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Medical Forum / General / Laboratory / October 2008

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Follow up: My FBG is now normal, but my RBCs are elevated

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douglas - 04 Oct 2008 22:26 GMT
Well guys, my FBG came back normal at 90 mg/dL, but my RBCs are
elevated:

RBC count: 5.97 million cells/uL
Hb: 17.9 g/dL
Hct: 53.2%
MCV: 89.2 fL
MCH: 30.0 pg
MCHC: 33.6 g/dL
RDW: 13.7%
Platlet count: 202000 cells/uL
Absolute neutrophils: 4847 cells/uL
Absolute lymphocytes: 2503 cells/uL
Absolute monocytes: 806 cells/uL
Absolute eosinophils: 235 cells/uL
Absolute basophils: 8 cells/uL
Neutrophils: 57.7%
Lymphocytes: 29.8%
Monocytes: 9.6%
Eosinophils: 2.8%
Basphils: 0.1%
Erythropoietin: 8.1 mIU/mL

My FP advise me to see a hematologist...should I? My RBC have been
like this for at least 5 years, and no symptoms related to it, I
think.

Thanks!
Manky Badger - 04 Oct 2008 22:51 GMT
> Well guys, my FBG came back normal at 90 mg/dL, but my RBCs are
> elevated:
[quoted text clipped - 22 lines]
> like this for at least 5 years, and no symptoms related to it, I
> think.

What's your local reference ranges for all these tests? I wouldn't call
those results that abnormal.
Robert - 05 Oct 2008 21:22 GMT
> > Well guys, my FBG came back normal at 90 mg/dL, but my RBCs are
> > elevated:
[quoted text clipped - 27 lines]
>
> - Show quoted text -

I believe he uses labcorp and according to their reference range it is
within the normal reference range and not elevated.

The lab should credit all the additional testing pertaining to the
follow up of that 37 mg/dl glucose.
JEDilworth - 05 Oct 2008 23:26 GMT
To quote from douglas's previous entry:

"Actually, the lab report says that RBCs were present when they
recieved it. , but then it says "verified by repeat analysis". What
does this mean?

The lab was Quest Diagnostics."

Probably not a good idea to get into which lab is "better." If the
preanalytical problem was due to mishandling at the doctor's office, I
do not believe the lab owes anyone anything. Having worked for a
reference lab, if credit was given for all the repeated work that was
done due to doctor's office errors, the labs would have a hard time
making any money at all. If anyone owes anyone, I would think it is the
doc's office that possibly mishandled the specimen. That's obviously for
Douglas and his insurance company to fight about.

Douglas's results are high normal on the RBC, and the hematocrit is a
bit over. Dr. Ed Uthman has a great discussion of CBC results here:

http://web2.airmail.net/uthman/blood_cells.html

Follow-up with a hematologist depends, obviously, on symptomatology,
age, history, etc.

Judy Dilworth, M.T. (ASCP)
Microbiology

I believe he uses labcorp and according to their reference range it is
within the normal reference range and not elevated.

The lab should credit all the additional testing pertaining to the
follow up of that 37 mg/dl glucose.
douglas - 06 Oct 2008 01:52 GMT
On Oct 5, 3:26 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> To quote from douglas's previous entry:
>
[quoted text clipped - 29 lines]
> The lab should credit all the additional testing pertaining to the
> follow up of that 37 mg/dl glucose.

I've been getting headaches, occasional pain in the legs when walking,
esp. when going up stairs, occasional orthostatic hypotension.
Manky Badger - 06 Oct 2008 08:16 GMT
I've been getting headaches, occasional pain in the legs when walking,
esp. when going up stairs, occasional orthostatic hypotension.
__________________________________________________________

Lots of people feel dizzy when they stand up suddenly.
No patient ever in the history of medicine has ever had "orthostatic
hypotension".

Perhaps you should stop reading the medical books and hang out with people
of your own age?
Mike Collins - 06 Oct 2008 21:30 GMT
> To quote from douglas's previous entry:
>
[quoted text clipped - 29 lines]
> The lab should credit all the additional testing pertaining to the
> follow up of that 37 mg/dl glucose.

The preanalytical problem would not have been a problem if the lab had
not accepted unpreserved glucose samples. This is a textbook example
of why they should stop doing it.
douglas - 06 Oct 2008 01:51 GMT
> > "douglas" <Protoman2...@gmail.com> wrote in message
>
[quoted text clipped - 39 lines]
>
> - Show quoted text -

I use Quest.
JEDilworth - 05 Oct 2008 06:16 GMT
http://www.emedicine.com/MED/topic1863.htm
http://www.drkaslow.com/html/blood_cell_counts.html
http://www.aafp.org/afp/20040501/2139.html

Doc wants to rule out polycythemia vera. See the above articles for a
lot more information. It is not good to have too high of a hematocrit.
You can sustain blood clots and other symptoms. I would definitely see a
hematologist if your counts have been running this way for a long time.

