ds DNA question

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spam2death - 04 May 2004 22:25 GMT

High ANA, achy joints, thirst, fatigue

Are repeated tests indicating very high dsDNA results indicative of developing or
undiagnosed SLE?

Any other autoimmune diseases that also have high dsDNA results as part of the
disease profile?

--
"Dissent is the highest form of patriotism" Thomas Jefferson

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J - 04 May 2004 22:43 GMT

> High ANA, achy joints, thirst, fatigue
>
[quoted text clipped - 6 lines]
> --
> "Dissent is the highest form of patriotism" Thomas Jefferson

Sorry again, I didn't realize you were about to ask a Lupus queston
anti-dsDNA?
http://www.ghg.net/schwerpt/ASLFAQ/diag.htm
J

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KCat - 04 May 2004 22:51 GMT

dsDNA is considered highly specific for SLE. It does occur occasionally in
other autoimmune diseases but not typically in high amounts.

I believe with the other positive test (ANA) and other symptoms that most
docs would look at the dsDNA and be strongly steered toward Lupus as a
diagnosis.

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Andy - 05 May 2004 09:17 GMT

>High ANA, achy joints, thirst, fatigue
>
[quoted text clipped - 4 lines]
>Any other autoimmune diseases that also have high dsDNA results as part of the
>disease profile?

I *think* dsDNA is pretty specific to SLE - but I'm not a doctor.
Thirst, however, isn't. Have you any dryness symptoms (I'm thinking
Sjogrens)? Could it be diabetes? It is possible to have all three of
these in the same person at the same time (eg my wife!)

Signature

Andy Taylor [Chair, N E Lupus Group]
See http://www.northeastlupus.org.uk for more!

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spam2death - 05 May 2004 20:28 GMT

> >High ANA, achy joints, thirst, fatigue
> >
[quoted text clipped - 12 lines]
> Andy Taylor [Chair, N E Lupus Group]
> See http://www.northeastlupus.org.uk for more!

I'm getting checked for diabetes in the AM. thanx

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spam2death - 06 May 2004 22:42 GMT

> > >High ANA, achy joints, thirst, fatigue
> > >
[quoted text clipped - 14 lines]
>
> I'm getting checked for diabetes in the AM. thanx

well, I tested negative for diabetes but I do have symptoms of Sj?gren's Syndrome.
My lab tests from last summer and fall don't indicate having positive SSA or SSB
antibodies then but my ANA, SED and dsDNA were all very high plus my most recent
dsDNA results were off the scale high. I go back to the rheumatologist in 3 weeks.
I'm guessing I'll get an SLE diagnosis with a dash of Sj?gren's thrown in for
flavoring.

"Dissent is the highest form of patriotism" Thomas Jefferson

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J - 06 May 2004 20:33 GMT

> I *think* dsDNA is pretty specific to SLE - but I'm not a doctor.
> Thirst, however, isn't. Have you any dryness symptoms (I'm thinking
> Sjogrens)? Could it be diabetes? It is possible to have all three of
> these in the same person at the same time (eg my wife!)

Good catch, Andy.
I had a 2-hour glucose testing. Some people tell me the 6-hour is better?
J

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