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Medical Forum / Diseases and Disorders / Lupus / December 2006Porphyria caused by iron cured by vitamin C
<<snip>> ascorbate suppresses hepatic URO accumulation at low, but not high hepatic iron levels <<snip>> Effect of iron and ascorbate on uroporphyria in ascorbate-requiring mice as a model for porphyria cutanea tarda. Gorman N, Zaharia A, Trask HS, Szakacs JG, Jacobs NJ, Jacobs JM, Balestra D, Sinclair JF, Sinclair PR Hepatology. 2006 Dec 22; 45(1): 187-194 Excess hepatic iron is known to enhance both porphyria cutanea tarda (PCT) and experimental uroporphyria. Since previous studies have suggested a role for ascorbate (AA) in suppressing uroporphyria in AA-requiring rats (in the absence of excess iron), the present study investigated whether AA could suppress uroporphyria produced by excess hepatic iron. Hepatic URO accumulation was produced in AA-requiring Gulo(-/-) mice by treatment with 3,3',4,4',5-pentachlorbiphenyl, an inducer of CYP1A2, and 5-aminolevulinic acid. Mice were administered either sufficient AA (1000 ppm) in the drinking water to maintain near normal hepatic AA levels or a lower intake (75 ppm) that resulted in 70 % lower hepatic AA levels. The higher AA intake suppressed hepatic URO accumulation in the absence of administered iron, but not when iron dextran (300-500 mg Fe/kg) was administered. This effect of iron was not due to hepatic AA depletion since hepatic AA content was not decreased. The effect of iron to prevent AA suppression of hepatic URO accumulation was not observed until a high hepatic iron threshold was exceeded. At both low and high AA intakes, hepatic malondialdehyde (MDA), an indicator of oxidative stress, was increased three-fold by high doses of iron dextran. MDA was considerably increased even at low iron dextran doses, but without any increase in URO accumulation. The level of hepatic CYP1A2 was unaffected by either AA intake. Conclusion: In this mouse model of PCT, AA suppresses hepatic URO accumulation at low, but not high hepatic iron levels. These results may have implications for the management of PCT. (HEPATOLOGY 2007;45:187-194.). Abstract · PubMed FullText · SFX · GS Clip Export InterDB · Terms Related · Graph Tag · Scopus · Cites 10.1002/hep.21474 Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk The iron loading diseases .. hemochromatosis and hepatitis C .. may CAUSE .. porphyria .. Sooo .. eating .. meat .. that highly absorbable form of iron FOUND in meat .. then raises iron levels .. and therefore may CAUSE .. porphyria. http://exchange.healthwell.com/news.cfm?news=1746 <<snip>> "it is probable that a chronically high intake of heme iron can lead to high body iron stores and thus may elevate the risk of diabetes," the authors said. " <<snip>> http://en.wikipedia.org/wiki/Porphyria <<snip>> Some liver diseases may cause porphyria even in the absence of genetic predisposition. These include hemochromatosis and hepatitis C. Treatment of iron overload may be required. <<snip>> Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk |
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