"PV should be suspected when hemoglobin and/or hematocrit levels are
elevated (i.e., hemoglobin level greater than 18 g per dL [180 g per L]
in white men and 16 g per dL [160 g per L] in blacks and women;
hematocrit level greater than 52 percent (0.52) in white men and 47
percent (0.47) in blacks and women).3 PV also should be suspected in
patients with portal venous thrombosis and splenomegaly with or without
thrombocytosis and leukocytosis."

The fact that your Hematocrit (Hct) is >52% is a red flag.

Are you an asthmatic? Do you live at a high altitude (>5000 feet)? These
can also be causes of high hematocrits.

Interesting that your blood glucose is now normal. I really think it was
mishandling of the blood the first time.

Judy Dilworth, M.T. (ASCP)
Microbiology

> Well guys, my FBG came back normal at 90 mg/dL, but my RBCs are
> elevated:
[quoted text clipped - 6 lines]
> like this for at least 5 years, and no symptoms related to it, I
> think.
douglas - 06 Oct 2008 01:50 GMT
On Oct 4, 10:16 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> http://www.emedicine.com/MED/topic1863.htmhttp://www.drkaslow.com/html/blood_cel
l_counts.htmlhttp://www.aafp.org/afp/20040501/2139.html

>
[quoted text clipped - 34 lines]
>
> - Show quoted text -

I have been an asthmatic, but it's been a while since I've had an
attack. No, I don't live in high altitudes.
JEDilworth - 06 Oct 2008 06:35 GMT
Being an asthmatic can cause your body to compensate by producing more
RBC's, hence making your hematocrit go higher.

Does your doc think your RBC's/Hct are elevated due to your asthmatic
condition or something else? I would think once an asthmatic, always an
asthmatic, regardless of attacks or not. If you're using an inhaler,
you're considered an asthmatic, even if you are under good control. Big
question - if your RBC's have been elevated for 5 years, have you had
asthma for over 5 years???????

These are basic inquiries you should be making before you go trotting
off to an expensive hematologist. This is part of the basic differential
diagnosis. If your FP doc doesn't know this, perhaps you should be
seeing an internist. If you are symptomatic, then that is another
situation all together and you should see a specialist.

Douglas, did you look over any of those links I posted????

Judy Dilworth, M.T. (ASCP)
Microbiology

> > RBC count: 5.97 million cells/uL
> > Hb: 17.9 g/dL
[quoted text clipped - 3 lines]
> > like this for at least 5 years, and no symptoms related to it, I
> > think.

I have been an asthmatic, but it's been a while since I've had an
attack. No, I don't live in high altitudes.
douglas - 06 Oct 2008 23:20 GMT
On Oct 5, 10:35 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> Being an asthmatic can cause your body to compensate by producing more
> RBC's, hence making your hematocrit go higher.
[quoted text clipped - 27 lines]
> I have been an asthmatic, but it's been a while since I've had an
> attack. No, I don't live in high altitudes.

I haven't had an attack in two years, or needed my inhaler, even my
fluticasone one.

He just said "go see a hematologist; here's ones in your area".
JEDilworth - 07 Oct 2008 06:29 GMT
So, are you going to do this? What do your parents think (assuming your
<18 years old)?

If this is "new patient" blood work, how do you know you've run a high
RBC count for 5 years????

Douglas, getting information out of you is like pulling teeth!

Judy Dilworth, M.T. (ASCP)
Microbiology

I haven't had an attack in two years, or needed my inhaler, even my
fluticasone one.

He just said "go see a hematologist; here's ones in your area".
douglas - 07 Oct 2008 18:41 GMT
On Oct 6, 10:29 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> So, are you going to do this? What do your parents think (assuming your
> <18 years old)?
[quoted text clipped - 11 lines]
>
> He just said "go see a hematologist; here's ones in your area".

B/c the last time I had a CBC, it was w/ my old pediatrician, who I
saw 5 years ago, and my FP's group bought out his group, so they have
those records.
JEDilworth - 08 Oct 2008 06:02 GMT
So, you're consistently running a high hematocrit/RBC count. This is
obviously not a new event. However you are or not developing symptoms?
Not quite sure with your vague answers. What prompted you to see the doc
in the first place? Anything going on?

