<<snip>>
Oxidative stress may contribute to the pathogenesis of chronic
pancreatitis
<<snip>>

Assessment of oxidative stress in chronic pancreatitis patients.
Verlaan M, Roelofs HM, van-Schaik A, Wanten GJ, Jansen JB, Peters WH,
Drenth JP
World J Gastroenterol. 2006 Sep 21; 12(35): 5705-10

AIM: To assess the levels of antioxidant capacity and oxidative damage
in blood of chronic pancreatitis (CP) patients in comparison with those
in healthy control subjects, by using several different analytical
techniques. METHODS: Thirty-five CP patients and 35 healthy control
subjects were investigated prospectively with respect to plasma levels
of thiols, ferric reducing ability of plasma (FRAP, i.e. antioxidant
capacity), levels of protein carbonyls and thiobarbituric acid reactive
substances (TBARS). Additionally, we evaluated the production of
reactive oxygen species (ROS) in whole blood. RESULTS: The
antioxidative thiols including cysteine, cysteinylglycine and
glutathione were significantly lower in CP patients. In addition, the
non-enzymatic antioxidant capacity was significantly lower in CP
patients, which correlated with the amount of oxidative protein
(protein carbonyls) and the extent of lipid damage (TBARS), both were
significantly higher in CP patients. The ROS production in whole blood
after stimulation with phorbol 12-myritate 13-acetaat, demonstrated a
strong tendency to produce more ROS in CP patients. CONCLUSION:
Oxidative stress may contribute to the pathogenesis of chronic
pancreatitis by decreasing antioxidant capacity and increasing
oxidative damage in CP patients may be a rationale for intervention
with antioxidant therapy.

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