Survival rate .. seems about the same .. ?

<<snip>>
Retinopathy in SLE was a marker of poor prognosis for survival
<<snip>>

Arthritis Rheum. 1988 Sep;31(9):1105-10. Links
Comment in:
Arthritis Rheum. 1989 Aug;32(8):1053-4.
Lupus retinopathy. Patterns, associations, and prognosis.Stafford-
Brady FJ, Urowitz MB, Gladman DD, Easterbrook M.
University of Toronto, Rheumatic Disease Unit, Wellesley Hospital,
Ontario, Canada.

In a prospective study of 550 patients with systemic lupus
erythematosus (SLE), 41 were found to have retinopathy. Lupus
retinopathy in the majority of cases consisted of a microangiopathy,
with an excellent prognosis for vision. Five patients developed other
complications that resulted in loss of visual acuity. Lupus
retinopathy was associated with active SLE in 88% of patients and with
lupus cerebritis in 73% of cases. Retinopathy in SLE was a marker of
poor prognosis for survival.

PMID: 3422014 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------------------------
<<snip>>
The patient died 7 weeks after
<<snip>>
<<snip>>
Ocular manifestations of polycythemia vera include vaso-occlusive
disease, and retinal hemorrhages
<<snip>>

Titre du document / Document title
Retinopathy secondary to anemia from myeloid metaplasia in
polycythemia vera
Auteur(s) / Author(s)
BLOOD A. M. (1) ; LOWENTHAL E. A. (2) ; NOWAKOWSKI R. W. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) School of Optometry, University of Alabama at Birmingham,
Birmingham, Alabama, ETATS-UNIS
(2) School of Medicine, University of Alabama at Birmingham,
Birmingham, Alabama, ETATS-UNIS

Résumé / Abstract
A B S T R A C T Polycythemia vera is a chronic clonal disorder
associated with excessive proliferation of erythrocytes, leukocytes,
and thrombocytes, as well as an accompanying splenomegaly, Ocular
manifestations of polycythemia vera include occipital cortex transient
ischemic attacks, tran sient monocular blindness, vaso-occlusive
disease, and retinal hemorrhages A 56-year old man with longstanding
polycythemia vera sought treatment for a chief symptom of blurred
vision in the left eye and a red tinge to things first noticed on awak
ening that morning He had preretinal and intraretinal hemorrhages and
was subsequently found to be severely anemic as a result of
postpolycythemic myeloid metaplasia after years of phlebotomy.
Splenectomy controlled his anemia and thrombocytopenia, allowing
transient improvement of the retinal hemorrhages Acute leukemia
subsequently developed and the patient died 7 weeks after initial
examination In this case, preretinal and intraretinal hemorrhages were
found in a patient with longstanding polycythemia vera The exact
origin of these hemorrhages is uncertain, They are probably secondary
to anemia, but the possibility that they are sites of extramedullary
hematopoiesis must be considered. The appearance of retinal
hemorrhages warrants careful investigation to rule out diabetes,
hypertension, and anemia, as well as the various other blood
dyscrasias.
Revue / Journal Title
Journal of the American Optometric Association  (J. Am. Optom.
Assoc.)  ISSN 0003-0244   CODEN JAOPBD
Source / Source
1997, vol. 68, no11, pp. 734-738 (11 ref.)
Langue / Language
Anglais

Editeur / Publisher
American Optometric Association, Saint-Louis, MO, ETATS-UNIS (1929-
1999) (Revue)

Mots-clés anglais / English Keywords
Polycythemia vera ; Anemia ; Vascular retinopathy ; Case study ;
Complication ; Adult ; Male ; Human ; Hemopathy ; Myeloproliferative
syndrome ; Eye disease ; Cardiovascular disease ; Vascular disease ;
Mots-clés français / French Keywords
Polyglobulie vraie ; Anémie ; Rétinopathie vasculaire ; Etude cas ;
Complication ; Adulte ; Mâle ; Homme ; Hémopathie ; Myéloprolifératif
syndrome ; Oeil pathologie ; Appareil circulatoire pathologie ;
Vaisseau sanguin pathologie ;

002b19b ;
Mots-clés espagnols / Spanish Keywords
Policitemia vera ; Anemia ; Retinopatía vascular ; Estudio caso ;
Complicación ; Adulto ; Macho ; Hombre ; Hemopatía ;
Mieloproliferativo síndrome ; Ojo patología ; Aparato circulatorio
patología ; Vaso sanguíneo patología ;
Localisation / Location
INIST-CNRS, Cote INIST : 18907, 35400007964787.0070

Copyright 2006 INIST-CNRS. All rights reserved

Toute reproduction ou diffusion même partielle, par quelque procédé ou
sur tout support que ce soit, ne pourra être faite sans l'accord
préalable écrit de l'INIST-CNRS.
No part of these records may be reproduced of distributed, in any form
or by any means, without the prior written permission of INIST-CNRS.

Nº notice refdoc (ud4) : 2084710
--------------------------------------------------------------------------------

Korean J Intern Med. 2001 Sep;16(3):210-3. Links
Systemic lupus erythematosus presenting earlier as retinal vaso-
occlusion.
Song YH, Kim CG, Kim SD, Kim YY, Choe JY.
Department of Internal Medicine, Catholic University of Daegu, School
of Medicine, Korea.