What are you going to do about the hematologist??

Judy Dilworth, M.T. (ASCP)
Microbiology

> He just said "go see a hematologist; here's ones in your area".

B/c the last time I had a CBC, it was w/ my old pediatrician, who I
saw 5 years ago, and my FP's group bought out his group, so they have
those records.
douglas - 09 Oct 2008 01:54 GMT
On Oct 7, 10:02 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> So, you're consistently running a high hematocrit/RBC count. This is
> obviously not a new event. However you are or not developing symptoms?
[quoted text clipped - 11 lines]
> saw 5 years ago, and my FP's group bought out his group, so they have
> those records.

It was time for a checkup, and my Mom wanted some tests run. This was
an incidental finding, but I guess my FP was concerned enough to run
an erythropoietin level. The hematologist's office will be calling us
back to schedule the appointment, after some strong-arming by the FP,
b/c apparently, even though I'm 17 and ~200lbs, they considered me a
child, notwithstanding the fact that my body is anatomically and
physiologically an adult; any medications I needed would be titrated
for an adult. But no, they want me to see a pediatric
hematologist...apparently the MA doesn't know that pediatric and adult
hematology is VASTLY different, esp. w/ regards to fellowships.
JEDilworth - 09 Oct 2008 05:37 GMT
But, hematologically, you are not quite an adult. Even though you are a big kid, your marrow status might be more pediatric than adult at this point. Bone plates don't fuse until your 20's, especially in boys, as they develop later than girls. Also, at 200 pounds, unless you are really tall, you should probably think about cutting out those sugary lattes...

http://www.jamesline.com/news/publications/frontiers/archives/?ID=2416

You'll notice on this chart that cancer rates don't really drop until mid-20's, so, hematologically speaking, you're still more in the pediatric part of the graph. Hematologists also deal with cancers - that is the only reason I posted this.

http://doctor.mcw.edu/clinic.php?75 - most of the pediatric hematologists/oncologists on this list give ages of 0-18 and some even go up to age 30.

http://tinyurl.com/4onno3 - Lab Corp normals for Erythropoietin - please notice the different results for different age levels. Adult normals are different than for your age group. What was your result? Please realize different labs' normals may vary a bit.

What does your appointment and health have to do with fellowships???? Who is the MA? Your mom?

Judy Dilworth, M.T. (ASCP)
Microbiology

It was time for a checkup, and my Mom wanted some tests run. This was
an incidental finding, but I guess my FP was concerned enough to run
an erythropoietin level. The hematologist's office will be calling us
back to schedule the appointment, after some strong-arming by the FP,
b/c apparently, even though I'm 17 and ~200lbs, they considered me a
child, notwithstanding the fact that my body is anatomically and
physiologically an adult; any medications I needed would be titrated
for an adult. But no, they want me to see a pediatric
hematologist...apparently the MA doesn't know that pediatric and adult
hematology is VASTLY different, esp. w/ regards to fellowships.
douglas - 09 Oct 2008 14:06 GMT
On Oct 8, 9:37 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> But, hematologically, you are not quite an adult. Even though you are a big kid, your marrow status might be more pediatric than adult at this point. Bone plates don't fuse until your 20's, especially in boys, as they develop later than girls. Also, at 200 pounds, unless you are really tall, you should probably think about cutting out those sugary lattes...
>
[quoted text clipped - 21 lines]
> hematologist...apparently the MA doesn't know that pediatric and adult
> hematology is VASTLY different, esp. w/ regards to fellowships.

I'm 6' 1", BTW.

The MA was not my Mom. My Mom's an RN. My erythropoietin is 8.1
Manky Badger - 09 Oct 2008 16:55 GMT
"douglas" <Protoman2050@gmail.com> wrote in message
news:8d1cc419-ac3e-4afb-b356-

My Mom's an RN. My erythropoietin is 8.1

_________________________________________

8.1 what ? Meganewtons per cubic parsec?
douglas - 09 Oct 2008 20:11 GMT
> "douglas" <Protoman2...@gmail.com> wrote in message
>
[quoted text clipped - 5 lines]
>
> 8.1 what ? Meganewtons per cubic parsec?

mU/mL
Manky Badger - 09 Oct 2008 21:02 GMT
On Oct 9, 8:55 am, "Manky Badger" <you.m...@be.joking> wrote:
> "douglas" <Protoman2...@gmail.com> wrote in message
>
[quoted text clipped - 5 lines]
>
> 8.1 what ? Meganewtons per cubic parsec?

mU/mL
__________________________________________

And the relevant age & gender related reference range is.....
douglas - 10 Oct 2008 00:39 GMT
> On Oct 9, 8:55 am, "Manky Badger" <you.m...@be.joking> wrote:
>
[quoted text clipped - 12 lines]
>
> And the relevant age & gender related reference range is.....

