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Medical Forum / Diseases and Disorders / Lupus / May 2004Do x-rays cause problems?
Hi everyone, Not feeling so hot, got to thinking, I have had quite a few x-rays lately. Would that cause mood/exhaustion changes? Such a knowledgeable group here, I have sle <not the organ involvement> , sjogrenes, other things that may not be pertinent to my question. thanks, Zinn Hi Zinn! I really don't know for sure, but from what I understand; if you were shielded properly, you shouldn't be affected by it. At least not enough to worry. My feeling is that it's all just been overwhelming. I mean, who wants to go for one x-ray after another & then follow-ups & then worrying & the anticipation of finding out the results. IMO, that could easily be the culprit....just the process of it all. Wishing you some worry-free time & an x-ray-free period...to simply rest. HugsHoney, Maggie thanks Maggie, had several rounds of mammograms and surgery with follow up mammograms, things bear watching but is not cancer. Could be just the pace of it all, but oh my, the tired is tired. Zinn > Hi Zinn! > [quoted text clipped - 10 lines] > HugsHoney, > Maggie > Hi everyone, > [quoted text clipped - 3 lines] > Such a knowledgeable group here, I have sle <not the organ involvement> , > sjogrenes, other things that may not be pertinent to my question. Hello Z, well I think (regardless of no organ involvement) SLE can cause fatigue. But when I look back to your e-mails (I saved), it does seem like you've been mentioning it more on each e-mail since last summer...so I would ask "what changed last year that might be contributing?" and are your doctors checking you for anemias and B12 deficiency? and with the extra running around lately, no wonder you're exhausted.. but do check your labwork results. I do hope you can re-energize for that special meeting - later this month? Hugs J > > Hi everyone, > > [quoted text clipped - 16 lines] > Hugs > J Sometimes a forget memory comes in handy, thanks for reminding me of my busy life style of late. Yes, doc just took tests. CRP, Quant was high C3 was high and the Total Compliment was high. I haven't a clue what it means, but been looking it up. Sed rate not in yet, but I don't expect it to show much. Yes, the special meeting is priority and I need to feel better. <For those who are curious, seems my dad fathered a child in Germany in 1947, and I get to meet him over labor day> :))) but its a 12 hour drive. Thanks J Zinn > Yes, doc just took tests. > CRP, Quant was high [quoted text clipped - 4 lines] > > Sed rate not in yet, but I don't expect it to show much. There's a thread called "negative SED rate" which might be helpful. Otherwise when you get the most recent test results in, perhaps post them. If they can perhaps Andy or KC or BJ would help. > Yes, the special meeting is priority and I need to feel better. > > <For those who are curious, seems my dad fathered a child in Germany in > 1947, and I get to meet him over labor day> :))) but its a 12 hour drive. Get better soon. I'm so excited for you and look forward to hearing about it afterwards. Hugs j > "J" <ugh@example.net> wrote in message > , [quoted text clipped - 17 lines] > <For those who are curious, seems my dad fathered a child in Germany in > 1947, and I get to meet him over labor day> :))) but its a 12 hour drive. Busy getting ready for your meeting with your half-brother? Or still feeling poorly? Hugs J I just don't feel well, and sleep is a non-event anymore :( hugs > > "J" <ugh@example.net> wrote in message > > , [quoted text clipped - 22 lines] > Hugs > J Did you get the sed rate results yet, Zinn? How very exciting to be meeting your half-brother for the first time. Something to look forward to as summer draws to a close. Do you have someone to take you there? It is a long trip, that is for sure. > > "J" <ugh@example.net> wrote in message > > , [quoted text clipped - 22 lines] > Hugs > J no, haven't called about the sed rate, I have standing appointments with doc so will address then, I suspect it was ok. My daughter will take me to Alabama in her very comfy van, and your right it is a long way. The opportunity may not present itself again, as it turns out this new found brother had his pancreas removed 3 years ago, and is unwell. Thanks BJ, your posts are always so kind and encouraging to everyone, its a great group. hugs, Zinn > Did you get the sed rate results yet, Zinn? How very exciting to be meeting > your half-brother for the first time. Something to look forward to as summer [quoted text clipped - 29 lines] > > Hugs > > J I am glad your daughter can take you, Zinn. I am sure you will do fine. See if you can get an air