DERMATOVENEROLOGY.
ABOUT SLE STUDY.
AUTHOR A LECTURE M.D.REBROV FROM SARATOV PUBLIC  MEDICINAL UNIVERSITY.

SLE-IS a disease,developming on basis of geneticaly due imperfection a
immunoregulatory processes,leading to a forming immunocomlex
inflammatory,consequence of which and being the defeate of many  organs
and systems.
Frequency a sle 4-250 cases for 100 000 population/year.In usa annual
prevalence a sle is =50-70 a new cases for 1 million population.
A more 70 percent with sle is age 14-40 year,peak of prevalence 14-25
y.old.COrrelation :womens and mans from 8:1 to 10:1,childrens -3:1.
ETHIOLOGY.
A staring role RNA-CONTAINING AND SLOW VIRUSES/RETROVIRUSES/:
forming antibodies to DNA and RNA-containing viruses.
presence paramixoviruse cytoplasmatic inclusions.
presence tubuloreticular inclusions in epithelium and inside a
lymphocytes.
HAS AND MEANING:genetic factors/HLA-A1,B8,DR2,DR3/.

endocrine factors/oestrogens influence/.
factors from environmen/ultraviolet rays,influence ,like bacterial and
viruse infection,drugs/
SLE-IS immunocomplex disease,for which is charactered uncontrolled
production the antibodies,forming immune complexs,consequensing a
different signs of disease.

Circulating immune complexs laying  in subendothelial layer a basal
membrane of vessels a many organs.

A place of fixation a diposits /skin,kidneys,choroidal plexus,serous
membranes/defining a such antigene parameter ,or antibody,like a
size,charge ,molecular configuration,immunoglobulin class.

CLINICAL PICTURE.

Skin defeat-is different ,in 20-25 percent skin syndrome-a begin sign
of disease,in 60-70 percent-is appearances on a different stages of
disease.

Observing 28 variants  a skin changes in sle from erythematosis spot to
difficult bullosa  rashs.

Jont problems and periarticular tissues-arthralgias in 100
percent,tendinitis,tendovaginitis,aseptic necrosis a bones-in 25
percent.

myalgias in 45-45 percent.

LUNG PROBLEMS:

in 50-80 percent  dry and exudative pleuritis.
vasculitis.
pneumonitis.
HEART AND VESSEL PROBLEMS:

dry and exudative pericarditis.
myocarditis.
endocarditis-mitral ,aortic,tricuspid  valve.
arteries a small and middle gauges.
aorta and her branches.
thrombosis a  great vessels.
trombophlebitis.
gastrointestinal and liver in 50 percent cases.

gullet defeat-10-15 percent.
ishemia of walls a stomach and intestine.
hepatomegaly.
KIDNEY DEFEAT:

LUPUS NEPHRITIS,LIKE ACTIVE FORMS:

fastprogressing ,
nephriti with nephrotic syndrome.
nephritis with marked nephritic syndrome.
nephritis with minimal urine syndrome.

CNS DEFEATE:

vasculopathy-65 percent.
thrombosis and natural vasculitis-15 percent.
infarctions and hemmorhagias.
antibody and immunocomplex inflammatory.
CLINICAL DISPLAYS:

headache.
psychical dissorders.
defeat of scull and peryphery nerves.
seizures.
visual breachs.
transient breachs a cerebral circulation of the blood.
LABORATORY RESEARCHS.

le-cells.
antinuclear antibodies.
antibodies to twospiral DNA.
antibodies to onespiral DNA.
anemia normocyte and
normochrome,leucopenia,lymphocytopenia,thrombocytopenia.

CLASSIFICATION A SLE.

VARIANT OF COURSE:ACUTE,SUBACUTE,CHRONIC.

A DEGREE OF ACTIVITY:1-MINIMAL,2-MODERATE,3-HIGH.

ALSO INCUDING AND ARA/1982/.