4.1-15, if I remember.
Manky Badger - 10 Oct 2008 08:05 GMT
On Oct 9, 1:02 pm, "Manky Badger" <you.m...@be.joking> wrote:
> "douglas" <Protoman2...@gmail.com> wrote in message
>
[quoted text clipped - 14 lines]
>
> And the relevant age & gender related reference range is.....

4.1-15, if I remember.
________________________________________________

So your red-cell related parameters are a tad to the top end of the
reference range, but not excessively so, and your Epo is well within the
expected range.

I'm sorry Dougas, but I'm suspecting another of your wind-ups here.
douglas - 10 Oct 2008 21:29 GMT
> On Oct 9, 1:02 pm, "Manky Badger" <you.m...@be.joking> wrote:
>
[quoted text clipped - 27 lines]
>
> - Show quoted text -

It's not, trust me. I see the hematologist on Wednesday at 2pm.
JEDilworth - 10 Oct 2008 17:26 GMT
So, Douglas, for the SECOND time, who is the MA and what is all this to
do with fellowships? If your mom is a nurse she should be asking some
hard questions about the necessity for this referral at this point.
Please realize that all of this stuff will go into your permanent
medical record and will count towards your insurability as an adult. Do
you want this stuff on the big medical insurance computer in Boston or
not? That's where it will go and could possibly affect your buying life
insurance AND/OR medical insurance in the near/far future. I would want
a GOOD REASON for seeing a hematologist. This is not BS. My husband has
high BP issues and I've been through this many times with him.

Your EPO is normal, I guess. So, why the referral? Obviously I am not a
doc or a hematologist, so just curious.

Judy Dilworth, M.T. (ASCP)
Microbiology

On Oct 8, 9:37 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
> hematologist...apparently the MA doesn't know that pediatric and adult
> hematology is VASTLY different, esp. w/ regards to fellowships.

I'm 6' 1", BTW.

The MA was not my Mom. My Mom's an RN. My erythropoietin is 8.1
douglas - 10 Oct 2008 21:28 GMT
On Oct 10, 9:26 am, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> So, Douglas, for the SECOND time, who is the MA and what is all this to
> do with fellowships? If your mom is a nurse she should be asking some
[quoted text clipped - 21 lines]
>
> The MA was not my Mom. My Mom's an RN. My erythropoietin is 8.1

My FP ordered the consult, and I was saying that adult hematologists
get exposed to different diseases in their training than pediatric
hematologists. The MA was the girl who answered the phone of the
hematologist's office. My mom did ask the FP why, and she was also
concerned about my headaches and leg pain.
Manky Badger - 10 Oct 2008 23:21 GMT
> my headaches and leg pain.

Anything else you've not mentioned?
douglas - 11 Oct 2008 03:24 GMT
> > my headaches and leg pain.
>
> Anything else you've not mentioned?

No, just occasional itching of my skin.
JEDilworth - 11 Oct 2008 05:46 GMT
MA = Medical assistant. Now I get it.

Hematologically, you are considered an adolescent, not quite an adult.
You are going to the correct specialist.

If you are having symptoms along with the high RBC/hematocrit, then you
definitely have to get it checked out.

Good luck.

Judy Dilworth, M.T. (ASCP)
Microbiology

My FP ordered the consult, and I was saying that adult hematologists
get exposed to different diseases in their training than pediatric
hematologists. The MA was the girl who answered the phone of the
hematologist's office. My mom did ask the FP why, and she was also
concerned about my headaches and leg pain.
douglas - 11 Oct 2008 08:17 GMT
On Oct 10, 9:46 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> MA = Medical assistant. Now I get it.
>
[quoted text clipped - 14 lines]
> hematologist's office. My mom did ask the FP why, and she was also
> concerned about my headaches and leg pain.

So, what tests could I expect from Dr L, the hematologist? Flow-
cytometry-analysed bone marrow aspiration, 2,3-DPG levels, sonogram of
my legs to check for microthrombi?

