Hi Winny.

I got this from the net a while back.   My rheumy said to be careful because
it is unregulated and that you never really know how your immune system will
react..
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Glucosamine is less toxic than nonsteroidal anti-inflammatory drugs.
However, it can worsen insulin resistance, so it should therefore be used
cautiously by patients who have diabetes.
Patients who are allergic to shellfish should not use glucosamine because it
is derived from crustacean chitin.

Also, glucosamine is considered a food supplement and therefore is not
regulated by the Food and Drug Administration. The purity and the
concentration of glucosamine can vary despite claims made by the
manufacturer.

Although no study has addressed the correct dose of glucosamine or the
actual time to onset of pain relief, the human clinical trials seem to
suggest that a 12-week course of treatment is required at a dosage of 500 mg
three times a day.

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David