mattress for the back of the van, if there is nothing in it to rest on. You could stretch out, even if you can't sleep. Keep in touch with us. It is so nice to see you posting more often. My best to you. BJ-Sk. Canada > no, haven't called about the sed rate, I have standing appointments with doc > so will address then, I suspect it was ok. [quoted text clipped - 47 lines] > > > Hugs > > > J Hope you will have a nice trip meeting your h-brother. Take care and post pictures!! Bin > > "J" <ugh@example.net> wrote in message > > , [quoted text clipped - 22 lines] > Hugs > J Hi Zinn, I am sorry to hear that you are not feeling well. The x-rays themselves would not cause that. However, you could be bothered by contrast dyes, if they used those with any of the x-rays. It could also be the stress and running around to appointments has worn you out. It is good to see you, by the way. I hope you feel better soon. BJ-Sk. Canada > Hi everyone, > [quoted text clipped - 6 lines] > thanks, > Zinn > Hi Zinn, > I am sorry to hear that you are not feeling well. The x-rays themselves [quoted text clipped - 13 lines] > > thanks, > > Zinn No dyes BJ, guess I wanted a 'simple' explanation. Since I lurk I 'see' you all the time <G> I really don't feel like I have any knowledge to respond to posts, I mostly 'learn' here.. I wish I had more knowledge of Lupus, since I have several things I don't know where one starts and the other stops :( Yes, stress, doing its thing. Thanks BJ Zinn Hi Zinn, It doesn't matter if you have knowledge to share. You have experiences and feelings. Those are just as important. Sometimes it is a comfort to know that someone listened and cared. Jump in anytime. BJ-Sk. Canada > > Hi Zinn, > > I am sorry to hear that you are not feeling well. The x-rays themselves [quoted text clipped - 27 lines] > Thanks BJ > Zinn Thanks BJ, did I mention I am not dependable :(( in my 'other life' I was but this phase seems to call the shots !! Zinn > Hi Zinn, > It doesn't matter if you have knowledge to share. You have experiences and [quoted text clipped - 37 lines] > > Thanks BJ > > Zinn > Thanks BJ, did I mention I am not dependable :(( in my 'other life' I was > but this phase seems to call the shots !! > Zinn hehe... hugs J >Hi everyone, > >Not feeling so hot, got to thinking, I have had quite a few x-rays lately. >Would that cause mood/exhaustion changes? The stress might.  SignatureAndy Taylor [Chair, N E Lupus Group] See http://www.northeastlupus.org.uk for more! >Subject: Do x-rays cause problems? >From: "Zinn" zswbisns@noearthlink.net [quoted text clipped - 5 lines] >Not feeling so hot, got to thinking, I have had quite a few x-rays lately. >Would that cause mood/exhaustion changes? Since you are KNOWN to have a higher than normal level of oxidative stress / low antioxidant reserves .. then the x-ray which causes EVEN MORE .. free radicals / oxidative stress / rust .. would .. seem .. to .. be .. making .. you ... worse .. >Such a knowledgeable group here, I have sle <not the organ involvement> , >sjogrenes, other things that may not be pertinent to my question. > >thanks, >Zinn Int J Mol Med. 2003 Feb;11(2):149-52. Related Articles, Links Radiation-induced reactive oxygen species formation prior to oxidative DNA damage in human peripheral T cells. Ogawa Y, Kobayashi T, Nishioka A, Kariya S, Hamasato S, Seguchi H, Yoshida S. Department of Radiology, Kochi Medical School, Oko-cho, Nankoku-shi, Kochi-Prefecture 783-8505, Japan. ogaway@kochi-ms.ac.jp Previously, we demonstrated that human peripheral T lymphocytes revealed early apoptotic changes (annexin V-positive) and late apoptotic changes (propidium iodide-positive), at 13 and 24 h, respectively, after irradiation of 5 Gy. Changes in mitochondrial membrane potential were observed at 10 h after irradiation of 5 Gy. Subsequently, mitochondrial cytochrome c-release was confirmed. In order to elucidate the mechanism which acts prior to the mitochondrial membrane potential changes, we examined in the previous study the radiation dose and the timing of oxidative DNA damage induced in human peripheral T lymphocytes following 10 MV X-ray irradiation. As a result, the production of 8-oxoguanine, i.e., the product of oxidative DNA damage, was clearly identified starting at 10, 6, and 3 h, after 2, 5, and 20 Gy of irradiation, respectively. Therefore, we examined in the present study reactive oxygen species (ROS) formation in T lymphocytes following 5 Gy of irradiation. Using a CCD camera system, we monitored fluorescence in T lymphocytes loaded with the succinimidyl ester of dichlorodihydrofluorescein diacetate (H2DCFDA), which is non-fluorescent until oxidized by ROS. We found that ROS formation occurred immediately