Think my erythrocytosis is causing PVD, b/c I've also noticed my toes
tend to be paler then the rest of my body? Would I be put on
clopidogrel+acetylsalicylic acid for the presumable PVD?
Robert - 11 Oct 2008 10:19 GMT
> On Oct 10, 9:46 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
> wrote:
[quoted text clipped - 31 lines]
>
> - Show quoted text -

You need to take a deep breathe there. It does bring up one important
point and that is O2 saturation levels. If it less than 92% then one
needs to look at cardiopulmonary disease or obesity. Sometimes sleep
apnea can cause polycythemia. Also splenomegaly is also important and
becomes more so as hematocrit raises. The normal erythropoietin sort
of implies that it is not an increased red cell mass however. In
secondary polycythemia EPO is increased and in primary EPO is
decreased. One can measure red cell mass by Cr51 isotope studies. What
it appears to be is relative erythrocytosis or a plasma volume being
decreased rather than red cell mass increased. The most common cause
is dehydration although some can be idiopathic. I take it you are not
a smoker and so if one looks at the probability of etiology of
polycythemia nonsmokers in adults one finds that P vera comprises 33%
with Relative erythrocytosis comprising 65% and tumors and other
causes yielding 1%. This would be for adults and so it probability
breaks down  different in peds for obvious reasons. The bone marrow
exam is way down the list at the very end once everything else has
been looked at.
douglas - 11 Oct 2008 18:05 GMT
> > On Oct 10, 9:46 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
> > wrote:
[quoted text clipped - 52 lines]
>
> - Show quoted text -

I don't smoke, and my electrolytes --I had a CMP done at the same time
as the CBC-- show I'm not dehydrated. I think Dr L will do a pulse
oximetry on me. And I have other people confirming I don't have sleep
apnea.
JEDilworth - 11 Oct 2008 18:18 GMT
Thanks for the great post, Robert. My Hematology days are WAY in the
past, and there's lots of new stuff out there. I agree that a bone
marrow exam is far down the list. Invasive testing is usually not the
first thing docs do unless there's a huge suspicion of something bad
going on. My mother-in-law was diagnosed with CLL (chronic lymphocytic
leukemia) back in the mid-80's after two suspicious CBC's. She was in
her early 60's at the time. She was referred to a hematologist and they
did a marrow right away. She had no symptoms of a viral infection but
her absolute lymphocyte count was very elevated and smudge cells were
present. The slides had been reviewed by pathologists and her internist
made the referral immediately. She lived another 12 years after that.

Douglas, you need to take a deep breath and let the doctor do their job.
They have spent years doing what they do. You can "internet" yourself to
death on this stuff. They usually don't order the really expensive
testing unless they have to do so. Insurance companies complain about
overutilization if they do. This is what they do for a living and they
deal with this stuff a lot.

Judy Dilworth, M.T. (ASCP)
Microbiology

> - Show quoted text -

You need to take a deep breathe there.
Robert - 11 Oct 2008 20:01 GMT
On Oct 11, 10:18 am, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> Thanks for the great post, Robert. My Hematology days are WAY in the
> past, and there's lots of new stuff out there. I agree that a bone
[quoted text clipped - 21 lines]
>
> You need to take a deep breathe there.

The role of the hematological consult is to rule out primary
hematological disease. They don't follow every led. The question they
answer is it a hematologic disorder or is it reactive to some other
disorder and they punt the ball back to the PCP. They aren't
cardiologist or pulmonologist.
Some of the issues people have already mentioned pertaining to PV,
secondary polycemia pertaining to lung, heart and abdominal masses.The
only other remote possibility is a high affinity hemoglobin but no
family history or it being a congenital condition as it seems to be
acquired and not present at birth. All of the specific tests have
varying sensitivities and specificity with regards to all of the above
possibilities and there is some overlap.

At the heart of the question and a major branch in the flow
diagnostics involves on determining if it is an increase red cell mas
or not. If there isn't then it's a relative polycythemia. In males
with a >60% HCT or in females with a > 55% HCT one can assume a 99%
probability that the red cell mass is truly increased. In patients
with a high hematocrit, splenomegaly is almost 100% specific for P.
vera.

There is a Criteria for diagnosis of PV.
Category A                                   Category B
A1 Total RBC Mass increased        B1 Thrombodytosis > 400K
A2 Arterial saturation O2 > 92%      B2 Leukocytosis > 12K
A3 Spenomegaly                           B3 LAP score >100
                                                   B4 Serum B12 >900

PV: A1 + A2 + A3 or A1 + A2 + any two from category B

A search for a renal mass or abdominal mass would involve IVP,
ultrasound or CT in those suspected of having a tumor secreting EPO.

Maybe the hematologist will see something pointing to a primary
hematological disorder but the only thing so far is erythrocytosis.

