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Medical Forum / Diseases and Disorders / Lupus / July 2005

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Immuran versus Cellcept

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dropbear1@gmail.com - 06 Jul 2005 02:22 GMT
I had been on immuran for the last two years with mixed results. So my
doc and I decided to switch to Cellcept. Since then, my symptoms have
worsened, and I have just developed Shingles, which has left me totally
debilitated and popping a Vicodin every 4 hours for the pain. Has
anybody else has a similar experience, or an experience with Shingles
at all? I know that Shingles and immunosupressive therapy is a bad
combination, so now I am on Acyclovir.
J - 06 Jul 2005 11:06 GMT
> I had been on immuran for the last two years with mixed results. So my
> doc and I decided to switch to Cellcept. Since then, my symptoms have
[quoted text clipped - 3 lines]
> at all? I know that Shingles and immunosupressive therapy is a bad
> combination, so now I am on Acyclovir.

Hello,
BJ's been on Imuran for years. Last year, she got shingles.
I forget which pain medications she took for that.
It took quite a while for that to go away.
As I recall, she was holding a soft pillow under one arm, while she
continued her daily routine.
That was because the arm or clothing brushing against the shingles flared
the pain worse.
She has since cut back on her dose of Imuran (for other reasons).

She's been very busy lately. I'm not sure when she'll be posting.

Meantime, you could save us some time by rereading previous posts about
that and which medications helped or didn't.
http://groups-beta.google.com/advanced_search?q=&\
type shingles
type alt.support.lupus
sort by date
Start in July (2nd page) and read each thread through September.
That mgiht give you some tips and websites to read.
Hope this helps and you feel better soon,
J
Judy - 06 Jul 2005 18:11 GMT
I had exactly the same thing happen.
Dr. said we would try Cellcept to help me get off the Prednisone.
My request because I heard it was so awful.
I was on 10 mg of Pred. at the time with Plaquenil.
I took 500 mg. of Cellcept, twice a day for one month and the next month I
got shingles.
When you get an illness, you have to go off it he said so your immune system
won't be too suppressed, so you can get well.
After the shingles, I got back on it and seemed every other month was sick
with something.
I finally told him to forget it, I'd rather stay on the Prednisone.
Shingles kept me off work for 2 months.
I pray I never get shingles again.

I have been fine since I went off Cellcept and managed to taper to 6-7 mg of
Pred.
I don't think I would take it again unless it was a life threatening
problem.
Judy
=====

> Has
> anybody else has a similar experience, or an experience with Shingles
> at all? I know that Shingles and immunosupressive therapy is a bad
> combination, so now I am on Acyclovir.
john - 09 Jul 2005 02:52 GMT
>I had been on immuran for the last two years with mixed results. So my
> doc and I decided to switch to Cellcept. Since then, my symptoms have
[quoted text clipped - 3 lines]
> at all? I know that Shingles and immunosupressive therapy is a bad
> combination, so now I am on Acyclovir.

I haven't posted hear for a long time, I came back to ask a question and
thought I maybe could answer yours.

I had a similar experience.  I was on plaquenil and methotrexate and 40 mg
of pred, I switched to 2000mg a day of cellcept and was able to taper the
pred down to 5mg and 10mg on alternate days.  I got shingles after about 3
months, it not fun, not at all.  I started acyclovir too late too help, I
took vicodin for the pain and then neurontin for quite a while.  The whole
thing lasted several months before I could put it on the back burner.  I
never stopped cellcept, I've been on the same regimen for 3 or 4 years now
with no more shingles and no more bad flares.  I'm a happy camper with the
cellcept. Wish I could get the pred down further but can't seem to.  Good
luck, it will get better.

I'm going to start a new thread with my question.

john
dropbear1@gmail.com - 09 Jul 2005 21:11 GMT
Thanks for all the responses. I managed to get most of my rash in the
groin area, which means I can't sit down, drive, or walk very far (or
work). I'm not sure if I'm going to dump the cellcept (2000mg/day)  and
go back to immuran (I'm also taking 10mg prednisone and 400 mg
plaquenil). Perhaps the cellcept is working "too well." I really dont
mind taking 10 mg of prednisone since i don't have a weight
problem--I'm 6 foot one and 150 lbs., but my doc is worried about
osteoporosis in the long run since i'm only 28 years old and i'll
probably be on these drugs most of my life.
BJ - 18 Jul 2005 16:28 GMT
I had shingles last summer. I am on Imuran. I believe that is why it took
months for the lesions to heal. I still have discomfort occasionally, even
after all this time. I had just returned from a holiday which involved days
of driving. I  was overtired from that and was a bit run down. I think that
is why I got shingles at that particular time.
BJ-Sk. Canada
> I had been on immuran for the last two years with mixed results. So my
> doc and I decided to switch to Cellcept. Since then, my symptoms have
[quoted text clipped - 3 lines]
> at all? I know that Shingles and immunosupressive therapy is a bad
> combination, so now I am on Acyclovir.
 
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