebotomy is consistently effective and probably exerts its effect mainly by reduction of iron stores. PMID: 6962627 [PubMed - indexed for MEDLINE] Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Here we have .. polycythemia .. AND porphyria .. **together** .. 'coincidentally' .. AND again coincidentally the SAME lab work .. as .. lupus .. Remember .. ? "The erythrocyte protoporphyrin, urinary uroporphyrin and faecal coproporph rin and faccal protoporphyrin were found to be significantly raised as compared to the controls." <<snip>> Laboratory investigation shows polycythemia, increased urine uroporphyrins and coproporphyrins and increased erythrocyte porphyrins. <<snip>> Dermatol Online J. 2005 Dec 1;11(3):15. Links Congenital erythropoietic porphyria in two siblings.[Article in English, Portuguese] Jacobo A, Almeida HL Jr, Jorge VM. Catholic University of Pelotas, Brazil. Congenital erythropoietic porphyria is a very rare autosomal recessive disease, with mutation in the gene that codifies uroporphyrinogen-III synthetase, leading to porphyrin accumulation in many tissues, with marked skin photosensitivity. Two male siblings, aged 43 and 29, are described. The oldest shows severe sclerodermiform mutilation and the youngest exhibits initial involvement with hypertrichosis. Laboratory investigation shows polycythemia, increased urine uroporphyrins and coproporphyrins and increased erythrocyte porphyrins. PMID: 16409911 [PubMed - indexed for MEDLINE] --------------------------------------------------------------------------------- Sooo .. erythrocytosis / polycythemia leads TO .. **porphyrin related disease states** .. ? .. due to increased red blood cell destruction .. ? .. hence increased red blood cell garbage / porphyrins .. ? Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk This article shows the erythropoietin level goes DOWN when there is iron present. The erythropoietin level in lupus and polycythemia are consistently down or normal .. indicating .. iron BEING .. present. Eur J Haematol. 2003 Jul;71(1):44-50. Links Haemoglobin during pregnancy: relationship to erythropoietin and haematinic status.McMullin MF, White R, Lappin T, Reeves J, MacKenzie G. Department of Haematology, The Queen's University of Belfast, Belfast, UK. m.mcmullin@qub.ac.uk OBJECTIVE: To investigate the effect of haematinic status on erythropoietin throughout pregnancy in order to assess whether haematinic supplementation is appropriate for all pregnant women or should be reserved for individuals in whom deficiency has been identified. METHODS: A prospective, repeated-measures, longitudinal study of 263 women enrolled at an antenatal clinic in a district general hospital who received standard obstetric management including haematinic supplements. Haematological indices, iron status, folate and B12 status, and erythropoietin levels were measured by standard methods at scheduled intervals throughout pregnancy. The relationships between the measurements were analysed using statistical models which took into account the serial correlation between repeated measurements on the same individuals. RESULTS: Erythropoietin levels rose throughout pregnancy from a mean of 22.8 mU/mL at booking to 43.7 mU/ mL at 38 wk. There was a significant relationship between erythropoietin levels and haemoglobin, ferritin, TIBC and folate. The relationship was strongest between erythropoietin and haemoglobin. Erythropoietin levels were influenced by parity but not maternal age. CONCLUSION: Haematinic levels, particularly iron are related to the rise in serum EPO which occurs during pregnancy. Therefore, haematinic deficiency in pregnancy will result in increased stimulation of erythroid progenitor cells by erythropoietin. While haematinic supplementation is not always prescribed throughout pregnancy, haematinic status must be assessed on an individual basis and supplementation provided as required. PMID: 12801298 [PubMed - indexed for MEDLINE] Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk |
Reply to this Message |
 Sign In
 Join
 My Latest Posts My Monitored Threads My Blog My Photo Gallery My Profile My Homepage Start New Thread Enable EMail Alerts Rate this Thread
|
©2009 Advenet LLC Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.