The info above came from "Reasoning and Decision making in
Hematology", edited by Benjamin Djulbegovic.

With regards to CLL, apart from the smudge cells and elevated
lymphocytes, is the classic look of the cells themselves. I have seen
them in relatively mildly elevated white counts of 12K. They have a
unique chromatin pattern.
JEDilworth - 12 Oct 2008 03:51 GMT
Thanks again for all the good information on PV. If we covered that in
our basic MT training at all, I've forgotten it all, as I only did
hematology for a bit as a generalist over 20 years ago and never got
into anything abnormal. It makes sense what you are telling me about
hematologists in their consultant roles.

As I recall, my MIL's white count was not particularly elevated when she
presented with CLL. She came to the lab draw station I was working at
then (a two year stint as a generalist) and I decided (good thing) not
to do her CBC and send it up to the main lab. When it came back abnormal
and she was calling about results (in the days before HIPAA) I didn't
know what to do. The hematology department at our main lab had a real
sharp supervisor, and her diff had been referred to her due to the
abnormalities in absolute lymph count. She ultimately referred it to the
pathologist for review, but she picked up on "the look" of the cells
immediately and hit the diagnosis. The pathologist just confirmed it.
After being referred to the hematologist, my MIL was told she had
probably had CLL for a couple of years before it was discovered via the
blood count, which would make the onset somewhere around 1983. She died
of complications from a stroke in 1997, which was probably caused by her
platelet problems that she developed years later, althoug when first
diagnosed her platelets were low but not extremely so.

She needed heart valve surgery in 1995 (due to deterioration from
rheumatic fever in the 1930's) and needed platelet transfusions before
the surgery because of the CLL. Afterwards, she stroked out the day
before she was to go home when they were weaning her from heparin to
coumadin. She lived another year and a half without being able to walk
or talk due to right-sided paralysis and went to a nursing home. She
developed a bowel obstruction after going to live with her son in
another state, and no surgeon would take on the surgery due to her
extremely complicated health issues of stroke, atrial fibrillation, CLL
issues (platelets up and down, white count up and down, etc.),
paralysis, inability to communicate, etc. and she died from this. It was
12 years after she was diagnosed with CLL.

Thanks again Robert. Are you a technologist, doctor, ?? You give great
explanations :-).

Judy Dilworth, M.T. (ASCP)
Microbiology

The role of the hematological consult is to rule out primary
hematological disease. They don't follow every led. The question they
answer is it a hematologic disorder or is it reactive to some other
disorder and they punt the ball back to the PCP. They aren't
cardiologist or pulmonologist.
Robert - 12 Oct 2008 08:50 GMT
On Oct 11, 7:51 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> Thanks again for all the good information on PV. If we covered that in
> our basic MT training at all, I've forgotten it all, as I only did
[quoted text clipped - 43 lines]
> disorder and they punt the ball back to the PCP. They aren't
> cardiologist or pulmonologist.

Thanks Judy no I am a MT in a large teaching hospital. I get called in
on difficult cases because of my all around experience and years of
put in which I have seen some rare cases some of which includes basic
micro, gram stains, wet preps, malaria, etc. I have seen Borrelia on
blood smears, and even Capnocytophaga from a dog bite on a blood
smear. So I do get involved in teaching including answering interns
questions. I did take the week long hematology ASCP workshop for
hematologist and pathologist which was more clinical than the MT
workshops. Actual microscope slides included rare blood disorders but
that was a few years back and like anything else things continually
change. It really is hard to keep up with all areas of the lab as a
generalist and not miss anything.

It's sad to be the bearer of bad news and to see how such a diagnosis
can impact a person and it just isn't a laboratory finding and go home
and forget it. We have to go on code blues also. It is emotionally
draining especially seeing the family. That is especially true of
difficult cases that cause the person to stay in the hospital for
months or for major trauma cases requiring massive transfusions. We
aren't at the beside but we fight for our patients. When we win one it
feels so good and when we lose one then there is always hope for the
next one.
douglas - 13 Oct 2008 19:44 GMT
On Oct 11, 10:18 am, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> Thanks for the great post, Robert. My Hematology days are WAY in the
> past, and there's lots of new stuff out there. I agree that a bone
[quoted text clipped - 21 lines]
>
> You need to take a deep breathe there.

I'm letting them do their job; is it wrong to be an informed patient?
JEDilworth - 13 Oct 2008 21:49 GMT
Not at all. You just seem to be enamored with complicated expensive lab
testing, that's all.

Let us know what happens.