Retinal vascular lesions are the most common ophthalmologic
manifestation of systemic lupus erythematosus (SLE), occurring in 3%
to 29% of cases, generally late in the disease. More rare is the
severe vaso-occlusive disease, often termed "retinal vasculitis",
which includes central retinal artery occlusion, multifocal arteriolar
occlusions, extensive capillary nonperfusion and central venous
occlusion. Patients with SLE and raised serum concentrations of
anticardiolipin antibodies (ACA) have a higher risk of developing
occlusive ocular vascular disease. We report a case in which retinal
involvement was an earlier manifestation of SLE in a patient without
ACA.

PMID: 11769581 [PubMed - indexed for MEDLINE]
-------------------------------------------------------------------------------------

<<snip>>
Retinal vascular disease is frequent in patients with SLE.
<<snip>>

Semin Arthritis Rheum. 1999 Apr;28(5):326-32.  Links
Association of antiphospholipid antibodies with retinal vascular
disease in systemic lupus erythematosus.Montehermoso A, Cervera R,
Font J, Ramos-Casals M, Garcia-carrasco M, Formiga F, Callejas JL,
Jorfan M, Grino MC, Ingelmo M.
Department of Medicine, Institut d'Investigacions Biomediques August
Pi I Sunyer, School of Medicine, University of Barcelona, Catalonia,
Spain.

OBJECTIVES: To study the prevalence and characteristics of retinal
vascular disease in patients with systemic lupus erythematosus (SLE)
and to analyze their relationship with antiphospholipid antibodies
(aPL) and other serological markers. PATIENTS AND METHODS: Eighty-two
consecutive patients (77 women and 5 men; mean age, 36 years) were
studied. All patients fulfilled the 1982 revised criteria of the
American College of Rheumatology for the classification of SLE.
Ophthalmologic examination included assessment of best corrected
visual acuity, tonometry, slit-lamp biomicroscopy, and fundus
examination. Serologic studies included determination of
anticardiolipin antibodies (aCL) (ELISA), lupus anticoagulant (LA)
(coagulation tests), antinuclear antibodies (indirect
immunofluorescence), anti-DNA (Farr's test), and anti-ENA antibodies
(counterimmunoelectrophoresis). RESULTS: Retinal vascular disease was
detected in 13 (15%) of 82 SLE patients. The retinal lesions consisted
of retinal vascular occlusions in six patients (five arterial and one
venous), cotton-wool spots in three, optic disc edema in three,
retinal hemorrhages in three, and ischemic optic neuropathy in one.
Antiphospholipid antibodies were detected in 10 (77%) of these 13
patients: nine had aCL and two had the LA. When compared with patients
without retinal vascular disease, patients with retinopathy had a
higher prevalence of aPL (77% v. 29%, P = .005). CONCLUSIONS: Retinal
vascular disease is frequent in patients with SLE. The presence of aPL
is associated with a higher prevalence of retinal abnormalities in SLE
patients.

PMID: 10342390 [PubMed - indexed for MEDLINE]
------------------------------------------------------------------

This article shows .. lack of blood .. **flow** to the .. eye .. leads
to .. retinal vascular disease ..

And what causes .. lack of blood .. flow .. ? .. erythrocytosis ..
and / or thick blood and coincidentally .. erythrocytosis .. causes ..
thick blood.

Invest Ophthalmol Vis Sci (1990) 31: 464-70.

The patency of the retinal vasculature to erythrocytes in retinal
vascular disease.

J Ben-Nun, VA Alder, IJ Constable, CE Roberts
Department of Ophthalmology, Tel Aviv Medical Centre, Israel. This
paper presents the first evidence that in retinas with experimentally
induced vascular disease some vessels contain only plasma. This was
demonstrated by a histologic technique developed specifically to test
the hypothesis that at some stage in retinal vascular disease, vessel
patency to erythrocytes is lost before vessels close to plasma. Using
this technique, we visualized three major components of the
circulation at all retinal locations: the erythrocytes; the plasma as
marked by the presence of 0.2-micron fluorescent microspheres; and all
functioning endothelial cell nuclei, which were marked by the
fluorochrome bis-Benzimide. It was assumed that the distributions of
the erythrocytes and small particles in retinal whole mounts reflected
accurately the true in vivo distributions at the moment of circulation
arrest. Postenucleation the retina can be viewed and photographed
within 45 min of circulation arrest. The technique was used on normal
rats and on rats induced with a fast-developing model of retinal
vasculopathy. With this model, we demonstrated retinal vascular
segments perfused by plasma but containing no erythrocytes with
functioning endothelial cells in the vessel walls. This may mean that
an early factor in some retinal vascular pathologies is tissue hypoxia
caused by reduced erythrocyte perfusion.

[Pubmed Record - new window]

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bill, as much fun as it can be - and i've done my fair share of it:

          _____________________
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                   ||__||     |  feeding the troll  |
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          /   |   |           |      --|
          |   |   |           |____  --|
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  *      ___ c_c_c_C/ \C_c_c_c____________

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