Re Rixtuximab treating SLE

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blader - 23 May 2004 16:01 GMT

Successful treatment with anti-CD20 monoclonal antibody (rituximab) of
life-threatening refractory systemic lupus erythematosus with renal and
central nervous system involvement.
Lupus. 2003;12(10):798-800.
Saito K, Nawata M, Nakayamada S, Tokunaga M, Tsukada J, Tanaka Y.

Bruce

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Shelagh - 23 May 2004 18:56 GMT

However, I read that because in some 'study patients', they
observed high levels of antibodies against rituximab (human anti
chimeric antibodies -*HACA)
they think that for future treatments the monoclonal antibody
(rituximab) will probably be used in combination with other
immunosuppressive treatments.
Where did you get your info Bruce?
Hugs from Shelagh
http://members.shaw.ca/tiderington.

"blader" <blader@chartermi.net> wrote in message

> Successful treatment with anti-CD20 monoclonal antibody (rituximab) of
> life-threatening refractory systemic lupus erythematosus with renal and
[quoted text clipped - 3 lines]
>
> Bruce

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J - 23 May 2004 20:24 GMT

> However, I read that because in some 'study patients', they
> observed high levels of antibodies against rituximab (human anti
> chimeric antibodies -*HACA)
> they think that for future treatments the monoclonal antibody
> (rituximab) will probably be used in combination with other
> immunosuppressive treatments.

It's in Phase I (usually toxicity) trials
http://www.clinicaltrials.gov/ct/show/NCT00036491?order=6
J

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NW - 23 May 2004 20:36 GMT

Those HACA antibodies can be a major problem, since they can both
cancel the treatment effects and cause severe allergic reactions. Remicade
(infliximab), which I have been on, is also a monoclonal antibody with
non-human regions and I developed HACA antibodies against the mouse part in
it.

Anyway, concomitant use of Imuran or Methotrexate reduces the formation of
antibodies in Remicade patients (although it didn't in me), so it makes
sense that same would apply to Rituximab.

Nnia

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blader - 24 May 2004 00:51 GMT

To the question, "where did I get my information?", from a search of the
Medline data base using either http://gateway.nlm.nih.gov/gw/Cmd
or http://www.ncbi.nlm.nih.gov/entrez/query.fcgi

Bruce

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