after irradiation, continued for several hours, and resulted in oxidative DNA damage. Therefore, the origin of hyper-radiosensitivity of T lymphocytes seemed to be the high production of ROS in the mitochondrial DNA following irradiation. PMID: 12525868 [PubMed] -------------------------------------------------------------------------- ------ Who loves ya. Tom SignatureJesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking Wow, thanks.... I will just go with the simple 'yes'... my brain is scrambled and I don't completely understand the information, but will keep re-reading. Zinn > >Subject: Do x-rays cause problems? > >From: "Zinn" zswbisns@noearthlink.net [quoted text clipped - 58 lines] > Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore > DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > Wow, thanks.... I will just go with the simple 'yes'... my brain is > scrambled and I don't completely understand the information, but will keep > re-reading. > Zinn I thought you were filtering. J > > Wow, thanks.... I will just go with the simple 'yes'... my brain is > > scrambled and I don't completely understand the information, but will keep [quoted text clipped - 3 lines] > I thought you were filtering. > J lol, I said my brain is scrambled.... and you thought I was kidding <wink> So, that one goes in the filter eh!! I will be the resident 'duh' poster. hugs, Zinn > I will be the resident 'duh' poster. You, me, Bruce and Janers...oopsie. In other words, we all have our bad days. Hugs all J You forgot me, J. I am duh most of the time. The light goes on once in a dog's age. <g> > > I will be the resident 'duh' poster. > > You, me, Bruce and Janers...oopsie. > In other words, we all have our bad days. > Hugs all > J Well then, I will consider meself in good company eh. I do have trouble connecting the dots, thats mostly why I don't post, I get lost in the conversations anymore :( good day to all, Zinn > You forgot me, J. I am duh most of the time. The light goes on once in a > dog's age. <g> [quoted text clipped - 5 lines] > > Hugs all > > J >Subject: Re: Do x-rays cause problems? >From: "Zinn" zswbisns@noearthlink.net [quoted text clipped - 29 lines] >> >thanks, >> >Zinn This article specifically shows the rust / reactive oxygen species / oxidative stress is mediated through .. iron .. Hence the effectiveness of the iron chelator deferoxamine IN the diminishing of the tissue damage CAUSED BY .. the radiation .. Which might just explain why taking vitamin E (antioxidant / antifreeradicals/ antioxidativestress) prior to radiation treatments .. allow the patient to ..keep .. their .. hair .. Neurotoxicol Teratol. 2004 May-Jun;26(3):477-83. Related Articles, Links Deferoxamine antioxidant activity on cerebellar granule cells gamma-irradiated in vitro. Guelman LR, Pagotto RM, Di Toro CG, Zieher LM. 1(a) Catedra de Farmacologia and Instituto de Neurociencias Aplicadas, Facultad de Medicina, UBA, Paraguay 2155, piso 15 (1121) Buenos Aires, Argentina. Oxidative stress has been implicated in the pathogenesis of many neurodegenerative and neurological disorders, with reactive oxygen species (ROS) as part of the intracellular effectors of damage formed in the presence of an excess of iron. Ionizing radiation induces tissue damage on developing CNS through different simultaneous mechanisms, including ROS-induced oxidative damage; therefore, exogenously added iron chelators might contribute to protect cells from free-radical injury. Cerebellar granule cells grown in vitro were exposed to 0.3 Gy of gamma radiation, and 30-60 min before irceradiation, deferoxamine (Dfx), an iron chelator, was added at different nontoxic concentrations. When cell viability and ROS levels were evaluated in Dfx-treated cultures, a partial prevention of radiation-induced cell death and ROS increase were found, being this prevention concentration independent. These data support the involvement of an iron-driven hydroxyl radical formation pathway in the acute toxic mechanism of radiation in cultures of cerebellar granule cells, being ROS-induced oxidative damage one of the mechanisms through which radiation might induce cell death. Therefore, blocking ROS production through the use of a chelating agent, such as Dfx, would be a useful therapeutic tool in different experimental models. PMID: 15113608 [PubMed] -------------------------------------------------------------------------- ------ Therefore, the origin of >> hyper-radiosensitivity of T lymphocytes seemed to be the high production >of ROS [quoted text clipped - 7 lines] >> Who loves ya. >> Tom SignatureJesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking |
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