Judy Dilworth, M.T. (ASCP)
Microbiology

I'm letting them do their job; is it wrong to be an informed patient?
Manky Badger - 09 Oct 2008 08:29 GMT
On Oct 7, 10:02 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> So, you're consistently running a high hematocrit/RBC count. This is
> obviously not a new event. However you are or not developing symptoms?
[quoted text clipped - 15 lines]
> saw 5 years ago, and my FP's group bought out his group, so they have
> those records.

It was time for a checkup, and my Mom wanted some tests run.
___________________________________________________________

Why are you having a checkup?
Why does your mother want  tests running?
none - 06 Oct 2008 09:02 GMT
A healthy person is a person who has not been thoroughly examined. We do not
all lie in the middle of the "normal range" - that is why we call it
reference range.

I don't think there is much to be alarmed over in those figures.
yes - the hct and the RBC is a bit high - and to be on the safe side, your
doc will probably dig into that (defensive practice)- but what about your
diurese? what if you are just a bit dehydrated for one or more reasons?
looking at the figures for MCV and MCHC does not suggest that your blood
pattern is disturbed - and your WBC looks quite ok as well - and eosinophils
are low suggesting that you are not suffering an allergic response.

You say in one letter that you suffer headaches and orthostatic
hypotension - first of all this is not unusual for a teenager (as you claim
to be, n'est ce pas?), secondly it could also suggest a tendency to be a
little dehydrated - eat and eat with a bit of sense (living on coffee and
coke and sugar is suicide - however slow it may be), and drink - water! - a
couple of liters per day.

Occasional pain during walking a stairs climbing - well well, get off the
computer and start exercising - loose some weight if you are too fat, gain
some muscle if you are too skinny.

Discussing your health by judging lab work only is impossible.
Remember - most doctors rely on the fact that many, many diseases are of the
kind that if it doesn't kill you it'll probably diappear by itself. -
And one last thing - you are not in a hospital setting, so most probably you
are a healthy individual -

I seem to have lost track - why did you have the blood work done in the
first place?
Manky Badger - 06 Oct 2008 10:39 GMT
> I seem to have lost track - why did you have the blood work done in the
> first place?

At the risk of appearing cynical, it's either hypochondria or attention
seeking.
Robert - 06 Oct 2008 18:51 GMT
> A healthy person is a person who has not been thoroughly examined. We do not
> all lie in the middle of the "normal range" - that is why we call it
[quoted text clipped - 27 lines]
> I seem to have lost track - why did you have the blood work done in the
> first place?

Yes, I would like to see the sodium level along with the questions you
pose about diuresis.
douglas - 06 Oct 2008 23:21 GMT
> A healthy person is a person who has not been thoroughly examined. We do not
> all lie in the middle of the "normal range" - that is why we call it
[quoted text clipped - 27 lines]
> I seem to have lost track - why did you have the blood work done in the
> first place?

My electrolytes are fine, according to the CMP. And my urine is
dilute.

The labwork was routine, new patient stuff.
Robert - 07 Oct 2008 00:01 GMT
> > A healthy person is a person who has not been thoroughly examined. We do not
> > all lie in the middle of the "normal range" - that is why we call it
[quoted text clipped - 34 lines]
>
> - Show quoted text -

I take it no history of heart disease in which a BNP would detect an
ineffective circulating blood volume?

One would usually see and increased urine specific gravity along with
prerenal azotemia involving increased hylaine casts and elevated BUN
and sodium levels with dehydration.

The other possibility again can be drawing artifacts of leaving the
tourniquet on too long with hemostasis (hemoconcentration)  showing
up. One should not squeeze hard or make a hard fist as it can also
elevate the potassium levels. I take it you are not a difficult draw.
douglas - 07 Oct 2008 03:26 GMT
> > > A healthy person is a person who has not been thoroughly examined. We do not
> > > all lie in the middle of the "normal range" - that is why we call it
[quoted text clipped - 48 lines]
>
> - Show quoted text -

Haven't done a urinalysis. I did have a congenital PFO which self-
corrected. Is that heart disease?

Refresh my memory...what's a BNP?
Robert - 07 Oct 2008 03:53 GMT
> > > > A healthy person is a person who has not been thoroughly examined. We do not
> > > > all lie in the middle of the "normal range" - that is why we call it
[quoted text clipped - 55 lines]
>
> - Show quoted text -

Don't worry about it as the other poster noted that the clinical
situation takes precedence over lab stuff. BNP info is here
http://www.labtestsonline.org/understanding/analytes/bnp/glance.html

I just wondering what else you have up your sleeve as we were talking
about hypoglycemia and then see an EPO result out of nowhere.
none - 08 Oct 2008 08:28 GMT
I just wondering what else you have up your sleeve as we were talking
about hypoglycemia and then see an EPO result out of nowhere.

Exactly - - "new patient stuff" - routine my ...
rickh - 14 Oct 2008 05:23 GMT
> Well guys, my FBG came back normal at 90 mg/dL, but my RBCs are
> elevated:
[quoted text clipped - 24 lines]
>
> Thanks!

Perhaps we should rename this thread much ado about nothing.  From my
limited pespective you are a teenage male with rbc/hgb/hct at the top
end or slightly above normal. If anyone is likely to run at the top of
the reference range for these measurements, I would think it would be
teenage boys. It seems like a slightly abberent measurment which has
led to a lot of speculation. Have you had a repeat CBC?
douglas - 14 Oct 2008 06:31 GMT
> > Well guys, my FBG came back normal at 90 mg/dL, but my RBCs are
> > elevated:
[quoted text clipped - 33 lines]
>
> - Show quoted text -

This WAS my repeat CBC.
Manky Badger - 14 Oct 2008 23:00 GMT
Perhaps we should rename this thread much ado about nothing.
____________________________________________________

What he said !!!!
douglas - 15 Oct 2008 06:34 GMT
> Perhaps we should rename this thread much ado about nothing.
> ____________________________________________________
>
> What he said !!!!

I'll inform you tomorrow what the hematologist said.
Manky Badger - 15 Oct 2008 17:31 GMT
On Oct 14, 3:00 pm, "Manky Badger" <you.m...@be.joking> wrote:
> "rickh" <harrison6...@rogers.com> wrote in message
>
[quoted text clipped - 4 lines]
>
> What he said !!!!

I'll inform you tomorrow what the hematologist said.
____________________________________________

Like we don't know already.

I'd also be interested to know what his opinion cost you (or your mother)
douglas - 16 Oct 2008 00:33 GMT
> On Oct 14, 3:00 pm, "Manky Badger" <you.m...@be.joking> wrote:
>
[quoted text clipped - 13 lines]
>
> I'd also be interested to know what his opinion cost you (or your mother)

He ordered an ABG, CXR, and US of my spleen and kidneys, as well as a
pulse oximetry, CBC, ferritin, uric acid, JAX2, LAP, one I can't
remember, and a blood film. e wants to see me again in a month.
Manky Badger - 16 Oct 2008 07:51 GMT
On Oct 15, 9:31 am, "Manky Badger" <you.m...@be.joking> wrote:

> I'd also be interested to know what his opinion cost you (or your mother)

He ordered an ABG, CXR, and US of my spleen and kidneys, as well as a
pulse oximetry, CBC, ferritin, uric acid, JAX2, LAP, one I can't
remember, and a blood film. e wants to see me again in a month.
______________________________________________________________

Of course he did.
He loves patients like you. He'll want to see you for evermore.

You've found out all about these big words and you are saying "why not do
this, why not do that". From the symptoms yuo've disclosed (so far) there's
very little (if anything) wrong with you so he's not got to actually *do*
anything.
However you're asking for all these uttlerly unececsary tests and so he's
laughing all the way to the bank.
douglas - 16 Oct 2008 14:10 GMT
> On Oct 15, 9:31 am, "Manky Badger" <you.m...@be.joking> wrote:
>
[quoted text clipped - 14 lines]
> However you're asking for all these uttlerly unececsary tests and so he's
> laughing all the way to the bank.

Actually, he said the tests I wanted were overkill, let's start here
first; my Mom wanted him to do some of them to.

I didn't disclose EVERYTHING now did I? Headaches, joint pain, ad some
balance problems are the main ones.
Manky Badger - 16 Oct 2008 20:58 GMT
"douglas" <Protoman2050@gmail.com> wrote in message
news:70e1725c-e99b-4287-b1f8-

Actually, he said the tests I wanted were overkill, let's start here
first; my Mom wanted him to do some of them to.

I didn't disclose EVERYTHING now did I? Headaches, joint pain, ad some
balance problems are the main ones.
__________________________________________________________

So you've got him struggling trying to make sense of your games with only a
fraction of the required information too.
douglas - 17 Oct 2008 00:29 GMT
> "douglas" <Protoman2...@gmail.com> wrote in message
>
[quoted text clipped - 9 lines]
> So you've got him struggling trying to make sense of your games with only a
> fraction of the required information too.

I said I didn't disclose everything to you...I did disclose everything
to my physicians.
 
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